Matulane

This page contains recent news articles, when available, and an overview of Matulane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Matulane (when available)

Pharmacology and use:
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division. For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Mechanism Of Action:
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA.

News Articles on Procarbazine

Pharmacy lawsuits settled in silence  -  11 Mar 2008
But instead, a Walgreens store in suburban St. Louis gave her Matulane, a chemotherapy drug that interferes with cell growth. According to the federal Baxter Bulletin,

Walgreen Co. sued over wrong drug  -  Oct 19, 2007
Instead, Mefford said, Givens was given Matulane, a chemotherapy drug for treatment of Hodgkin's disease. The lawsuit states that drug is designed to CNNMoney.com

WALGREENS Suit: Chemo drug led to miscarriage  -  Oct 19, 2007
The pharmacist at her local Walgreens instead gave her Matulane, used to treat Hodgkin's disease. The drug is designed to interfere with the growth of cells Chicago Tribune,

Walgreen's Sued for Wrongful Death  -  Oct 24, 2007
The incident occurred outside St. Louis where Chanda Givens tried to fill a prescription for Materna, a prenatal vitamin, and was allegedly given Matulane, InjuryBoard.com,

St. Louis Couple Sues Walgreens  -  Oct 20, 2007
...filled a prescription for prenatal vitamins, Materna, with an anti-cancer medication, Matulane, often used in the treatment of Hodgkin's disease. MedHeadlines,

Walgreens Sued Over Woman's Miscarriage  -  Oct 19, 2007
The pharmacist at her local Walgreens instead gave her Matulane, used to treat Hodgkin's disease. Lawyers for Givens and her husband state that Walgreens Dog Flu Diet and Diseases,

Lawsuit: Walgreens Substituted Chemo Drug For Prenatal Vitamins  -  Oct 19, 2007
Chanda Givens was given a presription for Materna, a prenatal vitamin, but her local Walgreens pharmacist gave her Matulane, a drug used to treat advanced The Consumerist,

Suit claims Walgreen error caused miscarriage  -  Oct 19, 2007
The lawsuit says that instead, she was given Matulane, a chemo drug for treatment of Hodgkin's disease. Givens suffered a miscarriage a month later, WQAD,

Don't be a victim of pharmacy errors  -  Oct 25, 2007
She later learned that instead of being given a prescription for Materna, a prenatal vitamin, she received one for Matulane, a chemotherapy drug used to CNN

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Philippines describes spokesman for direction of contents.  -  Jun 13, 2007
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Matulane’s new album ready for market Feb 19, 2006
BULAWAYO-based musician, Obediah Matulane has finished working on his new album which will be available on the market next month. ... - Chronicle,

Brand Names/Synonyms:
Matulane is also known by the following brand names and/or synonymsCCRIS 2389; CHEMBANK3199; HSDB 3250; IBZ; Ibenzmethyzin; Ibenzmethyzine; Ibenzmethyzine Hydrochloride; MBH; MIH; Matulane; Mih Hydrochloride; NSC-77213; Nathulane; Natulan; Natulan Hydrochloride; Natulanar; Natunalar; PCB; PCX; Pcb Hydrochloride; Procarbazin; Procarbazin [German]; Procarbazina [Inn-Spanish]; Procarbazine; Procarbazine Hydrochloride; Procarbazinum [Inn-Latin]; Ro 4 6467/1

Drug Category:
Matulane is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01XB01

Dosage Forms:
CAPSULE

Absorption:
Procarbazine is rapidly and completely absorbed.

Interactions:
Interactions for Procarbazine: To minimize CNS depression and possible potentiation, barbiturates, antihistamines, narcotics, hypotensive agents or phenothiazines should be used with caution. Ethyl alcohol should not be used since there may be an Antabuse (disulfiram)-like reaction. Because Matulane exhibits some monoamine oxidase inhibitory activity, sympathomimetic drugs, tricyclic antidepressant drugs (e.g., amitriptyline HCl, imipramine HCl) and other drugs and foods with known high tyramine content, such as wine, yogurt, ripe cheese and bananas, should be avoided. A further phenomenon of toxicity common to many hydrazine derivatives is hemolysis and the appearance of Heinz-Ehrlich inclusion bodies in erythrocytes. No cross-resistance with other chemotherapeutic agents, radiotherapy or steroids has been demonstrated.

Chemical IUPAC Name:
N-(1-methylethyl)-4-[(N'-methylhydrazino)methyl]benzamide

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