Irbesartan

This page contains recent news articles, when available, and an overview of Irbesartan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Irbesartan (when available)

Pharmacology and use:
Irbesartan, an angiotensin II receptor antagonist similar to losartan and valsartan, is used alone or with hydrochlorothiazide to treat hypertension For the treatment of hypertension.

Mechanism Of Action:
Irbesartan antagonizes angiotensin II, the primary vasoactive hormone of the renin-angiotensin system, at the AT₁ receptor subtype. As angiotensin II is vasoconstrictor which stimulates aldosterone secretion by the adrenal gland, blockage of its effects results in a decrease in systemic vascular resistance.

News Articles on Irbesartan

Can We Rely on RE-LY?  -  30 Aug 2009
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of New England Journal of Medicine (subscription)

Acute coronary syndromes Randomized to a Controlled evaluation in ...  -  ‎Aug 28, 2009‎
The goal of the trial was to evaluate treatment with irbesartan compared with enalapril (and early versus late treatment) among patients with Cardiosource

Drug shortages affecting patients, new survey finds  -  ‎Aug 27, 2009‎
...another experienced rising blood pressure while waiting for the antihypertensive Aprovel (irbesartan), and that a shortage of the blood thinner Plavix Pharma Times

Ranbaxy launches generic Losartan in Malaysia  -  ‎Aug 7, 2009‎
...to other similar compounds like Valsartan, Irbesartan and Telmisartan because some patients will be switched from these medicines to generic Losarta. Gerson Lehrman Group

It is not universal  -  ‎Aug 25, 2009‎
Instead of putting on the list only irbesartan and telmisartan among so-called angotensin-II-receptor blockers, all sartans—losartan, eprosartan, Business Mirror

Onglyza Approved for Treatment of Type 2 Diabetes  -  ‎Aug 10, 2009‎
Their top 3 selling products include PLAVIX® (clopidogrel bisulfate), ABILIFY® (aripiprazole), and AVAPRO®/AVALIDE® (irbesartan and MediNEWS.Direct!

DoH cracks down on erring drugstores  -  ‎Aug 27, 2009‎
Meanwhile, the 16 medicines that fall under the voluntary price reduction scheme are Telmisartan and Irbesartan (anti-hypertensives); Manila Bulletin

What's going to be hot at ESC Congress 2009?  -  ‎Aug 25, 2009‎
These include the 9000-patient ACTIVE I trial, looking at irbesartan in AF patients; the 3000-patient KYOTO Heart Study, looking at the effects of valsartan TheHeart.Org

Cheaper medicines act lists medicines at reduced prices  -  ‎Aug 28, 2009‎
There are additional 16 medicines dubbed as Government Mediated Access Price (GMAP) namely ; Telmisartan and Irbesartan for hypertension; Clopidorel for Philippine Information Agency

Ligand Pharmaceuticals Inc. Q2 2009 Earnings Call Transcript  -  ‎Aug 3, 2009‎
The high dose produced a statistically significant greater reduction in blood pressure than the active comparator, irbesartan which was tested at its Seeking Alpha

Cheap medicines law registers 90% compliance  -  ‎Aug 19, 2009‎
These are telmisartan and irbesartan, which are antihypertensive drugs; the anti-thrombotic drug clopidogrel; the anti-diabetic drug gliclazide; Inquirer.net

Take drug price plaints to health centers  -  ‎Aug 16, 2009‎
Medicines now under price control include telmisartan and irbesartan, which are antihypertensive drugs; the anti-thrombotic drug clopidogrel; Inquirer.net

Diagnosis and management of hypertension in advanced renal cell ...  -  ‎Aug 16, 2009‎
Normal BP was ensured prior to sunitinib initiation with the successive use of hydrochlorothiazide + irbesartan, nebivolol, amlodipine. UroToday

Hospitals and pharmacies won't go bankrupt with cheaper meds law - CHO  -  ‎Aug 17, 2009‎
Medicines now under price control include telmisartan and irbesartan, which are hypertensive drugs; the antithrombotic drug clopidogrel; the antidiabetic Philippine Information Agency

Un congrès 2009 sous le signe de la prévention  -  ‎Aug 25, 2009‎
...une hypertension non contrôlée et des facteurs de risque et l'étude ACTIVE I celui de l'irbesartan dans la FA (l'étude compare l'irbesartan au placebo). theheart.org/fr

Какво да очакваме от тазгодишни�? конгре�? по кардиологи�? на ECS в ...  -  ‎Aug 29, 2009‎
Тук идват проучването ACTIVE I, анализиращо ефекта на irbesartan върху пациенти �? пред�?ърдно мъждене; KYOTO Heart Study, из�?ледващо ефектите на valsartan DoctorBG.com

Mga 'di magbababa sa presyo ng gamot dapat daw parusahan  -  ‎Aug 21, 2009‎
Nagboluntaryo naman ang kumpanya ng gamot na ibaba ang presyo ng kanilang mga produkto na telmisartan at irbesartan na antihypertensive drugs; GMA news.tv

Magas vérnyomás ellen: az Angiotenzin II-receptor blokkolók működése  -  ‎Aug 25, 2009‎
Irbesartan: ez a legjobban hasznosuló származék, kis mennyiség is elég belőle. Candesartan: vérnyomáscsökkentő hatása ellenére növeli az agy vérellátását, WEBBeteg

沙�?�类�?�物销售�?少70亿美元 �?�临被仿之痛  -  ‎Aug 4, 2009‎
...之�?�，ATIIRa类�?�诞生了诸如诺�?�公�?�的代文（缬沙�?��?Diovan）�?默沙东公�?�的科素亚（氯沙�?��?Cozaar）和赛诺�?�-安万特公�?�的厄�?沙�?�（Irbesartan�?Avapro）等销售中国食品商务网

沙�?�类�?�物销售�?少70亿美元 �?�临被仿  -  ‎Aug 3, 2009‎
...之�?�，ATIIRa类�?�诞生了诸如诺�?�公�?�的代文（缬沙�?��?Diovan）�?默沙东公�?�的科素亚（氯沙�?��?Cozaar）和赛诺�?�-安万特公�?�的厄�?沙�?�（Irbesartan�?Avapro）等销售慧聪网

Countdown to drug price ceiling list as firms offer alternative  -  13 Jul 2009
The 22 drugs are: Amlodipine, Telmisartan, Irbesartan, Clopidogrel, Atovarsitatin, Gliclazide, Piperacillin, Tazobactam, Ciprofloxacin, Azithromycin, BusinessWorld Online

Losartan counteracts the hyper-reactivity to angiotensin II and ...  -  ‎Jun 22, 2009‎
AT-II contracture was similarly reduced in all groups by AT-II receptor antagonists, irbesartan or irbesartan plus PD123319. HA-1077 (10 microM), 7thSpace Interactive (press release)

Rasilez - Japanese Ministry of Health approves Rasilez®, a first ...  -  ‎Jul 7, 2009‎
Blood Pressure Reduction Following A Simulated Missed Dose Of Aliskiren, Irbesartan, or Ramipril: A Comparative Ambulatory Blood Pressure Monitoring Study. Ad-Hoc-News (Pressemitteilung)

Комбинаци�? а�?пирина и клопидогрел�? более �?ффективно �?нижает ...  -  ‎Jun 23, 2009‎
В и�?�?ледовании Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE) оценивала�?ь �?ффективно�?ть двойной Medicus Amicus

Absurdistan zvaný Kategorizácia liekov.  -  ‎Jul 9, 2009‎
Napriek tomu na�?alej zostávajú v platnosti preskrip�?né obmedzenia špecialistov, ktorí majú v sú�?asnosti k dispozícii irbesartan, candesartan, telmisartan, SME.sk

ノ�?ルティス�?直接的レニン阻害剤（ＤＲＩ）「ラジレス錠１５�?�?ｇ ...  -  ‎Jul 7, 2009‎
...ＭｉｓｓｅｄＤ�?ｓｅＯｆＡｌｉｓｋｉｒｅｎ，Ｉｒｂｅｓ�?ｒｔ�?ｎ， �?ｒＲ�?�?ｉ�?ｒｉｌ：ＡＣ�?�?�?�?ｒ�?ｔｉｖｅＡ�?ｂｕｌ�?ｔ�?ｒｙＢｌ�?�?ｄ日本経済新聞 (プレスリリース)

Plavix(R) Plus Aspirin More Effective Than Aspirin Alone in ...  -  ‎Mar 31, 2009‎
0.2% per year, RR=1.37, p=NS) ACTIVE (Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events) is a comprehensive program FOXBusiness

Clopidogrel plus aspirin decreases stroke risk in patients with AF ...  -  ‎Apr 14, 2009‎
In the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events (ACTIVE)-A, 7554 patients with documented AF and with at Modern Medicine

ACTIVE (Atrial Fibrillation Clopidogrel Trial With Irbesartan for ...  -  ‎Mar 31, 2009‎
études distinctes : ACTIVE-W, ACTIVE-A et ACTIVE-I. Les études ACTIVE-A et W l'association Plavix(r)-aspirine. Aucune différence statistiquement deux Zonebourse.com

Dans la FA, ACTIVE-A montre qu'à défaut d'AVK, il faut associer le ...  -  ‎Apr 3, 2009‎
Orlando, FL, E.-U. — Après l'étude ACTIVE-W (Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events), publiée en 2006 [1], theheart.org/fr

시오노기 항비만제 日서�?� 제품화  -  ‎Mar 30, 2009‎
...시오노기는 주력제품�?� 고지혈�? 치료제 '�?�레스토'(Crestor, rosuvastatin)와 고혈압치료제 '�?�베탄'(Irbetan, irbesartan)과 같�?� �?활습관병분야로 분류�?�는 항비만 디지틀보사

플�?�빅스�? 아스피린 병용 뇌졸중�?만 효과  -  ‎Apr 14, 2009‎
...임�?시험�?�ACTIVE A (Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events Aspirin) 결과를 발표하고 �?�같�?� 결론내렸다. 메디칼트리뷴

혈압강하제 등 �?�약품 120개 15�?�부터 신규 보험등재  -  ‎Apr 5, 2009‎
...�?� ‘�?�화�?�베사탄정150mg(irbesartan)’, 보람제약�?� ‘�?시아정15/25mg(moexipril HCl), 한국화�?��?제약�?� ‘노바스�?�정10mg(amlodipine)’ 등 �? 16개가 추가�??다. 헬스코리아뉴스

[ACC 2009]ACTIVE-A：Clopidogrel與阿斯匹�?��?低心房纖維顫動之心血管事件  -  ‎Apr 3, 2009‎
...在「Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE)�?試驗計畫中，心房纖維顫動且有一個以上其他中風風險因素之臺灣新浪網

Treatment With Amiodarone to Prevent Atrial Fibrillation  -  ‎Mar 10, 2009‎
Patients treated with amiodarone plus irbesartan may have a lower rate of recurrence of atrial fibrillation than patients treated with amiodarone alone. Journal of American Medical Association (subscription)

Drug majors put on bid alert  -  ‎Mar 13, 2009‎
The two firms already have a partnership for the antithrombotic Plavix (clopidogrel) and the antihypertensive Avapro (irbesartan). "Overall, the most likely CITY A.M.

Office management of patients with diastolic heart failure  -  ‎Mar 4, 2009‎
A smaller randomized trial (n = 151) comparing the addition of irbesartan to standard therapy with the use of standard therapy alone found no benefit in CMAJ

Irbesartan nie poprawił rokowania u chorych z niewydolnością serca ...  -  ‎Mar 9, 2009‎
I: irbesartan po początkowo 75 mg 1 x dz., dawkę zwiększano do 300 mg 1 x dz. w ciągu 2-4 tygodni Chorzy w obu grupach otrzymywali ponadto: diuretyki (na Medycyna Praktyczna

Scompenso cardiaco con frazione d’eiezione preservata: Aprovel non ...  -  ‎Mar 3, 2009‎
I Ricercatori dello studio I-PRESERVE hanno studiato gli effetti dell’Irbesartan ( Aprovel, Karvea ) nei pazienti con questa sindrome. XagenaSalute

Sanofi-Aventis fronteggia la crisi  -  ‎Feb 24, 2009‎
...insulina glargine (+27,7%), docetaxel (+13,2%), enoxaparina sodica (+10,6%), clopidogrel bisolfato (+10,5%), irbesartan (+14,2%) e dei vaccini (+9,6%). Pharma Marketing

Ligand drug reduces hypertension in midstage study  -  Feb 2, 2009
The drug was given in either 200-milligram, 400-milligram, or 800-milligram doses and compared with placebo or 300-milligram doses of irbesartan, Forbes,

Beta-blocker benefit questioned in heart failure with preserved ...  -  Jan 9, 2009
The I-PRESERVE trial, as recently reported by heartwire, found no effect on mortality or CV events from the angiotensin-receptor blocker irbesartan (Avapro, TheHeart.Org,

Ирбе�?артан при �?ердечной недо�?таточно�?ти �? �?охранной �?и�?толиче�?кой ...  -  Feb 2, 2009
В �?той �?в�?зи было проведено крупное рандомизированное двойное �?лепое плацебо-контролируемое и�?пытание Irbesartan in Heart Failure with Preserved Ejection Medicus Amicus,

Casi un millar de nuevos EFG financiados el año pasado  -  Jan 11, 2009
...de uso hospitalario), ketorolaco trometanol (para dolor leve o moderado de uso hospitalario) y prednisona e irbesartan (de dispensación en farmacias). Correo Farmacéutico,

Irbesartan in Patients With Heart Failure and Preserved Ejection ...  -  Dec 3, 2008
Study Question: What are the effects of renin-angiotensin-aldosterone system (RAAS) blockade with irbesartan in patients with heart failure and preserved Cardiosource,

Irbesartan in Patients with Heart Failure and Preserved Ejection ...  -  Dec 3, 2008
Therefore, we studied the effects of irbesartan in patients with this syndrome. Methods We enrolled 4128 patients who were at least 60 years of age and had New England Journal of Medicine (subscription),

Treatment Fails To Improve Common Form Of Heart Failure, Study Finds  -  Dec 13, 2008
One group received 300 milligrams of irbesartan, an anti-hypertensive medication marketed as AvaproTM. The other group was given a placebo. Science Daily (press release)

B-MS to reduce workforce by an additional 10%  -  Dec 17, 2008
Plavix (clopidogrel), and other big earners such as the antipsychotic Abilify (aripiprazole) and the antihypertensive Avapro/Avalide (irbesartan). Pharma Times,

New heart research path opens  -  Dec 15, 2008
Irbesartan appeared ideal because the drug reduces the hardening of tissue and showed promising results in heart failure patients whose hearts didn't pump Charleston Post Courier,

Irbesartan in scompenso a frazione di eiezione preservata non ...  -  Dec 6, 2008
...in pazienti con insufficienza cardiaca e frazione di eiezione ventricolare sinistra preservata irbesartan non riduce significativamente gli eventi Pillole.org,

BMS, 제조시설 50% �??쇠-추가 구조조정�?� 단행  -  Dec 19, 2008
...제품�?� 항 �?�고제 프�?�빅스(clopidogrel), 정신병 치료약 �?빌리파�?� (aripiprazole) �? 고혈압 치료제 아바프로/아바�?��?�드(irbesartan) 등�?� 특허가 만료�?�다. 메디�?�뉴스,

Brand Names/Synonyms:
Irbesartan is also known by the following brand names and/or synonymsAvalide; Avapro; CHEMBANK1635; Irbesarran; Irbesartan; Irbesartan [Usan:Inn]; Lrbesartan

Drug Category:
Irbesartan is categorized under the following by the FDA: Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA04

Dosage Forms:
Oral tablets

Absorption:
60-80%

Interactions:
-->Interactions for Irbesartan:

No significant drug-drug pharmacokinetic (or pharmacodynamic) interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, and nifedipine.

In vitro studies show significant inhibition of the formation of oxidized irbesartan metabolites with the known cytochrome CYP 2C9 substrates/inhibitors sulphenazole, tolbutamide and nifedipine. However, in clinical studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin were negligible. Based on in vitro data, no interaction would be expected with drugs whose metabolism is dependent upon cytochrome P450 isozymes 1A1, 1A2,2A6,2B6,2D6,2E1,or 3A4.

In separate studies of patients receiving maintenance doses of warfarin, hydrochlorothiazide, or digoxin, irbesartan administration for 7 days had no effect on the pharmacodynamics of warfarin (prothrombin time) or pharmacokinetics of digoxin. The pharmacokinetics of irbesartan were not affected by coadministration of nifedipine or hydrochlorothiazide.

Chemical IUPAC Name:
3-butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one

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