Hesperetin

This page contains recent news articles, when available, and an overview of Hesperetin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Hesperetin (when available)

Pharmacology and use:
Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80% For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again

Mechanism Of Action:
Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT₁ and ACAT₂) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.

News Articles on Hesperetin

Does grapefruit intake raise breast cancer risk?  -  Mar 31, 2008
The researchers tested orange and grapefruit juice concentrates, two citrus flavonoids, hesperetin and naringenin found in oranges and grapefruit and four Food Consumer,

Citrus flavanones show neuroprotection potential  -  Jan 21, 2008
The flavanones hesperidin, hesperetin, and neohesperidin were shown to protect against the toxicity of hydrogen peroxide (H2O2), as well as protecting FoodNavigator.com,

The secret of youth? It’s chocs and wine  -  Jan 24, 2008
These and other citrus fruits give us hesperetin, a flavonoid that helps to regenerate vitamin C, allowing it to play its part in deactivating free radicals Times Online,

Polyphenol-rich fruit protect against Alzheimer's: study  -  Jan 31, 2008
...which claimed to be the first to report that the flavanones hesperidin, hesperetin, and neohesperidin from citrus could protect against the toxicity of NutraIngredients.com,

Flavonoids In Orange Juice Make It A Healthy Drink, Despite The Sugar  -  Jul 18, 2007
Science Daily (press release)However the two types of flavonoids in orange juice -- hesperetin and naringenin -- inhibited ROS generation by 52 percent and 77 percent, respectively.

Brand Names/Synonyms:
Hesperetin is also known by the following brand names and/or synonymsCyanidanon 4'-Methyl Ether 1626; Hesperetin; Hesperin; Hesperitin; YSO2

Drug Category:
Hesperetin is categorized under the following by the FDA: Anticholesteremic Agents

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-chroman-4-one

:

Web health.mongabay.com

Disclaimer:

Contact a physician with regard to health concerns. Email requests for further health information will be discarded.

The materials contained on this Web site are for informational purposes only and do not constitute health or medical advice. Use of information on this site does not create or constitute any kind of agreement or contract between you and the owners or users of this site, the owners of the servers upon which it is housed, or anyone else who is in any way connected with this site.

Many links on health.mongabay.com lead to other sites. health.mongabay.com does not sponsor, endorse or otherwise approve of the materials appearing in such sites. Nor is health.mongabay.com responsible for dead or misdirected links.