Metoprolol Succinate

This page contains recent news articles, when available, and an overview of Metoprolol Succinate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Effects of β-Blocker Titration on Glucose Homeostasis in Heart Failure  -  20 Apr 2009
OBJECTIVE: To evaluate the effects of metoprolol succinate or carvedilol up-titration on fasting glucose, insulin resistance, and β 2 -mediated glucose The Journal of Pharmacy Technology

Orbus Announces Signing Of Anda Development, Manufacturing and ...  -  ‎Mar 30, 2009‎
The Metoprolol Succinate extended release tablet is a once a day beta blocker that can be used alone or in combination with other medications to treat high FOXBusiness

FDA Safety Changes: Toprol XL, Revlimid, Fludara  -  ‎Apr 15, 2009‎
On February 12, the FDA approved safety labeling revisions for metoprolol succinate (Toprol-XL extended-release tablets; AstraZeneca LP) to provide Medscape

Par Pharmaceutical Reports Fourth Quarter and Full Year 2008 Results  -  ‎Mar 2, 2009‎
...the launch of dronabinol in July, and the launch of sumatriptan succinate in November, and increased sales of metoprolol succinate to new customers. PR Newswire (press release)

People's Pharmacy: Can the FDA be fixed?  -  ‎Mar 15, 2009‎
Among them were metoprolol succinate and nitroglycerin sublingual tablets. As a result, shortages of these important heart medicines have developed. Houston Chronicle

Growth in Health Care Spending Slows, But Still Outpaces Rate of ...  -  ‎Feb 24, 2009‎
In 2007, amlodipine besylate, amlodipine and benazepril, carvedilol, metoprolol succinate, and zolpidem lost patent exclusivity. The 7.3% hospital spending Journal of American Medical Association (subscription)

10-K: WATSON PHARMACEUTICALS INC  -  ‎Feb 23, 2009‎
...on sales by Sandoz of metoprolol succinate 50 mg extended-release tablets which were all negatively impacted by the introduction of competing products. MarketWatch (press release)

Watson Pharmaceuticals Reports Fourth Quarter and Full Year 2008 ...  -  ‎Feb 20, 2009‎
Generic other revenue decreased $28.0 million to $2.1 million, due primarily to a decline in royalties related to Sandoz's sales of metoprolol succinate Lifescience-online

Metoprololo nell'ipertensione pediatrica  -  ‎Feb 22, 2009‎
Efficacy and Safety of Extended Release Metoprolol Succinate in Hypertensive Children 6 to 16 Years of Age: A Clinical Trial Experience. Pillole.org

Dozens of generic drugs recalled  -  04 Feb 2009
...more than 60 generic drugs distributed to wholesalers, and two generic drugs, hydromorphone HCl and metoprolol succinate, distributed to retailers. MiamiHerald.com,

Metoprolol Succinate Recalled: Brand Name Drug Scarce But Still ...  -  Jan 30, 2009
Due to recent recalls, many US pharmacies are now out-of-stock of the popular beta-blocker metoprolol succinate. The original, brand name version, PR Web (press release),

Toprol-XL Competitors Hampered by Production Issues  -  Feb 2, 2009
KV Pharmaceutical and Novartis’ Sandoz unit are the only companies that have FDA approval to manufacture generic Toprol-XL (metoprolol succinate). FDA news (subscription),

Generic Toprol XL Scarce, After Problems at Novartis and KV  -  Jan 28, 2009
Novartis tells the Health Blog that it hasn’t yet been able to resume shipping supplies of the generic beta blocker, metoprolol succinate ER. Wall Street Journal Blogs,

Ethex Corp. expands generic drug recall  -  Jan 30, 2009
...pharmaceuticals (Hydromorphone HCI tablets - 2mg, 4 mg and 8mg - and Metoprolol Succinate ER tablets - 25mg, 50mg, 100mg and 200mg) included as well. AAP News (subscription)

Another Ethex and KV Pharma Drug Recall  -  Feb 2, 2009
ETHEX Corporation has initiated recall notifications to wholesalers (and to retailers for Hydromorphone HCl and Metoprolol Succinate only) nationwide who InjuryBoard.com,

US shortage of blood pressure drug affects Tulsans  -  Jan 31, 2009
...shipping of all its products, including prescription metoprolol succinate tablets, amid concerns they may contain excess doses of the active ingredient. Tulsa World,

Labaton Sucharow LLP Filed a Class Action Lawsuit Against KV ...  -  Jan 21, 2009
...the expiration of the Company's exclusive sales period for the drug metoprolol succinate; (7) that KV's financial statements failed to comply with GAAP; MSNBC

Milberg LLP Announces Its Investigation on Behalf of Certain ...  -  Jan 14, 2009
...sales period for the drug metoprolol succinate; (vii) that KV's financial statements failed to comply with Generally Accepted Accounting Principles; CNNMoney.com

Cohen Milstein Announces That It Has Filed A Securities Class ...  -  Jan 9, 2009
...sales period for the drug metoprolol succinate; and (vii) that KV’s financial statements failed to comply with Generally Accepted Accounting Principles. Earthtimes (press release),

December 2008 Mayo Clinic Health Letter Highlights: Colorectal ...  -  Dec 9, 2008
...legs syndrome -- Toprol-XL (metoprolol succinate) for blood pressure, heart failure and angina -- Zyrtec-D (cetirizine/pseudoephedrine) for allergies. MarketWatch

Izard Nobel LLP Announces Class Action Lawsuit Against KV ...  -  Dec 5, 2008
...(vi) that KV's post-January 2008 sales of generics declined following the expiration of KV's exclusive sales period for the drug metoprolol succinate. CNNMoney.com

Coughlin Stoia Geller Rudman & Robbins LLP Files Class Action Suit ...  -  Dec 2, 2008
...sales period for the drug metoprolol succinate; (vii) that KV’s financial statements failed to comply with Generally Accepted Accounting Principles; WELT ONLINE,

Comparative Effectiveness of β-Blockers in Elderly Patients With ...  -  Dec 8, 2008
...metoprolol succinate, and bisoprolol fumarate (evidence-based β-blockers [EBBBs]) improve survival in patients with heart failure (HF) is unknown. Archives of Internal Medicine

Company and People Notes: BMS and AstraZeneca Expand Collaboration ...  -  Dec 11, 2008
3)—The US Food and Drug Administration announced a recall of 6.37 million bottles of Sandoz’s (Princeton, NJ) generic metoprolol succinate extended-release Pharmaceutical Technology Magazine,

KV Pharmaceutical Company Provides Additional Financial, Business ...  -  Nov 17, 2008
Contribution of $72.6 million in net sales for the first six months of fiscal 2009 from all four strengths of metoprolol succinate extended-release tablets, MarketWatch

Sandoz lays off 30, but may soon boost employment  -  Nov 22, 2008
Good Manufacturing Practice regulations in the manufacturing of drug products, which include Metoprolol Succinate ER tablets, according to the Aug. Trading Markets (press release),

AstraZeneca reports strong third quarter  -  Oct 31, 2008
A $141 million loss of Toprol XL (metoprolol succinate) sales to generic competition counteracted the 5% increase in the rest of the US business Scrip World Pharmaceutical News (subscription),

Orbus Pharma Inc. Reports Third Quarter 2008 Results  -  Nov 13, 2008
Metoprolol Succinate XR: "Push" for market authorization in both Europe and the United States as soon as possible. We have validated our marketing FOXBusiness

Meta-Analysis Questions Safety of Perioperative Beta Blocker Use  -  Nov 13, 2008
They did point out that it cannot be excluded that the high (starting) dose of metoprolol succinate that was used in POISE might have caused an unfavorable MedPage Today,

Beta Blockers Up Risk of MI, Death After Noncardiac Operations  -  Oct 29, 2008
Specific beta-blockers used included metoprolol succinate or metoprolol tartrate, atenolol, and propranolol hydrochloride. The preoperative heart rate, Medscape (registration)

Watson Pharmaceuticals Reports Third Quarter 2008 Results  -  Oct 29, 2008
Generic other revenue decreased $19.9 million to $11.6 million due to a decline in royalties from Sandoz's sales of metoprolol succinate extended-release SYS-CON Media,

Sandoz Factory Cited in South Africa  -  Oct 17, 2008
NC, facility for various GMP deficiencies, including inadequate validation of the production process for generic Toprol XL (metoprolol succinate). FDA news (subscription),

Sandoz Gets Warning Letter for Generic Toprol XL Production Operations  -  Sep 26, 2008
The company manufactures metoprolol succinate at its facility in Wilson, NC The warning letter resulted from a March inspection. FDA news (subscription),

Bulgarian Drug Agency takes AstraZeneca heart medicine off the shelves  -  Oct 15, 2008
In a press statement issued on the morning of October 14, AstraZeneca said that packaging of the metoprolol succinate (a beta-blocker) medication was in Sofia Echo,

Beta-Blockers for Primary Prevention of Heart Failure in Patients ...  -  Oct 3, 2008
The trials included in this meta-analysis did not include trials using carvedilol or long-acting metoprolol succinate, both of which have favorable effects Cardiosource,

Once-a-day carvedilol "noninferior" to twice-daily version in ...  -  Sep 24, 2008
Clinical-trial data support the use of only bisoprolol, metoprolol succinate, and carvedilol in systolic heart failure out of all the available beta TheHeart.Org,

FDA Sends Warning Letter to Sandoz Regarding Manufacturing Facility  -  Aug 26, 2008
Specifically, you have failed to appropriately validate the manufacturing process for Metoprolol Succinate ER (25 and 50 mg) tablets prior to product PharmaLive.com (press release),

UPDATE 2-US warns Novartis generic unit on plant problems  -  Aug 26, 2008
Food and Drug Administration inspectors found the company failed to properly validate the manufacturing process for metoprolol succinate ER tablets before Reuters

Should You Be POISEd to Give Perioperative Beta Blockers?  -  Sep 5, 2008
Effects of Extended-Release Metoprolol Succinate in Patients Undergoing Non-Cardiac Surgery (POISE trial): A Randomized Controlled Trial. Medscape (subscription)

FDA finds Sandoz paperwork troubling: Letter cites quality control ...  -  Aug 27, 2008
The plant, which employs about 450, makes generic medicines, including the heart drug metoprolol succinate, muscle relaxer orphenadrine citrate and Trading Markets (press release),

Novartis/Sandoz erhält Verwarnung von US-Gesundheitsbehörde FDA  -  Aug 26, 2008
Die Verstösse würden den Produktionsbetrieb in Wilson im US-Bundesstaat North Carolina, insbesondere die Herstellung von "Metoprolol Succinate ER"-Tabletten Swissinfo,

Novartis: "Good News" zu Glivec und Lucentis - "Gelbe Karte"in den ...  -  Aug 27, 2008
Die Verstösse würden den Produktionsbetrieb in Wilson im US-Bundesstaat North Carolina, insbesondere die Herstellung von "Metoprolol Succinate ER"-Tabletten Swissinfo,

Novartis/Sandoz reçoit un avertissement de la FDA  -  Aug 26, 2008
Cela concerne le site de production de Wilson, en Caroline du Nord, et la fabrication des comprimés "Metoprolol Succinate ER", apprend-on mardi sur le site swissinfo.ch,

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Watson Pharmaceuticals Reports Second Quarter 2008 Results  -  Aug 6, 2008
...following a 1999 legal settlement, and reflects the addition of royalties from Sandoz's sales of metoprolol succinate extended-release tablets 50mg. PharmaLive.com (press release),

KV Pharmaceutical Company Reports Fiscal 2008 Results  -  Jun 16, 2008
The increase in sales was lower than management anticipated due to the delay in the approval of the 50 mg strength of Metoprolol Succinate Extended-Release Trading Markets (press release),

KV Pharmaceutical Company Completes Fiscal 2008 Filings With ...  -  Jun 25, 2008
The anticipated new products, continued momentum from KV's generic Metoprolol Succinate Extended Release tablets, and expansion of the Company's branded Earthtimes (press release),

2008-06-16, Source: KV Pharmaceutical Company  -  Jun 17, 2008
...of 56.1% was achieved through the approval, launch and contribution of two first-to-file strengths of Metoprolol Succinate Extended-Release Tablets. Lifescience-online,

KV Pharmaceutical Company Announces Approval for the 50 mg ...  -  May 15, 2008
KV is Now Offering The Complete Line of All Four Dosage Strengths of Generic Metoprolol Succinate Extended-Release Tablets Following Approval of the 50 mg Earthtimes (press release),

KV Pharmaceutical gets FDA approval for generic heart drug dosage  -  May 15, 2008
The FDA approved KV's Abbreviated New Drug Application (ANDA) for its 50 mg strength of the metoprolol succinate extended-release tablets. Bizjournals.com,

KV Pharmaceutical Company Announces Approval For The 50 mg  -  May 16, 2008
As a result of the 50 mg approval, KV is now offering the complete line of all four dosage strengths of metoprolol succinate extended-release tablets -- 200 Pharmaceutical Online (press release),

Generic Heart Drug Dosage Approved  -  May 21, 2008
KV Pharmaceutical has received final approval from the FDA of its ANDA to market its 50-mg strength of metoprolol succinate extended-release tablets. FDA news (subscription),

KV Pharmaceutical Wins Approval for Generic Anti-Hypertension Drug  -  May 16, 2008
Metoprolol succinate extended-release tablets are indicated for the treatment of hypertension used alone or in combination with other antihypertensive RedOrbit,

Beta-blocker use after non-cardiac surgery increases death risk  -  May 14, 2008
...or at risk from atherosclerosis undergoing surgery, participants were randomly assigned to receive the beta-blocker metoprolol succinate or placebo. Healthcare Republic

Orbus Pharma Inc. Reports First Quarter 2008 Results  -  May 6, 2008
The company is concentrating on completing advanced stage development work for its priority projects; Metoprolol Succinate XR, Fluvastatin XR and Filing Services Canada (press release),

POISE study questions value of perioperative beta-blockers  -  May 15, 2008
The publication of a large-scale randomised trial with extended-release metoprolol succinate (AstraZeneca’s Toprol XL) has re-ignited a debate over whether Pharma Times (subscription),

POISE Published, Debate on Perioperative Beta Blockers Continues  -  May 15, 2008
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial. Lancet 2008. Medscape (subscription)

Why Are So Many Pills Used To Treat Heart Failure?  -  May 23, 2008
The most effective beta-blockers for heart failure are carvedilol (Coreg) and metoprolol succinate (Toprol XL). At first, patients on a beta blocker may Tampa Tribune,

Market Report -- In Play (KV.A)  -  May 15, 2008
As a result of the 50 mg approval, KV is now offering the complete line of all four dosage strengths of metoprolol succinate extended-release tablets -- 200 MSN Money

Effectiveness of generics called into question  -  Apr 10, 2008
...equivalent to AstraZeneca's Toprol XL (metoprolol succinate), a drug to counter high blood pressure and the fifth most prescribed medicine in the US. In-PharmaTechnologist.com,

Concern about grapefruit, estrogen pills  -  Mar 10, 2008
Generic timed-release metoprolol (metoprolol succinate) is available in both scored and non-scored tablets, so make sure you have the scored version. Press of Atlantic City,

KV Pharmaceutical Reports Record Revenues for Fiscal 2008 Third ...  -  Feb 28, 2008
ETHEX net revenue growth was positively affected by important ANDA products including the 100 mg and 200 mg strengths of Metoprolol Succinate Extended FOXBusiness

Par Pharmaceutical Reports Fourth Quarter and Full Year 2007 Results  -  Feb 29, 2008
The third quarter 2007 launch of three additional strengths of metoprolol succinate ER (50mg, 100mg, and 200mg), coupled with the fourth quarter 2006 launch Earthtimes,

KV Pharmaceutical Company (KV-A) Completes Unaudited Fiscal 2007 ...  -  Feb 18, 2008
The approval of metoprolol succinate extended release tablets was received during the first quarter of fiscal 2008. The 100 mg and 200 mg strengths of Lifescience-online,

Watson Pharmaceuticals Reports Fourth Quarter and Full Year 2007 ...  -  Feb 20, 2008
Generic other revenue increased $21.5 million to $30.2 million, due primarily to the addition of royalties from Sandoz's sales of metoprolol succinate PharmaLive.com (press release),

Watson Pharmaceuticals Turns To Profit In Q4; Adj. EPS Tops ...  -  Feb 20, 2008
...addition of royalties from Sandoz's sale of metoprolol succinate extended-release tablets 50 mg and GlaxoSmithKline's sales of Wellbutrin XLP 150 mg. RTT News,

FDA starts inspecting stalled Watson facility  -  Feb 18, 2008
...hyperactivity disorder, and of the antihypertensives Cardizem LA (extended-release diltiazem) and Toprol XL (extended-release metoprolol succinate). OutSourcing-Pharma.com,

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