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FosamaxThis page contains recent news articles, when available, and an overview of Fosamax but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Fosamax (when available) Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women. For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women Mechanism Of Action: The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass. News Articles on Alendronate Denosumab Osteoporosis Trial Finds Patients Transitioned from ... - 16 Sep 2008 ...women with low bone mass who transitioned from weekly oral alendronate (Fosamax ® ) to denosumab versus those who continued alendronate therapy. WELT ONLINE, Amgen Sheds Three Products to Focus on 'Bigger Picture' - 16 Sep 2008 The potential for denosumab in the $7 billion osteoporosis market also will depend on how it stacks up to bisphosphonates like Fosamax (alendronate, BioWorld Online, Sun Pharma wins FDA approval for generic osteoporosis drug - 16 Sep 2008 These generic versions of alendronate sodium tablets 5mg (base), 10mg (base), 35mg (base) and 70mg (base) are bio-equivalent to Fosamax tablets distributed Trading Markets (press release), ASBMR: Alendronate Exonerated in 'Atypical' Femoral Fractures - 16 Sep 2008 Explain to interested patients that alendronate (Fosamax) has been shown to reduce the risk of hip and other osteoporotic fractures, but that recent case MedPage Today, ASBMR: Teriparatide Superiority in Steroid-Induced Osteoporosis ... - 16 Sep 2008 ...patients with glucocorticoid-induced osteoporosis, teriparatide (Forteo) increased bone-mineral density almost twice as much as alendronate (Fosamax), MedPage Today, UPDATE: Amgen Sells Products to Swedish Drug Company - 16 Sep 2008 ...treated with denosumab achieved significantly greater gains in bone mineral density than those using a currently approved Merck drug called Fosamax. Los Angeles Business Journal (subscription), Fosamax: twee keer zo duur - 16 Sep 2008 Mevrouw D. gebruikt al jaren het geneesmiddel Fosamax. In juli jongstleden merkt ze dat de prijs ervan is verdubbeld. Mag dat zomaar? Test-Aankoop.be, Pillegigant kutter 53 ansatte - 16 Sep 2008 Bakgrunnen var at MSD tapte sitt nest største produkt, Fosamax mot benskjørhet, da kopiene kom allerede fem Ã¥r før patentet gikk ut. Drammens Tidene, Sun Pharma gets USFDA approval for Generic Fosamax tablets - Sep 14, 2008 These generic versions of alendronate sodium tablets 5 mg (base), 10 mg (base), 35 mg (base) and 70 mg (base) are bio-equivalent to Fosamax (R) tablets Antara, Sun Pharma Gets US FDA Approval For Generic Fosamax Tabs - Sep 14, 2008 The generic versions of alendronate sodium of 5 mg, 10 mg, 35 mg, and 70 mg strengths are bio-equivalent to Fosamax tablets that have annual sales of about RTT News, Sun Pharma Gets FDA Approval For Generic Fosamax Tablets - Sep 12, 2008 ...s (MRK) Fosamax tablets, which are indicated for the treatment and prevention of osteoporosis in post menopausal women. The approval is for doses of 5 CNNMoney.com India's Sun Pharma gets US FDA approval for generic of Merck's Fosamax - Sep 12, 2008 Ltd. said it has won final approval from the US Food & Drug Administration (FDA) for its generic version of Merck & Co Inc.'s osteoporosis drug Fosamax. Trading Markets (press release), Investors await bone drug data from Amgen - Sep 12, 2008 A reduction in fracture risk of between 50 percent and 60 percent would place it roughly on a par with Fosamax, Boniva, and Eli Lilly and Co's Evista, Reuters Expiring Patents Ignite Biotech Boom - Sep 13, 2008 Take Fosamax for example. Fosamax is Merck’s current top selling drug. It’s designed to help treat osteoperoasis by making bones stronger. Seeking Alpha, Amgen’s Osteoporosis Drug: Make Or Break - Sep 12, 2008 Investors will be looking to see how the twice-a-year injectable drug can fare in a $6 billion bisphosphonate market dominated by Merck’s Fosamax, Pharmalot, Sun Pharmaceuticals gets USFDA nods for Alendronate Sodium tablets - Sep 13, 2008 The drug is the generic version of Merck & Co's Fosamax and the approval is for doses of 5 mg, 10 mg, 35 mg and 70 mg. Fosamax tablets are prescribed for Stock Watch, India's Sun Pharma gets US FDA approval for generic of Merck's Fosamax - Sep 12, 2008 In a statement, Sun Pharma added that Fosamax had annual sales of around $560 million in the United States. The copying, republication or redistribution of Forbes, Amgen May Hold Off On Finding Partner For Bone Drug - Sep 9, 2008 ...s (MRK) Fosamax, which is available in generic form. Some expect the Thousand Oaks, Calif.-based Amgen , in order to be competitive, to form a partnership CNNMoney.com Bone-building drugs may actually have opposite effect in some - Sep 9, 2008 Nineteen had been using the bone drug Fosamax for an average of 6.9 years. Last year, the Journal of Bone and Joint Surgery published a Singapore report of The Plain Dealer - cleveland.com, Panel cites benefits of Pfizer osteoporosis drug - Sep 8, 2008 Inc.'s Fosamax. Pfizer, the world's largest pharmaceutical maker, has asked the FDA to approve the estrogen-regulating drug for postmenopausal women with BusinessWeek Amgen Isn't Seeking a Partner for Bone Drug - Sep 10, 2008 Next week, the release of key data on the drug will show its effectiveness compared with currently marketed drugs, including Merck & Co.'s Fosamax, which is Los Angeles Business Journal (subscription), Amgen keeping bone drug to itself - Sep 10, 2008 Amgen will release additional study data next week, including comparison data with potential future rival Fosamax (made by Merck), and those data will FiercePharma, How to survive generic erosion - Sep 9, 2008 Between the launch of generic Aledronate in March 2008 and July 2008, the market share of Fosamax has declined from a market leader 45 percent to 10 percent FiercePharma, The spotlight in on Vitamin D - Sep 3, 2008 My doctor wants me to consider taking Fosamax. What's going on? I worry about getting too much vitamin D. How does a person know how much is too much? Kilgore News Herald, BRIC Investing: India - Sep 2, 2008 RDY recently received approval from the FDA to make a generic version of Fosamax, an osteoporosis drug. The company has many other generic drugs in the AskMen Amgen's D-mab emerged from early protein research - Aug 26, 2008 Those trials include two Phase III trials that have produced positive data indicating that denosumab is superior to Fosamax, a standard osteoporosis therapy FierceBioResearcher, Amgen Pins Hopes on Bone-Drug Study - Sep 10, 2008 ...most notably Merck's(MRK - Cramer's Take - Stockpickr) Fosamax (now generic and administered as a daily or weekly pill) and Novartis'(NVS - Cramer's TheStreet.com A Pfizer Drug With a Cloudy Future - Sep 10, 2008 Other non-SERM osteoporosis treatments include GlaxoSmithKline's (NYSE: GSK) Boniva and Merck's (NYSE: MRK) Fosamax, along with various generics. Motley Fool Are Drug Companies Being Shortsighted with R&D? - Sep 10, 2008 The company came back from the loss of Vioxx and it seems to be planning for another comeback after the loss of osteoporosis drug Fosamax and slowing sales Motley Fool Pfizer's Experimental Drug Is Linked to Excess Deaths (Update3) - Sep 4, 2008 ...s Fosamax, the market leader before it went generic in February. Amgen Inc. is also developing denosumab, a drug that has been shown to strengthen bones and Bloomberg FDA Panel Recommends Pfizer’s Osteoporosis Drug For Postmenopausal ... - Sep 10, 2008 Roche Holding AG’s Boniva, Proctor and Gamble’s Actonel, and Merck & Company’s Fosamax. According to the Nation Osteoporosis Foundation, osteoporosis is HealthNews, Pipeline for Breast Cancer Therapies is Focus of New MedPredict Report - Aug 27, 2008 Imclone (IMC-A12, IMC-1121B), Kosan (tanespimycin), Merck (Fosamax, odanacatib, MK-0646), Myriad (BRCA1/BRCA2 Screening), Merck/Ariad (deforolimus), MarketWatch Fractures more than unlucky breaks - Aug 20, 2008 Bisphosphonates such as risedronate (Actonel) and alendronate (Fosamax) improve bone density and reduce the risk of osteoporotic fractures by 30 to 50 per Sydney Morning Herald, Provisioning not to hit pharma firms - Aug 17, 2008 Similarly, prospects for Aurobindo Pharma are also good, considering the day-one launch of generic equivalent of Merck & Co’s Fosamax tablets for Business Standard, DOTmed Industry Sector Report: Bone Densitometers Sales and Service - Aug 27, 2008 Examples include Merck's Fosamax and GlaxoSmithKline's Boniva, among others. The treatment has finally caught up to the diagnostic capability of bone DOTmed.com (press release), Web Site Can Help Determine Whether You Need Medication to Prevent ... - Aug 26, 2008 Treatment typically involves medications in the bisphosphonate family, such as Fosamax, which are intended to slow bone loss. Lewiecki said he wants to RedOrbit, Teriparatide Approved in Canada for Steroid-Induced Osteoporosis - Aug 21, 2008 ...teriparatide significantly increased lumbar spine bone mineral density (BMD) from baseline (7.2%) compared with alendronate sodium (Fosamax [3.4%]). DG News Bisphosphonate Prevents Bone Loss during Breast Cancer Therapy - Aug 19, 2008 The more potent drug alendronate (Fosamax) can cause potentially severe adverse gastrointestinal effects, a particular concern for women receiving MedPage Today, Risk Factors, Prevention, and Treatment of Corticosteroid-induced ... - Aug 19, 2008 27 Alendronate (Fosamax; Merck, Whitehouse Station, New Jersey), and risedronate (Actonel; Procter and Gamble, Cincinnati, Ohio) have FDA indications for Ortho SuperSite, Amgen may not need partner for osteoporosis drug, CEO says - Sep 10, 2008 ...s Fosamax and other bone treatments, Sharer said. Wall Street Journal, The (subscription required) (09/10) CNNMoney.com (09/09) Want to dig deeper? SmartBrief, Ligand Pharmaceuticals, Inc. Q2 2008 Earnings Call Transcript - Aug 25, 2008 ...than the currently approved antiresorptive drugs, and we have shown the effects of our SARM to be additive to a bisphosphonate drug such as Fosamax. Seeking Alpha, Amgen may not need partner for osteoporosis drug, CEO says - Sep 10, 2008 ...s Fosamax and other bone treatments, Sharer said. Wall Street Journal, The (subscription required) (09/10) CNNMoney.com (09/09) Want to dig deeper? SmartBrief, En disputa el mercado de medicamentos para osteoporosis - Sep 12, 2008 Por si no fuera suficiente problema el vencimiento de la patente de su medicamento para osteoporosis Fosamax, Merck Sharp & Dohme enfrenta diversas crÃticas Excélsior, Gevaarlijke medicijnen gestolen in Schimmert - Sep 8, 2008 Prednisolon, drie witte doosjes, per doos drie doordrukstrips met tien roze tabletjes. - Fosamax, drie of vier doosjes, met per doosje vier witte tabletten. Dagblad de Limburger, Piden que se eleve a juicio caso “Viagraâ€? - Aug 28, 2008 El caso tiene que ver con la incautación de unas 800 mil pastillas falsificadas de Viagras, Cialis, Fosamax, entre otras, provenientes de la China. ABC Color, Brand Names/Synonyms: Fosamax is also known by the following brand names and/or synonymsALENDRONIC ACID; Acide Alendronique [Inn-French]; Acido Alendronico [Inn-Spanish]; Acidum Alendronicum [Inn-Latin]; Adronat; Alendronate; Alendronate Sodium; Alendronic Acid; Alendronic Acid [Ban:Inn]; Alendros; Arendal; CHEMBANK1709; Fosamax; MK 217; Onclast Drug Category: Fosamax is categorized under the following by the FDA: Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; ATC:M05BA04 Dosage Forms: 10 mg (Rx) Fosamax lactose 40 mg (Rx) Fosamax lactose Absorption: Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast. Interactions: Intravenous ranitidine was shown to double the bioavailability of oral alendronate. The clinical significance of this increased bioavailability and whether similar increases will occur in patients given oral H2-antagonists is unknown; no other specific drug interaction studies were performed. Products containing calcium and other multivalent cations likely will interfere with absorption of alendronate. Chemical IUPAC Name: (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid : |
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