Gallamine Triethiodide

This page contains recent news articles, when available, and an overview of Gallamine Triethiodide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Gallamine Triethiodide (when available)

Pharmacology and use:
Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures. For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation

Mechanism Of Action:
It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.

News Articles on Gallamine Triethiodide

Bioniche Pharma Acquires Baxter's ENLON(R) and ENLON-PLUS(R) - 03 Jul 2008
ENLON(R) is also useful whenever a curare antagonist is needed to reverse the neuromuscular block produced by curare, tubocurarine, gallamine triethiodide Earthtimes (press release),

Brand Names/Synonyms:
Gallamine Triethiodide is also known by the following brand names and/or synonyms3697 R.P.; Benzcurine Iodide; Benzkurin; CHEMBANK1257; F 2559; Flacedil; Flaxedil; Fourneau 2559; G104; Gallaflex; Gallamin; Gallamin Triethiodide; Gallamine; Gallamine Iodide; Gallamine Triethiiodide; Gallamine Triethiodide; Gallamine Triiodoethylate; Gallamine-3eti; Gallamone Triethiodide; Gallamonum; HL 8583; Miowas G; Parexyl; Pirolakson; Pyrolaxon; RP 3697; Relaxan; Remyolan; Retensin; Sincurarine; Syncurarine; Tricuran; Triiodoethylate de Gallamine

Drug Category:
Gallamine Triethiodide is categorized under the following by the FDA: Neuromuscular Nondepolarizing Agents; Nicotinic Antagonists; Skeletal Muscle Relaxants; ATC:M03AC02

Dosage Forms:
LIQUID

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
N-[2-[2,3-bis(2-diethylaminoethoxy)phenoxy]ethyl]-N-ethyl-ethanamine

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