Mephenytoin

This page contains recent news articles, when available, and an overview of Mephenytoin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Mephenytoin (when available)

Pharmacology and use:
Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, Mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. For the treatment of refractory partial epilepsy

Mechanism Of Action:
The mechanism of action of Mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

News Articles on Mephenytoin

The role of CYP2D6*4 variant in bladder cancer susceptibility in ... - Feb 28, 2008
Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res 1987; 47: 5488-93. Bulletin du Cancer (Abonnement),

Brand Names/Synonyms:
Mephenytoin is also known by the following brand names and/or synonymsDilantin; Dilantin-125; Epiazin; Epilan; Fenantoin; Gerot-Epilan; Insulton; Mephentoin; Mephenytoin; Mesantoin; Mesdontoin; Mesontoin; Methoin; Methyl Hydantoin; Methylphenetoin; Metydan; NSC-34652; Phenantoin; Phentytoin; Phenylethylmethylhydantoin; Phenytoin; Sacerno; Sedantional; Sedantoin; Sedantoinal; Triantoin

Drug Category:
Mephenytoin is categorized under the following by the FDA: Anticonvulsants; ATC:N03AB04

Dosage Forms:
Tablet

Absorption:
Not Available

Interactions:
Drug Interactions: Some anticonvulsants may interact with Mephenytoin. They can either increase or decrease the effect of Mephenytoin. Those anticonvulsants include divalproex sodium, valproic acid, and phenobarbital. Mephenytoin may also affect the effects of other drugs, which include some steroid medications, warfarin, certain heart medicines, birth control pills, anti-infective medicines, furosemide and theophylline Please note that Mephenytoin may interact with other drugs that are not listed here.

Chemical IUPAC Name:
5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione

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