Medroxyprogesterone

This page contains recent news articles, when available, and an overview of Medroxyprogesterone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Medroxyprogesterone (when available)

Pharmacology and use:
Medroxyprogesterone, a synthetic progestin more potent than progesterone, is used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions. Contraception

Mechanism Of Action:
Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

News Articles on Medroxyprogesterone

Wyeth's Motion to Overturn Punitive Damages Award Granted by ...  -  Jul 9, 2008
Premarin (conjugated estrogens tablets USP) and Prempro (conjugated estrogens/medroxyprogesterone acetate tablets) are approved by the US Food and Drug MarketWatch

A Journey to Continence: A Case Study of Overactive Bladder Syndrome  -  Jul 23, 2008
After examination by her gynecologist, Anna was prescribed medroxyprogesterone acetate (Provera(R)) to use for 10 days (Nothnagle & Taylor, 2004). RedOrbit,

Wyeth’s Motion to Overturn Punitive Damages Award Granted by ...  -  Jul 15, 2008
Premarin (conjugated estrogens tablets USP) and Prempro (conjugated estrogens/medroxyprogesterone acetate tablets) are approved by the US Food and Drug WebWire (press release),

Comparative actionsof progesterone, medroxyprogesterone acetate ...  -  Jun 9, 2008
Methods: We investigated the effects of progesterone (P), medroxyprogesterone acetate (MPA), drospirenone (DRSP) and nestorone (NES) alone or with 7thSpace Interactive (press release),

La. gov. signs chemical castration bill  -  Jun 26, 2008
On a second offense, injections of medroxyprogesterone acetate, which suppresses a man's sex drive by reducing testosterone levels. would be mandatory. United Press International

Notes and quotes from the Louisiana Legislature  -  Jun 16, 2008
The bill would give judges the option of imposing chemical castration, in which the convict would be treated with the drug medroxyprogesterone acetate, The Times-Picayune - NOLA.com,

House changes, OKs castration bill  -  Jun 11, 2008
On a first offense, a judge would have the option of ordering injections of medroxyprogesterone acetate, which suppresses a man’s sex drive by reducing 2TheAdvocate,

Chemical castration not the solution for repeat offenders  -  Jun 30, 2008
Chemical castration, which consists of injecting an individual with medroxyprogesterone acetate, could be recommended for first-time offenders but would be LSU The Reveille,

Chronic Pelvic Pain in Women  -  Jun 3, 2008
The evidence supports the use of oral medroxyprogesterone, goserelin, adhesiolysis for severe adhesions, and a multidisciplinary treatment approach for RedOrbit,

Counting the pills  -  Jun 23, 2008
Pfizer imports the only injectable marketed in India, Depo-Provera (depot medroxyprogesterone acetate--DMPA). ICs are not produced in India. Express Pharma,

Acetazolamide for Monge's Disease: Efficiency and Tolerance of 6 ...  -  Jun 17, 2008
However, either adverse effects (female hormones given to male subjects in the case of medroxyprogesterone, potential risk of systemic hypotension with RedOrbit,

Colorectal Cancer in Women After Stopping Postmenopausal Hormone ...  -  Jun 17, 2008
They reported that the lower risk of colorectal cancer that had been observed in women prescribed conjugated equine estrogens plus medroxyprogesterone Journal of American Medical Association (subscription),

Cardiac Safety of Lapatinib: Pooled Analysis of 3689 Patients ...  -  Jun 14, 2008
4 patients who received capecitabine monotherapy, and 1 patient who received medroxyprogesterone. b Full recovery (left ventricular ejection fraction RedOrbit,

Effects in Postmenopausal Women of Estradiol and ...  -  May 7, 2008
...biopsies from 55 postmenopausal women before and after 3-month therapy with estradiol (E2), medroxyprogesterone acetate (MPA), E2 plus MPA, or placebo. Journal of Clinical Endocrinology and Metabolism,

Castration bill goes to House  -  May 21, 2008
By MICHELLE MILLHOLLON Offenders who commit simple kidnapping or molestation of a juvenile would not be subject to injections of medroxyprogesterone acetate 2TheAdvocate,

Part two: Are Hormones Safe?  -  May 23, 2008
Yes, its chemical name is medroxyprogesterone named by its inventor--not natural, but man-made. What's the problem with Provera? Well, progesterone is a 21 Seattle Post Intelligencer

Bill forbids masking by sex offenders  -  May 13, 2008
Offenders could choose to be physically castrated rather than submit to injections of medroxyprogesterone acetate, which suppresses a man’s sex drive by 2TheAdvocate,

Key Challenges and Issues facing the World Contraceptives Markets  -  May 15, 2008
...(Dihydroxy Progesterone Acetophenide 75 mg and Estradiol Enanthate 5 mg), (Medroxyprogesterone Acetate 25 mg and Estradiol Cypionate 5 mg), Market Wire (press release)

No increased CHD risk with HRT in women with favorable lipid profile?  -  May 28, 2008
...women without a uterus, and the other examining CEE plus medroxyprogesterone acetate (MPA) in postmenopausal women who had not undergone a hysterectomy. TheHeart.Org,

A Shaky Performance on Corrections  -  May 10, 2008
The company -- Hormones Etc., Inc./John Lee MD Solutions LLC -- said that the study used medroxyprogesterone acetate (MPA), a drug that mimics progesterone Washington Post,

Transdermal estrogen does not up risk of venous thromboembolism?  -  May 22, 2008
...but most studies of this association were done among women taking oral conjugated equine estrogens either alone or with medroxyprogesterone acetate, TheHeart.Org,

House committee approves castration of some sex offenders  -  May 22, 2008
Gautreaux's bill would give a judge the option of sentencing first offenders to be treated for sexual aggression with medroxyprogesterone acetate, or MPA, The Times-Picayune - NOLA.com,

Today at the Legislature  -  May 20, 2008
SB144 Authorizes the administration of medroxyprogesterone acetate to or voluntary castration of persons convicted of a crime which classifies the convicted 2TheAdvocate,

Debiopharm Signs License Agreement for Marketing of Salvacyl(R ...  -  May 15, 2008
...weekly injections required with antiandrogens such as cyproterone acetate (CPA) and medroxyprogesterone acetate (MPA) and there are fewer side effects. PR Newswire (press release),

Can Your Contraceptive Today Cause Heart Disease Later?  -  May 14, 2008
The contraceptive, synthetic progestin medroxyprogesterone acetate (MPA), is a component of Depo/Provera, an injectable contraceptive favored by millions of MedHeadlines,

Benefits of Hormone Replacement on Breast Cancer Survival Are ...  -  May 9, 2008
In complementary basic-science experiments, the authors measured the effects of oestrogen and medroxyprogesterone acetate (MPA) on breast cancer cells in DG News

Hormones, the Brain, and Me  -  May 6, 2008
Impact of progestins on estrogeninduced neuroprotection: Synergy by progesterone and 19norprogesterone and antagonism by medroxyprogesterone acetate. RedOrbit,

Product launch for family planners  -  Apr 16, 2008
Stressing on the Depot-Medroxyprogesterone Acetate (DMPA) method, Sinha said, it is an indictable contraceptive, which works for a period of three months at Calcutta Telegraph,

Louisiana Approves Castration For Sex Offenders  -  Apr 15, 2008
Chemical castration requires the use of the drug medroxyprogesterone acetate, which diminishes the offender's sexual urges. The bill prohibits the offender AHN

Senate passes bill to protect kids  -  Apr 21, 2008
If the bill becomes law Medroxyprogesterone acetate (MPA) would be used to chemically castrate. MPA is a hormonal agent that reduces the production of LSU The Reveille,

Getting a Bead on Natural Family Planning  -  Apr 21, 2008
Women who have used the three-month birth control shot, medroxyprogesterone (Depo-Provera), need to wait a full three months since their last shot, Nurse.com,

Legislative briefs  -  Apr 16, 2008
The bill calls for a judge to have the option of chemical castration using medroxyprogesterone acetate (MPA) upon conviction for a first offense major crime The Daily Advertiser,

One Hormone Used In Hormone Replacement Therapy Linked To Breast ...  -  Apr 1, 2008
The synthetic progestin Hyder's team studied is known as medroxyprogesterone acetate (MPA), which is commonly used in HRT. Using an animal model, Science Daily (press release)

KV Begins Shipping Evamist(TM) to Wholesalers  -  Apr 14, 2008
79 years of age) during 5.6 years of treatment with daily oral CE 0.625 mg combined with medroxyprogesterone acetate (MPA 2.5 mg), relative to placebo. PR Newswire (press release),

Castration bill goes to Senate  -  Apr 8, 2008
The proposal allows courts to order offenders to receive periodic injections of medroxyprogesterone acetate, known as MPA, which reduces testosterone levels 2TheAdvocate,

Unmasking sex offenders; Gautreaux's bill would provide a ...  -  Apr 8, 2008
A judge would have the option of sentencing a first-offender to treatment with the drug medroxyprogesterone acetate, with the aim of diminishing his sexual The Daily Advertiser,

Study confirms hormone-induced breast cancer risk  -  Apr 1, 2008
The hormone used in the study is known as medroxyprogesterone acetate (MPA), which is commonly used in HRT. In the study, the researchers found human breast Food Consumer,

Louisiana Senate approves sex offender castration  -  Apr 15, 2008
Chemical castration would involve treatment with the drug medroxyprogesterone acetate, with the aim of diminishing the offender’s sexual impulses. The Daily Advertiser,

Kidney Failure Independently Predicts Sudden Cardiac Death  -  Apr 15, 2008
HERS was a double-blind, placebo-controlled, randomized trial to examine the effect of 0.625 mg of conjugated estrogens and 2.5 mg of medroxyprogesterone Medscape (subscription)

Certain Oral Contraceptives May Pose Health Risks, Study Suggests  -  11 Mar 2008
11, 2008) — The widely used synthetic progestin medroxyprogesterone acetate (MPA) decreased endothelial function in premenopausal women in a study done at Science Daily (press release)

Estrogen Plus Progestin and Breast Cancer Detection by Means of ...  -  Feb 25, 2008
The effects of conjugated equine estrogens plus medroxyprogesterone acetate on breast cancer detection was determined throughout 5.6 years of intervention Archives of Internal Medicine

Higher rate of abnormal mammograms in women on combined HT  -  Feb 29, 2008
Post-menopausal women (n=16608) were randomly assigned to receive conjugated equine estrogens (0.625 mg/d) plus medroxyprogesterone acetate (2.5 mg/d) or to Endocrine Today,

Hormone Therapy Increases Frequencies of Abnormal Mammography ...  -  Feb 26, 2008
..."Use of conjugated equine oestrogens plus medroxyprogesterone acetate for approximately 5 years resulted in more than 1 in 10 and 1 in 25 women having DG News

Women's Health Initiative Follow Up Study Confirms Health Risks  -  Mar 10, 2008
...of estrogen (0.625 milligrams of conjugated equine estrogens per day) plus progestin (2.5 mg of medroxyprogesterone acetate) or placebo (inactive pill). Kansas City infoZine,

Hormone Replacement Therapy Increases Risk For Breast Scan ...  -  Mar 3, 2008
The women received either a combination of oestrogen and medroxyprogesterone in a single daily tablet (HRT) or a placebo tablet. Women were not included in Medical News Today (press release),

Cancer risk still higher after women stop HRT  -  Mar 4, 2008
...a combination of estrogen (0.625 milligrams of conjugated equine estrogens per day) plus progestin (2.5 mg of medroxyprogesterone acetate), or placebo. CTV.ca,

Combination Hormone Therapy Compromises Diagnostic Performance of ...  -  Feb 29, 2008
The Women's Health Initiative (WHI) previously reported that combination conjugated equine estrogens plus medroxyprogesterone acetate was associated with an Medscape (subscription)

Drug maker Wyeth appealing $19M lawsuit in Arkansas  -  Mar 7, 2008
Premarin (conjugated estrogens tablets USP) and Prempro (conjugated estrogens/medroxyprogesterone acetate tablets) are approved by the US Food and Drug Reliable Plant Magazine,

Estrogen-Progestin Found to Blunt Sensitivity of Mammography  -  Feb 26, 2008
They recommended that the "usable, quantifiable estimates of the adverse effect of conjugated equine estrogens plus medroxyprogesterone acetate on breast MedPage Today,

Hormone Therapy Compromised Breast Cancer Diagnosis Via Mammogram ...  -  Feb 26, 2008
The hormone group received a combination of estrogen and progestin (equine estrogens at 0.625 mg a day and medroxyprogesterone acetate at 2.5 mg a day). Medical News Today,

LA BioMed Research Finds Combined Hormone Therapy Can Increase ...  -  Feb 26, 2008
The study examined the use of conjugated equine estrogens plus medroxyprogesterone acetate for approximately five years. A total of 8506 women were randomly Medical News Today (press release),

Breast Cancer Risk Remains After Stopping HRT  -  Mar 5, 2008
...plus medroxyprogesterone acetate (MPA) prevented cardiovascular disease and fractures and to examine any associated change in the risk of breast cancer. Medscape (subscription)

Cancer risk after combined HRT  -  Mar 5, 2008
...to either receiving combined HRT (0.625mg conjugated equine oestrogen plus 2.5mg medroxyprogesterone acetate daily) or a placebo between 1993 and 1998. NHS Choices,

WHI follow-up study confirms combined HT risks outweigh benefits  -  Mar 5, 2008
This study provides further follow-up data about patients randomized to 0.625 mg conjugated equine estrogens plus 2.5 mgm medroxyprogesterone acetate or Endocrine Today,

Risks of Estrogen/Progestin Treatment Linger While Benefit Fades  -  Mar 4, 2008
The WHI randomized 16608 post-menopausal women to conjugated equine estrogens (0.635 mg/d) plus medroxyprogesterone acetate (2.5 mg/d) or placebo. MedPage Today,

Women who have stopped estrogen plus progestin therapy may be at ...  -  Mar 4, 2008
...which included 16608 postmenopausal women, assessed whether conjugated equine estrogens (CEE) plus medroxyprogesterone acetate (MPA) prevents heart EurekAlert (press release),

Health Risks and Benefits 3 Years After Stopping Randomized ...  -  Mar 4, 2008
...placebo-controlled, randomized trial of conjugated equine estrogens (CEE) 0.625 mg daily plus medroxyprogesterone acetate (MPA) 2.5 mg daily, Journal of American Medical Association (subscription),

Concerns raised in study of equine estrogen use  -  Feb 27, 2008
The researchers took 16608 postmenopausal women, about half of whom (8506) received a combination of conjugated equine estrogens and medroxyprogesterone Horsetalk,

Rate of Biopsy Over 50% Higher in Those Taking Hormones  -  Feb 25, 2008
For this trial, the women were randomized to treatment with the combination of 0.625 mg conjugated equine estrogens plus 2.5 mg medroxyprogesterone daily or Insider Medicine,

Many Physician Weight Loss Programs Should Come With Warning ...  -  Feb 21, 2008
...such as Premarin (conjugated esterified estrogen from horse urine) and Prempro (medroxyprogesterone), that medical studies now link to an increased risk PR Web (press release),

HRT: updating the evidence  -  Feb 12, 2008
...plus 2.5mg medroxyprogesterone acetate) or oestrogen-only replacement (0.625mg conjugated equine oestrogens) with placebo in women aged 50–79 years. New Zealand Doctor Online,

Wyeth Divests Manufacturing Facility  -  Jan 23, 2008
...produces hormone-replacement therapies Premarin (conjugated estrogens) and Prempro (conjugated estrogens/ medroxyprogesterone acetate), Akrimax said. FDA news (subscription),

Water In White House Press Room Contaminated!  -  Jan 9, 2008
...by Kamal El-Din Unconfirmed Sources report medroxyprogesterone - the drug used for chemical castration has been found in the White House Press Room water Unconfirmed Sources (satire)

Education: Medical Faculty Hradec Králové, Charles University ...  -  Jan 17, 2008
Chemical hormones have different molecules, like medroxyprogesterone, and more side effects. Blood testing before the treatment is obligatory and we prepare Prague Post,

Hair today gone tomorrow  -  Jan 12, 2008
Similarly, with HRT, the formulations that are better for your hair contain drospirenone, dydrogesterone, medroxyprogesterone acetate and natural Times Online,

Need to Know - Contraception  -  Jan 29, 2008
Depo-Provera (medroxyprogesterone acetate) is known to lower circulating levels of oestrogens in some women and be associated with a reduction in bone Pulse,

FDA warns compounded menopause hormone therapy drugs no better  -  Jan 9, 2008
...including a large study to determine the effects of estrogen with the progestin medroxyprogesterone acetate on the prevention of heart disease. Food Consumer,

Effect of Hyperbaric Oxygen on Flow-Mediated Vasodilation  -  Jan 18, 2008
Effects of estrogen replacement with and without medroxyprogesterone acetate on brachial flow-mediated vasodilator responses in postmenopausal women with Journal of Ultrasound in Medicine (subscription)

BioSante Pharmaceuticals Receives Milestone Payment from Bradley ...  -  Dec 18, 2007
...age) during five years of daily treatment with 0.625 mg of oral conjugated equine estrogens combined with 2.5 mg of medroxyprogesterone acetate per day. Business Wire (press release),

Abnormal Levels of Coagulation Factors Mean Increased Risk for ...  -  Dec 10, 2007
...double-blind, randomized WHI trials evaluating conjugated equine estrogens alone (E), or estrogen plus medroxyprogesterone acetate (E + P), or placebo. DG News

Research Highlights New Approaches to Management of Blood Clotting ...  -  Dec 8, 2007
These two placebo-controlled double-blind randomized trials evaluated two E regimens - E (conjugated equine estrogens) or E+P (E + medroxyprogesterone PR Newswire (press release),

Brand Names/Synonyms:
Medroxyprogesterone is also known by the following brand names and/or synonymsAmen; Aragest; Aragest 5; Asconale; CBP 1011; Clinofem; Clinovir; Colirest; Crinone; Curretab; Cycrin; DMPA; Depo-Clinovir; Depo-Prodasone; Depo-Progestin; Depo-Promone; Depo-Provera; Depo-Subq Provera 104; Depomedroxyprogesterone Acetate; Depot-Medroxyprogesterone Acetate; Farlutal; Farlutin; G-Farlutal; Gestapuran; HSDB 3114; Hematrol; Hydroxymethylprogesterone; Hysron; Indivina; Lunelle; Lutopolar; Lutoral; MAP; MPA; Med-Pro; Medroprogesterone Acetate; Medrossiprogesterone [Dcit]; Medroxiprogesterona [Inn-Spanish]; Medroxiprogesteronum; Medroxyprogesteron; Medroxyprogesteron Acetate; Medroxyprogesterone; Medroxyprogesterone Acetate; Medroxyprogesterone Base; Medroxyprogesteronum [Inn-Latin]; Meprate; Metigestrona; Mpa Gyn 5; Nadigest; Nidaxin; Novo-Medrone; Oragest; Perlutex; Perlutex Leo; Prempro/Premphase; Prodasone; Progestalfa; Progestasert; Progesterone; Progeston; Progevera; Prometrium; Provera; Proverone; Ralovera; Repromap; Repromix; Sirprogen; Sodelut G; U 8839; U 8840; Veramix

Drug Category:
Medroxyprogesterone is categorized under the following by the FDA: Contraceptives; Progestins; ATC:G03AC06; ATC:G03DA02; ATC:L02AB02

Dosage Forms:
Oral tablets, and Depo injection

Absorption:
Rapidly absorbed from GI tract

Interactions:
-->Interactions for Medroxyprogesterone:

No drug-drug interaction studies have been conducted with depo-subQ provera 104.

Aminoglutethimide administered concomitantly with depo-subQ provera 104 may significantly decrease the serum concentrations of MPA.

Laboratory Tests

The pathologist should be advised of progestin therapy when relevant specimens are submitted. The physician should be informed that certain endocrine and liver function tests, and blood components may be affected by progestin therapy:

(a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol).

(b) Plasma and urinary gonadotropin levels are decreased (e.g., LH, FSH).

(d) T₃-uptake values may decrease.

(e) There may be small changes in coagulation factors.

(f) Sulfobromophthalein and other liver function test values may be increased slightly.

(g) There may be small changes in lipid profiles.

Chemical IUPAC Name:
17-acetyl-17-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

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