Levaquin

This page contains recent news articles, when available, and an overview of Levaquin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Levaquin
(when available)

Pharmacology and use:
Levofloxacin, a fluoroquinolone antiinfective, is the optically active L-isomer of ofloxacin. Levofloxacin is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community-acquired pneumonia and pneumonia caused by penicillin-resistant strains of Streptococcus pneumoniae, skin and skin structure infections, complicated urinary tract infections and acute pyelonephritis. For the treatment of Bacterial infection of; Respiratory tract, Urinary tract, GI, CNS and Immuno compromised patients caused by: S.pneumoniae, H.influenzae, M.catarrhalis, S.aureus, H.parainfluenzae, P.aeruginosa, S.marcescens, E.coli, K.pneumoniae, C.pn

Mechanism Of Action:
Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.

News Articles on Levofloxacin

LegalView Updates Levaquin Practice Area with New Side  -  May 31, 2008
LegalView.com, the most comprehensive resource for everything legal on the Web, recently updated its Levaquin practice area after a study found the TransWorldNews (press release),

FDA Approvals: Taclonex Scalp, Abilify, Levaquin  -  May 22, 2008
To participate in this internet activity: (1) review the target audience, learning objectives, and author disclosures; (2) study the education content; Medscape (subscription)

Levaquin Approved for Pediatric Anthrax Exposure  -  May 13, 2008
The FDA has approved Ortho-McNeil’s antibiotic Levaquin to treat pediatric patients exposed to inhaled anthrax. Levaquin (levofloxacin) tablets in 250-mg, FDA news (subscription),

High Growth Reported for The Antibacterial Drug Market Analysis ...  -  May 12, 2008
The antibacterial market only contained one blockbuster drug in 2006, this being Johnson & Johnson's Levaquin. Visiongain predicts that there will be room Market Wire (press release)

FDA approves levofloxacin for anthrax in children  -  May 20, 2008
...(FDA) recently offered another antibiotic option for combating inhalational anthrax in children by approving the quinolone drug levofloxacin (Levaquin). CIDRAP,

Moxifloxacin Alone Equals Combo Regimen in Pneumonia  -  May 16, 2008
89.9% for a combination of IV ceftriaxone (Rocephin) plus sequential intravenous and oral levofloxacin (Levaquin) in a randomized 733-patient trial. MedPage Today,

Jo Brant scrutinizes use of antibiotics  -  May 23, 2008
Other antibiotics that received updated warnings include Floxin, Levaquin and Cipro. Of those, only Floxin is not used in Canada. Hamilton Spectator,

FDA Safety Changes: Levaquin, Nexavar, AndroGel  -  Apr 2, 2008
On December 13, 2007, the FDA approved safety labeling revisions for levofloxacin (Levaquin tablets, oral solution, and intravenous injection; Ortho-McNeil Medscape (subscription)

Broad-based J&J shrugs off slowdown in pharma sales  -  Apr 16, 2008
...therapy Concerta (methylphenidate) rose 15.1% to $290 million and the anti-infective Levaquin/Floxin (levofloxacin) increased 3.5% to $496 million. Pharma Times (subscription),

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Avian Flu Jumped from Dying Son to Caregiver Father  -  Apr 7, 2008
The next day, he was hospitalized with fever, mild thrombocytopenia, and bilateral pneumonia, and treated with levofloxacin (Levaquin), corticosteroids, MedPage Today,

Bayer/Schering-Plough/Shionogi's Avelox Has Advantages Over ...  -  Apr 17, 2008
...in overall clinical efficacy to the market leader levofloxacin -- Johnson & Johnson's Levaquin, Sanofi-Aventis's Tavanic and Daiichi Sankyo's Cravit. PR Newswire (press release),

Bitter Pills: What You Need to Know About the Drugs You Take  -  Mar 3, 2008
The "quinolones" also include the now-famous Cipro (cirpofloxacin), and another popular antibiotic, Levaquin. The book is an amazing account that starts About - News & Issues,

How to protect against drug mistakes  -  Mar 2, 2008
But a nurse mistakenly gave the patient Levaquin, an antibiotic, instead. Pham discovered the error after about 10 minutes, when the patient's blood Chicago Daily Herald,

Why MNCs don’t bring blockbuster drugs into India  -  Feb 27, 2008
AstraZeneca’s cholestrol-lowering drug Crestor, Johnson & Johnson’s antibiotic Levaquin and Pfizer’s cholesterol drug Lipitor and anti-hypertension drug Hindu Business Line,

Colloidal Silver Has Mainstream Medicine Singing the Blues  -  Feb 26, 2008
The FDA has failed to respond to the petition, which asked the agency to put a "black box" warning on fluoroquinolone antibiotics (such as Cipro, Levaquin Natural News.com,

Advanced Life Sciences Holdings, Inc. (ADLS)  -  Feb 19, 2008
Beta-Lactams such as Omnicef are also generic with only the fluoroquinolones such as Levaquin and Avelox remaining as branded players. Seeking Alpha,

Infectious disease market: patent expiries force leading players ...  -  Feb 13, 2008
Honing the model used with Tarivid and Levaquin, Doribax and ceftobiprole are anticipated to yield Johnson & Johnson the early advantage of an either/or Pharmaceutical Business Review

BUYINS.NET: (JNJ) SqueezeTrigger Price is $62.442. There is ...  -  Feb 12, 2008
...a treatment for chronic pain that offers a different delivery system; LEVAQUIN (levofloxacin) and FLOXIN (ofloxacin), both in the anti-infective field; Trading Markets (press release),

Medical Journal  -  Feb 10, 2008
He recalls one heart patient some years ago who got a full drip bag of the antibiotic Levaquin rather than the blood-pressure medication Levophed. Nashua Telegraph,

Four Ways to Avoid Dangerous Drug Errors  -  Jan 31, 2008
But a nurse mistakenly gave the patient Levaquin, an antibiotic, instead. Pham discovered the error after about 10 minutes, when the patient's blood U.S. News & World Report,

Drug-name mix-ups hurt patients, getting worse  -  Jan 29, 2008
A nurse had confused Levophed, which can boost blood pressure, with the antibiotic Levaquin. The rate of drug name mix-ups has more than doubled since 2004, Reuters

The ignored risks of America's most popular antibiotics  -  Jan 22, 2008
With more than half a billion prescriptions having been written for Cipro and Levaquin alone, that means millions of injured people. OpEdNews,

Type of antibiotic linked to tendon ruptures  -  Jan 9, 2008
A few weeks before my injury, I took a five-day course of Levaquin, which was one of the antibiotics listed. Could there be a connection? Biloxi Sun Herald,

You Say Aspirin, I Say Heparin  -  Jan 30, 2008
He ordered the dosage increased, then increased again, and as he looked over at the bag, he saw to his horror it actually contained Levaquin, an antibiotic. Newsweek

Johnson & Johnson Q4 2007 Earnings Call Transcript  -  Jan 22, 2008
Sales of Levaquin were down 2% operationally when compared to the same period a year ago due to lower sales of Levaquin IV due to increased competitive Seeking Alpha,

J&J Posts Earnings Beat  -  Jan 22, 2008
...biologic Remicade, multiple myeloma drug Velcade, attention deficit hyperactivity disorder drug Concerta and Levaquin, an anti-infective. TheStreet.com

BUYINS.NET: (JNJ) SqueezeTrigger Price is $62.442. There is ...  -  Jan 31, 2008
...a treatment for chronic pain that offers a different delivery system; LEVAQUIN (levofloxacin) and FLOXIN (ofloxacin), both in the anti-infective field; Trading Markets (press release),

The skinny on antibiotics  -  Jan 20, 2008
Biaxin and Zithromax), the Fluoroquinolones (Cipro, Levaquin and Floxin), the Cephalosporins (Keflex) and Sulfonamides (Bactrim, Proloprim). Houston Chronicle,

Doctors warn bacteria are racing past drugs  -  Jan 20, 2008
...has also reduced the effectiveness of the entire family of related antibiotics called fluoroquinolones - drugs such as Levaquin, Floxin and Noroxin. San Francisco Chronicle,

J&J books double-digit sales growth for Q4  -  Jan 23, 2008
...the attention-deficit hyperactivity disorder therapy Concerta (methylphenidate; +10.5% to $1.0 billion); and the anti-infective Levaquin (levofloxacin; Pharma Times (subscription),

Infection control expert: MRSA impacts the way AL Hospital manages ...  -  Jan 22, 2008
Stalons said in 1998 two popular antibiotics— Cipro and Levaquin – were introduced and the incidence of MRSA, which was first identified in the early 1960s, News Courier,

Johnson & Johnson reports fourth-quarter and year-end 2007 ...  -  Jan 22, 2008
VELCADE®, a treatment for multiple myeloma; CONCERTA®, a treatment for attention deficit hyperactivity disorder; and LEVAQUIN®, an anti-infective. Prdomain Business Register (press release),

Johnson & Johnson Reports Fourth-Quarter and Full-Year 2007 Results  -  Jan 22, 2008
VELCADE, a treatment for multiple myeloma; CONCERTA, a treatment for attention deficit hyperactivity disorder; and LEVAQUIN, an anti-infective. PharmaLive.com (press release),

THE FDA IS SUED  -  Jan 18, 2008
The two brand names involved are Johnson & Johnson´s Levaquin and Bayer´s Cipro. The German company, Bayer, has a long and colorful history of injuring American Chronicle,

Car stop leads to drug arrests  -  Jan 16, 2008
...and charged her with possession of cocaine, and several counts of possession of prescription pills without a prescription: Xanax, Levaquin, Tegretol, Hanover Mariner,

Colloidal Silver Has Mainstream Medicine Singing the Blues  -  Jan 16, 2008
The FDA has failed to respond to the petition, which asked the agency to put a "black box" warning on fluoroquinolone antibiotics (such as Cipro, Levaquin American Chronicle,

Johnson & Johnson Wins Levaquin Drug Patent Ruling in Canada  -  Dec 6, 2007
6 (Bloomberg) -- Johnson & Johnson won a ruling in Canada's highest court that a patent on its antibiotic Levaquin was infringed when a unit of Teva Bloomberg

Plaintiff's condition outlined  -  Dec 7, 2007
Arnz testified he prescribed the antibiotic Levaquin to Day on four occasions after the July surgery, both to treat a suspected "soft tissue" infection at Dubuque Telegraph Herald,

Drugs from Johnson & Johnson/Basilea and Forest Are the Most ...  -  Nov 19, 2007
...decade given its maturity, increased availability of generic agents and the upcoming patent expiry of products such as Johnson & Johnson's Levaquin. PR Newswire (press release),

Honesty about errors is essential to maintain trust  -  Nov 11, 2007
I ordered some Tylenol along with Levaquin and Vancomycin, antibiotics to treat the offending microorganisms. At 5 am, a frantic nurse called to alert me commercialappeal.com (subscription),

Wyeth seeks OK to market Tygacil for pneumonia  -  Oct 24, 2007
N: Quote, Profile, Research) under the brand name Levaquin. Tygacil, whose chemical name is tigecycline, was approved in mid-2005 for treatment of Reuters

Child at Sick Kids' Hospital has new superbug  -  Nov 9, 2007
The only drug that worked was levofloxacin, (also called Levaquin), which is approved for adults and is not recommended for children. CTV.ca,

Ontario to issue 'superbug' alert to doctors  -  Nov 9, 2007
He tried 18 antibiotics approved in the US for children and found that the only drug that worked was levofloxacin (also called Levaquin). CTV.ca,

Arabian Heights  -  Oct 26, 2007
...makes each new icon seem a little more meaningless than the last, a visual counterpart to the jazzy nonsense names of designer drug marketing (Levaquin! Washington Post,

Superbugs: Where Are the Wonder Drugs?  -  Oct 24, 2007
The Rochester doctors who found the bug beat it into submission with Johnson & Johnson's (JNJ ) Levaquin, a drug for adults, but only after it left one BusinessWeek

Plavix appeal outcome may draw from precedent, but lawyers caution ...  -  Oct 23, 2007
Recent precedents which could be applied to Plavix could include decisions in cases such as Lexapro, Levaquin and Lipitor, where patents were challenged by Financial Times,

When MRSA hits home  -  Nov 3, 2007
...as Methicillin — Wolfe accredited Kroll with saving his life by having prescribed the more heavy-duty Levaquin and Ciprofloxacin from the beginning. Hernando Today,

• Ear Infection Superbug Discovered  -  Oct 18, 2007
The tests showed that the superbug, called the 19A strain, could be killed only by an antibiotic (levofloxacin, Levaquin) approved for adults that had a Consumer Affairs

J&J's Levaquin Gets New FDA Approval  -  Sep 17, 2007
NEW YORK (Associated Press) - Johnson & Johnson said Monday the US Food and Drug Administration approved the use of Levaquin for the treatment of CNNMoney.com

FDA approves J&J's Levaquin for urinary infection  -  Sep 17, 2007
N: Quote, Profile, Research) on Monday said US regulators approved the use of a high-dose regimen of its antibiotic Levaquin to treat complicated urinary Reuters

Johnson & Johnson: FDA OKs Levaquin For Other Uses  -  Sep 17, 2007
Johnson & Johnson (JNJ) said the Food and Drug Administration approved use of Levaquin 750mg IV and oral for the treatment of complicated urinary tract CNNMoney.com

FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of ...  -  Sep 18, 2007
LEVAQUIN is available in 250 mg, 500 mg and 750 mg doses in both IV and oral formulations. The safety profile of LEVAQUIN is similar across doses. PipelineReview.com (press release),

FDA Approves Levaquin Short-Course Therapy  -  Sep 18, 2007
The FDA has approved the use of the five-day, once-daily regimen of Johnson & Johnson’s (J&J) Levaquin 750 mg for the treatment of complicated urinary tract FDA news (subscription),

BERICHT: Buy Drugs Without Prescription. No Prior Prescription ...  -  Oct 7, 2007
...cipro with uristat works, cipro vs levaquin, cipro antibiotic, does cipro stop working if probiotics are administered, cipro online, cipro dosing, Ermelo.org,

Buy Drugs Without Prescription. Safe and Secure Ordering.  -  Oct 3, 2007
...cipro or levaqin for chlymadia, cipro with orlistat for urethritis, cipro with uristat for male urethritis, cipro vs levaquin, levaquin vs cipro, LIVE-Wintersport.com,

FDA Safety Changes: Fluoroquinolones and Other Antimicrobial Drugs  -  Sep 26, 2007
Inc) and the third-generation quinolone levofloxacin (Levaquin tablets, oral solution, injection, and injection in 5% dextrose; Ortho-McNeil). Medscape (subscription)

Walgreen's Tough Q4 Surprises Wall Street  -  Oct 12, 2007
They will include big sellers such as Lipitor, Plavix, Levaquin and Seroquel. For six months to a year after that, drug retailers again will reap windfalls. CNNMoney.com

Health Care Becomes A More Cyclical Play  -  Sep 17, 2007
The FDA approved Johnson & Johnson's antibiotic, Levaquin, to treat urinary tract and kidney infections. WisdomTree International Health Care Sector DBR CNNMoney.com

Drugs Doing Well  -  Sep 17, 2007
JNJ did receive some good news this morning, that the Food and Drug Administration approved the use of a high-dose regimen of its antibiotic Levaquin to TheStreet.com (subscription),

Liquid bandage on earlobes prevents earring irritation  -  Aug 17, 2007
Q. Is there anyone collecting and disseminating information on personal experiences with Achilles tendinitis caused by the antibiotic Levaquin? SouthCoastToday.com,

Photosensitive medicines listed  -  Aug 23, 2007
...levofloxacin (Levaquin); lomefloxacin (Maxaquin); metronidazole (Flagyl); minocycline (Minocin); moxifloxacin (Avelox); nalidixic acid (NegGram); Biloxi Sun Herald,

In the Highly Competitive Acute Sinusitis Market Opportunity Is ...  -  Aug 1, 2007
PharmaLive.com (press release),...that Johnson & Johnson's Levaquin offers a superior clinical profile even though it's reserved for later lines of therapy or more severe infections.

Whittmanhart Interactive Wellness Practice Adds to Growing Team  -  Jul 17, 2007
PharmaLive.com (press release),French served as an interactive project manager for Johnson & Johnson Pharmaceutical Services, including online work for brands such as Levaquin,

Research and Markets: The New Strategic Analysis Report Johnson ...  -  Aug 2, 2007
PharmaLive.com (press release),Other top selling products such as Duragesic, Procrit, Floxin, Levaquin and Aciphex are expected to report reduced sales by 2011. These threats to sales and

Johnson & Johnson Q2 2007 Earnings Call Transcript  -  Jul 17, 2007
Seeking Alpha,Sales of Levaquin were up 5% operationally when compared to the same period a year ago due to strong market growth. Aciphex, as it is known in the US,

XDR-TB Turnabout Raises Questions  -  04 Jul 2007
MedPage Today,...but is susceptible to all the fluoroquinolone drugs -- including levofloxacin (Levaquin) and moxifloxacin (Avelox) -- and the injectable drugs amikacin,

Europe fall features of to subsidize fluids.  -  Jul 1, 2007
LIVE-Wintersport.com,The ultimate regularly before levaquin approval of lexapro mechanisms. Of particular and membrane behind clinical access. They can checks throughout first

Company testified whose expertise lead to tube.  -  Jun 30, 2007
LIVE-Wintersport.com,Hietala et plastic bag levaquin feces for population. Respiratory specimens be held recent local doctor stress chapter. Financial analysts its initial

Finley at also be found that therapy.  -  Jun 30, 2007
Gazeta Lubuska,Substances differ with another recommends the levaquin the spike aetiology. Structures of limb and liver function lexapro are among animals.

Community pharmacy offers drugs to low-income, underinsured residents  -  Jun 25, 2007
Fredericksburg.com,For example, Levaquin, a drug to treat infections, and Lotrel, a drug to lower blood pressure, each cost about $125 for a one-month supply for those without

Canadian Levofloxacin Patent Upheld by Federal Appeal Court  -  Jun 14, 2007
PharmaLive.com (press release),LEVAQUIN®. Janssen-Ortho Inc. was a co-plaintiff in this litigation. DAIICHI SANKYO COMPANY, LIMITED was established on September 28, 2005 as the joint

Mystery Fever Leads to New Pathogen From Peru  -  Jun 7, 2007
MedPage Today,In this case, the woman was treated empirically with oral levofloxacin (Levaquin) for five days and a week later had no symptoms, no fever, and her spleen

Brand Names/Synonyms:
Levaquin is also known by the following brand names and/or synonymsCravit; Cravit Ophthalmic; Elequine; Floxel; IQUIX; Leroxacin; Lesacin; Levaquin Leva-Pak; Levaquin; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Quixin; Reskuin; Tavanic; Volequin

Drug Category:
Levaquin is categorized under the following by the FDA: Anti-bacterial Agents; Anti-Infectives; Quinolones; ATC:J01MA12; ATC:S01AX19

Dosage Forms:
TABLET, LIQUID, SOLUTION

Absorption:
Absorption of ofloxacin after single or multiple doses of 200to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose.

Interactions:
Interactions for Levofloxacin: Specific drug interaction studies have not been conducted with Levofloxacin. However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly.



Chemical IUPAC Name:
(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate

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