Lioresal

This page contains recent news articles, when available, and an overview of Lioresal but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Lioresal (when available)

Pharmacology and use:
Baclofen is a muscle relaxant and antispastic. Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Although Baclofen is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, Baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination. For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity

Mechanism Of Action:
Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.

News Articles on Baclofen

AGI Therapeutics plc announces Interim Results  -  Sep 8, 2008
...terms of both R- and S-isomers of baclofen with the fasted exposure following a single 10mg dose of Lioresal(R) (a marketed form of racemic baclofen). MarketWatch

Pharmacologic Management of Multiple Sclerosis  -  Jul 23, 2008
Additional symptomatic treatment may include clonazepam (Klonopin(R)) and propranolol (Inderal(R)) for ataxia and tremors; baclofen (Lioresal(R)), RedOrbit,

AGI Therapeutics plc announces key findings of clinical PK study ...  -  Apr 2, 2008
...(3) There was comparable plasma exposure of R-isomer from 5mg of arbaclofen compared to 10 mg of Lioresal, confirming that the exposure to the R-isomer is FOXBusiness

AGI Therapeutics, plc announces Financial results for the twelve ...  -  Apr 3, 2008
...in terms of both R-and S-isomers of baclofen with the fasted exposure following a single 10mg dose of Lioresal(R) (a marketed form of racemic baclofen). FOXBusiness

Actavis Extends Portfolio With Four New Products in the US  -  Feb 28, 2008
Baclofen tablets: the generic equivalent of Lioresal(R) tablets by Novartis, will be available in 10mg and 20mg strengths. Baclofen tablets are used to FOXBusiness

Another Use for Baclofen - Binge Eating?  -  Jan 10, 2008
Only a week or so ago wrote about the use of baclofen (Lioresal®), a muscle relaxant, for treating addiction to alcohol. Now there's a report of a new use HealthandAge.com

The Chronic Pain of Multiple Sclerosis  -  Dec 9, 2007
This is typically treated with prescription medications such as baclofen (Lioresal) or tizanidine (Zanaflex). In addition to medication, American Chronicle,

Many treatments can ease chronic pain  -  Nov 20, 2007
...and muscle relaxants like baclofen (Lioresal) and dantrolene sodium (Dantrium). These are often used in combination with specific pain-relieving drugs. International Herald Tribune,

Hiccups may have even more treatments than they do causes  -  Sep 17, 2007
The muscle relaxant baclofen (Lioresal) and the antiemetic metoclopramide (Reglan) have also been successful in treating persistent or intractable hiccups. Denver Post,

BCLI: Begins Efficacy and Safety Studies for ALS (Lou Gehrig's ...  -  Oct 8, 2007
Lioresal(R)(baclofen) and Zanaflex(R)(tizanadine) may relieve spasticity. Ultram(R)(tramadol) is often prescribed for pain relief. Trading Markets (press release),

Lannett Gets Added Baclofen Approval  -  Jul 12, 2007
Forbes,Other companies selling generic Lioresal, or Baclofen, include Caraco Pharmaceutical Laboratories (other-otc: PHLB.PK - news - people ) Ltd.

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Fighting spasticity  -  May 4, 2007
Spokane Journal of Business,The device pumps the liquid form of baclofen, called Lioresal Intrathecal, through the catheter into the fluid surrounding the spinal cord, where it blocks

Study Supports Cost-Effectiveness of Medtronic's Spasticity ...  -  Apr 26, 2007
PharmaLive.com (press release),Actual results may differ materially from anticipated results. Lioresal(R) is a registered trademark of Novartis Pharmaceuticals Corporation.

Study Supports Cost-Effectiveness of Medtronic's Spasticity ...  -  26 Apr 2007
PharmaLive.com (press release),Actual results may differ materially from anticipated results. Lioresal(R) is a registered trademark of Novartis Pharmaceuticals Corporation.

Blepharospasm and Paget's cancer  -  Jan 3, 2007
Sarasota Herald-Tribune,Cogentin, Klonopin, Lioresal and trihexyphenidyl are examples. If neither Botox nor medicine is effective, surgical removal of some of the eyelid muscles is

Botox could ease spasms from stroke  Nov 6, 2006
Often there sa lot of pain. Baclofen (Lioresal), a muscle relaxant, isn t very effective. Diazepam (Valium) relaxes muscles but makes people drowsy. ... -Denver Post, Stroke Survivors Benefit Significantly from Targeted Spasticity ...  Nov 8, 2006
...of a programmable drug pump connected to a thin tube, or catheter, to deliver precise amounts of a muscle relaxant called Lioresal ® Intrathecal (baclofen ... -Business Wire (press release), Caraco Gets FDA Approval on Baclofen  Aug 16, 2006
Laboratories Ltd. said Wednesday the Food and Drug Administration approved its generic version of Novartis AG's Lioresal. The drug ... -Houston Chronicle

Drinking Problem? Try Drugs  Apr 19, 2006
Scientists see promise in other drugs for treating alcoholism, including Abilify, approved for psychosis, Zofran for nausea and Lioresal for muscle spasms. ... - Wired News

From the analyst's couch: The GERD market  Apr 7, 2006
For example, baclofen (Lioresal; Novartis), metoclopramide (Reglan; Schwarz Pharma) and domperidone (Motilium; Janssen-Cilag) are all effective at improving ... - Nature.com (subscription)

No laughing matter: Hiccups could signal a medical problem  Apr 4, 2006
Serious cases of hiccups can be treated with a number of medications, including baclofen (Lioresal), chlorpromazine (Thorazine), gabapentin (Neurontin), and ... - NorthJersey.com

Brand Names/Synonyms:
Lioresal is also known by the following brand names and/or synonymsApo-Baclofen; Ba 34647; Baclofen; Baclon; C 34647ba; Kemstro; Lioresal; Lioresal Intrathecal; Novo-Baclofen; Nu-Baclofen; Pms-Baclofen

Drug Category:
Lioresal is categorized under the following by the FDA: Muscle Relaxants; Skeletal Muscle Relaxants; GABA Agonists; ATC:M03BX01

Dosage Forms:
TABLET; INTRATHECAL INJECTION;

Absorption:
Rapidly and extensively absorbed

Interactions:
-->Interactions for Baclofen:
Injection

There is inadequate systematic experience with the use of baclofen injection in combination with other medications to predict specific drug-drug interactions. Interactions attributed to the combined use of baclofen injection and epidural morphine include hypotension and dyspnea.

SIDE EFFECTS (KEMSTRO)

The most common adverse reaction during treatment with baclofen is transient drowsiness (10-63%).

In one controlled study of 175 patients, transient drowsiness was observed in 63% of those receiving baclofen tablets compared to 36% of those in the placebo group. Other common adverse reactions are dizziness (5-15%), weakness (5-15%) and fatigue (2-4%). Others reported:

Neuropsychiatric: Confusion (1-11%), headache (4-8%), insomnia (2-7%); and, rarely, euphoria, excitement, depression, hallucinations, paresthesia, muscle pain, tinnitus, slurred speech, coordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizure.

Cardiovascular: Hypotension (0-9%). Rare instances of dyspnea, palpitation, chest pain, syncope.

Gastrointestinal: Nausea (4-12%), constipation (2-6%); and, rarely, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhea, and positive test for occult blood in stool.

Genitourinary: Urinary frequency (2-6%); and, rarely, enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, hematuria.

Other: Instances of rash, pruritus, ankle edema, excessive perspiration, weight gain, nasal congestion.

Some of the CNS and genitourinary symptoms may be related to the underlying disease rather than to drug therapy. The following laboratory tests have been found to be abnormal in a few patients receiving baclofen: increased SGOT, elevated alkaline phosphatase, and elevation of blood sugar.

The adverse experience profile seen with KEMSTRO^TM was similar to that seen with baclofen tablets.

Chemical IUPAC Name:
4-amino-3-(4-chlorophenyl)-butanoic acid

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