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HalothaneThis page contains recent news articles, when available, and an overview of Halothane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Halothane (when available) Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. For the induction and maintenance of general anesthesia Mechanism Of Action: Halothane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Halothane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Halothane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor. News Articles on Halothane Visiting Veterinarian : Seven dwarves - Jul 30, 2008 Most veterinary cases have been connected to the inhalant anesthetic halothane (which we do not use), but other drugs and environmental factors, Martha's Vineyard Times, Rate This Article - 03 Jul 2008 The global critical care division markets a range of important hospital pharmaceuticals, including Halothane / Isoflurane inhalation anaesthetics. Financial Express, Pain, numbness, pain - Jun 23, 2008 Some of the non-pungent drugs, like halothane, have other undesirable effects — such as causing cardiac arrhythmias — or are more expensive, Science News Lights to brighten Shores paths - Jun 25, 2008 The City Council gave staff the OK on Tuesday to purchase 19 more Halothane Mongoose fixtures from Distribution Design Consultants to complete Phase 2 of Daytona Beach News-Journal, Anesthesia and memory loss - 02 Jun 2008 Some commonly inhaled anesthetics like isoflurane and halothane have been linked to dementia in mouse research (Neurobiology of Aging online, March 7, Seattle Times, Inside the house of horrors - May 24, 2008 ...who died at the Robinson Rd property in February 1999 from the combined toxic effect of the horse tranquilliser ketamine and the anaesthetic halothane. Sunday Times.au, Large-scale lawsuit seeks to ban chemical poisoning of water supply - May 13, 2008 If someone goes into surgery and they use anesthesia gas, they would be using fluorothane or halothane, or one of these other fluoride products. WorldNetDaily, Effect of Preemptive Epidural Analgesia on Cytokine Response and ... - May 9, 2008 Melamed et al.26 reported on the suppression of NK cell activity and the promotion of tumor metastasis by ketamine, thiopental, and halothane, RedOrbit, Lawyers fight $1.7m confiscation - Apr 5, 2008 A toxic combination of the horse tranquilliser ketamine and the anaesthetic halothane killed the formerly athletic youth, who took the drugs _ supplied by Sunday Times.au, '88 Minutes': Jon Avnet's thriller is downright loony - Apr 18, 2008 Same use of halothane to subdue the victim, same ropes and pulleys, same underwear and bloody outcome, only this time the vic is one of Gramm’s pretty PopMatters, Rare Genetic Syndrome May Hold Key To Cure For Heat Stroke - Apr 4, 2008 They found that these mice indeed exhibited full-body contractions that lead to death during exposure to anesthesia (eg halothane), a hallmark of malignant Science Daily (press release) Florida Teen Death: Anesthesia Choice Likely Creates Another ... - Mar 27, 2008 Triggering agents for MH are inhaled general anesthetic (GA) agents (ie halothane, desflurane and sevoflurane) and the muscle relaxant, succinycholine (SCH) FOXBusiness Alternative medicine: Ephedra - Apr 9, 2008 Guanethidine, ergot alkaloids (bromocriptine, dihydroergotamine, ergotamine), oxytocin, diuretics, morphine, and anesthetic drugs (halothane, cyclopropane, PRESS TV, Ephedra Hazards - Mar 7, 2008 Concurrent use with cardiac glycosides or halothane may disturb heart rhythm. Additive pharmacodynamic effects may be seen when ephedra is used with CNS Los Angeles Chronicle, Safely Using Anesthetic Gases - Oct 9, 2007 However, the reported odor threshold for halothane, for example, is 33 ppm, which is very close to the TLV of 50ppm. Therefore, do not rely on the presence Animal Lab News, Perth vet exploited boy for sex: coroner - Oct 4, 2007 ...dead at the property of vet Marcel Christiaan-Rauch, east of Perth, in February 1999 after overdosing on animal tranquillisers ketamine and halothane. Sydney Morning Herald, Drug use lifestyle to blame for tranquilliser death: coroner - Oct 5, 2007 David Spry was living with Roleystone vet Marcel Christiaan-Rauch in 1999 when he died from an overdose of ketamine and halothane. ABC Regional Online, OSHA and Lab Animal Care - Oct 9, 2007 Examples are isoflurane, enflurane, and halothane. Halogenated anesthetic agents have been linked to reproductive effects in women and neurological effects Animal Lab News, C4: Critical Cleaning For Contamination Control - Oct 9, 2007 ...dioxin, polychlorobiphenyls, the pesticide DDT, chlorobenzenes, the anaesthetic halothane, the dye feedstock methylenedianiline, and the explosive TNT. Controlled Environments Magazine, Roleystone vet took advantage of local teens: inquest - Oct 4, 2007 Mr Spry was found dead at the Robinson Road property in February 1999 after overdosing on the anaesthetic ketamine, known as Special K, and halothane. The West Australian, Dead boy 'was slave to drug' - Aug 14, 2007 17, was found dead at the property of veterinarian Marcel Christiaan-Rauch, east of Perth, in February 1999 after overdosing on ketamine and halothane. NEWS.com.au, Club scene - Sep 6, 2007 SATURDAY: Voices of Anatole, Halothane, Panic Strikken, Pour The Coal, 5 Nights. (304) 522-6570. The Sound Factory, 812 Kanawha Blvd. East, Charleston. Huntington Herald Dispatch, Few answers in Faith Williams death - Jul 11, 2007 Trinidad News,He said that amid this equipment, the halothane vaporisers were supposed to have been returned to the supplier in favour of the newer sevoflurane vaporisers Use of Gases in Anesthesia - Jul 11, 2007 Express Pharma,Important discoveries have been made with such volatile liquids as halothane and synthetic opiates. The technology of delivery systems has been greatly Gaza West Bank – ICRC Bulletin No. 23 / 2007 - Jun 19, 2007 Reuters AlertNet,The ICRC is also sending into Gaza 250 bottles of halothane, which is used to produce anaesthetic gas. Over the last few days, the organization had already The Return of N*gger Wetb*ck Ch*nk - Jun 27, 2007 LA Weekly,And my mother used her precise knowledge of atropine, halothane and sodium pentothal to restock Viva paper towels on the shelves of the Kmart in National Use of Gases in Anesthesia - Jun 20, 2007 Express Healthcare Management,Important discoveries have been made with such volatile liquids as halothane and synthetic opiates. The technology of delivery systems has been greatly CLUB SCENE - May 24, 2007 Huntington Herald Dispatch,FRIDAY: Broken Shadows, Dead for the Last Time, Halothane, Dead Neighbor Society. SATURDAY: Dying Ground, Family Conspiracy, Doubt the Lie, Immune the Saint The Consequences of huffing and Inhalants - May 8, 2007 Market-Day.net,...spray paint,hair spray, deodorant spray, and fabric protector spray; medical anestheticgases, such as ether, chloroform, halothane, and nitrous oxide. Anesthesia-Alzheimer Disease Link Probed - Apr 24, 2007 Journal of American Medical Association (subscription),In 2004, a team of researchers from the University of Pennsylvania demonstrated that the inhaled anesthetic agents isoflurane and halothane caused amyloid Anesthesia might pose risks for children - Mar 30, 2007 Boston Globe,Even detecting the effect of ketamine, halothane, and other anesthetics on the central nervous system is difficult if not impossible in the young, Anesthesia Drugs Can Be Dangerous For Children's Developing Brain - Mar 29, 2007 All Headline News...the effect of anesthesia drugs like ketamine and halothane on the central nervous system as many drugs appear to cause more harm to animals than others. Is there really a truth serum? - Apr 22, 2007 Scienceline,However, the barbituate is not what keeps someone under during surgery – gases like sevoflurane or halothane are used instead because patients regain Anesthesia risk for children worries FDA - Mar 29, 2007 Kansas City Star,Even detecting the effect of ketamine, halothane and other anesthetics on the central nervous system is difficult if not impossible in the young, Anesthesia hurts animal brain growth - Mar 30, 2007 Kentucky.com,Detecting the effect of ketamine, halothane and other anesthetics on the central nervous system is difficult if not impossible in the young, according to MPATT: Why the delay? - Jan 15, 2007 Trinidad News,The report stated that a Halothane Vaporiser used during the surgery had delivered lethal concentrations of gas to the patient which caused severe Board to notify doc of allegations - Jan 17, 2007 Trinidad News,The halothane vaporiser used during the surgery was found to be defective although it was in the operating theatre. The Ministry has asked the Board to Are there two reports on Faith’s death - Jan 15, 2007 Trinidad News,The report stated that a faulty Halothane Vaporiser used in anaesthetising Williams, resulted in her receiving a “lethal�dose of gas. Spare the rod now; pay the bail bondsman later Nov 5, 2006 ..."Yes," I didn't say, "let's make this a happy deal; how 'bout the rest of us ante up for a couple of whiffs of Halothane for each of these lovely children, and ... -Huntsville Times, Alzheimer's alarm over anesthetics Oct 25, 2006 Last week at the annual meeting of the Society for Neuroscience in Atlanta, Georgia, Mandal revealed that the inhaled anaesthetics halothane and isoflurane ... -EurekAlert (press release), Anesthetics may Increase Risk of Alzheimer's Disease Oct 26, 2006 Three anesthetics -- halothane, isoflurane, and propofol -- were found to encourage clumping of the protein, all at higher concentrations than are normally ... -Ivanhoe, Anesthetics can raise Alzheimer’s risk Oct 26, 2006 ...the new findings last week at the annual meeting of the Society for Neuroscience in Atlanta, Mandal said that exposure to anesthetics like halothane for just ... -South Asian Women's Forum, ALZHEIMER'S RISK IN OPS Oct 26, 2006 University of Pittsburgh scientists found that halothane - more common in Asia and Africa because of its cheapness - could trigger the memory-inhibiting clumps ... -Mirror.co.uk, COMFORTABLY NUMB Aug 29, 2006 Muscle relaxants were introduced in the early 1950s and then a major advance came in the form of Halothane – a revolutionary inhalation agent that is much ... -Phuket Post Deliver and capture anaesthesic gas Aug 1, 2006 ...a safety hood. Fluosorbers effectively adsorb halogenated gases such as Isoflurane, Sevoflurane, or Halothane. The Fluovac protects ... -Laboratory Talk C. Frederick Mosteller, a Pioneer in Statistics, Dies at 89 Jul 28, 2006 In the late 1950’s, Dr. Mosteller assisted in analyzing data from a large clinical study looking at the anesthetic halothane, which was suspected of causing ... -New York Times Easy application to the breathing pathway Jul 14, 2006 ...and Anesthesia Gas Adapter is an addition to any system requiring application of different gases, gas anesthesia (Isoflurane, Halothane, Sevoflurane) and/or ... -Laboratory Talk Army Officer Takes MDF to Task Over Presidential Pilot 07 Mar 2006 Hospital in Blantyre shows that Mwale paid K243,365.65 medical care, accommodation, major theatre, oxygen and nitrous oxide, halothane/ Fluothane, guardians ... - AllAfrica.com, Upper Airway Collapsibility in Anesthetized Children Feb 21, 2006 A secondary aim was to compare differences in upper airway collapsibility after the administration of sevoflurane or halothane. ... - Anesthesia & Analgesia (subscription), The Ventilatory Stimulant Doxapram Inhibits TASK Tandem Pore (K 2P ... Feb 21, 2006 ...brainstem. Acidic pH values and hypoxia inhibit TASK-1 and TASK-3 channel function, and halothane enhances this function. These ... - Anesthesia & Analgesia (subscription), The Tongue Flap: An Iatrogenic Difficult Airway? Feb 21, 2006 ...airway. Anesthesia was induced with IV ketamine 75 mg followed by ventilation with oxygen and nitrous oxide 50:50 and 1% halothane. ... - Anesthesia & Analgesia (subscription), Pharmacokinetics and Pharmacodynamics of a 0.1 mg/kg Dose of ... Feb 21, 2006 Pharmacodynamic results were comparable to those obtained in pediatric studies during halothane or opioid anesthesia with the exception of a longer recovery to ... - Anesthesia & Analgesia (subscription), Going Under Feb 6, 2006 ...he adds. Drugs used for inhalation anesthesia in horses include halothane, isoflurane, and sevoflurane, says Hubbell. For intravenous ... - TheHorse.com, Routine Inhaled Induction in Adults: A Safe Practice? Feb 14, 2006 ...nasal). The authors refer to anesthesiologists’ concerns over the risks of halothane and the relative safety of sevoflurane. Though ... - Anesthesia & Analgesia (subscription), Brand Names/Synonyms: Halothane is also known by the following brand names and/or synonymsAlotano; Alotano [Dcit]; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; CCRIS 6244; Cf3chclbr; Chalothane; Fluktan; Fluorotane; Fluorothane; Fluothane; Freon 123b1; Ftorotan; Ftorotan [Russian]; Ftuorotan; HSDB 6753; Halan; Halotan; Halotano; Halotano [Inn-Spanish]; Halothan; Halothane; Halothane [Anaesthetics, Volatile]; Halothane [Ban:Inn:Jan]; Halothanum [Inn-Latin]; Halsan; Narcotan; Narcotane; Narcotann Ne-Spofa; Narcotann Ne-Spofa [Russian]; Narkotan; Phthorothanum; Rhodialothan Drug Category: Halothane is categorized under the following by the FDA: Anesthetics; Anesthetics, Inhalation; General Anesthetics; ATC:N01AB01 Dosage Forms: SOLUTION Absorption: Not Available Interactions: Interactions for Halothane: FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides. FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine. Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated. For this reason the dose of adrenaline should be restricted and an antiarrhythmic agent administered as appropriate. Caution should also be applied for other sympathomimetics, and for aminophylline and theophylline and tricyclic antidepressants, which may also precipitate arrhythmias. Chemical IUPAC Name: 2-bromo-2-chloro-1,1,1-trifluoro-ethane : |
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