Galantamine

This page contains recent news articles, when available, and an overview of Galantamine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Galantamine (when available)

Pharmacology and use:
Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Galantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, Galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that Galantamine alters the course of the underlying dementing process. For the treatment of mild to moderate dementia of the Alzheimer's type.

Mechanism Of Action:
Galantamine's proposed mechanism of action involves the increase of the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase.

News Articles on Galantamine

Rare plant that counteracts Alzheimer’s discovered in Lam Dong  -  Jun 12, 2008
This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease. Clinical trials in China VietNamNet Bridge,

People With Dementia Should Avoid Certain Drugs  -  Jun 27, 2008
When used appropriately, the CIs (donepezil, Aricept, rivastigmine (Exelon) and galantamine (Razadyne) may slow the decline of cognitive and functional RedOrbit,

J&J Sues Novartis Unit to Block Generic Version of Razadyne ER  -  Jun 16, 2008
...said Sandoz's product would infringe a patent for a controlled-release form of galantamine hydrobromide, the active ingredient in Razadyne. Bloomberg

Bladder and dementia therapy may be incompatible  -  Jun 4, 2008
Examples of cholinesterase inhibitors include donepezil (Aricept), galantamine (Razadyne), rivastigmine (Exelon), and tacrine (Cognex). Reuters

What is the Mini Mental State Examination (MMSE)?  -  Jun 14, 2008
...rivastigmine (Exelon) or galantamine (Reminyl). The MMSE is a series of questions and tests, each of which scores points if answered correctly. Daily Mail,

Incontinence and Dementia Treatment  -  Jun 10, 2008
Examples include donepezil (Aricept®), galantamine (Razadyne®), rivastigmine (Exelon®), and tacrine (Cognex®). These drugs are designed to increase levels Advance for Speech-Language Pathologists and Audiologists,

Research and Markets: New Report Gives Insight Into the Latest ...  -  May 29, 2008
NC758; Neurochem) - Xaprila (xaliproden); Sanofi-Aventis Cholinesterase Inhibitors - Exelon (rivastigmine; Novartis) - Razadyne ER (galantamine; PR-Inside.com (Pressemitteilung),

HALF-YEAR FINANCIAL RESULTS 2007/2008  -  May 29, 2008
The primary sources of past revenues such as galantamine and torsemide are no longer the engines of growth that they once were and now only make up around Ad-Hoc-News (Pressemitteilung),

Galantos Pharma Receives Research Grant Expansion of technology ...  -  May 28, 2008
The lead candidate of Galantos Pharma is Memogain, a derivative of galantamine, a nicotinic acetylcholine receptor sensitizer and weak choline esterase PharmaLive.com (press release),

UK Court Rules Against NICE Over Alzheimer's Guidance  -  May 9, 2008
Ortho McNeil's Razadyne (galantamine) and Lundbeck's Ebixa (memantine), should no longer be funded by the National Health Service. RedOrbit,

The Muscarinic Hypothesis of Schizophrenia: Implications for ...  -  Apr 15, 2008
Cholinesterase inhibitors (donepezil, galantamine, and rivastigmine) increase the intrasynaptic concentration of ACh through inhibition of the enzyme Psychiatric Times,

Combating Childhood Obesity and Nerve Gas  -  Apr 7, 2008
The company sees an opportunity in repurposing an Alzheimer’s drug called galantamine to block nerve agents on the battlefield. NJBIZ,

NICE forced into court again on Alzheimer's drugs  -  Apr 14, 2008
...hit out at the need to once again defend its decision to restrict the availability of Alzheimer disease drugs donepezil, rivastigmine, and galantamine. OnMedica,

Does Pa. Tax Magazines Or Bibles? What Color Sunglasses Are Best?  -  Apr 21, 2008
...just published clinical practice guidelines for use of the five FDA-approved drugs: donepezil, galantamine, rivastigmine, tacrine and memantine. Evening Bulletin,

Guideline: Dementia Drugs’ Benefits Uncertain  -  Apr 15, 2008
Four are cholinesterase inhibitors: donepezil, galantamine, rivastigmine, and tacrine. The fifth is the neuropeptide-modifying agent memantine. Journal of American Medical Association (subscription),

UK appeal against NICE Alzheimer’s decision process begins  -  Apr 15, 2008
...now Razadyne (galantamine) and Lundbeck’s Ebixa (memantine) - should no longer be funded by the NHS on the grounds of cost-effectiveness. Pharma Times (subscription),

Caregivers sought for UVic study  -  Apr 14, 2008
The medications now temporarily covered by PharmaCare are donepezil (Aricept), galantamine (Reminyl) and rivastigmine (Exelon). Currently these are the only Times Colonist,

Caring for the Complex Senior Patient in Ambulatory Care  -  11 Mar 2008
US Food and Drug Administration-approved treatments include the anticholinesterase inhibitors donepezil, rivastigmine, and galantamine. Medscape (subscription)

Galantamine selectively improves aspects of cognition in schizophrenia  -  Feb 15, 2008
By Michelle Rizzo NEW YORK (Reuters Health) - While galantamine does not provide a significant global benefit for cognitive impairments in schizophrenic Therapeutics Daily (subscription) (press release),

New Pharmacologic Guideline Issued for Treatment of Dementia  -  Mar 7, 2008
Evidence of improvement on global assessment was available for donepezil, galantamine, rivastigmine, and memantine. However, these changes were generally Medscape (subscription)

Primary Care Panel Finds Dementia Drugs to be Peas in a Pod  -  Mar 4, 2008
Galantamine. Pooled evidence showed statistically significant improvement in cognition, but not clinical improvement. Three individual studies suggested a MedPage Today,

DJ DGAP-Adhoc: Sanochemia Pharmazeutika AG:withdrawal from planned ...  -  Feb 26, 2008
...(Marlton, New Jersey) announced that it had acquired exclusive rights to develop and market galantamine as an antidote from the University of Maryland upon VisAvis (Pressemitteilung),

Groups Issue New Dementia Drug Guidelines  -  Mar 4, 2008
These include four acetylcholinesterase inhibitors -- donepezil (Aricept), galantamine (Razadyne, Reminyl, Nivalin), rivastigmine (Exelon), Washington Post,

Review finds no superior drugs for dementia  -  Mar 4, 2008
The medications were: galantamine, sold in Canada generically and under the brand name Reminyl. Sold in the US as Razadyne, and Nivalin; rivastigmine, CTV.ca,

US review finds no good drugs for dementia  -  Mar 3, 2008
Four are in a class of drugs called cholinesterase inhibitors -- Pfizer and Eisai Co Inc's Aricept; galantamine, sold generically and under the brand names Reuters

Medical Organizations Issue New Guideline On Drugs To Treat Dementia  -  Mar 6, 2008
Currently five drugs are approved by the FDA for dementia: four acetylcholinesterase inhibitors [donepezil (Aricept®), galantamine (Razadyne™, Reminyl™, Medical News Today (press release),

Shire plc: Excellent Performance Across All Areas of the Business ...  -  Feb 21, 2008
REMINYL (galantamine) (trademark of Johnson & Johnson, excluding UK and Republic of Ireland) REMINYL XL (galantamine) (trademark of Johnson & Johnson, PR Newswire (press release),

AAFP-ACP Guideline Looks at Drug Treatment of Dementia  -  Mar 5, 2008
The five drugs are the cholinesterase inhibitors donepezil (Aricept), galantamine (Nivalin, Razadyne, Reminyl), rivastigmine (Exelon) and tacrine, AAFP News Now

Priced out of the UK market  -  Feb 22, 2008
Eisai manufactures Aricept (donepezil; copromoted in the US with Pfizer of New York), which, along with two other Alzheimer's drugs, Reminyl (galantamine) Nature.com (subscription),

BUYINS.NET: (JNJ) SqueezeTrigger Price is $62.442. There is ...  -  Feb 12, 2008
...for the treatment of overactive bladder; RAZADYNE (galantamine HBr), for patients with mild-to-moderate Alzheimer's disease; NATRECOR (nesiritide), Trading Markets (press release),

All about Alzheimer's disease  -  06 Feb 2008
This group of medications (donepezil (Aricept), rivastigmine (Exelon) and galantamine (Reminyl)) improves the brain's neurotransmitters levels. PRESS TV,

BUYINS.NET: (JNJ) SqueezeTrigger Price is $62.442. There is ...  -  Jan 31, 2008
...for the treatment of overactive bladder; RAZADYNE (galantamine HBr), for patients with mild-to-moderate Alzheimer's disease; NATRECOR (nesiritide), Trading Markets (press release),

Dr Thomas Stuttaford answers your questions on dementia  -  Nov 7, 2007
Three drugs, Aricept donepezil, Exelon rivastigmine and Reminyl galantamine, are all drugs that can be used to treat mild dementia of any origin as they may Times Online,

A distant memory  -  Oct 31, 2007
There are three drugs, Exelon rivastigmine, Aricept donepezil and Reminyl galantamine, that may be useful in mild to moderately severe dementia. Times Online,

Further Upgrade to 2007 Financial Guidance Based on Strong Revenue ...  -  Nov 1, 2007
...(mesalamine) MEZAVANT(R) (mesalazine) REMINYL(R) (galantamine hydrobromide) (UK and Republic of Ireland) REMINYL XL(TM) (galantamine hydrobromide) (UK PR Newswire (press release),

Anti-dementia drugs effective over long-term  -  Oct 12, 2007
Guidelines addressing duration of therapy have not been established for donepezil, galantamine, rivastigmine and memantine, Rountree said. Reuters UK,

Shire to Support Appeal Against Outcome of Judicial Review of NICE ...  -  Oct 1, 2007
In the UK and Ireland, Shire markets REMINYL(R) (galantamine hydrobromide) and REMINYL(R) XL (galantamine hydrobromide) acetylcholinesterase inhibitors that Earthtimes.org

Alzheimer’s drugs battle rages on; Eisai to appeal  -  Oct 1, 2007
NICE first ruled against the use of the acetyl cholinesterase inhibitors Aricept, Novartis’ Exelon (rivastigmine) and Shire’s Reminyl (galantamine) on the Pharma Times (subscription),

Eisai Announce Application to Appeal NICE Judicial Review Verdict  -  Sep 28, 2007
...approved the use of these medicines by the NHS (donepezil, rivastigmine and galantamine) for the treatment of mild and moderate Alzheimer’s disease. BourSonews,

Mortality Risk in Patients With Dementia Treated With ...  -  Sep 26, 2007
...effects may increase mortality risks, we controlled for use of these agents (donepezil, rivastigmine, tacrine, and galantamine) in all analyses. Am J Psychiatry (subscription)

Medication And Care Given To Alzheimer Patients  -  Sep 23, 2007
Cholinesterase Inhibitors: These groups of medications are galantamine (Reminyl), donepezil (Aricept), and rivastigmine (Exelon). They all work the same way PR-GB.com (press release),

Brand Names/Synonyms:
Galantamine is also known by the following brand names and/or synonymsGalantamin; Galantamine; Galanthamine; Galanthamine Base; Galanthamine Hydrobromide; Jilkon; Lycoremin; Lycoremine; Reminyl

Drug Category:
Galantamine is categorized under the following by the FDA: Nootropic Agents; Parasympathomimetics; Parasympathomimetics; ATC:N06DA04

Dosage Forms:
CAPSULE, EXTENDED RELEASE

Absorption:
Not Available

Interactions:
Not Available

Chemical IUPAC Name:
(4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol

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