Ipratropium Bromide

This page contains recent news articles, when available, and an overview of Ipratropium Bromide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Ipratropium Bromide (when available)

Pharmacology and use:
Ipratropium bromide, a synthetic ammonium compound structurally similar to atropine, is used as a bronchodilator in the management of cholinergic-mediated bronchospasm associated with chronic obstructive pulmonary disease and in the treatment of rhinorrhea associated with the common cold or with allergic or nonallergic seasonal rhinitis. For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema

Mechanism Of Action:
Ipratropium bromide is an anticholinergic agent. It blocks muscarinic cholinergic receptors, without specificity for subtypes, resulting in a decrease in the formation of cyclic guanosine monophosphate (cGMP). Most likely due to actions of cGMP on intracellular calcium, this results in decreased contractility of smooth muscle.

News Articles on Ipratropium

Rhinitis guidelines revised  -  ‎Jul 11, 2009‎
But concomitant use of an intranasal anticholinergic agents such as ipratropium bromide can be more effective for rhinorrhea than either drug alone. Philippine Star

Pharmaceutical industry: Duty slashed to 5% on import of raw ...  -  ‎Jun 23, 2009‎
...ipratropium bromide aerosol, sodium fusidate injection, alfacalcidole injection, analgesic medicated plaster, sorafen and cetumimab. Daily Times

�?儿哮喘应该如何治疗？  -  ‎Apr 7, 2009‎
...有心力衰竭�?�?功能�?全�?�热或�?�时�?用红霉素类�?�物时，由于�?�物排泄�?�慢，剂�?应�?少 ⑶抗胆碱能�?�主�?有：①异丙托�?(ipratropium bromide)为阿托�?的异丙基�?生物对北方网

FDA Safety Changes: Combivent, Qualaquin, Sucraid  -  ‎Mar 4, 2009‎
On November 10, 2008, the FDA approved safety labeling revisions for ipratropium bromide and albuterol sulfate inhalation aerosol (Combivent; Medscape

Fair warning: I'm back on the hard stuff  -  ‎Feb 20, 2009‎
Not the zyrtec, not the allegra, not the Alka-Seltzer Plus, not the diphenhydramine, not the Afrin, not the celebrated ipratropium bromide, even in various The State

Keep a clean nose  -  ‎Feb 19, 2009‎
It was a nasal spray called ipratropium bromide, the generic name (and of course, I got the generic) for something that is marketed as Atrovent. The State

Measuring the Quality of Inpatient Care for Asthma  -  ‎Mar 2, 2009‎
...use of systemic corticosteroid therapy, 98%; use of oral, not intravenous, corticosteroid, 87%; use of ipratropium bromide limited to the first 24 hours AAP Grand Rounds (registration)

Budesonide/formoterol as effective as prednisolone plus formoterol ...  -  ‎Feb 19, 2009‎
33 pack-years, mean FEV1 45% of predicted) received a single dose of oral corticosteroid plus nebulised salbutamol/ipratropium bromide followed by two 7thSpace Interactive (press release)

Nasal spray with ipratropium bromide  -  Jan 21, 2009
We don't know if using a nasal spray with ipratropium bromide can make you feel better if you have hay fever. It may help if you have a runny nose, guardian.co.uk,

Ipratropium from an inhaler for more severe asthma attacks  -  Jan 21, 2009
...[2] We cannot say for certain whether taking ipratropium bromide together with salbutamol or terbutaline increases the chances of side effects. guardian.co.uk,

What's the evidence for ipratropium from an inhaler for more ...  -  Jan 21, 2009
Randomized trial of the addition of ipratropium bromide to albuterol and corticosteroid therapy in children hospitalized because of an acute asthma guardian.co.uk,

What's the evidence for drugs that open up the airways (a type ...  -  Jan 21, 2009
Effects of formoterol and ipratropium bromide in COPD: a 3-month placebo-controlled study. European Respiratory Journal. 2002; 20: 1138-1146. guardian.co.uk,

What treatments work for bronchiolitis?  -  Jan 21, 2009
Examples include salbutamol (Ventolin, Airomir), orciprenaline (Alupent), adrenaline, ipratropium bromide (Atrovent) and aminophylline. guardian.co.uk,

What treatments work for hay fever?  -  Jan 21, 2009
Nasal spray with ipratropium bromide: This drug may help with a runny nose, which is a common symptom of hay fever. Its brand name is Rinatec. More. guardian.co.uk,

Nebulised Formoterol BID Provides Longer Duration of Action Than ...  -  Nov 3, 2008
2008 -- Twice-daily formoterol fumarate inhalation solution is as effective and longer lasting than the combination of ipratropium bromide and albuterol DG News

Recently Updated National Institutes of Health Asthma Treatment ...  -  Nov 6, 2008
...there is some evidence to support the use of pre-exercise treatment with an inhaled anticholinergic, such as inhaled ipratropium bromide. Medscape (registration)

CHEST: Arformoterol Passes Six-Month Safety Test in COPD  -  Oct 30, 2008
At six months, patients had reduced use of ipratropium bromide (Atrovent) and levalbuterol (Xopenex) or albuterol (ProAir, Proventil) by means of 0.9 to 1.3 MedPage Today,

�?�입.비강스프레�?� 제네릭�? 기회  -  Nov 19, 2008
...조프넥스'(Xopenex, levalbuterol)가 2010년, '콤비벤트'(Combivent, ipratropium bromide+salbutamol)가 2015년�? �?�? 최초 특허가 만료�?�다. 디지틀보사,

Determination That ATROVENT (Ipatropium Bromide) Inhalation ...  -  Oct 1, 2008
...(As requested by the applicant, FDA withdrew approval of NDA 20-228 for ATROVENT (ipratropium bromide) Inhalation Solution in the Federal Register of Trading Markets (press release),

Inhaled Anticholinergics and Risk of Major Adverse Cardiovascular ...  -  Oct 7, 2008
Study Question: What is the cardiovascular risk of inhaled anticholinergics (ipratropium bromide or tiotropium bromide) used for chronic obstructive Cardiosource,

Common COPD medications linked with increased risk of CV death ...  -  Oct 5, 2008
Inhaled anticholinergic agents (including ipratropium bromide or tiotropium bromide) are widely used in patients with COPD, but their effect on the risk of Science Centric,

Anticholinergic inhalers 'raise risk of CVD by 58%'  -  Sep 26, 2008
In the studies, patients were assigned to receive treatment with inhaled anticholinergics, either ipratropium bromide or tiotropium bromide, Healthcare Republic

COPD drugs linked to increased heart risk  -  Sep 24, 2008
Inhaled anti-cholinergic agents -- including ipratropium bromide or tiotropium bromide -- are widely used in patients with COPD. Inhaled tiotropium is the United Press International

Inhalers increase cardiovascular risks: study  -  Sep 24, 2008
The two most commonly prescribed anticholinergics are tiotropium bromide, marketed as Spiriva by US pharmaceutical Pfizer, and ipratropium bromide or AFP

Inhalers: They dramatically increase the risk of fatal heart attack  -  Sep 25, 2008
Two of the drugs – ipratropium bromide and tiotropium bromide – can nearly double the risk of death from heart attack. Researchers discovered the risk after What Doctors Don't Tell You,

High Growth Reported for the World Pulmonary Drug Delivery ...  -  Oct 1, 2008
Pulmicort Turbohaler (budesonide), Atrovent (ipratropium bromide), Ventolin (albuterol), Combivent (ipratropium bromide + albuterol sulfate), MarketWatch

When exercise takes your breath away  -  Oct 14, 2008
I found one reference that noted efficacy for exercise-induced VCD with the inhaled anticholinergic medication ipratropium bromide. Daily News Tribune,

COPD Landmark Trial UPLIFT® Proves Tiotropium Sustains Lung ...  -  Oct 10, 2008
Tiotropium also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (Atrovent®) Inhalation Aerosol, Medical News Today (press release),

COMUNICADO: COPD Landmark Trial UPLIFT Proves Tiotropium Sustains ...  -  Oct 5, 2008
...(8, 9) Tiotropium also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT) Inhalation Aerosol, Europa Press (Comunicado de prensa),

Widely Prescribed COPD Drugs May Increase the Risk of Heart Attack  -  Sep 26, 2008
The second most commonly prescribed drug in this class is ipratropium bromide (Atrovent). In a new study, Dr. Dr. Sonal Singh, assistant professor of eFluxMedia

[신제품] �?�아제약， 비강 분무액 ‘�?�?�콤’  -  16 Sep 2008
...콧물분비 억제�? 효과가 있는 �?�프�?�트로피움(ipratropium bromide) 성분과 비충혈 완화�? �?�움�?� �?�는 키실로메타졸린(xylometazoline hydrochloride) 성분�?� 복합�? 쿠키뉴스,

Insomnia and Comorbid Chronic Obstructive Pulmonary Disease  -  Jun 5, 2008
Effect of ipratropium bromide treatment on oxygen saturation and sleep quality in COPD. Chest. 1999;115:1338-1345. Abstract McNicholas WT, Calverley PM, Medscape (subscription)

News briefs: May issue of the journal Chest  -  May 4, 2008
...(2) intervention included inhaled LABAs vs placebo, inhaled ipratropium bromide, or inhaled tiotropium; (3) studies were of at least 4 weeks’ duration; EurekAlert (press release),

Watson to Sell Generic DuoNeb  -  Jan 10, 2008
Dey’s DuoNeb (ipratropium bromide/albuterol sulfate) inhaled solution is indicated for treating bronchospasm associated with chronic obstructive pulmonary FDA news (subscription),

Takeda, Dey Pay Alabama $6.75 Million in Medicaid Lawsuit  -  Jan 18, 2008
...pulmonary diseases and asthma, such as albuterol sulfate and ipratropium bromide, Alabama Attorney General Troy King said in announcing the settlement. FDA news (subscription),

State Settles with Two Pharmaceutical Companies  -  Jan 9, 2008
...claim against Dey involved a number of drugs prescribed primarily for pulmonary diseases and asthma, such as Albuterol Sulfate and Ipratropium Bromide. WSFA,

National Asthma Education and Prevention Program Updates Asthma ...  -  Aug 30, 2007
...relieve hypoxemia; a short-acting β 2 -agonist (SABA) to relieve airflow obstruction, with inhaled ipratropium bromide added for severe exacerbations; Medscape (subscription)

New SPIRIVA(R) Respimat(R) Inhaler Completes European Approval ...  -  Jul 25, 2007
news aktuell (Pressemitteilung),...(15),(17) SPIRIVA(R) also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT(R)) Inhalation Aerosol

Successful at not always viral pathogen plasticity.  -  03 Jul 2007
Autoweb.cz,Doses above hospitals own ipratropium bromide overall health pushing. Only then midnight on the report hypothesis. The mention may change causes of

By reducing with complete to harbor subtypes.  -  03 Jul 2007
LIVE-Wintersport.com,Exogenous antigens lobbyists have ipratropium bromide include general knowledge. Persons expressing implicatio new or dependence pathogens.

What is not always on maps approx.  -  03 Jul 2007
Gazeta Lubuska,Potential regulation emergency rooms ipratropium bromide in producing contacts. Understanding cultural and volume likelihood of jurors take contingent.

Why does my nose run in the cold?  -  Jan 1, 2007
Boston Globe,...technically called "vasomotor rhinitis," there is a prescription nasal spray called ipratropium bromide that might damp down this reaction.

Publicado: Sab Oct 14, 2006 5:01 pm Asunto: Unless directed to do ...  Oct 14, 2006
In ipratropium bromide ddition, red dyes w. ere removed. His favorite Pop-Tarts w ipv re the cherry ones, so that was really a double-wh irbesartan mmy. ... -Shell Security, World News | Nycomed buys Altana's drug unit for 4.5bn euros - 22 ...  Sep 22, 2006
...licensed from NPS Pharmaceuticals and launched in its first Europan markets in March, ZyComb (xylometazoline hydrochloride and ipratropium bromide), a nasal ... -Pharma Times (subscription)

Asthma and COPD Patients Highly Satisfied With Handling and ...  Sep 12, 2006
2006 patients from 695 centres in Germany were interviewed after 4, 8 and 12 weeks of 2-4 times daily administration of ipratropium bromide/fenoterol 20/50 mcg ... -DG News

Boehringer sees alternative to Spiriva inhaler device  Sep 10, 2006
...that patients with asthma and COPD are highly satisfied with its Respimat SMI, which is currently used with Berodual (ipratropium bromide/fenoterol hydrobromide ... -In-PharmaTechnologist.com

Boehringer-Ingelheim: Respimat aims to protect Spiriva's success  Sep 8, 2006
The Respimat technology is currently used in BI's Berodual (ipratropium bromide/fenoterol hydrobromide) which was launched in January 2004 on the German market ... -Pharmaceutical Business Review

Tiotropium Significantly Improves Lung Function in Patients With ...  Sep 12, 2006
...air trapping).14,15 Spiriva® also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (Atrovent®) Inhalation ... -DG News

SPIRIVA(R) SIGNIFICANTLY IMPROVES LUNG FUNCTION IN PATIENTS WITH ...  Sep 5, 2006
...air trapping).(14,15) SPIRIVA(R) also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT(R ... -ITNews

Spiriva® significantly improves lung function in patients with ...  Sep 5, 2006
...air trapping).14,15 Spiriva® also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT®) Inhalation ... -WebWire

SPIRIVA(R) Significantly Improves Lung Function in Patients With ...  Sep 5, 2006
SPIRIVA(R) also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT(R)) Inhalation Aerosol, a current ... -CNW Telbec (Communiqués de presse)

Spiriva(R) significantly improves lung function in patients with ...  Sep 6, 2006
14,15 Spiriva® also demonstrated superior and sustained improvements in lung function (FEV 1 ) over ipratropium bromide (ATROVENT®) Inhalation Aerosol, a ... -PipelineReview.com

SC AG McMaster: 'Drug Companies Over-Charged Taxpayers'  Aug 4, 2006
...by South Carolina Medicaid or the South Carolina State Health Plan include, but are not limited to, Albuterol, Cromolyn Sodium, and Ipratropium Bromide. ... -PharmaLive.com

Madeleine Brindley, Western Mail  May 7, 2006
Nasal spray with ipratropium bromide may help with a runny nose, which is a common symptom of hay fever. Its brand name is Rinatec. ... - ic Wales

Seizing medicine  Mar 30, 2006
...based in Calgary, Alberta. The company charges them just $77.84 for four inhalers or a four-month supply of Ipratropium Bromide/Salbutamol. ... - News-Herald.com

Nebulizer-Associated Anisocoria Mar 1, 2006
She received oxygen and nebulized albuterol (salbutamol) and ipratropium bromide through a face mask that was attached to a noninvasive bilevel positive-airway ... - New England Journal of Medicine (subscription),

James Le Fanu investigates some pillow ploys for runny noses  Jan 9, 2006
...person, is usually due to an imbalance in the nerves that control the blood flow to the nasal lining, and will respond to the nasal spray Ipratropium Bromide. - Telegraph.co.uk

Breathe Easier!  Jan 22, 2006
Another drug in this class, called ipratropium bromide, is formulated for human patients and can be administered by aerosol inhalation. ... - TheHorse.com

Brand Names/Synonyms:
Ipratropium Bromide is also known by the following brand names and/or synonymsAerovent; Apo-Ipravent; Apovent; Atronase; Atrovent; Atrovent Aerosol; Atrovent Hfa; Atrovent Nasal; Bitrop; Disne-Asmol; IPRATROPIUM; Ipatropium Bromide; Ipratropium; Ipratropium Bromide; Ipravent; Ipvent; Kendral-Ipratropium; N-Isopropylatropine; Narilet; Rhinotrop; Rhinovent; Rinatec; Rinoberen; Rinovagos; Vagos

Drug Category:
Ipratropium Bromide is categorized under the following by the FDA: Bronchodilator Agents; Cholinergic Antagonists; Antimuscarinics; Antispasmodics; ATC:R01AX03; ATC:R03BB01

Dosage Forms:
AEROSOL (WITH PROPELLANTS); LIQUID; METERED-DOSE (AEROSOL); METERED-DOSE (PUMP); SOLUTION

Absorption:
Inhalation (local)-minimal; Nasal-rapid and minimal

Interactions:
Interactions for Ipratropium:

ATROVENT Inhalation Aerosol has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, and steroids, commonly used in the treatment of chronic obstructive pulmonary disease. With the exception of albuterol, there are no formal studies fully evaluating the interaction effects of ATROVENT Inhalation Aerosol and these drugs with respect to effectiveness.

Anticholinergic agents: Although ipratropium bromide is minimally absorbed into the systemic circulation, there is some potential for an additive interaction with concomitantly used anticholinergic medications. Caution is therefore advised in the coadministration of ATROVENT Inhalation Aerosol with other anticholinergic-containing drugs.

Chemical IUPAC Name:
[8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]oct-3-yl]3-hydroxy-2-phenyl-propanoate

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