|
 |
MetoclopramideThis page contains recent news articles, when available, and an overview of Metoclopramide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Metoclopramide (when available) Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemotherapy-induced emesis and as a radiosensitizing agents in the treatment of non-small cell lung carcinoma and glioblastomas in the future. For the treatment of gastroesophageal reflux disease (GERD) Mechanism Of Action: Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide's dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals. News Articles on Metoclopramide Salix Initiates Phase 3 For Rifaximin In Non-Constipation ... - 03 Jul 2008 Vapreotide acetate, metoclopramide-ZYDIS®, balsalazide tablet, granulated mesalamine and rifaximin for additional indications are under development. Medical News Today (press release), Ipca, Ranbaxy alliance gets US FDA nod for Metoclopramide tablets - Jun 17, 2008 ...has received an approval from the US Food and Drugs Administration to manufacture and market Metoclopramide tablets, used to treat nausea and vomiting. Forbes, IPCA, Ranbaxy Alliance gets approval from USFDA for Metoclopramide - Jun 18, 2008 Metoclopramide tablets are also used in the treatment of nausea related to postoperative state and cancer chemotherapy. Under the agreement, Ipca will Stock Watch, Ipca - Ranbaxy alliance receive US FDA marketing approval for ... - Jun 17, 2008 Ipca Laboratories Ltd (IPCA) has announced that the Company had earlier announced strategic alliance with Ranbaxy Pharmaceuticals Inc. (Ranbaxy) based in Equity Bulls, TOP NEWS* India - Jun 16, 2008 Jet Airways-paper [nBOM265484] Ipca Labs gets US nod for metoclopramide HCL [nBOM278724] Press Digest [nBOM272840] COMMODITIES India soybean seen down Reuters India, Messer wins award for best scientific presentation - Jun 25, 2008 This presentation concerned the results regarding the production of pharmaceutical formulations containing metoclopramide with Variosol technology. openPR (press release), Gastrointestinal Complications of Diabetes - Jun 17, 2008 Prokinetic agents (eg, metoclopramide, erythromycin) may be helpful in controlling symptoms of gastroparesis. Treatment of diabetes-related constipation and RedOrbit, Treatment Modalities for Parkinson's Disease - Jun 12, 2008 Even at low doses, drugs such as chlorpromazine, haloperidol, and metoclopramide can precipitate parkinsonism, particularly in elderly female individuals. Medscape (subscription) Indian shares may open lower on oil, inflation - Jun 16, 2008 BO: Quote, Profile, Research) after it secured the US Food and Drug Administration approval for sale of its metoclopramide hydrochloride tablets in multiple Reuters India, Doctor faces malpractice raps - Jun 19, 2008 Maluto also prescribed “relestal dropsâ€? for gas pain, indicating the generic “metoclopramide.â€? Sensing the baby’s relief, Julie Ann said her father told her Manila Standard Today, Salix Pharmaceuticals Reports 1Q2008 Results - May 6, 2008 Additionally, the FDA has granted a November 30, 2008 PDUFA date for metoclopramide-ZYDIS, licensed from Wilmington Pharmaceuticals. Business Wire (press release), Breaking the faith - May 13, 2008 For instance, combination of metoclopramide with other molecules, except aspirin and paracetamol, was banned several years ago. But due to defective wording Express Pharma, Salix Presents New Rifaximin Phase IIb Data Demonstrating ... - May 20, 2008 Balsalazide tablet, encapsulated mesalamine granules, vapreotide acetate, metoclopramide-Zydis ® and (XIFAXAN ® ) rifaximin for additional indications are Business Wire (press release), Salix Pharmaceuticals Ltd. Q1 2008 Earnings Call Transcript - May 6, 2008 Additionally the FDA has credit November 30 2008 PDUFA date for Metoclopramide-ZYDIS licensed from Wilmington Pharmaceutical. Seeking Alpha, Salix Pharmaceuticals Announces 1Q2008 Financial Results ... - Apr 22, 2008 Current development projects include balsalazide tablet, metoclopramide-Zydis ® , encapsulated mesalamine granules, vapreotide acetate, and rifaximin for Business Wire (press release), Heartburn - Causes, Symptoms and Prevention - Mar 29, 2008 The medications metoclopramide and domperidone are both prokinetic medications. This medication may be beneficial in those people whose reflux symptoms are Los Angeles Chronicle, Salix Pharmaceuticals "neutral," target price reduced - Mar 6, 2008 Eisai co-promotion and the launch of the 1100mg Colazal in 2H08 and of Granulated Mesalamine and Metoclopramide-Zydis in early-2009, the analysts add. newratings.com, Salix Pharmaceuticals Reports 4Q2007 and FY2007 Results - Mar 3, 2008 Wilmington Pharmaceuticals, which licensed metoclopramide-ZYDIS to us, is moving forward in seeking FDA approval to market this fast-dissolving formulation. Business Wire (press release), Salix Pharmaceuticals Brings Colorectal Screening Outreach to ... - Mar 4, 2008 Further product information may be found at www.salix.com Current development projects include balsalazide tablet, metoclopramide–Zydis®, WELT ONLINE, Salix Pharmaceuticals to Present at Two Investment Conferences ... - Feb 27, 2008 Current development projects include balsalazide tablet, metoclopramide-Zydis®, encapsulated mesalamine granules, vapreotide acetate, and rifaximin for WELT ONLINE, MedThink Communications Selected by Salix Pharmaceuticals to ... - Feb 11, 2008 Salix recently licensed the rights to market the orally disintegrating metoclopramide tablet and will bring the drug to market following approval from the PR Newswire (press release), Migraine FAQs: An interview with a Mayo Clinic specialist - Feb 20, 2008 Or we may add in another medication, for instance the anti-nausea drug metoclopramide, which actually helps the stomach to empty during a migraine attack, MayoClinic.com Exam may be needed to find cause of beagle's barfing [6 mins ago] - Feb 11, 2008 A late-night snack of the pet's regular food and treatment of metoclopramide or Reglan generally will help remedy the situation. Your veterinarian may want NewsOK.com (subscription), Salix Announces Appointment of Mark Sirgo to Board of Directors - 07 Feb 2008 Current development projects include balsalazide tablet, metoclopramide-Zydis(R), encapsulated mesalamine granules, vapreotide acetate, and rifaximin for PharmaLive.com (press release), Ginger Herb - Dosage and Useful Properties-Herbal Medicines - 07 Feb 2008 A study of acetone extracts in mice found them to have similar stimulatory effects on GI motility as those seen with metoclopramide and domperidone . American Chronicle, Salix Announces Appointment of Mark Sirgo to Board of Directors - 07 Feb 2008 Current development projects include balsalazide tablet, metoclopramide-Zydis®, encapsulated mesalamine granules, vapreotide acetate, and rifaximin for Carolina Newswire (press release), Your browser does not support script - Jan 26, 2008 I give you a checklist of the drugs you may need either singly or in combination to prevent vomiting: metoclopramide, dexamethasone, Malaysia Star, FDA Panel Votes to Support Adolor's GI Postsurgery Drug - Jan 23, 2008 Some hospitals use drugs, such as metoclopramide and erythromycin, off-label to treat the condition, noted Ruyi He, medical team leader in the FDA's BioWorld Online, GERD: A Disease for Kids, Too - Jan 14, 2008 Drugs that accelerate gastric emptying such as metoclopramide rarely are used for children with pediatric GERD because of the risk of potential adverse Nurse.com, Reglan named in federal product liability claim - Jan 9, 2008 7, alleging the prescription medication Reglan or its generic, metoclopramide, was defective and unreasonably dangerous. Shirley Brinkley claims that in Madison County Record, 35 Ulmer & Berne LLP Attorneys Chosen as Ohio Super Lawyers for 2008 - Jan 15, 2008 Recent national counsel engagements have included ADHD, antidepressant, hormone-replacement-therapy, metoclopramide, ephedra, and fen/phen litigations, Business Wire (press release), Six Ulmer & Berne LLP Attorneys Distinguished as 2008 Leading ... - 20 Dec 2007 Recent national counsel engagements have included ADHD, antidepressant, hormone-replacement-therapy, metoclopramide, ephedra, and fen/phen litigations, Business Wire (press release), Dissolvable Aspirin Effective for Migraine - Nov 23, 2007 Recently, effervescent aspirin without metoclopramide has been shown to be more effective than inactive "placebo" pills against migraines. Online - International News Network, Sanofi-Aventis, Astellas to Restructure Japanese Joint Venture - Dec 3, 2007 It owns the rights to several sanofi-aventis products, including Myslee (zolpidem), Dogmatyl (sulpiride), Primperan (metoclopramide) and Gramalil (tiapride) FDA news (subscription), Sanofi and Astellas to restructure JV activities in Japan - Dec 3, 2007 ...certain products originating from Sanofi-Aventis such as Myslee (zolpidem), Dogmatyl (sulpiride), Primperan (metoclopramide) and Gramalil (tiapride). Pharmaceutical Business Review Chemist on tour - Nov 30, 2007 Janne Leino: The value of hard gelatin capsules as a rectal dosage form in man using ibuprofen and metoclopramide hydrochloride as model drugs. Universitas Helsingiensis, BUYINS.NET: (POZN) SqueezeTrigger Price is $10.416. There is ... - Nov 29, 2007 In September 2005, after an FDA advisory committee concluded that the potential risk of tardive dyskinesia associated with the use of metoclopramide, Trading Markets (press release), Salix Pharmaceuticals to Present at Piper Jaffray Health Care ... - Nov 21, 2007 Current development projects include balsalazide tablet, metoclopramide-Zydis(R), encapsulated mesalamine granules, vapreotide acetate, and rifaximin for PR-Inside.com (Pressemitteilung), Salix Pharmaceuticals Reports 3Q2007 Results - Nov 6, 2007 ...“In September Salix acquired the exclusive, worldwide rights to metoclopramide-Zydis ® . We are pleased to announce that today Wilmington Pharmaceuticals, Business Wire (press release), BUYINS.NET: (POZN) squeezetrigger Price is $10.416. There is ... - Nov 7, 2007 In September 2005, after an FDA advisory committee concluded that the potential risk of tardive dyskinesia associated with the use of metoclopramide, Trading Markets (press release), Antiemetics, Their Function, and Their Role in Controlling ... - Oct 18, 2007 Domperidone (commercially Motilium) and metoclopramide (Reglan) are the two main dopamine receptor antagonists used for antiemetic treatment. Cancer Focus, Chronic Restlessness With Antipsychotics - Nov 1, 2007 Tomruk O, Turkcuer I, Ergin N: Midazolam vs diphenhydramine for the treatment of metoclopramide-induced akathisia: a randomized controlled trial. Am J Psychiatry (subscription) What to do if stomach empties slowly - 15 Oct 2007 If no contributing illness is discovered, a medicine such as Reglan (metoclopramide) is prescribed to speed the transit of food through the stomach. DetNews.com, Case 29-2007 — A 51-Year-Old Man with Gastric Cancer and Lung Nodules - Sep 19, 2007 Omeprazole and metoclopramide were administered, and the hiatal hernia was surgically repaired. Pain, persistent gastroesophageal reflux, and weight loss New England Journal of Medicine (subscription), Wal-Mart Launches Phase Two of Prescription Program With New $4 ... - Sep 27, 2007 HYOSCYAMINE 0.125MG QTY 60 HYOSCYAMINE 0.375 ER QTY 30 LACTULOSE SYRUP QTY 237ML METOCLOPRAMIDE 10MG QTY 60 METOCLOPRAMIDE SYRUP QTY 60ML PROMETHAZINE CNNMoney.com BUYINS.NET: (POZN) SqueezeTrigger Price is $10.393. There is ... - Oct 9, 2007 In September 2005, after an FDA advisory committee concluded that the potential risk of tardive dyskinesia associated with the use of metoclopramide, Trading Markets (press release), Wedgewood Introduces Twist-a-Dose(TM) Transdermal Applicator: Easy ... - Sep 27, 2007 ...for these medicines: Amitriptyline HCl Diltiazem HCl Metoclopramide Atenolol Enalapril Methimazole Buspirone HCl Famotidine Phenoxybenzamine Cisapride PR Newswire (press release), What Should You Know about Acid Cure Reflux? - Sep 24, 2007 Reglan which is known as metoclopramide and Urecholine which is known as bethanecol both directly increase the strength of the LES muscle. American Chronicle, Do guns kill? No, antidepressants do. - Sep 21, 2007 Certain anti-emetic drugs, particularly the dopamine blockers, such as metoclopramide (Reglan) and prochlorperazine (Compazine). Certain drugs of abuse, renewamerica.us, Hiccups may have even more treatments than they do causes - Sep 17, 2007 The muscle relaxant baclofen (Lioresal) and the antiemetic metoclopramide (Reglan) have also been successful in treating persistent or intractable hiccups. Denver Post, How To Protect Yourself From Drug-Induced Disorders - Sep 16, 2007 Some of the drugs prescribed for gastrointestinal problems also can induce Parkinsonism such as metoclopramide (Reglan), prochlorperazine (Comazine) and Evening Bulletin, Salix Pharmaceuticals Acquires Patent-Protected Metoclopramide-Zydis® - Sep 5, 2007 Metoclopramide is indicated for short-term (4-12 weeks) therapy for adults with symptomatic documented gastroesphageal reflux who fail to respond to Carolina Newswire (press release), Salix Pharma Completes Phase IIb Trial Of Rifaximin And Phase III ... - Sep 5, 2007 Salix also said it has received the exclusive, worldwide right to metoclopramide-Zydis from Wilmington Pharmaceuticals. The Phase IIb trial is a multicenter RTT News, Salix Pharma Completes Phase IIb Trial Of Rifaximin And Phase III ... - Sep 5, 2007 Salix also said it has received the exclusive, worldwide right to metoclopramide-Zydis from Wilmington Pharmaceuticals. The Phase IIb trial is a multicenter Trading Markets, Reglan gave me Neuroleptic Malignant Syndrome - Aug 19, 2007 Reglan (Metoclopramide) is used to treat Gastroesophageal Reflux Disease (GERD), heartburn and acid reflux disease. Among the side effects is Tardive Lawyers and Settlements, Players Still Trying To Widen Market For Migraine Therapy - Aug 17, 2007 Two earlier compounds - MT 300, a new formulation of dihydroergotamine mesylate, and MT 100, a naproxen/metoclopramide combo - got not-approvable letters BioWorld Online, Reglan: “I started shaking right awayâ€? - Aug 14, 2007 Reglan is known clinically as metoclopramide hydrochloride, and is often used to prevent post-operative nausea and vomiting. One of its many adverse effects Lawyers and Settlements, Questcor Announces Financial Results for 2007 Second Quarter - Aug 9, 2007 In June 2007, Questcor divested its non-core development-stage product Emitasol (nasal metoclopramide) for net proceeds of $0.4 million. Business Wire (press release), Dyax, Bayer Schering Pharma AG Collaborate For Discovery Of ... - Sep 5, 2007 In addition, Salix Pharma. said it earned exclusive, worldwide right to metoclopramide-Zydis from Wilmington Pharmaceuticals. Metoclopramide is indicated RTT News, Market Report -- In Play (SLXP) - Sep 5, 2007 As well, the co also announced that Wilmington Pharmaceuticals has granted it the exclusive, worldwide right to metoclopramide-Zydis. MSN Money French regulator warns on Primperan overdosing - Jul 17, 2007 ReutersPrimperan is a trade name for Metoclopramide, a dopamine receptor antagonist used to treat nausea and vomiting and discovered in the 1960s. OC police subpoena woman's medical records - Aug 2, 2007 The News Journal,The 2003 hospital bill shows that Freeman was given the antibiotics ceftriaxone and doxycycline, strong painkillers and metoclopramide, used to relieve Common Causes of Nausea and Vomiting and Treatment Reviewed - Jul 12, 2007 Medscape (subscription)During pregnancy, prochlorperazine, chlorpromazine, metoclopramide, and methylprednisolone are recommended for hyperemesis gravidarum; meclizine, Tranzyme Receives Fast Track Status for Intestinal Drug - Jul 26, 2007 WRAL.com,One approved treatment for the condition called Metoclopramide is associated with unwanted adverse events, Kosutic said. Tranzyme Drug Candidate Receives FDA Fast Track Status - Jul 12, 2007 Local Tech Wire,A drug known as Metoclopramide has been approved for gastroparesis but can trigger side effects, Kosutic said. Gastroparesis involves delayed emptying of Tranzyme Pharma Receives FDA Fast Track Designation for its Novel ... - Jul 12, 2007 Carolina Newswire (press release),Metoclopramide, the only drug approved by the FDA for gastroparesis, is associated with unwanted adverse events including extrapyramidal reactions and Brand Names/Synonyms: Metoclopramide is also known by the following brand names and/or synonymsApo-Metoclop; CHEMBANK734; Cerucal; Clopra; Clopra-Yellow; Clopromate; DEL; DEL 1267; DEL-1267; Duraclamid; Elieten; Emetid; Emperal; Eucil; Gastrese; Gastro-Timelets; Gastrobid; Gastromax; Gastronerton; Gastrosil; Gastrotablinen; Gastrotem; Imperan; M0763; M117; Maxeran; Maxolon; Meclopran; Metaclopramide; Metaclopromide; Metamide; Methochlopramide; Methoclopramide; Metochlopramide; Metoclol; Metoclopramida [Inn-Spanish]; Metoclopramide; Metoclopramide Hcl; Metoclopramide Hydrochloride; Metoclopramide Intensol; Metoclopramide Omega; Metoclopramidum [Inn-Latin]; Metocobil; Metramid; Moriperan; Mygdalon; Neu-Sensamide; Nu-Metoclopramide; Octamide; Parmid; Paspertin; Peraprin; Plasil; Pms-Metoclopramide; Pramiel; Pramin; Primperan; Reclomide; Reglan; Reliveran; Terperan Drug Category: Metoclopramide is categorized under the following by the FDA: Antiemetics; Prokinetic Agents; Dopamine Antagonists; ATC:A03FA01 Dosage Forms: LIQUID; SYRUP; TABLET Absorption: Rapidly and well absorbed (oral bioavailability 80±15.5%). Interactions: DRUG INTERACTIONS The effects of metoclopramide on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when metoclopramide is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers. The finding that metoclopramide releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, in patients receiving monoamine oxi-dase inhibitors. Absorption of drugs from the stomach may be diminished (e.g., digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine). Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some patients. Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of metoclopramide will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment. Chemical IUPAC Name: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxy-benzamide : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |