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MevacorThis page contains recent news articles, when available, and an overview of Mevacor but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Mevacor (when available) Lovastatin, an antilipemic agent produced by fermentation of Aspergillus terreus, is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovastatin is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovastatin, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation. For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease Mechanism Of Action: Lovastatin is a lactone that is readily hydrolyzed in vivo to the corresponding b-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol. News Articles on Lovastatin Enzyme may reduce benefit of cholesterol drugs - Apr 1, 2009 NEW YORK (Reuters Health) - New research suggests that the cholesterol-lowering ability of "statin" drugs, like Lipitor and Mevacor, is blunted when the Reuters Statins Cut Stroke Risk by One-Fifth in Meta-Analysis - Apr 14, 2009 Other drugs tested in the trials included rosuvastatin (Crestor), pravastatin (Pravachol), atorvastatin (Lipitor), and lovastatin (Mevacor). MedPage Today Grapefruit and Prescription Drugs: Mix Carefully - Mar 30, 2009 In addition, widely prescribed drugs for lowering cholesterol have been added to the list -- well-known drugs such as Lipitor, Mevacor, and Zocor (but not Online - International News Network Una enzima reduce beneficio de los fármacos para el colesterol - Apr 2, 2009 NUEVA YORK (Reuters Health) - La capacidad de reducir el colesterol de las estatinas, como Lipitor y Mevacor, disminuye cuando la sangre contiene altos elEconomista.es 혈액내 효소 'ì½œë ˆìŠ¤í…Œë¡¤ 낮추는 약물' 약발 떨어뜨린다 - Apr 1, 2009 ...ë¦¬í”¼í† ë‚˜ 메바코(Mevacor) ê°™ì?€ ì½œë ˆìŠ¤í…Œë¡¤ì?„ 낮추는 스타틴 약물ì?˜ 효과가 'phospholipid transferprotein'ì?´ë?¼ëŠ” 혈액내 효소가 높ì?„ ì‹œ 떨어질 수 있다는 연구결과 Medical Today Alternative options that can help improve memory - 18 Mar 2009 ...statin drugs that are prescribed to control cholesterol levels—such as Liptor, Mevacor, Zocor, Lescol, Crestor and Advicor—can cause severe memory loss. BCLocalNews Satin drugs: A health hazard? - Mar 16, 2009 According to news reports, statin drugs (Lipitor, Zocor, Pravachol, Crestor, Lescol and Mevacor) are the most effective cholesterol-lowering drugs available Merinews The People's Pharmacy - Mar 4, 2009 A: Red-yeast rice contains some lovastatin, the ingredient in the prescription drug Mevacor. There are also other statinlike compounds in this dietary Seattle Times Loss of Power Could Stem From Medication - Mar 11, 2009 He writes: “Statin drugs (Lipitor, Zocor, Pravachol, Crestor, Lescol and Mevacor) are the most effective cholesterol-lowering drugs available. Korea Times Cholesterol Drugs May Help Asthma Patients - Mar 16, 2009 The other patients were on Pravachol, Mevacor, Lescol, or a combination of drugs. Over a one-year period, 20.5% of patients taking statins were hospitalized WebMD The People's Pharmacy - Mar 4, 2009 A: Grapefruit slows elimination of some statin drugs (Mevacor, Lipitor and Zocor). That means that if you eat grapefruit or drink grapefruit juice, Seattle Times Do cholesterol drugs really work? - Feb 25, 2009 ...(Statins are: Zocor, Pravachol, Crestor, Lescol, Mevacor and Lipitor.) Muscle pain occurs in 1 in 1000 users. Muscle damage occurs in much fewer. Payson Roundup Anti-Cholesterol Drug May Ease Back Pain - Feb 24, 2009 23 (HealthDay News) — The cholesterol-lowering drug lovastatin (Mevacor) might improve outcomes for people who have surgery for degenerative disc disease, Health.com Cholesterol Drugs Linked to Increased Fatigue - Mar 12, 2009 Other popular statins include drugs such as Crestor, Lipitor and Mevacor. What's the potential link? According to Golomb, it's possible that the drugs may U.S. News & World Report Statins Cut Deaths From Prostate Cancer - Feb 26, 2009 Zocor, and Crestor were linked to a lower risk of dying from prostate cancer even more than weaker statins like Mevacor, Pravachol, and Lescol. WebMD New study supports statin's anti-dementia effects - Mar 2, 2009 Examples of fat soluble statins are atorvastatin (Lipitor), simvastatin (Zocor), lovastatin (Mevacor), or fluvastatin (Lescol). Canada.com Just what is a total cholesterol count? - Mar 5, 2009 My only recommendation would be for periodic lab testing, since red yeast rice can affect the liver because it is a natural statin similar to Mevacor. Telegraph-Journal Статины могут вызывать повышенную утомлÑ?емоÑ?Ñ‚ÑŒ - Mar 15, 2009 Также они Ñ?читают, что и другие популÑ?рные Ñ?татины - Crestor, Lipitor и Mevacor – имеют Ñ?хожий Ñ?ффект. БиатриÑ?Ñ? Голомб, Ñ?оавтор иÑ?Ñ?ледованиÑ?, предполагает, МЕДСТРИМ.РУ - консультации врачей, новости медицины Статины помогут облегчить боль в поÑ?Ñ?нице - Feb 25, 2009 Препарат длÑ? Ñ?нижениÑ? уровнÑ? холеÑ?терина lovastatin (Mevacor) улучшает Ñ?оÑ?тоÑ?ние людей, которые перенеÑ?ли операции в Ñ?вÑ?зи Ñ? дегенеративным заболеванием МЕДСТРИМ.РУ - консультации врачей, новости медицины 스타틴 '메바코' 디스í?¬ 환ìž? ê°œì„ íš¨ê³¼ ë³´ì—¬ - Feb 23, 2009 ...ì½œë ˆìŠ¤í…Œë¡¤ ì¹˜ë£Œì œì?¸ '메바코(Mevacor, lovastatin)'ê°€ 퇴행성 디스í?¬ 질환으로 ìˆ˜ìˆ ë°›ì?€ 환ìž?ì?˜ ì¦?ìƒ? ê°œì„ ì—? ë?„움ì?„ 준다는 연구결과가 ë?¼ìŠ¤ë² 가스ì—?ì„œ 열리는 메디게이트뉴스 Aching Back? Cholesterol Medication Might Help - Feb 23, 2009 Back pain, a hallmark of degenerative disc disease, sends millions of people to their doctor. In fact, more than 80 percent of patients who undergo spine PhysOrg.com CoQ10, ubiquinol same nutrient, but differ in quality, brands - Jan 17, 2009 Leg cramps and muscle pain can be the result of the drug mugging effect of statin cholesterol medicines such as Advicor, Pravachol, Zocor, Lipitor, Mevacor Tulsa World, Are doctors minimizing side effects of statins? - Jan 28, 2009 Include lovastatin (brand name Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor) and rosuvastatin San Diego Union Tribune, Firm joins drug giant in venture - Jan 13, 2009 Many pharmaceuticals are polyketides, such as the anti-cholesterol drugs Mevacor, Pravachol and Zocor; the anticancer drugs Torisel and Ixempra; Pharmacy Europe, Research and Markets: Case Studies and Future Considerations ... - Jan 12, 2009 In 2001, a generic version of the statin Mevacor entered the US market. How did Mevacor's manufacturer, Merck, respond" How did makers of other branded PR-Inside.com (Pressemitteilung), Red Yeast Rice Slows Prostate Cancer Growth - Jan 29, 2009 ...the cholesterol-lowering drug, lovastatin (Mevacor). In fact, studies have shown that Chinese red yeast rice lowers cholesterol as well as lovastatin. Cancer Monthly, New study supports statin's anti-dementia effects - Jan 9, 2009 Examples of fat soluble statins are atorvastatin (Lipitor), simvastatin (Zocor), lovastatin (Mevacor), or fluvastatin (Lescol). MSNBC What you can do after a heart attack - Jan 21, 2009 ...[2] Some common statins are atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol) and simvastatin (Zocor). guardian.co.uk, Nuevo estudio respalda efectividad de estatinas contra demencia - Jan 14, 2009 Algunas de las estatinas solubles en grasa son la atorvastatina (Lipitor), la simvastatina (Zocor), la lovastatina (Mevacor) o la fluvastatina (Lescol). Buena Salud Estatinas podem ter efeito protetor contra Alzheimer, indica estudo - Jan 9, 2009 Entre as lipossolúveis estão a atorvastatina (Lipitor/Citalor), a sinvastatina (Zocor), a lovastatina (Mevacor) ea fluvastatina (Lescol). O Globo, El colesterol es tu mejor amigo - Jan 28, 2009 ...a surgir todos los efectos secundarios del veneno que es Crestor (y todas las otras statinas como Lipitor, Vytorin, Mevacor, Pravachol, Zocor y Caduet). Claridad, Over-the-counter statins aren't available in U.S. - Dec 22, 2008 In the most recent denial, issued in December 2007, an expert panel advised the FDA that Mevacor could be a safe and effective option for lowering Sun-Sentinel.com, Nobel Laureate Calls for Public Funding of Drug Trials - Dec 16, 2008 In the case of statins, for example, the first drug in the class was Merck’s Mevacor, which was later supplanted by the likes of Zocor and Pfizer’s Lipitor Wall Street Journal Blogs, Read instructions that come with prescription meds - Dec 15, 2008 The trade names of these drugs are Lipitor, Zocor and Mevacor. Several drugs prescribed for insomnia, depression and anxiety have interactions with Jackson Clarion Ledger, The Power of Statins - Dec 6, 2008 This concept led to the development of cholesterol-lowering statins, such as Mevacor (lovastatin), Zocor (simvastatin), Pravachol (pravastatin), Lipitor, Newsweek Statins Do Not Interfere With Rituximab Treatment For Lymphomas ... - Dec 8, 2008 Examples of commonly used statins in the US include Lipitor, Zocor, Parvachol, Lescol, Mevacor and Crestor. Rituximab (Rituxan), a monoclonal antibody, Science Daily (press release) Low Thyroid Hormone Increases Risk of Death from Heart Attack by ... - Dec 8, 2008 Natural thyroid hormone is dirt cheap, makes you feel great, and is about 50 times more effective than Lipitor or Mevacor (toxic drugs which cost billions Natural News.com, Dr. Donohue: Most recover fully from statin-induced muscle problems - 23 Nov 2008 A Statin drugs (Lipitor, atorvastatin; Zocor, simvastatin; Pravachol, pravastatin; Crestor, rosuvastatin; Lescol, fluvastatin; and Mevacor, lovastatin) are Pioneer Press, Crestor FAQ: New Benefits for Statins - Nov 10, 2008 Three other statin drugs are available as brand name or generic drugs: lovastatin (original brand name, Mevacor), pravastatin (original brand name, WebMD Eating grapefruit can work against several prescription medications - Nov 16, 2008 Grapefruit can influence Lipitor, Mevacor and Zocor. Grapefruit will cause these levels to be increased. When this occurs, it causes more muscle aches, News Chief, What can I do about my cholesterol? - Nov 5, 2008 Red yeast rice, an over-the-counter supplement used by some people to lower cholesterol levels, is a naturally occurring statin drug similar to Mevacor. GoErie.com, Dietary pills laced with drugs - Nov 10, 2008 Recalled March 28 because it contained lovastatin, the active ingredient in the prescription drug Mevacor. Metaboslim Apple Cider Vinegar dietary supplement Atlanta Journal Constitution, Eat Your Statins - Nov 16, 2008 Merck's (nyse: MRK - news - people ) Mevacor, built on Endo's work, hit the market in 1987. Trials in 1994 and 1995 of Merck's more potent follow-up, Zocor, Forbes, Merck: We're staying in heart disease research - Nov 8, 2008 The most important of Merck's heart drugs, according to Pasternak, was Mevacor, the first cholesterol-lowering statin drug when it came on the market in the BusinessWeek Statins Lower Prostate Cancer Marker - Oct 28, 2008 The statin drugs Crestor, Lescol, Lipitor, Mevacor, Pravachol, and Zocor lower cholesterol. Recent studies suggest they may lower men's risk of advanced WebMD Have a Placebo - Oct 28, 2008 ...disease but without a history of heart disease get no benefit from statin medications like Zocor, Lipitor, Pravachol and Mevacor, only side effects. Huffington Post, Statins Reduce Pneumonia Related Deaths - Oct 29, 2008 Statins include atorvastatin (Lipitor), pravastatin (Pravachol), fluvastatin (Lescol), lovastatin (Mevacor), rosuvastatin (Crestor) and several others. eMaxHealth.com, An Analysis of Effective Drug Life Cycle Management: Understand ... - Nov 9, 2008 The statin market as a life cycle case study: Mevacor; Pravachol; Zocor; Lescol; Lipitor; Baycol; Crestor. - Outlook and implications for the pharmaceutical PR-Inside.com (Pressemitteilung), Data continue to show differences in gastrointestinal and lipid ... - Oct 27, 2008 St. John’s wort (Hypericum perforatum), Mevacor® (lovastatin), Zocor® (simvastatin), Orap® (pimozide), Crixivan® (indinavir), or Viramune® (nevirapine). PipelineReview.com (press release), Cholesterol drug could cause cancer - Nov 6, 2008 Red yeast rice, an over-the-counter supplement used by some people to lower cholesterol levels, is a naturally occurring statin drug similar to Mevacor. New Haven Register (subscription), En quoi les hypocholestérolémiants peuvent-ils être utiles ? - Nov 10, 2008 ...la fluvastatine (Lescol®), la lovastatine (Mevacor® et génériques), la pravastatine (Pravachol® et génériques), la rosuvastatine (Crestor®) et la Canoë, ×”×?×? ×¡×˜×˜×™× ×™×? מורידי×? ×?ת הסיכון לסרטן ×¢×¨×ž×•× ×™×ª? - Oct 29, 2008 ...תרופות ×”×¡×˜×˜×™× ×™×? קרסטור (Crestor), לסקול (Lescol), ליפיטור (Lipitor), מבקור (Mevacor), פרבקול (Pravachol) וזוקור (Zocor) מורידות ×?ת רמות הכולסטרול. Nfc חדשות מחלקה ר×?×©×•× ×”, La terapia aggressiva con statine può contrastare la progressione ... - Oct 28, 2008 ...in un disegno fattoriale 2x2, a Warfarin ( Coumadin ) oa placebo, ea terapia ipocolesterolemizzante aggressiva con Lovastatina ( Mevacor ) 40-80 mg/die Cardiologia.net, Foods that Help Keep Cholesterol Low - Oct 9, 2008 While many people take statin drugs such as Lipitor, Zocor, and Mevacor to reduce high cholesterol, health experts say that some foods act like statins to 13WHAM-TV, US Food & Drug Administration Approved the use of REYATAZ(R ... - Oct 1, 2008 Halcion ® (triazolam), ergot medicines, Propulsid ® (cisapride), St. John’s wort (Hypericum perforatum), Mevacor ® (lovastatin), Zocor ® (simvastatin), WELT ONLINE, Big Pharma R&D: Things Are Tough All Over - Sep 24, 2008 Mevacor.) The research challenges multiply as scientists focus on newer targets that aren’t as well understood as those that led to statins or SSRIs. Wall Street Journal Blogs, FDA Study: Statins Don’t Pose Risk Of Lou Gehrig’s Disease - Sep 30, 2008 Inc’s Zocor and Mevacor; AstraZeneca Plc’s Crestor, Bristol-Myers Squibb Co.’s Pravachol and Novartis’ Lescol. Besides reducing heart risk, statins were eFluxMedia Meds can be a brain drain - Sep 7, 2008 Common cholesterol-lowering statin drugs such as Lipitor, Crestor, Zocor or Mevacor deplete one of the brain's critical antioxidant protectors called Chicago Tribune, This Year’s Lasker Awards for Medical Research: Top Five - Sep 15, 2008 Merck manufactured lovastatin (Mevacor), the first statin to be licensed, in 1987. Stanley Falkow, cancer research professor at the Stanford University eFluxMedia Natural ways to control cholesterol - Aug 25, 2008 The over-the-counter herbal supplement has chemical properties similar to lovastatin, a cholesterol-lowering medicine sold as Advicor, Altoprev and Mevacor. Arizona Republic, Statins: No Cancer Risk - Aug 20, 2008 Statin drugs include Lescol, Mevacor, Lipitor, Pravachol, Crestor, and Zocor. Karas and colleagues did not set out to look at cancer risk. WebMD Gene Behind Serious Statin Risk - Aug 20, 2008 Statin drugs -- Lipitor, Pravachol, Crestor, Lescol, Mevacor, and Zocor -- are considered remarkably safe. But one in every 10000 patients per year develops WebMD Start low with niacin treatment - Aug 26, 2008 As for red yeast rice, I do not recommend it because it is basically a natural form of the drug Mevacor, which is a statin. It is more likely to cause side GoErie.com, Discoverer Of Cholesterol Lowering Drugs Receives Lasker Award - Sep 14, 2008 In 1987, the FDA approved the drug (Mevacor®). The success of compactin and lovastatin inspired efforts to improve the statins by chemically modifying the eMaxHealth.com, Statin drugs: Benefits versus risks - Aug 26, 2008 Statin drugs such as Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin) and Zocor (simvastatin) work by partially Enid News & Eagle, Cholesterol Drug used to treat various cancers - Aug 21, 2008 ...‘Using laboratory cultures of esophageal cancer cells, the researchers found that adding simvastatin (Zocor), lovastatin (Mevacor), and pravastatin Justice News Flash, Can Drug Therapy Prevent Parkinson’s Disease? - Aug 25, 2008 ...includes the well-known and often-prescribed atorvastatin (Lipitor), simvastatin (Zocor), lovastatin (Altocor, Mevacor), and pravastatin (Pravachol). GNIF Brain Blogger, Xìu Tại Thuốc - Aug 29, 2008 Má»™t và i và dụ cho nhóm Statins nhÆ° Lovastatine (Mevacor), Pravastatine (Pravachol), Simvastatine (Zocor) …và má»™t và i và dụ cho nhóm fribrates nhÆ° Take2Tango Brand Names/Synonyms: Mevacor is also known by the following brand names and/or synonyms6alpha-Methylcompactin; Altocor; Altoprev; Artein; Belvas; Cholestra; Closterol; Colevix; Compactin; HSDB 6534; Hipolip; Hipovastin; Lestatin; Lipdip; Lipivas; Lipofren; Lovalip; Lovalord; Lovastatin; Lovastatin [Usan:Ban:Inn]; Lovastatina [Spanish]; Lovastatine [French]; Lovastatinum [Latin]; Lovasterol; Lovastin; Lozutin; MK 803; MK-803; ML-530B; MSD 803; Mevacor; Mevastatin; Mevinacor; Mevinolin; Mevlor; Monacolin K; Nergadan; Paschol; Pravastatin; Rodatin; Rovacor; Sivlor; Taucor; Tecnolip; Teroltrat Drug Category: Mevacor is categorized under the following by the FDA: Antineoplastic Agents; Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA02 Dosage Forms: Tablet Absorption: 30% Interactions: DRUG INTERACTIONS CYP3A4 Interactions Lovastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. Potent inhibitors of CYP3A4 (below) increase the risk of myopathy by reducing the elimination of lovastatin. Pharmacokinetics. Itraconazole Ketoconazole Erythromycin Clarithromycin Telithromycin HIV protease inhibitors Nefazodone Cyclosporine Large quantities of grapefruit juice (>1 quart daily) Interactions with lipid-lowering drugs that can cause myopathy when given alone. The risk of myopathy is also increased by the following lipid-lowering drugs that are not potent CYP3A4 inhibitors, but which can cause myopathy when given alone. See WARNINGS, Myopathy/Rhabdomyolysis. Gemfibrozil Other fibrates Niacin (nicotinic acid) (=1 g/day) Other drug interactions Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis). Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis). Coumarin Anticoagulants: In a small clinical trial in which lovastatin was administered to warfarin treated patients, no effect on prothrombin time was detected. However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin. Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs. Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of lovastatin is changed, the same procedure should be repeated. Lovastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants. Propranolol: In normal volunteers, there was no clinically significant pharmacokinetic or pharmacodynamic interaction with concomitant administration of single doses of lovastatin and propranolol. Digoxin: In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations. Oral Hypoglycemic Agents: In pharmacokinetic studies of MEVACOR in hypercholesterolemic noninsulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide Chemical IUPAC Name: [8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate : |
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