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GemfibrozilThis page contains recent news articles, when available, and an overview of Gemfibrozil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Gemfibrozil (when available) Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. For treatment of adult patients with very high elevations of serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and who do not respond adequately to a determined dietary effort Mechanism Of Action: Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. News Articles on Gemfibrozil Choosing lipid-lowering medication in HIV-associated lipodystrophy - Aug 13, 2009 If a statin is also prescribed, I prefer either fenofibrate or fenofibric acid instead of gemfibrozil. The risk for rhabdomyolysis when combining statin Endocrine Today Drug Interaction Confirmed Between Lopid and Kaletra - Aug 6, 2009 Kaletra (lopinavir/ritonavir) can significantly lower blood levels of the triglyceride-reducing drug Lopid (gemfibrozil), according to a study published AIDSmeds.com HIV/AIDS Treatment News "당뇨병 ë?™ë°˜ì§ˆí™˜ì?˜ 효과ì ?ì?¸ 치료와 ê·¸ 중요성" - Aug 27, 2009 ...ì?¼ì°¨ 예방연구ì?¸ Helsinki Heart Study(HHS)ì—?서는 í”¼ë¸Œë ˆì?´íŠ¸ì?˜ 하나ì?¸ gemfibrozilì?„ 투여하여 주요 심혈관질환ì?˜ ë°œìƒ?ì?„ ìœ ì?˜í•˜ê²Œ ê°?소시킬 수 ìžˆì—ˆë‹¤ê³ ë³´ê³ í•˜ì˜€ë‹¤ KMA Times Chicago water: In public reports, city silent over sex hormones ... - 13 Jul 2009 According to results posted on the city's Web site, the tests found small amounts of the sex hormones testosterone and progesterone; gemfibrozil, Chicago Tribune HEALTHY GEEZER - Jul 9, 2009 Fenofibrate, gemfibrozil and nicotinic acids often work to reduce triglycerides. Hypertriglyceridemia can run in families. While high triglycerides don't Santa Ynez Valley Journal Study Validates Safety and Efficacy of Red Yeast Rice in ... - Jul 3, 2009 ...lipid lowering agents like nicotinate and fish oils; however, lower or equivalent activity was observed when compared to fenofibrate and gemfibrozil. MediNEWS.Direct! è´?特类é™?è„‚è?¯ï¼šæ»‘势未å‡? - Jul 7, 2009 ...è´?特类é™?è„‚è?¯ä¸»è¦?包括å?‰é?žç½—é½?(gemfibrozil)ã€?æ°¯è´?ä¸?é…¯(clofibrate)ã€?é?žè¯ºè´?特(fenofibrate)ã€?苯扎è´?特(bezafibrate)和环丙è´?特(ciprofibrate)ç‰åœ¨å†…的一类调脂è?¯ç‰©ã€‚ 中国食品商务网 Endocrinology & Metabolism News - Apr 6, 2009 However, patients with HIV infection receiving NNRTI-based antiretroviral therapy and gemfibrozil had triglyceride responses similar to those in patients Journal of Clinical Endocrinology and Metabolism Excessive triglycerides pose cardiac,stroke risk - Mar 29, 2009 If lifestyle changes don't work, or if your triglyceride level is very high, you may need to take a medication, such as niacin, gemfibrozil (Lopid, Denver Post Five US Rivers Tainted with Pharmaceutical and Chemical Residues - Apr 4, 2009 Significantly, the cholesterol drug gemfibrozil (Lopid) was for the first time detected in wild fish. Other substances that tested positive in the study Natural News.com High Triglyceride Levels Common, Often Untreated Among Americans - Mar 29, 2009 A total of 1.3 percent of participants used one of three prescription medications (fenofibrate, gemfibrozil or niacin) that treat hypertriglyceridemia, Science Daily (press release) New Data for Abbott’s TRILIPIXâ„¢ (fenofibric acid) in Combination ... - Mar 31, 2009 ...increased with concurrent administration of some other lipid-lowering therapies (fibrates or niacin), gemfibrozil, cyclosporine, or lopinavir/ritonavir. WebWire (press release) 09年临床执业医师考试辅导：肾病综å?ˆå¾?治疗之高脂血症治疗 - Apr 14, 2009 ...å?¯é€‰ç”¨çš„é™?è„‚è?¯ç‰©æœ‰ï¼šâ‘ 纤维酸类è?¯ç‰©ï¼ˆfibricacids）：é?žè¯ºè´?特（fenofibrate）æ¯?æ—¥3次，æ¯?次100mg，å?‰é?žç½—é½?（gemfibrozil）æ¯?æ—¥2次，æ¯?次600mg，其é™?血甘油三酯作用 青年人 米国ã?®æ²³å·?éšã?¯è–¬å‰¤ã?«æ±šæŸ“ã?•ã‚Œã?¦ã?„ã‚‹ - Apr 1, 2009 ...コレステãƒãƒ¼ãƒ«ä½Žä¸‹è–¬gemfibrozil（Lopid）。ã?“ã‚Œã?¾ã?§ã?«é‡Žç”Ÿã?®éšã?‹ã‚‰æ¤œå‡ºã?•ã‚Œã?Ÿã?“ã?¨ã?¯ã?ªã?‹ã?£ã?Ÿã?¨ã?„ã?†ã€‚ 高血圧治療ã?«ç”¨ã?„られるカルシウム拮抗薬 日本経済新聞 Response to Newly Prescribed Lipid-Lowering Therapy in Patients ... - Mar 2, 2009 Patients with HIV infection beginning gemfibrozil therapy had substantially smaller reductions in triglyceride levels than patients without HIV infection Annals of Internal Medicine Long-Term Benefit of High-Density Lipoprotein Cholesterol-Raising ... - Mar 13, 2009 ...infers that the fibrate did not increase risk of cancer and other noncardiac deaths, as was suggested in the clofibrate and gemfibrozil trials. Cardiosource Celeste Robb-Nicholson, MD - Mar 1, 2009 If lifestyle changes don't work, or if your triglyceride level is very high, you may need to take a medication, such as niacin, gemfibrozil (Lopid, Newsday Response to Cholesterol-Lowering Drugs in Patients With and ... - Mar 2, 2009 However, HIV-infected patients who were receiving NNRTIs only and the cholesterol-lowering drug gemfibrozil had decreases in triglyceride levels similar to Annals of Internal Medicine CRESTOR Cuts Risk of Stroke by Nearly Half in JUPITER Study - Feb 19, 2009 ...increased with concurrent administration of some other lipid-lowering therapies (fibrates or niacin), gemfibrozil, cyclosporine, or lopinavir/ritonavir. PR Newswire (press release) Attacking high cholesterol - 04 Feb 2009 These include bezafibrate, ciprofibrate, fenofibrate and gemfibrozil (Lopid), but the latter is most commonly used here. They reduce triglycerides (another Jamaica Gleaner, PrandiMet®, First Repaglinide and Metformin HCl Fixed Dose ... - 04 Feb 2009 ...including diabetic ketoacidosis; patients receiving both gemfibrozil and itraconazole’ or patients with known hypersensitivity to repaglinide, Earthtimes (press release), What's the evidence for fibrates for people who don't have heart ... - Jan 21, 2009 We found one study that looked at the effects of the drug gemfibrozil over five years in more than 4000 men who had a moderate risk of having a heart attack guardian.co.uk, FDA Approves Four ANDAs for Sun Pharma - Jan 15, 2009 ...of Novartis’ Aredia (pamidronate disodium), Pfizer’s Lopid (gemfibrozil) and Wyeth’s Phenergan (promethazine HCl), India-based Sun says in a statement. FDA news (subscription), Fibrates for people who don't have heart disease - Jan 21, 2009 You shouldn't take a type of fibrate called gemfibrozil together with a statin.[5] If you want to know more about lipid disorders, see Inherited lipid guardian.co.uk, Sun Pharma Receives USFDA Approvals For 4 Generic Products - Jan 9, 2009 Generic Lopid contains gemfibrozil 600 mg, a cholesterol reducing agent and has annual sales of about USD 44 million in the US. Pharmaceutical Online (press release), Healthy yet good cholestrol is low - Jan 12, 2009 Lastly, the triple-drug regimen of niacin, cholestyramine and gemfibrozil has been shown to increase HDL cholesterol substantially but this drug combination AsiaOne, Search This Blog using Google - Jan 14, 2009 Conversely, the most frequently detected prescription pharmaceuticals (carbamazepine, gemfibrozil, meprobamate, sulfamethoxazole, and trimethoprim) were not ScienceBlogs Production and Purification of Esters of Polyunsaturated Fatty Acids - Jan 22, 2009 LIPITOR (atorvastatin calcium), LESCOL (fluvastatin), LOPID (gemfibrozil), or PRAVACHOL (pravastatin sodium)); policosanols; fibrates; Clioquinol; FLEXNEWS, Neu auf dem Markt Micafungin und Rosuvastatin - Feb 3, 2009 Das Risiko von Muskelbeschwerden steigt, wenn gleichzeitig Wirkstoffe wie Gemfibrozil, Fenofibrat, andere Fibrate oder lipidsenkende Dosierungen von Pharmazeutische Zeitung online, Zuwachs für Statin-Familie - Jan 15, 2009 Das Risiko von Muskelbeschwerden steigt, wenn gleichzeitig Wirkstoffe wie Gemfibrozil, Fenofibrat, andere Fibrate oder lipidsenkende Dosierungen von Pharmazeutische Zeitung online, FDA OKs New Cholesterol Drug Trilipix - Dec 15, 2008 That's not a new class of drugs; other fibrates include gemfibrozil (sold generically and under the brand name Lopid), fenofibrate (sold under the brand WebMD Tracking Eye Disorders in Statin Users; Predicting Visual Outcomes ... - Dec 1, 2008 Eye disorders related to statins are rare, occurring in about 0.1 percent of patients (0.5 to 2.5 percent when gemfibrozil, another type of MarketWatch Pharmaceuticals found in Erie's drinking water - Dec 1, 2008 Detected in the water were ibuprofen, a common painkiller, at 2.5 ppt; gemfibrozil, a cholesterol-lowering drug, about 2.5 ppt; and carbamazepine, GoErie.com, Dyslipidemia and chronic kidney disease - Dec 3, 2008 I have added gemfibrozil 600 mg, also orally twice per day before meals and will re-check his levels in late January. He made it quite clear that the family Endocrine Today, Impact, sur la maladie veineuse thromboembolique, des médicaments ... - Dec 16, 2008 Néanmoins, il semble que le gemfibrozil soit capable de diminuer la concentration de fragment 1 + 2 de la prothrombine chez des patients présentant une Médecine Thérapeutique (Abonnement), Drug can cause muscle problem - 21 Nov 2008 People simultaneously taking drugs like gemfibrozil, some anti-fungals, macrolide antibiotics like erythromycin, the heart medicine digoxin and the blood DetNews.com, CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin ... - Nov 9, 2008 ...increased with concurrent administration of some other lipid-lowering therapies (fibrates or niacin), gemfibrozil, cyclosporine, or lopinavir/ritonavir. MarketWatch Statin side effects: Weigh the benefits and risks - Oct 30, 2008 Certain other cholesterol-lowering drugs, such as gemfibrozil (Lopid) and niacin, increase the risk of liver problems even more in people who take statins. MayoClinic.com Ezetimibe and Other Statins Achieve Established Low-Density ... - Oct 29, 2008 ...mean dose 32.0 mg); rosuvastatin (7.8%, mean dose 13.2 mg); pravastatin (1.1%, mean dose 35.0 mg); and gemfibrozil (0.6%, mean dose 1200 mg). DG News Statin類藥物 - Nov 17, 2008 ...è¦?注æ„?的是fibrate類藥物與statiné¡žè—¥ç‰©ä¸¦ç”¨æœƒå¢žåŠ è‚Œè‚‰ç—…è®Šå?Šæ©«ç´‹è‚Œæº¶è§£çš„機會，如果真的需è¦?å?ˆä½µä½¿ç”¨fenofibrate比gemfibrozil å?°ç?£æ–°ç”Ÿå ±, En quoi les hypocholestérolémiants peuvent-ils être utiles ? - Nov 10, 2008 Fibrates : Cette classe d'hypocholestérolémiants, qui comprend le fénofibrate (Lipidil®), le gemfibrozil et le bezafibrate, agit en dégradant le cholestérol Canoë, Ha magas a koleszterin- és vérzsÃrszint - Hogyan hatnak a gyógyszerek? - Sep 28, 2008 A következÅ‘ gyógyszercsoport a fibrátok csoportja (bezafibrát, fenofibrát, gemfibrozil), melyek nem a koleszterin, hanem a zsÃrszintet csökkentik a vérben, WEBBeteg, AP Enterprise: Report prompts more water tests - Sep 11, 2008 ...___ TESTED POSITIVE AFTER AP'S MARCH REPORTS: Aurora, Ill.: 1 (gemfibrozil) Beaufort and Jasper counties, SC: 1 (carbamazepine) Chandler, Ariz. The Associated Press 46 million drink drugged water - Sep 15, 2008 In May, city officials announced they had found small amounts of gemfibrozil, a cholesterol medication, in both treated and untreated water. Chicago Sun-Times, Elgin not worried about drugs in drinking water - Sep 13, 2008 Six drugs - carbamazepine, continine, gemfibrozil, monensin, Deet and nicotine - were found in Elgin's water, which is treated after it's extracted from the Beep, Getting to the root of hair loss - Sep 2, 2008 Medications such as allopurinol, warfarin and gemfibrozil have the possible side effect of alopecia. Other reasons for women's hair loss includes changes in Jamaica Gleaner, Abbott And AstraZeneca Expand Relationship To Include - Aug 17, 2008 Combination therapy with rosuvastatin and gemfibrozil should be avoided. CRESTOR should be prescribed with caution in patients with predisposing factors for Pharmaceutical Online (press release), The Effect of Orlistat and Ezetimibe, Alone or in Combination, on ... - Aug 28, 2008 Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the RedOrbit, Ä?iá»?u trị máu nhiá»…m mỡ - Sep 7, 2008 Lopid có thà nh phần hoạt chất là Gemfibrozil là thuốc Ä‘iá»?u trị rối loạn lipide máu thuá»™c nhóm fibrate. Ở ngÆ°á»?i, các nghiên cứu lâm sà ng cho thấy rằng dùng VN Media, Test results say Illinois water supplies safe - 07 Aug 2008 The Rock Island samples contained minute traces of such things as nicotine, the anti-cholesterol drug gemfibrozil, the anti-bacterial sulfadimethoxine, Quad City Times, A Practical "ABCDE" Approach to the Metabolic Syndrome - Aug 5, 2008 Fibrates also modestly raise HDL-C and increase the size of LDL particles via pathways downstream of PPAR-alpha.69 Trials have shown that gemfibrozil RedOrbit, Geänderte Zulassung für Fibrate - Jul 16, 2008 ...(kig) Die Anwendungsgebiete der Lipidsenker Bezafibrat, Fenofibrat und Gemfibrozil werden mit Wirkung zum 30. September erheblich eingeschränkt. Springer Gesundheit und Pharmazie, å?¥åº·æŽ¢ç´¢ï¼šé˜³è?Žã€?æ€§çˆ±ä¸Žå† å¿ƒç—… - Jul 25, 2008 ...有一些è?¯ç‰©è¯¸å¦‚抗高血压è?¯(βå?—体阻滞剂，利尿剂)，é™?血脂è?¯ç‰©(gemfibrozil é?’网, Complicaciones gastrointestinales de la diabetes - Jul 8, 2008 Los fármacos como la metformina, el gemfibrozil y la pioglitazona (no aprobada en EE. UU.) disminuyen los niveles de transaminasas hepáticas y mejoran los Intramed.net (Suscripción), Scottsdale tap water nearly pharmaceutical-free - Jun 26, 2008 Carbamazepine, Sulfamethoxazole, Fluoxetine, Estradiol, Estrone, Ethynylestradiol, Testosterone, Progesterone, Gemfibrozil, Ibuprofen, Triclosan. East Valley Tribune, Pharmacoeconomics of Elevated Triglycerides and Their Management - Jun 19, 2008 Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med. Medscape (subscription) FDA Approves PrandiMetâ„¢, a Replaglinide and Metformin Fixed-Dose ... - Jun 24, 2008 PrandiMetâ„¢ is contraindicated in patients with renal impairment, metabolic acidosis, including diabetic ketoacidosis, or patients receiving both gemfibrozil Business Wire (press release), Gastrointestinal Complications of Diabetes - Jun 17, 2008 A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol. 1999;31(2):384. 28. Zein COo, et al. RedOrbit, Toward "Pain-Free" Statin Prescribing: Clinical Algorithm for ... - Jun 14, 2008 Frequency of creatine kinase elevation during treatment with fluvastatin in combination with fibrates (bezafibrate, fenofibrate, or gemfibrozil). RedOrbit, Plasma PCSK9 levels are significantly modified by statins and ... - Jun 11, 2008 Changes in plasma PCSK9 following fenofibrate or gemfibrozil treatments (fibric acid derivatives) were inversely correlated with changes in LDLC levels (r= 7thSpace Interactive (press release), Tests show water 'safe to drink' despite drug, insect repellent - May 10, 2008 The city testing found a trace amount of the drug gemfibrozil, typically used to treat blood triglycerides, in both treated and untreated water. Chicago Sun-Times, Traces of pharmaceuticals found in Chicago drinking water, city ... - May 10, 2008 The city also found small amounts of gemfibrozil, a prescription cholesterol-fighting drug, in water from the Jardine plant, which serves neighborhoods Chicago Tribune, Lowering cholesterol: what the options are - May 6, 2008 The two most common are gemfibrozil (Lopid) and fenofibrate (TriCor). They are prescribed mainly for people with high triglyceride levels. Myrtle Beach Sun News, Brand Names/Synonyms: Gemfibrozil is also known by the following brand names and/or synonymsApo-Gemfibrozil; Ausgem; Bolutol; Brozil; CCRIS 318; CHEMBANK796; CI 719; CI-719; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gem-S; Gemd; Gemfibril; Gemfibromax; Gemfibrozil; Gemfibrozil [Usan:Ban:Inn]; Gemfibrozilo [Inn-Spanish]; Gemfibrozilum [Inn-Latin]; Gemlipid; Gemnpid; Gen-Fibro; Genlip; Gevilon; Gevilon Uno; Gozid; Hidil; Hipolixan; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Low-Lip; Micolip; Normolip; Novo-Gemfibrozil; Nu-Gemfibrozil; Pilder; Po-Gemfibrozil; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; TEVA-A; Taborcil; Tentroc; Trialmin; Uno; Wl-Gemfibrozil; [Usan:Ban:Inn] Drug Category: Gemfibrozil is categorized under the following by the FDA: Antilipemic Agents; Fribic Acid Derivatives; ATC:C10AB04 Dosage Forms: CAPSULE; TABLET Absorption: Well absorbed from GI after oral administration (within 1-2 hours) Interactions: -->Interactions for Gemfibrozil: )
Chemical IUPAC Name: 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid : |
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