Fluoxetine

This page contains recent news articles, when available, and an overview of Fluoxetine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Fluoxetine (when available)

Pharmacology and use:
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level. For the treatment of depression; Obsessive compulsive disorder; Bulimia nervosa

Mechanism Of Action:
Metabolized to norfluoxetine, fluoxetine is a selective serotonin-reuptake inhibitor (SSRI), it blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

News Articles on Fluoxetine

CBT 'ineffective' in depressed adolescents on SSRIs  -  16 Sep 2008
They were assigned to receive 12 weeks of treatment with the SSRI fluoxetine plus CBT and routine clinical care, or to fluoxetine and clinical care only. Healthcare Republic (press release),

Pharma Attacks Black Boxes as Antidepressant Sales Fall  -  16 Sep 2008
He lent statistical support for a Lilly funded article in the August 18, 2004 JAMA (Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Food Consumer,

정신질환·우울�? 치료제 개발 양분  -  16 Sep 2008
...�?��? 기존 주요 브랜드 가운�?�선 제품주기 관리�? ‘심비악스’(Symbyax, olanzapine/ fluoxetine)처럼 기존 제제를 복합한 치료제를 출시하거나, ‘�?�펙사’(Effexor, 디지틀보사,

Fluoxetine Versus Placebo in Preventing Relapse of Major ...  -  Aug 26, 2008
Method: After a detailed evaluation, children and adolescents 7–18 years of age with major depressive disorder were treated openly with fluoxetine. Focus (subscription)

Dr. Emslie Replies  -  Sep 2, 2008
We have already demonstrated that fluoxetine is more effective than placebo acutely in three separate studies (1–3). These previous studies, along with Am J Psychiatry (subscription)

Selective Serotonin Reuptake Inhibitor Induced Neonatal Abstinence ...  -  Sep 11, 2008
Of the SSRI half-lives, fluoxetine, sertraline and citalopram have a long one with fluoxetine having the longest, paroxetine and fluvoxamine have an RedOrbit,

Body Dysmorphic Disorder: Treating an Underrecognized Disorder  -  Sep 2, 2008
Mr. H preferred a medication shown to be efficacious in a controlled study, so we chose fluoxetine. Even though Mr. H’s appearance beliefs were delusional, Am J Psychiatry (subscription)

Harvard Health Prozac's link to bleeding isn't clear cut  -  Aug 17, 2008
A:The news about a possible relationship between Prozac (fluoxetine) and related antidepressants came from a medical study recently published in the Denver Post,

GPs are not profligate with prescriptions  -  Aug 19, 2008
Fluoxetine capsules (Prozac) now cost just 69p for a month and the other most popular antidepressant is barely double that cost. The popular and effective The Herald,

To Be Young and Anxiety-Free  -  Sep 1, 2008
Antidepressants such as Prozac (fluoxetine) and Zoloft (sertraline) have been shown to alleviate anxiety symptoms in children. A 2001 study published in the Wall Street Journal

AP Enterprise: Report prompts more water tests  -  Sep 11, 2008
1 (nicotine) East St. Louis, Ill.: 11 (caffeine, carbamazepine, cotinine, fluoxetine, gemfibrozil, monensin, naproxen, nicotine, paraxanthine, The Associated Press

Woman gets jail on drug charges  -  Sep 12, 2008
She was ordered to serve a pair of one-year jail sentences on charges of possession of the controlled drugs Lorazepam and Fluoxetine in Keene, also in March The Keene Sentinel,

FDA Updates Bioequivalence Guidelines  -  Sep 11, 2008
...are available include: risedronate sodium, fosinopril sodium/hydrochlorothiazide, fluoxetine HCI/olanzapine, erlotinib HCI, and morphine sulfate. Pharmaceutical Technology Magazine,

FDA Safety Changes: Valium, Noxafil, Strattera  -  Sep 10, 2008
...potent cytochrome P450 isoenzyme 2D6 inhibitors (eg, paroxetine, fluoxetine, and quinidine) or used in cytochrome P450 isoenzyme 2D6 poor metabolizers. Medscape (subscription)

Learn about the World CNS Therapeutics Market  -  Sep 4, 2008
Drugs II-38 Zoloft (Sertraline) II-38 Prozac (Fluoxetine) II-39 Effexor (Venlafaxine) II-39 Paxil II-39 Wellbutrin (Bupropion) II-39 Attention Deficit MarketWatch

Methadone: a possible lower-cost chronic pain treatment  -  Sep 2, 2008
Examples include fluconazole to treat yeast infections and some drugs for depression (fluoxetine, sertraline and others). I recommend starting the methadone Newsday,

Health checkup: Drug mix-ups  -  Sep 10, 2008
Other examples include Propecia and Proscar (both finasteride) and Sarafem and Prozac (both fluoxetine). More examples of duplicate therapy may include Rochester Democrat and Chronicle,

Being unique is a disorder  -  Sep 3, 2008
..."We will evaluate whether fluoxetine (Prozac), used together with traditional psychotherapy, can reduce aggression in people who are physically violent Sydney Morning Herald,

More than 2 million US youths depressed  -  Sep 9, 2008
A woman holds a packet of the antidepressant drug Prozac, also known as fluoxetine, in Leicester, central England February 26, 2008. The Province,

New Research To Refine Approaches In Psychotherapy  -  Sep 8, 2008
...will build upon previously reported studies that found a combination of a moderate dose of the antidepressant fluoxetine (Prozac)—a selective serotonin eMaxHealth.com,

Geske ordered to stand trial for fatal crash  -  Aug 30, 2008
A second blood test determined Geske had two antidepressant drugs in her system: fluoxetine, often known by the brand name Prozac, and venlafaxine, Green Bay Press Gazette,

Older People in Danger from Common Drugs  -  Aug 28, 2008
Fluoxetine (Prozac) causes agitation and poor sleep. Consider citalopram (Celexa) paroxetine (Paxil) and sertraline (Zoloft) for alternatives. NewsMax.com,

Results from hot flash trials during past two decades analyzed  -  Aug 26, 2008
...moderately decreased by venlafaxine (Effexor, Wyeth), mildly to moderately decreased by fluoxetine and mildly decreased by clonidine, according to the Endocrine Today,

Efficacy, Safety, and Tolerability of Desvenlafaxine 50 Mg/Day and ...  -  Aug 28, 2008
Washout periods for prohibited therapies were: venlafaxine, 90 days; fluoxetine and antipsychotics, 30 days; sumatriptan, naratriptan, and zolmitriptan (and RedOrbit,

�?�鹤�?�业08年上�?�年净利润�?�比增长30%  -  Aug 17, 2008
...在2007年底，公�?�通过谈判顺利购买了Meloxicam片剂(美洛西康)和Fluoxetine 和讯网,

今日盘中潜力股追踪  -  Sep 2, 2008
...公�?�2007年底购买Meloxicam片剂（美洛西康）和Fluoxetine 和讯网,

今日盘中潜力股追踪  -  Sep 10, 2008
...公�?�2007年底购买Meloxicam片剂（美洛西康）和Fluoxetine �?券之星,

Serotonin 5-HT 1A receptor binding in people with panic disorder ...  -  Aug 31, 2008
In animal studies, Welner et al 34 and Li et al 35 found reduced 5-HT 1A binding in the midbrain following chronic fluoxetine administration. British Journal of Psychiatry (subscription),

hond ongelukkig? Geef hem dan Prozac  -  Aug 20, 2008
De werkzame stof in Reconcile is namelijk niets anders dan fluoxetine, beter bekend onder de merknaam Prozac. Eigenlijk gaat het hier om een inhaalslag: DePers.nl,

雙鶴藥業建基地拓美�?市場  -  Aug 17, 2008
...符�?�美國食�?藥�?管�?�局（FDA）的CGMP標准的年產10億片固體藥�?生產基地，並�?�期完�?Meloxicam片劑(美洛西康)和Fluoxetine 新浪網,

�?�鹤�?�业08年中期业绩�?�?�?续增长  -  Aug 18, 2008
...在2007年底，公�?�通过谈判顺利购买了Meloxicam片剂(美洛西康)和Fluoxetine 和讯网,

中�?�现代化的新路径：中西如何殊途�?�归  -  Aug 26, 2008
...“这款新�?�的功效�?�常接近美国礼�?�公�?�(Eli Lilly)生产的氟西汀(fluoxetine 新浪网,

抗抑�?�?��?酸氟西汀市场今�?�昔比  -  Sep 1, 2008
...礼�?�公�?�的�?�命性抗抑�?�?�物——首个SSRIs氟西汀（fluoxetine 中国医�?�网,

中�?�现代化的新路径：中西如何殊途�?�归  -  Aug 31, 2008
...“这款新�?�的功效�?�常接近美国礼�?�公�?�(Eli Lilly)生产的氟西汀(fluoxetine 中国生物技术信�?�网,

שפיכה מעוכבת: כשתגמרו לקרו�?, תגמרו  -  Aug 28, 2008
...תרופות נוגדות דיכ�?ון ממשפחת ה- SSRI כגון:fluoxetine (Prozac), paroxetine (Paxil),thioridazine (Mellaril) העלולות להשפיע על השפיכה ולעכבה. BeOK פורטל ברי�?ות ויופי,

中�?�现代化的新路径：中西如何殊途�?�归  -  Aug 28, 2008
...“这款新�?�的功效�?�常接近美国礼�?�公�?�(EliLilly)生产的氟西汀(fluoxetine 慧�?�网,

东方�?券：行业公�?��?闻解读  -  Aug 18, 2008
...美国食�?�?��?管�?�局（FDA）的CGMP 标准的年产10 亿片固体�?��?生产基地，并�?�期完�?Meloxicam 片剂(美洛西康)和Fluoxetine 百度网,

New Book Exposes Facts on Numerous Natural Medicines  -  07 Aug 2008
A new study not included in the book shows that taking 1000mg of omega-3 each day has the same therapeutic effects as taking 20mg of fluoxetine (Prozac) RedOrbit,

Anti-depressants and internal bleeding  -  Aug 5, 2008
The news about a possible relationship between Prozac (fluoxetine) and related anti-depressants came from a medical study recently published in the Archives Newsday,

A happy fish is a dead fish  -  Aug 5, 2008
Hybrid striped bass exposed to the antidepressant fluoxetine (the generic name for Eli Lilly's Prozac) are less interested in food and more prone to unusual Practical Fishkeeping,

Happy Fish Go Hungry?  -  Jul 21, 2008
Toxicologists at Clemson University in South Carolina have found that hybrid striped bass exposed to the antidepressant fluoxetine (the generic name for Eli Scientific American

Do Antidepressants Make Bones Brittle?  -  Jul 11, 2008
Charlie McAtee, a spokesperson for Eli Lilly and Company, which makes the popular SSRI Prozac (fluoxetine), agreed with Spangler that "the current data does Washington Post,

Empirically Supported Treatments Improve Care of Adolescents With ...  -  Jul 15, 2008
After 12 weeks of treatment, there was a 71.0% response rate in participants receiving the fluoxetine-CBT combination compared with 60.6% of those given Journal of American Medical Association (subscription),

Study: Meds-in-water alter fish appetite, behavior  -  Jul 23, 2008
CLEMSON, SC — Clemson University toxicologists have found that hybrid striped bass exposed to the antidepressant fluoxetine, which has been detected in some Water Technology Online,

Antidepressants Can Increase Fracture Risk  -  Jul 15, 2008
Charlie McAtee, a spokesperson for Eli Lilly and Company, maker of the SSRI antidepressant Prozac (fluoxetine), agreed with Spangler and said that “the Newsinferno.com,

Ariz. to receive some of Walgreen settlement  -  Jul 21, 2008
It also made similar switches to more expensive versions of fluoxetine and eldepryl. The June settlement stems from a whistle-blower lawsuit filed in 2003 AZ Central.com,

Obama vows to quit antidepressants if elected President  -  Jul 22, 2008
Berlin's Der Spiegel-Fritzl-Fuherer magazine had claimed Obama was keeping his Fluoxetine use secret in a similar quiet arrangement to George W Bush's The Spoof (satire),

Meta-analysis: SSRIs in the Treatment of PMS and PMDD  -  Aug 4, 2008
Various SSRIs have been studied (fluoxetine, sertraline, paroxetine), and they seem to have similar effects. Based on the results of this meta-analysis, Medscape (subscription)

Pharmacotherapeutic Options for the Treatment of Depression in ...  -  Jul 20, 2008
The SSRIs have variable effects on cytochrome P450 enzymes; fluoxetine, fluvoxamine, and paroxetine are the most potent inhibitors of specific cytochrome RedOrbit,

Pet Prescriptions  -  Aug 1, 2008
She said that Dr. Sueda visited her home and looked at the numerous spots that Calvin would “mark,�? and she ultimately prescribed a small dose of Fluoxetine Los Angeles Independent,

Animal pharm: prozac for pets  -  Jul 20, 2008
..."There's a generic Prozac called Fluoxetine, which can be used if the label version is prohibitively expensive," she said. "Valium is often used to calm Independent,

The Latest on Antidepressants: Be Careful Where You Get Your Facts  -  Jul 31, 2008
...evaluating four of the newer antidepressants--fluoxetine (Prozac), venlafaxine (Effexor), nefazodone (Serzone), and paroxetine (Paxil). Beliefnet.com,

Therapy seeks to unlock obsessions  -  Jul 18, 2008
The drugs were typically antidepressants such as fluoxetine (Prozac), or a drug called clomipramine, which works similarly but has slightly more side The Australian,

Which Drugs Do — And Don’t — Increase Fall Risks for the Elderly  -  Jul 16, 2008
Prozac, Eli Lilly’s antidepressant that’s sold generically as fluoxetine, can remain in the blood for days, Ferreri said. Glaxo’s Paxil, or paroxetine Wall Street Journal Blogs,

Regular exercise can be more effective than Prozac  -  Jul 29, 2008
Fluoxetine hydrochloride, best known by the trade name Prozac, is still a popular treatment for depression, but for many people, the right kind of exercise NewsoftheNorth.Net,

Bipolar Disorder Detection and Management  -  Jul 17, 2008
Efficacy of Olanzapine and Olanzapine-Fluoxetine Combination in the Treatment of Bipolar I Depression. Arch Gen Psychiatry. 2003;60:1079-1088. Medscape (subscription)

Drug Misuse Partially Accounts for Excess Mortality in Scotland  -  Jul 24, 2008
The investigators note that four deaths were due to overdoses of paracetamol, amitriptyline, colchicine, and a combination of fluoxetine and propranolol. Abkhazia,

Sildenafil May Improve Women's Antidepressant-Related Sexual ...  -  Jul 23, 2008
The antidepressants taken in the sildenafil group were fluoxetine (24.5%), paroxetine (20.4%), sertraline (18.4%), escitalopram (14.3%), citalopram (12.2%), Medscape (subscription)

How to get your RCGP credits  -  Jul 23, 2008
I now understand one of my patient’s problems much better, have had a constructive consultation with them and we have agreed to withdraw fluoxetine. Pulse,

Olympic Games Gold Medalist Nikki Stone Joins Chronic Pain Experts ...  -  Jul 24, 2008
Some common SSRIs are Paxil® (paroxetine), Prozac®/Sarafem® (fluoxetine), and Zoloft® (sertraline). Some common SNRIs are Cymbalta® (duloxetine) and Market Wire (press release)

FDA: Antipsychotics Risky for Elderly  -  Jul 22, 2008
...clozapine, ziprasidone, paliperidone, risperidone, quetiapine, olanzapine, and a combination drug containing olanzapine and fluoxetine. Journal of American Medical Association (subscription),

Saint Francis Hospital South Opens With Expanded Services  -  Jul 22, 2008
The study is comprised of 16 one-hour family therapy sessions delivered over a nine-month time period and a medication (either fluoxetine or placebo) Greater Tulsa Reporter Newspapers,

Why we should use simpler models if the data allow this: relevance ...  -  Jul 21, 2008
Results: An example is given from an experiment where rats were randomly assigned to receive either 0, 60, 180, or 240 mg/L of fluoxetine in their drinking 7thSpace Interactive (press release),

Medicinal Science Finds An Accurate Way To Diagnose ‘OCD’  -  Jul 19, 2008
Currently, a drug named fluoxetine, which was introduced by US drugmaker Eli Lilly and CO. in 1987 under the name of ‘Prozac’ for the treatment of OCD is TopNews,

Treating Depression Reduces Risk Of Heart Disease  -  Jul 19, 2008
All of the participants then completed eight weeks of a randomized, double-blind trial of antidepressant treatment with either desipramine or fluoxetine Medical News Today (press release),

SSRIs and Venlafaxine Linked to Greater Risk for Gastrointestinal ...  -  Jul 14, 2008
SSRIs such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline, and SNRIs such as venlafaxine are the most commonly prescribed Medscape (subscription)

Side-effects study opens up new drug leads  -  Jul 11, 2008
For example, the team found a link between Prozac (fluoxetine) and the anti-ulcer drug Aciphex (rabeprazole). Both drugs targeted the dopamine receptor D 3 Chemistry World,

FDA Safety Changes: Ultram ER, Reyataz, Duragesic  -  Jul 9, 2008
...quinidine, fluoxetine, paroxetine, and amitryptyline) and cytochrome P 450 isoenzyme 3A4 inhibitors (eg, ketoconazole and erythromycin). Medscape (subscription)

Lilly Reports Solid Second-Quarter Results  -  Jul 24, 2008
Lilly) Strattera(R) (atomoxetine hydrochloride, Lilly) Symbyax(R) (olanzapine fluoxetine combination, or OFC, Lilly) Xigris(R) (drotrecogin alfa PR Newswire (press release),

Brain region linked to obsessive disorder risk  -  Jul 17, 2008
US drug maker Eli Lilly and Co introduced Prozac in 1987 but the medicine is now off patent and widely available generically as fluoxetine. Globe and Mail,

Brand Names/Synonyms:
Fluoxetine is also known by the following brand names and/or synonymsAnimex-On; Deprex; Eufor; Fluctin; Fluoxeren; Fluoxetina [Inn-Spanish]; Fluoxetina [Spanish]; Fluoxetine; Fluoxetine Hcl; Fluoxetine Hydrochloride; Fluoxetine Hydrochloride: Adofen; Fluoxetinum [Inn-Latin]; Fluval; Fontex; Foxetin; HSDB 6633; Portal; Prozac; Prozac Weekly; Pulvules; Reneuron; Sarafem

Drug Category:
Fluoxetine is categorized under the following by the FDA: Antidepressants, Second-Generation; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB03

Dosage Forms:
CAPSULE; LIQUID; SOLUTION

Absorption:
72%

Interactions:
Do not take this medicine with thioridizine, or within 5 weeks of taking fluoxetine. Talk to your doctor if you are taking certain antibiotics such as erythromycin, clarithromycin or azithromycin. This medicine should not be taken with MAO inhibitors. Caution should be exercised when taking this medicine certain antibiotics, such as erythromycin, clarithromycin, or azithromycin. This medicine should not be taken with MAO inhibitors. If you think you are taking an MAO inhibitor talk to your doctor or pharmacist. Do not take this medicine with St. John's Wort because of the additive effects of sertonin. This medication should not be taken with MAO inhibitors. Your doctor or pharmacist can give you more information on MAO inhibitors. Wait 5 weeks after stopping escitalopram before starting a non-selective MAO inhibitor. Wait 2 weeks after stopping an MAO inhibitor before starting escitalopram. If you are taking medications for migraines such as Imitrex, talk to your doctor before starting this medicine. If you are taking a tricyclic antidepressant, talk to your doctor before taking this medicine. St. John��s Wort should be avoided while taking this medicine due to the additive effects of serotonin. Tell your doctor if you are taking any of the following drugs: blood thinners (Coumadin) other antidepressants metoprolol antihistamines carbamazepine (Tegretol) cimetidine (Tagamet) estrogens fluoxetine (Prozac) intraconazole (Sporanox) ketoconazole (Nizoral) levodopa lithium muscle relaxants birth control pills sleeping pills thyroid medications

Chemical IUPAC Name:
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-propan-1-amine

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