Methylphenidate

This page contains recent news articles, when available, and an overview of Methylphenidate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Methylphenidate
(when available)

Pharmacology and use:
Methylphenidate, a central nervous system stimulant chemically similar to the amphetamines, is used to treat narcolepsy, attention-deficit hyperactivity disorder (ADHD) in children, post-stroke depression or other depressive disorders. Children with attention deficit disorders

Mechanism Of Action:
Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result.

News Articles on Methylphenidate

Use Herbal Remedies for ADHD  -  20 Apr 2009
ADHD is typically treated with the medications methylphenidate or amphetamine, which are stimulant drugs. While they have been proven to be effective they Natural News.com

Tiny pill may deal to P  -  20 Apr 2009
By HAYDEN DONNELL - North Shore Times KICKING THE HABIT: Wayne Miles is trialling a methylphenidate pill that could treat P addiction. Auckland stuff.co.nz

Pharmaceutical Update  -  20 Apr 2009
The US Food and Drug Administration has granted marketing clearance for Ritalin LA (methylphenidate) extended-release capsules by Novartis Pharmaceuticals, ADVANCE for Physician Assistants

Attention-Deficit Hyperactivity Disorder, Methylphenidate, and ...  -  ‎Apr 17, 2009‎
When treated with methylphenidate (MPH) to manage the ADHD, they responded with immediate improvement in ADHD symptoms, accompanied by amelioration of Psychosomatics (subscription)

A modelled economic evaluation comparing atomoxetine with ...  -  ‎Apr 15, 2009‎
Methylphenidate (MPH), a mild stimulant, had long been the only approved medication available for ADHD children in Spain. Atomoxetine is a non-stimulant 7thSpace Interactive (press release)

Local business briefs -- 4/01  -  ‎Mar 31, 2009‎
A federal court in Delaware has ruled that Watson Pharmaceuticals Inc.'s generic version of Concerta, a drug that treats attention deficit disorder, Press-Enterprise

On Speed: The Many Lives of Amphetamine  -  ‎Mar 31, 2009‎
Alles’ creation is better known as amphetamine, which, with its numerous sister compounds, including methamphetamine, MDMA (ecstasy), methylphenidate and British Journal of Psychiatry

What Are Options for Treating PICA? Part 2  -  ‎Apr 16, 2009‎
Other drugs which have been tried for treatment of PICA with some benefit include bromocriptine and methylphenidate. At low dose, these drugs are fairly EmpowHer

Solid results for J&J as generic competition batters key drugs  -  ‎Apr 15, 2009‎
On the bright side, however, turnover from the attention-deficit hyperactivity disorder therapy Concerta (methylphenidate) climbed 18.6% to $344 million, Pharma Times

Biotech/Pharma Docket  -  ‎Apr 9, 2009‎
...of Concerta® (methylphenidate hydrochloride extended-release tablets) does not infringe ALZA Corporation's and McNeill-PPC's patent covering the drug. Patent Docs

Some admit illicit use of stimulants  -  ‎Apr 3, 2009‎
Between 1990 and 2005, prescriptions of methylphenidate and amphetamine (the generic terms for Ritalin and Adderall, respectively) jumped more than 3000 The Brown Daily Herald

Teva Active Again, Adds ADHD Medication  -  ‎Apr 5, 2009‎
Drugs such as Adderall and Ritalin (methylphenidate) have been highly controversial due to charges of their being over-prescribed. Arutz Sheva

09年执业西è?¯å¸ˆè?¯ç?†å­¦è¾…导:第å??ä¹?章第一节主è¦?兴奋大脑皮层的è?¯ç‰©  -  ‎Apr 14, 2009‎
...哌醋甲酯(methylphenidate)å?ˆå??利他林(ritalin),化学结构与具有中枢兴奋作用的感胺——苯丙胺相似。作用性质也相类似,但交感作用很弱,中枢兴奋作用较温和,能改善 青年人

Changing Rx Practices in the Treatment of Mental Illness: Impact ...  -  18 Mar 2009
In a somewhat similar manner, the effectiveness of the atypical antidepressant Bupropion compared favorably with that of Methylphenidate (the most popular Forensic Examiner

ADHD 치료제 연령기준 ê°•í™” "ì—†ë?˜ ì?¼ë¡œ"  -  18 Mar 2009
...앞서 복지부는 약물 오·남용 등ì?˜ ì?´ìœ ë¥¼ 들어 ADHD 치료ì—? 사용ë?˜ëŠ” Methylphenidate HCL 서방형 경구제(품명: 콘서타OROS서방정, 메타테ì?´íЏ CD서방캅셀) 급여ì?¸ì • 메디게이트뉴스

A warning on off-label use of sleep-disorder drug  -  ‎Mar 17, 2009‎
The conventional wisdom has been that modafinil is different from other stimulant drugs, such as amephetamines or methylphenidate — marketed as Ritalin for USA Today

Shire pulls EU filing for Daytrana, sues Barr over Fosrenol  -  ‎Mar 17, 2009‎
Also, the recent acquisition of non-US rights to the instant- and extended-release versions of UCB’s ADHD drug Equasym (methylphenidate) has led to a shift Pharma Times

Trying to teach a lost young soul  -  ‎Mar 15, 2009‎
Kathy has severe attention deficit disorder, controllable with a stimulant in the methylphenidate family. She'd been prescribed 40 milligrams a day, Denver Post

Effects of methylphenidate on motor system excitability in a ...  -  ‎Feb 27, 2009‎
In this study, we used TMS to investigate the effects of methylphenidate (MPH) on the temporal dynamics of motor system excitability during a go/nogo task. 7thSpace Interactive (press release)

What side effects does Adderall have?  -  ‎Mar 3, 2009‎
I started out on methylphenidate 5 mg but had violent nightmares and chest pain. I was then switched to bupropion SR 150 but it kept me awake most of the CNN

Impulsivity study may aid in understanding ADHD  -  ‎Mar 6, 2009‎
Part of the research observes how the psycho-stimulant drug methylphenidate (or Ritalin) affects rats, Sanabria said, which will help deliver results ASU Web Devil

UCB to divest Equasym(R)  -  ‎Feb 20, 2009‎
In the US, UCB will continue to market Metadate® CD (methylphenidate HCl) extended release tablet for the treatment of ADHD. MSNBC

Police arrest man on prescription drug charges  -  ‎Feb 20, 2009‎
Police said Aragon had 100 pills of Tamoxifen, 101 pills of Clomiphene, four tablets of Methylphenidate, five vials of Testosterone, 51 pills of Oxandrolone Iowa City Press Citizen

A beefy market calls for non-stimulant ADHD treatments  -  ‎Mar 15, 2009‎
Although the major classes such as amphetamine/lisdexamfetamine, methylphenidate and dexmethylphenidate have lost patent protection for the substance, PipelineReview.com (press release)

FDA Inhaler Instructions Doubts Cause Delay in UT's PAH Drug  -  ‎Mar 16, 2009‎
Shire plc, of Basingstoke, UK, has withdrawn its European marketing authorization application for Daytrana (methylphenidate transdermal system) as a TMCnet

Your 21st century brain on Facebook  -  ‎Feb 28, 2009‎
Methylphenidate, or Ritalin, prescriptions have also increased in the US. Interestingly, college students in the US who were already on Ritalin, Examiner.com

Networking sites reduce brain power  -  ‎Feb 24, 2009‎
...this can be linked to the increase of prescription drugs, especially for methylphenidate, the drug prescribed for attention-deficit hyperactivity disorder. TVNZ

Management of Excessive Daytime Sleepiness Reviewed  -  ‎Mar 16, 2009‎
These include dextroamphetamine, methylphenidate, and pemoline. Personality changes, tremor, hypertension, headaches, and gastroesophageal reflux may be Medscape

Shire earnings decline; buys rights to UCB ADHD drug  -  ‎Feb 20, 2009‎
As for Shire’s ADHD patch product Daytrana (methylphenidate), sales fell 23% to $17.8 million, hurt by a voluntary recall of certain product batches, Pharma Times

Attention-deficit hyperactivity disorder: treatment ...  -  ‎Feb 27, 2009‎
KS has received reimbursement of expenses by Janssen-Cilag, manufacturer of methylphenidate, for attending a conference. RDS has been reimbursed by British Journal of Psychiatry

Noven Announces 2008 Financial Results  -  ‎Mar 5, 2009‎
...the inability to obtain the active ingredient methylphenidate, and (iv) delays or inability to obtain necessary DEA methylphenidate procurement quota; Trading Markets (press release)

Fatigue: the most common problem your patient has, that you aren’t ...  -  ‎Mar 11, 2009‎
Psychostimulants such as methylphenidate, modafinil and pemoline are some of the best studied medications, but results are often mixed. HemOncToday

Students arrested after selling prescription medication at school  -  ‎Feb 26, 2009‎
Rt. 9 Cape Vincent, NY O'Connor, a student at Thousand Islands High School, allegedly brought Methylphenidate pills (Ritalin) to school and gave the pills EmpireStateNews.net

Shire to Enter European ADHD Market With the Acquisition of ...  -  ‎Feb 20, 2009‎
XL (methylphenidate hydrochloride) (excluding the USA, Canada and Barbados) used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). FOXBusiness

Other News To Note  -  ‎Feb 20, 2009‎
...to acquire the worldwide rights to Equasym IR and XL (methylphenidate hydrochloride) for the treatment of attention deficit hyperactivity disorder. TMCnet

Company and People Notes: Genentech Tells Shareholders to Reject ...  -  ‎Feb 26, 2009‎
Canada and Barbados, to "Equasym" IR and XL (methylphenidate hydrochloride), used for the treatment of attention deficit hyperactivity disorder. Pharmaceutical Technology Magazine

Narcolepsy Drug Being Used To Improve Cognitive Performance ...  -  ‎Mar 17, 2009‎
The mechanisms of action of modafinil are not well understood but are believed to differ from those of stimulant medications (such as methylphenidate and Medical News Today (press release)

Phenomenon of Wild Goose Fathers in South Korea  -  ‎Feb 22, 2009‎
Ritalin, Concerta, Metadate and Penid all contain methylphenidate (MPH), which has potential side effects including loss of appetite, sleeplessness, nausea, Korea Times

Shire Plc. Q4 2008 Earnings Call Transcript  -  ‎Mar 2, 2009‎
DAYTRANA as we mentioned in the past is our entry strategy a methylphenidate patch for ADHD. Again we wanted to get to Europe two years in front of VYVANSE, Seeking Alpha

Role of zinc in maternal and child mental health  -  ‎Feb 19, 2009‎
Zinc supplementation in a small group of Iranian children with ADHD aged 5–11 y enhanced the effects of methylphenidate; children in the zinc Am J Clin Nutr (subscription)

Diagnosis and Treatment of Sleep Disorders in Older Adults  -  ‎Feb 25, 2009‎
In particular, central nervous system stimulants (eg, dextroamphetamine, methylphenidate), antihypertensives (eg, beta-blockers, alpha-blockers, methyldopa, Focus (subscription)

Sucht an der Uni: Unter Drogen zur Klausur  -  ‎Mar 1, 2009‎
Bei gesunden Menschen wirken Methylphenidate, die Wirkstoffe in Ritalin, ähnlich wie Kokain auf das Hirn. Der Vorteil gegenüber Kokain: Es macht erst in Die Presse

Terapia con metilfenidato e successivo abuso di sostanze  -  ‎Feb 25, 2009‎
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry 2008; Pillole.org

Brand Names/Synonyms:
Methylphenidate is also known by the following brand names and/or synonyms4311/B Ciba; C 4311; CHEMBANK1663; Calocain; Centedein; Centedrin; Centedrine; Centredin; Concerta; Dea No. 1724; Focalin; Focalin Xr; HSDB 3126; METHYLPHEN; Meridil; Metadate; Metadate Cd; Metadate Er; Methyl Phenidyl Acetate; Methylin; Methylin Er; Methylofenidan; Methylphenidan; Methylphenidate; Methylphenidate Hcl; Methylphenidate Hydrochloride; Methylphenidatum [Inn-Latin]; Methylphenidylacetate Hydrochloride; Methypatch; Metilfenidat Hydrochloride; Metilfenidato [Inn-Spanish]; Metilfenidato [Italian]; Phenidylate; Plimasine; Pms-Methylphenidate; Riphenidate; Ritalin; Ritalin Hydrochloride; Ritalin La; Ritalin Sr; Ritalin-Sr; Ritaline; Ritcher Works

Drug Category:
Methylphenidate is categorized under the following by the FDA: Adrenergic Agents; Dopamine Agents; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:N06BA04

Dosage Forms:
Tablets, SR tablets

Absorption:
readily absorbed in a biphasic manner. It reaches peak absorption at approximately two hours for the first phase and five hours for the second phase. bioavailability is low (approx. 30%)

Interactions:
-->Interactions for Methylphenidate:

Ritalin may decrease the hypotensive effect of guanethidine. Use cautiously with pressor agents.

Human pharmacologic studies have shown that Ritalin may inhibit the metabolism of coumarin anticoagulants, anticonvulsants (phenobarbital, diphenylhydantoin, primidone), phenylbutazone, and tricyclic drugs (imipramine, clomipramine, desipramine). Downward dosage adjustments of these drugs may be required when given concomitantly with Ritalin.

Serious adverse events have been reported in concomitant use with clonidine, although no causality for the combination has been established. The safety of using methylphenidate in combination with clonidine or other centrally acting alpha-2 agonists has not been systemically evaluated.

 




Chemical IUPAC Name:
methyl2-phenyl-2-(2-piperidyl)ethanoate

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