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MS ContinThis page contains recent news articles, when available, and an overview of MS Contin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: MS Contin (when available) Morphine is a narcotic pain management agent indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Morphine exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Morphine appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers. For the relief and treatment of severe pain Mechanism Of Action: The precise mechanism of the analgesic action is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. News Articles on Morphine County Man Charged With TennCare Fraud - Sep 4, 2008 TennCare medical assistance by going to a TennCare provider for the prescription painkillers MS Contin, which is a time-released version of morphine; Greeneville Sun, Physician implicated in patient’s death - Aug 21, 2008 Under this diagnosis, excessive narcotics were prescribed including thirty-six 40 mg tablets of methadone, forty-eight 200 mg tablets of MS Contin or 9600 Macon County News, Alleged drunken driver goes on a tear - Aug 26, 2008 The suspect, a potential buyer, was allegedly found to have time-released pills of morphine sulfate – MS Contin – in her purse. River Falls Journal (subscription), UPS worker accused of stealing drug deliveries - 03 Jul 2008 Investigators say 26-year-old Joshua Jansen stole Morphine, Roxicodone, Methylphenidate, Focalin, Dexmethylpendate and MS Contin. Tampa Bay's 10, Florence man to enter pleas Aug. 13 - 03 Jul 2008 The charge of trafficking morphine relates to 83 pills of MS Contin found in Mr. White’s home. The dropped charges involved the seizure of more than 100 TheChronicleHerald.ca, UPS worker arrested for stealing drug shipments - 03 Jul 2008 The drugs found were Morphine, Roxicodone, Methylphenidate, Focalin, Dexmethylpendate and MS Contin. They also found a UPS box addressed to Jansen with WWSB ABC 7, Calls for greater controls over 'hillbilly heroin' - Jun 23, 2008 As revealed on AM this morning, drug dealers are getting their hands on large quantities of drugs like Oxycontin and MS Contin and selling them as ABC Online, 'Hillbilly heroin' makes its mark on Australian streets - Jun 23, 2008 In the United States drugs like OxyContin and morphine, usually sold as MS Contin, are widespread. They are called 'hillbilly heroin'. ABC Online, Pharmacy technician withdraws guilty plea in homicide case - Jun 14, 2008 Authorities allege Walker, who worked as a pharmacy technician at Walgreens, gave MS Contin pills to a 15-year-old, who then gave two pills to Jacobs. Chicago Tribune, KV Pharmaceutical Company Reports Fiscal 2008 Results - Jun 16, 2008 Morphine Sulfate Extended Release Tablets 100 mg and 200 mg (MS Contin(R) marketed by Purdue Pharma LP), which allows ETHEX to offer a full line of all Earthtimes (press release), East Tennessee man charged with TennCare "doctor shopping" - May 9, 2008 TennCare officials say Anthony W. Ausmus is charged with four counts of fraudulently obtaining the prescription drug MS Contin by going to multiple doctors WVLT, Drug, forgery charges pressed - 23 Apr 2008 The man said his prescription bottles of MS Contin and Xanax were missing as well, police said. The man told police that on April 5 he had gone on vacation Rutland Herald, Prescription drugs a hit on the street - Feb 27, 2008 Almost every day, he gets patients requesting potentially addictive painkillers such as OxyContin or Ms-Contin. "In our situation, you can't be naive and Canada.com, Health workers asked to help police in prescription drugs crackdown - Feb 14, 2008 Riverina health workers are being urged to help police crack down on an increase in the abuse of the morphine-based prescription drugs MS Contin and ABC Online, Foul Bawl! - Feb 20, 2008 Some of Purdue's most well-known drugs are MS Contin and OxyIR C-II, both of which are morphine-related pain relievers, and the infamous OxyContin, fairfieldweekly.com, TheraQuest Receives $3 Million in Equity Investment and Licensing ... - Dec 18, 2007 TQ- 1015 will compete with MS Contin(TM), OxyContin(TM), Duragesic(TM), Opana(TM) ER and short acting opioids. TQ-1011 is a proprietary injectable Genetic Engineering News (press release), KV Pharmaceutical Announces FDA Approval for Morphine ER 100 mg ... - Oct 25, 2007 ...and Drug Administration (FDA) on its application for the 100 mg and 200 mg strengths of Morphine ER Tablets (MS Contin(R) marketed by Purdue Pharma LP). Earthtimes, Painkillers: Overdose now leading cause of death for West ... - Nov 3, 2007 MS Contin. Duragesic. West Virginia’s overdose death rate is the nation’s worst, but overdoses have become a nationwide problem. For the first time, Charleston Gazette, Osteopathy Doctors and Medical Marijuana - Sep 20, 2007 I presume he is talking about OxyContin and MS Contin, which are among the worst addicting drugs. The article extols the use of Marinol, “Why would patients Salem-News.Com, Grand jury indicts Ursa man in death of Quincy teenager - Aug 31, 2007 He is being accused of supplying 17-year-old Shanea Jacobs with a lethal dose of MS Contin, a powerful form of morphine normally associated with cancer Quincy Herald Whig, Painful drug war victory - Aug 15, 2007 While injuries sustained during the Gulf War left him reliant on nearly a gram of OxyContin and MS Contin per day, it was the war on drugs that would ground Washington Times, Purdue Pharma, profits and the public health - Jun 17, 2007 TriCities.com,Purdue’s own MS Contin, a high-potency long-acting morphine preparation, had been abused in the late 1980s in a similar fashion as OxyContin was later to be Road to visit sister assumes a somber tone - Jun 25, 2007 San Diego Union Tribune,On my last trip to see my sister, on Father's Day, she was lost in a dense fog created by the cancer and MS Contin, a form of morphine. Some drugs that can cause memory loss - Jun 27, 2007 Baltimore Messenger,Narcotics and opioids, including morphine (MS Contin, Kadian, Avinza) and oxycodone/acetaminophen (Percocet). High blood pressure medications, TheraQuest Initiates GMP Manufacturing of Abuse Deterrent - Jun 22, 2007 American Digital Networks (press release),TQ-1015 will compete with MS Contin(TM), OxyContin(TM), Duragesic(TM), Opana(TM) and short acting opioids in the $8.3 Billion US opioid market. State Moves To Revoke Highland Park Surgeon's License - Jun 21, 2007 WBBM780,The state's complaint against Dr. Kane indicated that he had written 11 prescriptions for OxyContin, MS Contin, Oxycodone and Roxycodone for the patient, Viagra Buy Viagra Online Best prices CliCK HERE - Jun 14, 2007 Biznes blog money.pl,...levorphanol Levo-Dromoran, meperidine Demerol, methadone Dolophine, Methadose, morphine Kadian, MS Contin, Kadian, Oramorph; procainamide Procan, Oregon Toxicologist Says Treatment for PTSD Should Include Cannabis - May 8, 2007 Salem-News.Com,...and anti-depressant in the book as well as highly potent pain killers like Oxycontin and MS contin (morphine) with minimal success for PTSD. cARL GRACE: I was only trying to ease her suffering, just ... - Mar 29, 2007 Geelong Advertiser,Irene Bryant 58, was found dead at her Newtown home on January 8, 2002 after being prescribed abnormally-high doses of the morphine-based drug MS Contin. Alberta Sunflashes - Dec 21, 2006 Edmonton Sun,Several thousand dollars in cash, some hashish oil and 50 MS Contin pills were seized from the other suite, police said. Alberta Sunflashes - Dec 21, 2006 Edmonton Sun,Several thousand dollars in cash, some hashish oil and 50 MS Contin pills were seized from the other suite, police said. Addicts turn to hillbilly heroin - Dec 12, 2006 Edmonton Sun,In Edmonton, where heroin use is virtually nil, prescription painkillers like morphine, MS Contin and OxyContin are the opiates of choice, said the study, CONSCIOUS SEDATION - Dec 1, 2006 EndoNurse,It is perfect for the outpatient setting, although meperidine (brand name Demerol) and morphine (brand name MS Contin) are still used with success. Local Gal Gets Addicted To Oxycontin, Blames Hydrocodone Instead Sep 14, 2006 Amen.". "I suppose it could have been the Fioricet or the Talwin too, maybe the Neurontin, the ANSAIDS as a whole, Xanax, MS Contin, Flexeril, Percocets, Kadian ... -Smooth Operator (satire) Ex-deputy receives 13-year sentence Sep 15, 2006 ...more than 18 months before his arrest, a doctor had been prescribing Verbos increasing doses of addictive painkillers -- including MS Contin -- despite medical ... -OregonLive.com Region's drug overdose deaths hit plateau Jul 4, 2006 Although the category of drugs includes heroin, Massello said the bulk of the overdoses comes from morphine-based painkillers such as MS Contin and Roxanol. ... -Roanoke Times Doctor’s suspension worries group May 2, 2006 ...things. Opioids include drugs like Dilaudid, MS Contin and OxyContin, the abuse of which has led to a number of deaths in Cape Breton. ... - ChronicleHerald.ca Neuropathic Pain: An Update on Effective Management Strategies May 5, 2006 Oral long-acting opioids include morphine (MS Contin [Purdue Frederick], Kadian [Alpharma], Avinza [Ligand], and generic long-acting), oxycodone (OxyContin ... - Medscape (subscription) Ex-CB top doctor has licence to prescribe narcotics yanked Apr 25, 2006 Opioids include drugs like Dilaudid, MS Contin and OxyContin, the abuse of which has led to a worrisome trafficking trade and a number of deaths in Cape Breton ... - ChronicleHerald.ca Pensioners cash in on drugs Mar 11, 2006 Sales of morphine-based drug MS Contin – nicknamed "greys" – are at an all-time high on Brisbane's streets. Pensioners are faking ... - Queensland Sunday Mail Psychiatrist gives up his license Feb 24, 2006 ...a report from the state Drug Enforcement and Professional Practices Branch found that Broderson was prescribing large quantities of MS Contin, a controlled ... - Kentucky.com, Prescription for trouble Feb 11, 2006 For example, a 60-mg tablet of MS Contin (slow-release morphine) costs $1.70 by prescription but sells for, on average, $35 on the street — a 2,059 per cent ... - Toronto Star, Feds charge doctor, say he filled "hundreds of unlawful ... Feb 9, 2006 ...the federal indictment charges Stanch with writing prescriptions for painkillers such as OxyContin, Percocet, Endocet, Roxicet, MS Contin and Oramorph from ... - Asbury Park Press, Feds charge doctor, say he filled "hundreds of unlawful ... 09 Feb 2006 ...the federal indictment charges Stanch with writing prescriptions for painkillers such as OxyContin, Percocet, Endocet, Roxicet, MS Contin and Oramorph from ... - Asbury Park Press Brand Names/Synonyms: MS Contin is also known by the following brand names and/or synonymsAVINZA; Apokyn; Astramorph Pf; Avinza; Depodur; Diacetylmorphine Hydrochloride; Diamorphine Hydrochloride; Dulcontin; Duramorph; Duramorph Pf; Duromorph; Epimorph; Heroin Hydrochloride; Heroine Hydrochloride; Kadian; L-Morphine; M S Contin; M-Eslon; M.O.S; M.O.S.-S.R; MS IR; MS.IR; MS/L; MS/S; MSIR; Meconium; Morfina; Morphia; Morphin; Morphina; Morphine; Morphine Extra-Forte; Morphine Forte; Morphine H.P; Morphine Sulfate; Morphinism; Morphinum; Morphitec; Morphium; Moscontin; Ms Contin; Ms/L Concentrate; Nepenthe; O,O'-Diacetylmorphine Hydrochloride; Oms Concentrate; Oramorph Sr; Ospalivina; Rescudose; Rms Uniserts; Roxanol; Roxanol 100; Roxanol Ud; Statex; Statex Drops Drug Category: MS Contin is categorized under the following by the FDA: Narcotics; Analgesics; Opiate Agonists; ATC:G04BE07; ATC:N02AA01; ATC:N02AA04; ATC:N02AA09; ATC:N04BC07; ATC:R05DA01; ATC:R05DA05; ATC:S01XA06 Dosage Forms: CAPSULE (SUSTAINED-RELEASE); DROPS; LIQUID; SOLUTION; SUPPOSITORY; SUPPOSITORY (SUSTAINED-RELEASE); SYRUP; TABLET; TABLET (EXTENDED-RELEASE); TINCTURE Absorption: Bioavailability is ~30% Interactions: Interactions for Morphine: Use with Other Central Nervous System Depressants: The depressant effects of morphine are potentiated by the presence of other CNS depressants such as alcohol, sedatives, antihistaminics, or psychotropic drugs. Use of neuroleptics in conjunction with oral morphine may increase the risk of respiratory depression, hypotension and profound sedation or coma. Interaction with Mixed Agonist/Antagonist Opioid Analgesics: Agonist/antagonist analgesics (i.e., pentazocine, nalbuphine, butorphanol, or buprenorphine) should NOT be administered to patients who have received or are receiving a course of therapy with a proof opioid agonist analgesic. In these patients, the mixed agonist/antagonist may alter the analgesic effect or may precipitate withdrawal symptoms. Chemical IUPAC Name: (5α,6α)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol : |
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