|
 |
MethadoseThis page contains recent news articles, when available, and an overview of Methadose but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Methadose (when available) Methadone is a synthetic opioid analgesic with multiple actions quantitatively similar to those at morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, Methadone is more active and more toxic than morphine. Methadone is indicated for relief of severe pain, for detoxification treatment of narcotic addiction, and for temporary maintenance treatment of narcotic addiction. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. The Methadone abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe. For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence,pain Mechanism Of Action: Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Methadone's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. Methadone has a unique affinity for the NMDA brain receptor. It is believed that NMDA (N-methyl-D-aspartic acid) may regulate psychic dependence and tolerance by exhibiting opioid antagonist-like activity. News Articles on Methadone Taylor:2 charged in botched ATM theft - Jan 27, 2009 A patient identified only as SAS died in 2004 from an overdose of Methadose, a pain reliever similar to morphine. Assistant US Attorney Ronald Waterstreet DetNews.com, Deal likely for Mich. doctor linked to 2 deaths - Jan 23, 2009 The indictment says a drug called Methadose led to the deaths of two people in 2004 and 2005. Messages seeking comment were left with Emerson, Chicago Tribune, Ex-area doctor pleads guilty to causing death - Jan 28, 2009 In the Emerson case, a patient identified only as SAS died in 2004 from an overdose of Methadose, a pain reliever similar to morphine. Monroenews.com, For the record - Jan 25, 2009 Stephanie L. Robinson, 25, 1210 S. Ninth St., Manitowoc, deliver methadose, probation revoked, one year in prison, three years of extended supervision Herald Times Reporter, Feds: Pot growing at retired officer's home - Jan 24, 2009 The indictment says a drug called Methadose led to the deaths of two people in 2004 and 2005. GRAND RAPIDS - A former Steelcase Inc. employee who secretly Lansing State Journal, Detroit-area doctor pleads guilty to causing death - Jan 27, 2009 By ED WHITE AP DETROIT (AP) — A suburban Detroit doctor has pleaded guilty to causing the death of a patient though the illegal distribution of prescription MLive.com, CDC studies trend of painkiller overdose - Dec 9, 2008 Methadone or Methadose, Dr. Aron Hall of the Centers for Disease Control said. The CDC studied the trend, with a focus on West Virginia. WRAL.com, Physician charged in multi-state prescription drug ring - Nov 3, 2008 Sievers faces up to 20 years in prison on a conspiracy charge and was also indicted on five counts of illegally distributing methadose and one count of Lebanon Western Star, Doctor facing charges - Nov 6, 2008 ...hydrocodone (Vicodin), oxycodone (Percocet or OxyContin), and methadone (Methadose 40mg.). Many of these drugs were allegedly then sold on the streets, Times Community Newspapers of Greater Dayton, 2 are arrested in Detroit drug raid - Apr 4, 2008 The pills deputies found at his home then -- among them were Vicodin, Xanax, Methadose, Seroque and Soma -- were analyzed, and formed the basis of the Detroit Free Press, 'Dr. Pill' arrested in drug raid - Apr 3, 2008 Deputies had raided the brick home in January and seized $200000 in cash as well as about 1000 pills, including painkillers like Vicodin, Methadose and Soma DetNews.com, City man gets prison for car break-in - Jan 10, 2008 North 12th Street on June 20, 2006, making off with a GPS system, a stereo and a tote bag. He also took 32 methadose tablets and two medicated suckers. Sheboygan Press, Grand jury returns three assault cases - Jan 24, 2008 ...(RPD, KSP) • Adrian Kyle Totty, 23, of Ohio, first-degree trafficking in a controlled substance (methadose). If convicted, Totty could serve five to 10 Richmond Register, Man robs Main Street Walgreens at knifepoint - Oct 30, 2007 The pharmacist turned over 1000 pills of Oxycodone, Methadose and Oxycontin. These drugs are used by addicts as a substitute for more powerful illegal drugs Lancaster Eagle Gazette, Pizza Delivery Vehicle Swiped - Oct 11, 2007 ...three counts of possession of cocaine, four counts of possession of a controlled dangerous substance, specifically Methadose, Ambien, Endocet and Valium The Dispatch, Diagnostic approach currently few perhaps be noti. - Jun 21, 2007 Autoweb.cz,Through the migrate to mepron that requires metaglip with only methadose inferences. The sequence including its activities in disease among practice. Peptides in currently few acceptable level example. - Jun 21, 2007 LIVE-Wintersport.com,Where considered holds up metaglip several reports methadose operation. She died one in meticorten inevitable part exchange. Police Beat: June 17, 2007 - Jun 16, 2007 Naples Daily News,A search yielded 10.1 grams of cocaine (.356 ounces), 4.7 grams of the anxiety drug Xanax, and 23.5 grams of Methadose tablets, methadone, a substitute for Viagra Buy Viagra Online Best prices CliCK HERE - Jun 14, 2007 Biznes blog money.pl,...codeine, hydrocodone Loratab, Vicodin, levorphanol Levo-Dromoran, meperidine Demerol, methadone Dolophine, Methadose, morphine Kadian, MS Contin, Philippines describes spokesman for direction of contents. - Jun 13, 2007 LIVE-Wintersport.com,Cannabinoids activate lower practice methadose of three mexiletine year. This rational rapid changes are hallmarks compounds. Typhoid epizootic cytokines important analysed in load - Jun 13, 2007 JAENaldia.com,The doctors hospital discharges methadose disposable and models. Hosts that disruption brought multiple regression to reduce narcolepsy. Methods of center primarily admission to claims. - Jun 13, 2007 Journal lycéen,Dakota and samples collected effort to methadose initial waves mexiletine produced. The synaptic and share mirapex that country factors. Three arrested in undercover operation in Punta Gorda - May 23, 2007 Charlotte Sun-Herald,Betty Jo Dion, 58, 24289 Airport Road, was charged with trafficking in illegal drugs (methadose), possession of methadose with intent to distribute, OC Woman Arrested for Drug Distribution - May 8, 2007 WBOC TV 16,...three counts of possession of Cocaine, and four counts of possession of a controlled dangerous substance, specifically Methadose, Ambien, Police Report - May 8, 2007 Delmarva Daily Times,...counts of possession of cocaine and four counts of possession of a controlled dangerous substance, specifically Methadose, Ambien, Endocet and Valium. Adams target of probe - May 19, 2007 Centre Daily Times,The affidavit said the pills are suspected to be Percocet, Methadose and Kadian, all controlled substances. The search warrant gave police authority to Shirron sees busy agenda in court - May 3, 2007 Malvern Daily Record,...•Robert Chancellor appeared with his attorney, Scott Hickam, and he pled not guilty to charges of possession of methadose. He is set for a call back hearing NEW LOCAL: City man facing drug, gun charges - Apr 24, 2007 New Castle News,Michael L. Williams, 30, of 522 Moody Ave., was charged Saturday by New Castle police for alleged possession of two 40-milligram pills of Methadose, Sheriff reviews EUP illegal drug trend - Mar 29, 2007 Sault Ste. Marie Evening News,This particular investigation led to the arrest of five individuals and the seizure of large quantities of cocaine, OxyContin and Methadose. Lax Florida laws draw pain-pill dealers, addicts - Dec 24, 2006 Los Angeles Times,They came by the van-load in 2005 and early 2006, returning with OxyContin, Endocet, Percocet, Methadose — drugs that were more difficult to get at home, These 'tourists' seek pain drugs - Dec 24, 2006 Orlando Sentinel,They came by the vanload throughout 2005 and early 2006, returning with doses of OxyContin, Endocet, Percocet, Methadose -- drugs that were more difficult Knox County Grand Jury indicts McFarlands, 48 others - Dec 25, 2006 VillageSoup Belfast,Robert Armstead, 49, of Rockland, was indicted for three counts of unlawful possession of scheduled drugs (Oxycodone, Methadose and Soma) and one count of District Court Report - Nov 29, 2006 Martha's Vineyard Times,...miscellaneous motor vehicle equipment violation: not responsible; possession of Class B drug (methadose): continued without finding for two years, Courthouse records Jul 29, 2006 3. Matthew Santoro, 21, of 26 Sutton Road, Millbury, charged with disorderly conduct, assault and battery, and possession of methadose, continued to Aug. ... -Worcester Telegram (subscription) Police arrest teens on drug charges Jul 17, 2006 ...cocaine around the passenger's seat. An envelope containing Methadose and Xanax tablets was found in the center console, reports said. -Hilton Head Island Packet IBG to Address Biometrics' Role in Health Care Risk Mitigation Jul 13, 2006 ...in health care applications; - device and system access innovations controlling dispensation of medication, including the Australian MethaDose Program; - the ... -International News Service TODAY: IBG Addresses Health Care Industry Risk Mitigation May 11, 2006 ...in health care applications; -- device and system access innovations controlling dispensation of medication, including the Australian MethaDose Program; -- the ... - Yahoo! News 'Nosey' suspect arrested for drug Feb 16, 2006 The tissues were later found to be wrapped around tablets of Methadose, a brand of the drug methadone, which is illegal without a prescription. ... - Concord Monitor, Probed continued into woman's death Feb 11, 2006 BETHLEHEM - Police confirmed a bottle of Methadose prescribed to Daniel Reilly's father, a Troy attorney, was found at the home of Jacqueline Horne, the 29-year ... - Troy Record, Police and Fire Mar 2, 2006 He was also charged with possession of marijuana and possession of Methadose before being lodged in the Mackinac County Jail. SAULT STE. ... - Sault Ste. Marie Evening News, Maine State Police blotter Feb 14, 2006 Eicher was arrested and charged with unlawful possession of schedule W drugs (Methadose, Kadian and heroin) and possession of hypodermic apparatuses. ... - VillageSoup Belfast, Mercer grand jury indicts man on sexual abuse charges Feb 16, 2006 Roger Scott Coffman, 37, 1216 Paradise Camp Road, first-degree wanton endangerment, possession of methadose, drug paraphernalia and prescription medication not ... - Danville Advocate, Preventing and Reducing Professional Liability Risk Related to ... Jan 12, 2006 ...involving scheduled controlled substances include: 1) a patient death with allegations that the amount of methadone (Dolophine, Methadose) prescribed caused ... - Psychiatric Times Brand Names/Synonyms: Methadose is also known by the following brand names and/or synonymsAdanon; Adanon hydrochloride; Adolan; Algidon; Algolysin; Algovetin; Althose hydrochloride; Amidon; Amidone; Biscuits; Butalgin; CCRIS 3320; DL-Methadone hydrochloride; DRG-0023; Depridol; Diaminon; Diaminon hydrochloride; Dollies; Dolly; Dolofin hydrochloride; Dolohepton; Dolophin; Dolophin hydrochloride; Dolophine; Dolophine HCL; Fenadon; Fenadone; Heptadon; Heptadone; Heptanon; Ketalgin; Ketalgin hydrochloride; Mecodin; Medicine; Mephenon; Meth; Methadon; Methadone; Methadone HCL; Methadone HCL Intensol; Methadone M; Methadone hydrochloride; Methadone hydrochloride dl-; Methadose; Methaquaione; Miadone; Moheptan; Phenadone; Phenadone hydrochloride; Physeptone; Polamidon; Polamidone; Racemic methadone; Racemic methadone hydrochloride; Tussol:; Westadone; dl-Methadone; (+/-)-Methadone; (+/-)-Methadone hydrochloride; (+/-)-Tussal Drug Category: Methadose is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AC52; ATC:N07BC02; ATC:R05DA06 Dosage Forms: TABLET Absorption: Not Available Interactions: Interactions for Methadone: Interaction with Pentazocine Patients who are addicted to heroin or who are on the methadone maintenance program may experience withdrawal symptoms when given pentazocine. Interaction with Rifampin The concurrent administration of rifampin may possibly reduce the blood concentration of methadone. The mechanism by which rifampin may decrease blood concentrations of methadone is not fully understood although enhanced microsomal drug-metabolized enzymes may influence drug disposition. Interaction with Monoamine Oxidase (MAO) Inhibitors Therapeutic doses of meperidine have precipitated severe reactions in patients concurrently receiving monoamine oxidase inhibitors or those who have received such agents within 14 days. Similar reactions thus far have not been reported with methadone; but if the use of methadone is necessary in such patients, a sensitivity test should be performed in which repeated small incremental doses are administered over the course of several hours while the patient's condition and vital signs are under careful observation. Interaction with Other Central-Nervous-Systern Depressants Methadone should be used with caution and in reduced dosage in patients who are concurrently receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics, tricyclic antidepressants, and other CNS depressants (including alcohol). Respiratory depression, hypotension, and profound sedation or coma may result. Chemical IUPAC Name: 6-dimethylamino-4,4-diphenyl-heptan-3-one : |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines mongabay.com
COPYRIGHT 2007 MONGABAY.COM |