Marimastat

This page contains recent news articles, when available, and an overview of Marimastat but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Marimastat (when available)

Pharmacology and use:
Used in the treatment of cancer, it is an angiogenesis and metastasis inhibitor. As an angiogenesis inhibitor it limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes. For the treatment of various cancers

Mechanism Of Action:
Marimastat is a hydroxamic acid, matrix metalloprotease inhibitor. It mimics the peptide structure of natural MMP substrates. It binds to matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) thereby preventing the degradation of the basement membrane by these proteases. This antiprotease action prevents the migration of endothelial cells needed to form new blood vessels. Inhibition of MMPs also prevents the entry and exit of tymor cells into existing blood cells, thereby preventing metastasis.

News Articles on Marimastat

Ex-head of British Biotech signs GSK deal  -  20 Dec 2007
In 1998, a whistleblower alleged that investors had been misled as to the effectiveness of Marimastat - claims that were fiercely contested by the company. Guardian Unlimited,

Hello Dolly, but things aren’t looking swell  -  06 Aug 2007
Times Online,...whose value exceeded £1 billion in 1996 before collapsing amid claims that executives had overegged the prospects of Marimastat, its cancer treatment.

The cure?  -  Jan 12, 2007
Guardian Unlimited,...drug failure came from the company British Biotech, which spent several years in the late 1990s promoting a new drug for pancreatic cancer, marimastat.

Brand Names/Synonyms:
Marimastat is also known by the following brand names and/or synonymsBB 2516; BB 2516;; BB-2516; Marimastat; Marimastat [Usan]

Drug Category:
Marimastat is categorized under the following by the FDA: Antineoplastic Agents; ATC:L01X

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
N-[2,2-dimethyl-1-(methylcarbamoyl)propyl]-2-[hydroxy-(hydroxycarbamoyl)methyl]-4-methyl-pentanamide

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