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FludaraThis page contains recent news articles, when available, and an overview of Fludara but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Fludara (when available) Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells. For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen Mechanism Of Action: Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted. News Articles on Fludarabine Long-term Results of Fludara®, Cytoxan®, and Rituxan® for CLL - Jul 29, 2008 1 Fludara and Rituxan have been important developments in the treatment of patients with CLL. In 2005 researchers from the MD Anderson Cancer Center Cancer Consultants, Treating Cancer With Competence, Compassion and Laughter - Jul 17, 2008 My treatment - a combination of the drugs Rituxan and Fludara - called for five days of injections every 28 days over six months. The final cycle ended last RedOrbit, Antisoma boosts late-stage pipeline with Xanthus purchase - May 19, 2008 The latter is marketed outside the USA as Fludara by Bayer and has been submitted to the Food and Drug Administration for the second-line treatment of Pharma Times (subscription), Fludara®, Novantrone®, Zevalin® Effective First-line Therapy for ... - Mar 26, 2008 Researchers from Italy have reported that six cycles of Fludara® (fludarabine) and Novantrone® (mitoxantrone) followed by Zevalin® (yttrium-90 ibritumomab Cancer Consultants, Cephalon’s new CLL drug should please patients - Mar 31, 2008 PK) Fludara (fludarabine) and GlaxoSmithKline’s (GSK) Leukeran (chlorambucil) are purine analogues which are usually designated as primary therapy. Checkbiotech.org (press release), Eloxatin®-Based Regimen Effective for Richter’s Syndrome of ... - Feb 5, 2008 Researchers from the MD Anderson Cancer Center have reported that a regimen of Eloxatin (oxaliplatin), Fludara® (fludarabine), cytarabine and Rituxan® Cancer Consultants, Founder of ILEX Oncology and Triton Biosciences, Richard Love ... - Sep 23, 2007 ...for multiple sclerosis, two treatments for chronic lymphocytic leukemia, Fludara(R) and CAMPATH(R), and Clolar(R), a treatment for acute leukemias. CNNMoney.com New standard treatment for the most common form of leukemia in adults - Aug 2, 2007 TopCancerNews.com,An article published in The Lancet stated that the chemotherapy combination of Fludara plus Cytoxan improves progression free survival compared to therapy Fludara® and Cytoxan® Confirmed Standard Initial Treatment for CLL - Jul 23, 2007 Cancer Consultants (press release),Researchers affiliated with the LRF CLL4 Trial have concluded that Fludara (fludarabine) and Cytoxan (cyclophosphamide) should be the standard treatment for Fludara® plus Cytoxan® New Standard of Care for Chronic ... - Jul 20, 2007 Cancer Consultants (press release),According to an article recently published in The Lancet, the chemotherapy combination consisting of Fludara® (fludarabine) plus Cytoxan® (cyclophosphamide) Hybrid drugs may help children with leukaemia - Jul 20, 2007 Independent Online,Institute of Cancer Research doctors in Britain found that fludarabine (marketed as Fludara) and chlorambucil (Leukeran), when used together, were no better Umbilical Cord Blood Transplantation after a Reduced-Intensity ... - Jul 12, 2007 Cancer Consultants (press release),This study enrolled 110 adult patients with hematologic disease who were prepared for umbilical cord blood transplantation with a regimen of Fludara and Cell Therapeutics, Inc. (CTI) Announces Agreement to Acquire SMi ... - Jul 24, 2007 CNNMoney.com...important therapeutic products, four of which are currently used in the practice of medicine: Betaseron(R), Fludara(R), CAMPATH(R), and Clolar(TM). `Playing God,' UK Denies Cancer Drugs, Patients Say (Update2) - May 17, 2007 Bloomberg...s Taxol for early breast cancer and Bayer AG's Fludara for a type of leukemia. The agency also has issued preliminary opinions that the NHS shouldn't fund Expanded Label Filed for Campath® - Apr 9, 2007 Cancer Consultants (press release),...treatment of patients with B-CLL who have received prior therapy with an alkylating agent and have failed prior treatment with Fludara® (fludarabine). Nektar Appoints Howard W. Robin President and CEO - Jan 8, 2007 PharmaLive.com (press release),...may occur after the date of this release. Betaseron and Fludara are registered trademarks of Berlex, Inc. Exubera is a registered trademark of Pfizer Inc. Nektar Appoints Howard W. Robin President and CEO - Jan 8, 2007 Genetic Engineering News (press release),...multiple sclerosis and Fludara(R) (fludarabine phosphate) for chronic lymphocytic leukemia, generating annual global sales in excess of $800 million. Diamics Appoints Christine A. Meda as President - Jan 5, 2007 Genetic Engineering News (press release),...and as Medical Affairs Director, responsible for clinical trials for their hematological oncology drugs: Fludara, CamPath and Leukine. Fludara®-Novantrone® Induction and Zevalin® Consolidation Results ... - Dec 19, 2006 Cancer Consultants (press release),Researchers from Italy have reported a 100% complete response (CR) rate to induction therapy with oral Fludara (fludarabine) and Novantrone (mitoxantrone) Rituxan® and Campath® Show Significant Activity in Newly Diagnosed ... - Dec 8, 2006 Cancer Consultants (press release),Campath has significant activity for the treatment of patients with CLL who have failed Fludara® (fludarabine) and more recently has been evaluated as Nipent®, Cytoxan® and Rituxan® Effective for Untreated Poor ... Oct 30, 2006 One of the most active drug combinations for the treatment of CLL and low-grade NHL is Fludara® (fludarabine), Cytoxan and Rituxan. ... -Cancer Consultants (press release), Xanthus Pharmaceuticals Expands Oncology Pipeline with Late-Stage ... Oct 9, 2006 Oral fludarabine is currently marketed by Schering AG in the European Union and Canada under the trade name, Fludara(R), for the treatment of relapsed B-cell ... -Drug Newswire (press release), KaloBios Pharmaceuticals Appoints David W. Pritchard as President ... Oct 12, 2006 ...now Bayer). Triton developed Betaseron® for multiple sclerosis (2005 sales exceed $1 billion), and Fludara® for leukemia. He holds ... -Business Wire (press release), Genta's Stock Slides Again As ODAC Turns Back Genasense Sep 6, 2006 Drugs already approved in the space include Campath (alemtuzumab, from Genzyme Corp.) and Fludara (fludarabine, from Schering AG), and physicians also employ ... -BioWorld Online Early Reduced-intensity Stem Cell Transplantation Promising for ... Jul 26, 2006 Patients were treated with Fludara®, Cytarabine, and amsacrine followed by four days of rest, followed by total-body irradiation, cyclophosphamide, and ... -Cancer Consultants Schering AG raises earnings outlook after strong first half year Aug 9, 2006 ...months of 2006. Net sales of Fludara® and Campath® developed very positively with respective increases of above 20%. Net sales ... -Webbolt Business News Schering AG Raises Outlook After Strong First Half Year Jul 25, 2006 ...months of 2006. Net sales of Fludara(R) and Campath(R) developed very positively with respective increases of above 20%. Net sales ... -PR Newswire Reduced Intensity Allogeneic Stem Cell Transplantation in Fludara ... Jun 22, 2006 Researchers from the Fred Hutchinson Cancer Research Center have reported updated outcomes of 64 patients with Fludara-refractory chronic lymphocytic leukemia ... -Cancer Consultants Mini Transplants Provide Benefit in Patients with CLL Who Have ... Jun 22, 2006 ...benefit in patients with chronic lymphocytic leukemia who have stopped responding to standard therapies, including the chemotherapy agent Fludara® (fludarabine ... -Cancer Consultants NDA Filed for Genasense® Jun 30, 2006 The NDA is seeking approval for the use of Genasense plus Fludara® (fludarabine) and Cytosar® (cyclophosphamide) for treatment of patients with relapsed or ... -Cancer Consultants View Current Treatment Options for Chronic Lymphocytic Leukemia ... Jul 7, 2006 MabCampath, Berlex's Campath), which has achieved significant success when used in combination with fludarabine (Schering AG/Berlex's Fludara, generics) in ... -International News Service Campath® Following Fludara® Improves Responses in Chronic ... May 2, 2006 ...to an early online publication in the Journal of Clinical Oncology, the addition of Campath® (alemtuzumab) following Fludara® (fludarabine) improves ... - Cancer Consultants Survival Improving for Patients with Stage IV Follicular Lymphoma Apr 17, 2006 ...alternating non-cross resistant regimes with the addition of etoposide, cytarabine, cisplatin and mitoxantrone, the fourth added Fludara® (fludarabine) and ... - Cancer Consultants Schering AG Q1 Profit Jumps On Pharmaceutical Sales - Update Apr 26, 2006 While Oncology drug Fludara posted sales increase of 39%, sales of another Gynecology & Andrology therapeutic Microgynon rose 29% for the quarter. ... - Trading Markets Excellent Start for Schering AG in 2006 Apr 25, 2006 20%. Net sales of Fludara®, Campath® and Bonefos® developed exceptionally well with increases of over 30%, respectively. Furthermore ... - Yahoo! News Excellent Start for Schering AG in 2006 Apr 26, 2006 20%. Net sales of Fludara(R), Campath(R) and Bonefos(R) developed exceptionally well with increases of over 30%, respectively. Furthermore ... - PharmaLive.com Nipent®/Cytoxan®/Rituxan® Shows High Activity in Previously ... Apr 6, 2006 One of the most active drug combinations for the treatment of CLL and low-grade NHL is Fludara® (fludarabine), Cytoxan and Rituxan. ... - Cancer Consultants Cell Genesys to Present Data From GVAX(R) Cancer Immunotherapy and ... Mar 30, 2006 5:00 pm EDT) (Abstract ID: 1398) -- An armed oncolytic vector (OV1203) expressing E. coli purine nucleoside phosphorylase (PNP) combined with Fludara(TM) shows ... - Yahoo! News Treatment Response Linked with Symptom Improvement in CLL Feb 22, 2006 This trial included 241 patients with relapsed or refractory CLL; approximately half was treated with the chemotherapy agents Fludara® (fludarabine) and ... - Cancer Consultants, Addition of Cyclophosphamide to Fludarabine Improves Progression ... Jan 31, 2006 According to a recent article published in the journal Blood, the addition of cyclophosphamide (Cytoxan®) to fludarabine (Fludara®) improves anticancer ... - Cancer Consultants, Biopharmaceutical Industry Leader Joins Acologix, Inc. Board of ... Feb 15, 2006 As General Manager of Therapeutics at Berlex, Mr. Robin was responsible for the clinical development and commercialization of drugs such as Fludara(R) for ... - PharmaLive.com, Favrille Reports Fourth Quarter and Year End 2005 Financial ... Feb 9, 2006 ...the last 10 years specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin®, Fludara® and Taxotere ... - Yahoo! News Favrille Reports Fourth Quarter and Year End 2005 Financial ... 09 Feb 2006 ...the last 10 years specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin®, Fludara® and Taxotere ... - Yahoo! News Addition of Cyclophosphamide to Fludarabine Improves Progression ... Jan 31, 2006 According to a recent article published in the journal Blood, the addition of cyclophosphamide (Cytoxan®) to fludarabine (Fludara®) improves anticancer ... - Cancer Consultants Genetic Features Predict Response of Chronic Lymphocytic Leukemia ... Jan 20, 2006 ...among patients with chronic lymphocytic leukemia who are treated with the standard therapeutic combination of Rituxan® (rituximab) and Fludara® (fludarabine ... - Cancer Consultants Revlimid® Shows Activity in Chronic Lymphocytic Leukemia Jan 26, 2006 More than 50% of the patients had disease progression following treatment with the commonly used chemotherapy agent Fludara® (fludarabine). ... - Cancer Consultants Brand Names/Synonyms: Fludara is also known by the following brand names and/or synonymsFAMP; Fludara; Fludarabine; Fludarabine 5'-Monophosphate; Fludarabine Monophosphate; Fludarabine Phosphate; Fludarabine Phosphate [Usan:Ban]; Fludura Drug Category: Fludara is categorized under the following by the FDA: Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents; ATC:L01BB05 Dosage Forms: TABLET; POWDER FOR SOLUTION; IV Solution Absorption: Not Available Interactions: Interactions for Fludarabine: The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity. Chemical IUPAC Name: [5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid : |
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