Flupenthixol

This page contains recent news articles, when available, and an overview of Flupenthixol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Flupenthixol (when available)

Pharmacology and use:
Flupenthixol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood. For use in schizophrenia and depression

Mechanism Of Action:
Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS.

News Articles on Flupenthixol

Neural Stimulation Successfully Treats Depression in Patients With ...  -  02 Jun 2008
...methylphenidate, buspirone, amoxapine, flupenthixol, carbamazepine, topiramate, and valproic acid. All had failed to provide any sustained benefit. Am J Psychiatry (subscription)

Influence of 5-HT 2C receptor and leptin gene polymorphisms ...  -  May 31, 2008
These patients were receiving olanzapine (n=3), zotepine (n=2), clozapine (n=1), amisulpride (n=1) or flupenthixol (n=1). Forty-six of 120 patients (38%) British Journal of Psychiatry (subscription),

Doctor sees medicine as a money-saver in treating addicts  -  Oct 30, 2007
Shawn Hockenberry found some success through a schizophrenia drug, Flupenthixol, an antipsychotic that his doctor believes could have a future in treating DesMoinesRegister.com,

Brand Names/Synonyms:
Flupenthixol is also known by the following brand names and/or synonymsDepixol; Emergil; FLUPENTHIXOL; Fluanxol; Fluanxol Depot; Flupenthixol; Flupenthixole; Flupentixol; Flurentixol; Fluxanxol; Siplaril; Siplarol

Drug Category:
Flupenthixol is categorized under the following by the FDA: Antipsychotics; Thioxanthenes; Dopamine Antagonists

Dosage Forms:
TABLET; IM Injection

Absorption:
Fairly slow and incomplete after oral administration

Interactions:
Drug Interactions: Flupenthixol may interact with some drugs, like: - Monoamine oxidase inhibitors (MAOI): MAOI could theoretically affect flupenthixol pharmacodynamics - Arecoline - Eproxindine - Ethanol: Flupenthixol and Ethanol cause additive CNS depression - Tricyclic antidepressants: Flupenthixol increases the effect of Tricyclic antidepressants

Chemical IUPAC Name:
2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol

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