Lamisil

This page contains recent news articles, when available, and an overview of Lamisil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Lamisil
(when available)

Pharmacology and use:
Terbinafine is an allylamine antifungal agent and acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. in vitro, mammalian squalene epoxidase is only inhibited at higher (4000 fold) concentrations than is needed for inhibition of the dermatophyte enzyme. Depending on the concentration of the drug and the fungal species test in vitro, Terbinafine may be fungicidal. However, the clinical significance of in vitro data is unknown. For the treatment of interdigital tinea infections

Mechanism Of Action:
Terbinafine is hypothesized to act by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes.

News Articles on Terbinafine

People's Pharmacy: Magnesium supplements carry risks  -  ‎Apr 19, 2009‎
Q: My husband has toenail fungus, and our podiatrist prescribed a 30-day supply of Lamisil pills. They cost hundreds of dollars. There were no guarantees it Houston Chronicle

Lamisil: Salesmanship Over Science  -  ‎Apr 7, 2009‎
Lamisil, a drug used to treat toenail fungus, has been linked to 16 cases of liver failure, including 11 deaths. Yet despite this risk, Lamisil is a big Newsinferno.com

DR. BETSY NEAHRING: Use patience, persistence in treating ...  -  ‎Apr 12, 2009‎
Athlete's foot can generally be treated successfully with an over-the-counter cream like Lotrimin or Lamisil. Apply the cream to the affected area once or Evansville Courier & Press

Mets closing up in 'Port St. Laboratory'  -  ‎Apr 1, 2009‎
So acknowledging that poetic license was at work -- because athlete's foot was not the issue -- we named the camp Port St. Lamisil. MLB.com

Aurobindo gets first approval from Swissmedic for BPH drug  -  ‎Apr 7, 2009‎
Terbinafine is the generic equivalent of Novartis Pharmaceutical Canada Inc's Lamisil tablets, indicated for the treatment of fungal infections of the skin Business Standard

Beat Your 5 Workout Woes With These Easy Tips  -  ‎Apr 8, 2009‎
Treat It - Over-the-counter Lamisil AT Cream ($16; drugstore.com) can reduce the symptoms within several days. Prevent It - Wearing flip-flops in gym New York's CW11 / WPIX-TV

WFLV zeigt Wege zu den Geldtöpfen  -  ‎Apr 7, 2009‎
Er suchte gemeinsam mit dem Arzneimittelkonzern Norvatis, der sein Fußpflegeprodukt Lamisil ins Gespräch bringen wollte, die dreckigste Kabine Deutschlands Derwesten.de

ИнформациÑ? о побочных Ñ?ффектах лекарÑ?тв решает их Ñ?удьбу  -  ‎Mar 30, 2009‎
противогрибковые мази ("Lamisil" компании Novartis AG), контрацептивы ("Plan B" компании "Teva Pharmaceutical Industries") и другие, которые продаютÑ?Ñ? и ИИА. Ремедиум

Οι μυκητιάσεις των ποδιών ταλαιπωÏ?οÏ?ν το 15% του πληθυσμοÏ?  -  ‎Apr 8, 2009‎
Η νέα θεÏ?απεία με τεÏ?βιναφίνη (lamisil once) εμφανίζει εντυπωσιακά αποτελέσματα, καθώς εφαÏ?μόζεται μία φοÏ?ά και απομακÏ?Ï?νει κάθε δυσφοÏ?ία και ενόχληση και Ιατροnet

W!LDBRAIN Animation Studios News  -  18 Mar 2009
The studios' previous experience in computer animation ranges from the preschool animated series Higglytown Heroes and assorted commercial work for Lamisil Animation Insider

Dr. Chris Milkie: Milwaukee foot doctor first in Wisconsin to ...  -  ‎Feb 20, 2009‎
...of the disease and the pervasive television advertisements for Lamisil (http://www.youtube.com/watch?v=WI9J7MoBZbY), an oral anti-fungal medication. Wisbusiness.com

Ranbaxy gets TGA-Australia`s nod for SEBIFIN Terbinafine Tablets  -  ‎Mar 6, 2009‎
...and having the same therapeutic effect as that of the reference listed product, Lamisil tablets of Novartis Pharmaceutical Australia (P). Myiris.com

Forest, Cypress postpone fibromyalgia drug launch; Microsoft teams ...  -  ‎Mar 6, 2009‎
Report > Ranbaxy Laboratories got Australian regulatory approval to sell its version of the Novartis antifungal treatment Lamisil. FiercePharma

NovaBay Pharmaceuticals Announces Lead Anti-infective Product ...  -  ‎Mar 7, 2009‎
...based on an established animal model previously used in the preclinical evaluation of terbinafine (Lamisil(R)) and itraconazole (Sporanox(R)). PR Newswire (press release)

W!LDBRAIN Animation Powerhouse Expands Operations to Los Angeles  -  ‎Mar 4, 2009‎
...companies such as Smith & Tinker and continues to produce award-winning commercial animation work for long time clients, including Esurance and Lamisil. PR Newswire (press release)

Closing Bell  -  ‎Mar 6, 2009‎
The Ranbaxy formulation of Terbinafine is bioequivalent to and having the same therapeutic effect as that of the reference listed product, Lamisil Tablets, Economic Times

10 Questions With Kevin Blackistone  -  ‎Feb 26, 2009‎
We use Rogaine for our thinning hair, Prozac for depression, Xanax for anxiety, Prilosec for heartburn, Lamisil for toenail fungus, Viagra for fun, RealClearSports

Dangerous medicines in drugstores  -  ‎Mar 10, 2009‎
Medicine for losing the weight Xenical (Roche Holding AG) may lead to bleeding, Lamisil (made by Swiss pharmaceutical company Novartis AG), MIGnews.com.ua

Pondering pampering and pedicures  -  ‎Feb 23, 2009‎
The only treatment I ever gave them was a dose of Lamisil AT for a harsh case of athlete’s foot. The lady went to work. I didn’t get her name. The Charlatan

Athlete's foot common  -  ‎Feb 23, 2009‎
Lamisil Film Forming Solution is the only single dose treatment available against athlete's foot. Wash your feet at least once a day, more frequently if iAfrica.com

Ranbaxy Gets TGA-Australia Approval For Sebifin® Terbinafine  -  ‎Mar 10, 2009‎
...having the same therapeutic effect as that of the reference listed product, Lamisil® Tablets of Novartis Pharmaceuticals Australia Pty Ltd, Australia. Pharmaceutical Online (press release)

A 9. hét legnézettebb reklámfilmjei  -  ‎Mar 10, 2009‎
A Teva Magyarország például Neogranormon termékét támogatja a 11. helyre bekerült szpottal, míg a Novartis részérÅ‘l a Lamisil reklámja kapott helyet a Média Infó

Минздрав готовит "черный" Ñ?пиÑ?ок медицинÑ?ких препаратов  -  ‎Mar 12, 2009‎
Lamisil (швейцарÑ?кой фармкомпании Novartis AG) - противогрибковаÑ? мазь (выÑ?окий риÑ?к пÑ?ихичеÑ?ких раÑ?Ñ?тройÑ?тв), Diovan (Novartis AG), препарат, Версии.сом

Минздрав Ñ?оÑ?тавлÑ?ет "черный" Ñ?пиÑ?ок лекарÑ?тв  -  ‎Mar 9, 2009‎
..."Lamisil" (швейцарÑ?кой фармкомпании "Novartis AG") - противогрибковаÑ? мазь (выÑ?окий риÑ?к пÑ?ихичеÑ?ких раÑ?Ñ?тройÑ?тв), "Diovan" ("Novartis AG"), препарат, ЛІГА.Новости

Terbinafin: Leitlinienerweiterung vorgestellt  -  ‎Mar 9, 2009‎
Im Januar 2009 wurde nun auch die Terbinafin-Einmalanwendung (Lamisil® Once) in die Empfehlungen mit aufgenommen. Die Autoren begründen ihre Entscheidung Springer Gesundheit und Pharmazie

US FDA lists drugs under review for safety issues  -  04 Feb 2009
N) nail fungus treatment Lamisil and Roche's malaria drug Lariam, both for the risk of psychiatric events. Agency officials are also looking at Novartis' Reuters

Lamisil without prescription  -  Jan 17, 2009
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Lamisil pharmacy  -  Jan 17, 2009
Watch 5 lamisil pharmacy from people the give much home without mail to from particular lamisil pharmacy work Dizziness internet adipex adipex not NAISD. Griggs County Courier,

Lamisil pills  -  Jan 17, 2009
However with xanax not. lamisil pills lamisil pills occur Difficulty lamisil pills violate simply of to sufferers can sexual to sexual Alzheimer's and Griggs County Courier,

What treatments work for athlete's foot?  -  Jan 21, 2009
Terbinafine cream or spray: The brand name for terbinafine cream or spray is Lamisil. You can get it on prescription from your doctor, or you can buy it guardian.co.uk,

Aurobindo terbinafine approval- what effect will this have?  -  Jan 21, 2009
Implications: This article is important in that it confirms another terbinafine competitor to the Novartis Lamisil brand is being released. Gerson Lehrman Group,

Old Governor's Mansion revitalization approved  -  Jan 15, 2009
Retreat Plaza pharmacy filled a prescription for 200 milligrams of Lamisil, which treats toenail infections, with 200 milligrams of Lamictal instead. Kentucky.com,

Fungal nail infections  -  Jan 21, 2009
The tablets that doctors use most often are called itraconazole (brand name Sporanox) and terbinafine (Lamisil). Terbinafine seems to work slightly better. guardian.co.uk,

Terbinafine tablets  -  Jan 21, 2009
The brand name is Lamisil. You need a prescription from your doctor to get this medicine. About 13 in 20 people who take terbinafine tablets for six weeks guardian.co.uk,

What treatments work for fungal nail infections?  -  Jan 21, 2009
Terbinafine tablets (brand name Lamisil): These are antifungal tablets. They treat nail infections caused by a fungus. More... Fluconazole tablets (brand guardian.co.uk,

Manhattan Research Releases Top Pharma Brand Product Sites by ...  -  Feb 3, 2009
Crestor, Cymbalta, Depakote, Depo-Provera, Detrol LA, Effexor XR, Enbrel, Flomax, Flonase, Flovent, Fosamax, Gardasil, Humira, Imitrex, Lamisil, Lantus, PR Web (press release),

THIS JUST IN: Monongalia County  -  Jan 9, 2009
She intended to write a prescription for Lamisil, an anti fungal medication. Instead, Kelly wrote the prescription for Lamictal, an anti-seizure medication. West Virginia Record,

Woman sues over alleged medication error: Core Health Care, Giant ...  -  Jan 11, 2009
25, 2007, to seek treatment for nail fungus. She was examined by Kelly, who, intending to give her Lamisil for the fungus, erroneously prescribed Therapeutics Daily (press release) (registration),

Athlete's foot  -  Jan 21, 2009
The brand name is Lamisil. You might get a mild rash or itching when you use this cream or spray. This will go away when you stop treatment. guardian.co.uk,

Woman files suit after being prescribed wrong medication  -  Jan 21, 2009
After Dr. Kay Kelly examined Rose's nails, she prescribed Rose 250 mg of Lamictal, an anti-seizure medication, instead of the anti-fungal medication Lamisil West Virginia Record,

Aurobindo Pharma gets Canada nod for terbinafine  -  Dec 23, 2008
VX: Quote, Profile, Research) Lamisil indicated for the treatment of fungal infections in the skin and nails, the company said in a statement. Reuters India,

Woman struggles after medicine makes her sick  -  Dec 23, 2008
She walked out with a prescription for Lamisil, a drug that caused an adverse reaction in her system and caused the soles of her feet and hands to swell up, Royal Gazette,

Market Live  -  Dec 24, 2008
Terbinafine tablets is the generic equivalent of Novartis Pharmaceutical Canada Inc's lamisil tablets 125 mg and 250 mg, which is indicated for the Economic Times,

'En Dan Nu Het Roer Om'  -  Dec 14, 2008
Het nieuwe jaar is nog niet begonnen of ze zit nu al met een begrotingstekort, ze koopt zich nog steeds blauw aan Lamisil en Tryptizol én ze zit verlegen om Sterrennieuws,

Nail Fungus - Background and Treatments  -  Nov 22, 2008
Common oral medications for treating fungal infection are Sporanox, Diflucan, and Lamisil. Treatment of fungal infections can be long drawn. Best Syndication,

Lamasil Linked to Skin Reactions, Psychiatric Problems, Other Side ...  -  Nov 18, 2008
Lamisil, a medication used to treat nail fungus, should be monitored for side effects in children, according to a report by Food & Drug Administration (FDA) Newsinferno.com,

Ask Dr Chris: Fungal nail infection, ganglion  -  Nov 20, 2008
You may be given a tablet, such as terbinafine (Lamisil), to take once a day for up to six months, as toenails grow very slowly. goodtoknow,

FDA Staff Suggests Pediatric Warnings For Zyprexa  -  Nov 17, 2008
FDA reviewers also suggest that Lamisil, a Novartis fungus med, should be watched for potential psychiatric side effects in children. Pharmalot,

FDA staff warns of potential risk in children for Zyprexa, Lamisil  -  Nov 17, 2008
FDA employees posted reports on the agency's Web site recommending that labels for Zyprexa, a psychiatric medication from Eli Lilly and Co., and Lamisil, SmartBrief,

FDA Panel to Review Zyprexa Side Effects for Children  -  Nov 18, 2008
At the Pediatric Advisory Committee meeting on November 18, 2008, independent panel of experts will also consider potential side effects of Lamisil for AboutLawsuits.com

US FDA advisory meetings through Jan. 8  -  Nov 10, 2008
...bipolar mania and autism drug Risperdal (risperidone), Novartis' nail fungus drug Lamisil (terbinafine), and Sanofi Aventis sleep aid Ambien (zolpidem). FXstreet.com The Foreign Exchange Market,

FDA alerta para efeitos adversos de Zyprexa e Lamisil em crianças  -  Nov 18, 2008
...numa revisão de segurança, indicou que o fármaco antipsicótico Zyprexa (olanzapina), da Eli Lilly, eo medicamento antifúngico Lamisil (terbinafina), Farmacia,

Europe Mulls Easing Drug Rules  -  Oct 7, 2008
Novartis makes a drug called Lamisil for nail fungus, though this wasn't mentioned in the campaign. Still, doctors started prescribing Lamisil at much Wall Street Journal

Treating Nail Fungus - 3 Type of Oral Pharmaceutical Drugs Review  -  Sep 25, 2008
Lamisil is the most doctor prescribed medication for nail fungal infection. It is in tablet form and Lamisil has about the same success rate as that of Best Syndication,

Leigh Grogan: Nail fungus takes a year to clear up  -  Oct 3, 2008
The oral medication Jim is referring to is Lamisil, which I'll prescribe 20 percent to 30 percent of the time. However, the side effects of the drug can be Sacramento Bee,

Novartis International AG (SWF:NOVN) Novartis Delivers Sustained ...  -  Oct 19, 2008
US net sales fell 5%, but have been recovering from the negative impact of lower sales during 2007 from four products (Lotrel, Lamisil, Trileptal and ABN Newswire (press release),

October 2008 Mayo Clinic Health Letter Highlights Preventing ...  -  Oct 7, 2008
Antifungal oral medications: Two commonly prescribed medications are itraconazole (Sporanox) and terbinafine (Lamisil). Fluconazole (Diflucan) is another MarketWatch

EARNINGS PREVIEW: European Drug Cos 3Q To Offer Few Catalysts  -  Oct 14, 2008
...negative effects from generic competition to Lotrel, Trileptal, Lamisil and Famvir, as well as the withdrawal of Zelnorm, should have run their course. EasyBourse.com,

Desperate tyver stjal kuvaksine  -  Sep 27, 2008
...•Den vanligste behandlingsmetoden ved Ringorm er påførsel Lamisil-kre, eller andrer soppdrepende midler som for eksempel Canesten. Dagbladet.no,

DJ HUGIN NEWS/Novartis erzielt in den ersten neun -6-  -  Oct 19, 2008
...die auf Generikakonkurrenz für vier Produkte (Lotrel, Lamisil, Trileptal und Famvir) und den Verkaufsstopp für Zelnorm zurückzuführen waren. Ad-Hoc-News (Pressemitteilung),

DJ HUGIN NEWS/Novartis réalise une excellente -7-  -  Oct 19, 2008
...des ventes de quatre produits (Lotrel, Lamisil, Trileptal et Famvir) confrontés à la concurrence de génériques ainsi que de la suspension de Zelnorm. Ad-Hoc-News (Pressemitteilung),

Művészet a gyógyszergyártásban  -  Sep 28, 2008
Évek óta forgalmazzuk a bőr- és körömgombásodás elleni Lamisil termékcsaládot, és a közelmúltban két új szemészeti készítmény is bővítette a kínálatot: a HáziPatika.com,

Handwerker für Deutschlands baufälligste Umkleidekabine gesucht  -  Sep 24, 2008
Der von Lamisil® gesponserte Preis war von einer gemeinsam mit den Kooperationspartnern FC St. Pauli und MyHammer besetzten Jury dem SV Lieth zuerkannt PresseEcho.de (Pressemitteilung),

Brand Names/Synonyms:
Lamisil is also known by the following brand names and/or synonymsBramazil; Lamasil; Lamisil; Lamisil At; Terbina; Terbinafine; Terbinafine Hcl; Terbinafine Hydrochloride; Ternbinafine Hcl

Drug Category:
Lamisil is categorized under the following by the FDA: Trypanocidal Agents; Antifungals; Allylamines; ATC:D01AE15; ATC:D01BA02

Dosage Forms:
TABLET; CREAM; SPRAY

Absorption:
Readily absorbed from gastrointestinal tract.

Interactions:
-->Interactions for Terbinafine:

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, and cyclosporine. In vitro studies have also shown that terbinafine inhibits CYP2D6-mediated metabolism. This may be of clinical relevance for compounds predominantly metabolized by this enzyme, such as tricyclic antidepressants, ß-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAO-Is) Type B, if they have a narrow therapeutic window.

In vivo drug-drug interaction studies conducted in normal volunteer subjects showed that terbinafine does not affect the clearance of antipyrine or digoxin. Terbinafine decreases the clearance of caffeine by 19%. Terbinafine increases the clearance of cyclosporine by 15%.

There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarin, however, a causal relationship between LAMISIL® Tablets and these changes has not been established.

Terbinafine clearance is increased 100% by rifampin, a CyP450 enzyme inducer, and decreased 33% by cimetidine, a CyP450 enzyme inhibitor. Terbinafine clearance is unaffected by cyclosporine.

There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, theophyllines, phenytoins, thiazide diuretics, beta blockers, and calcium channel blockers.





Chemical IUPAC Name:
N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine

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