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FilgrastimThis page contains recent news articles, when available, and an overview of Filgrastim but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Filgrastim (when available) Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. Increases leukocyte production, for treatment in non-myeloid cancer,neutropenia and bone marrow transplant Mechanism Of Action: Filgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase News Articles on Filgrastim Amgen Sheds Three Products to Focus on 'Bigger Picture' - 16 Sep 2008 ...with the company's Neupogen (filgrastim) in patients at risk of poor peripheral blood progenitor cell mobilization in autologous PBPC transplantation. BioWorld Online, Amgen to unbundle anemia medications - Aug 29, 2008 Neulasta (pegfilgrastim) and Neupogen (filgrastim). Hawkins noted that customers have always been free to purchase Amgen medications separately. Medical Marketing and Media, The Gift of Life - Part 2 - Aug 27, 2008 For 5 days in a row the donor receives an injection of filgrastim, which is a medication that causes your bone marrow to release it’s immature blood cells, GNIF Brain Blogger, Hospira, Inc. Q2 2008 Earnings Call Transcript - 07 Aug 2008 We made progress as well with our second biogeneric, filgrastim, known more commonly as G-CSF, as the Phase 3 clinical trials for the drug are continuing on Seeking Alpha, Amgen Needs to Start Paying a Dividend. - 07 Aug 2008 Amgen was a duopoly for fifteen years - during this period, they sold two drugs - Epoetin Alfa (aka EPO, Epogen, Procrit), and Neupogen (Filgrastim). istockAnalyst.com, Single-dose Neulasta® Effective for Mobilization of Peripheral ... - 07 Aug 2008 The same technology has been used to develop Neulasta, a long-acting form of Neupogen® (filgrastim). Previous studies have shown that a single dose of Cancer Consultants, EU Panel Backs GSK's Pre-Pandemic Influenza Vaccine - Jul 25, 2008 Revised positive opinion for Filgrastim ratiopharm, Ratiograstim, Biograstim and Tevagrastim The CHMP adopted a revised positive opinion for Ratiograstim CNNMoney.com Giving until it hurts - Jul 18, 2008 This is done by injecting the donor, Vrem in this case, five times prior to the day of the donation with a drug called Filgrastim. So Md News, Dr Reddy`s to form JV for off-patent drugs - Jul 28, 2008 ...‘Grafeel,’ (generic of biotech cancer drug Filgrastim), right from the molecular biology phase upto commercial manufacturing, sources said. Business Standard, Amgen's Second Quarter 2008 Adjusted Earnings Per Share Increased ... - Jul 28, 2008 Combined worldwide sales of Neulasta(R) (pegfilgrastim) and NEUPOGEN(R) (Filgrastim) increased 15 percent to $1201 million in the second quarter of 2008 Trading Markets (press release), Rebounding Amgen Trumps Q2 Estimates Despite Profit Decline - Jul 29, 2008 Combined sales of infection-fighting drugs Neulasta (pegfilgrastim) and Neupogen (filgrastim) grew 15 percent to $1.2 billion over last year, while sales of BioWorld Online, NIAID Cancels HIV Vaccine Trial, but Adds More Focused One - Jul 18, 2008 ...based Amgen Inc.'s Neupogen (filgrastim), which had 2007 sales of about $1 billion. Insmed earlier this month reported that INS-19 demonstrated BioWorld Online, Europese registratie van geneesmiddelen in juli 2008 - Jul 30, 2008 De CHMP gaf opnieuw een positief advies af voor Ratiograstim (filgrastim), Biograstim (filgrastim), Tevagrastim (filgrastim) en Filgrastim ratiopharm apothekersnieuws.nl, For one couple, stress took a toll - Aug 3, 2008 One hundred ninety-two vials of Filgrastim to decrease infection during chemotherapy: $38112. But retired banker William Sayre never needed or received any MiamiHerald.com, Amgen/T2: bénéfice en baisse mais supérieur aux attentes, prévision - Jul 28, 2008 En revanche, les ventes du Neulasta (pegfilgrastim) et du Neupogen (Filgrastim), un immuno-stimulateur utilisé lors des chimiothérapies, ont bondi de 15% à Romandie.com, Normativa. BOE - Aug 4, 2008 ...del Servicio Andaluz de Salud, por la que se publica adjudicación definitiva de suministro de principios activos Pegfilgrastim, Filgrastim y Cinacalcet. EcoDiario.es, 管ç?†å¦çš„微观æ€?：è°?是下一个盖茨 - Jul 24, 2008 ...继1991年推出EPOå?Žï¼Œå®‰è¿›å…¬å?¸å?ˆæŽ¨å‡ºäº†ç¬¬äºŒä¸ªäº§å“?：é‡?组粒细胞集è?½åˆºæ¿€å› å?(filgrastim 和讯网, Wim Huppes adviseert een ieder te stoppen met DCA - Dichloorazijn ... - Aug 2, 2008 Pilot trial of infusional cyclophosphamide, doxorubicin, and etoposide plus didanosine and filgrastim in patients with human immunodeficiency Medical facts, El prometedor futuro de Teva - Jul 13, 2008 ...en inglés) ha recomendado recientemente conceder la autorización de comercialización a Tevagrastim, versión genérica de Neupogen (filgrastim) de Amgen. El Global, High-Dose Cyclophosphamide Shows Promise for Aggressive MS - Jun 9, 2008 Patients received 50 mg/kg/d of cyclophosphamide for four consecutive days, followed six days later by 5 μg/kg/d of growth factor support with filgrastim MedPage Today, Paragon of success - Jun 6, 2008 With the launch of Neupeg (Peg Filgrastim), we have gained monopoly in the domestic market in terms of being sole manufacturers of Peg Filgrastim in India. Express Pharma, Dose-dense Chemotherapy Effective for Localized Ewing’s Sarcoma - Jun 11, 2008 Filgrastim was given with all cycles of therapy. The total number of cycles of chemotherapy administered was 14. Surgery or radiation therapy was carried Cancer Consultants, Shortened Time Between Chemotherapy Beneficial for Patients With ... - 02 Jun 2008 Supportive care was given in the form of the granulocyte-colony stimulating factor filgrastim (5 mg/kg/day, maximum 300 mg). Patients in this study also DG News Intas to launch Filgrastim - May 22, 2008 Intas Biopharmaceuticals Limited (IBPL) has signed an agreement with Canada based Apotex for co-development and supply of its Filgrastim brand, Neukine, Express Pharma, Intas plans Filgrastim launch in North America, Europe - May 5, 2008 Intas Biopharmaceuticals Limited (IBPL) signed business agreement with Canada–based Apotex Inc. for co-development and supply of its Filgrastim brand, Moneycontrol.com (press release), New biosimilar edges towards Europe - May 29, 2008 No severe adverse reactions were reported, other than those commonly associated with Filgrastim." The study was a single-dose, randomized, double-blind, Pharmaceutical Technology Europe, Intas Biopharma joins hands with Canadian firm - May 5, 2008 ...for co-development and supply of its filgrastim brand, Neukine, in North America. Both Apotex and IBPL jointly plan to launch Neukine in the US market. Thaindian.com, ASCO - Shorter Chemo Interval Improves Ewing's Sarcoma Outcome - May 19, 2008 Chemotherapy consisted of vincristine, doxorubicin, and cyclophosphamide, alternating with ifosfamide and etoposide, with filgrastim between cycles. Cancerpage.com, Minnow will beat giants in biosimilar race to Europe - Apr 9, 2008 IBPL has completed the Phase I clinical trials on its recombinant granulocyte colony stimulating factor (G-CSF) product, Neukine (filgrastim), Daily News & Analysis, Sen. Chuck Grassley (R-Iowa) is continuing to investigate Amgen’s ... - Apr 7, 2008 ...asked Amgen to explain marketing practices involving the bundling of or discounts on Neupogen (filgrastim) and Neulasta (pegfilgrastim) when their sales FDA news (subscription), Myelosuppression: A Report from the 2007 International MASCC/ISOO ... - Mar 28, 2008 PubMed and EMBASE were searched for randomized controlled trials comparing pegfilgrastim to filgrastim utilizing only approved doses for both agents among Cancer Consultants, Myelodysplastic Syndrome: An Update from ASCO 2007 - Mar 31, 2008 The authors reported that comparable erythroid response rates were noted when using EPO alone or EPO plus filgrastim (response rate 49% versus 51%), Cancer Consultants, Threefold Dose Intensity of ICE Does Not Improve Outcomes in Small ... - Apr 17, 2008 A previous randomized Phase III study reported that intensified doses of ICE administered with autologous stem cell and Neupogen® (filgrastim) support Cancer Consultants, Updates on the Management of Hematopoietic Supportive Care - ASCO 2007 - Mar 31, 2008 In another study, dose-dense EC followed by Taxol was supported by epoetin alfa and filgrastim.[19] Thrombopoietin (TPO) or thrombopoietin-like drugs have Cancer Consultants, INTAS BIOPHARMA & KWIZDA COMPLETE PHASE I CLINICAL TRIAL OF ... - Apr 14, 2008 As per results of study conducted by European counterpart, NEUKINE®, IBPL’s registered trademark for Filgrastim, is safe and exhibits an identical openPR (press release), How bone marrow is donated - Apr 6, 2008 Before the procedure, doctors inject donors with a medication called filgrastim once a day for four or five days. The medication draws stem cells out from OCRegister, Neutropenia: Biosimilar Product from India Moves one Step Closer ... - Apr 4, 2008 No severe adverse reactions were reported, other than those commonly associated with Filgrastim. We are very confident that our joint clinical trials with ScienceBlog.com, Minority bone marrow donors needed - Apr 2, 2008 ..."So it started on a Saturday morning when I went to Stanford Medical and got injected with Filgrastim which is a medicine that stimulates my stem cell abc7news.com, Dingell and Stupak Investigating Anemia Drug Marketing - Apr 2, 2008 ...alfa) in conjunction with Neupogen (filgrastim) and Neulasta (pegfilgrastim) has “helped fuel excessive and dangerous off-label use of Aranesp. FDA news (subscription), Anemia Drugs' Marketing in Congressional Crosshairs - Apr 1, 2008 ...filgrastim (Neupogen) and pegfilgrastim (Neulasta). The latter drugs had previously been marketed to consumers on television and elsewhere. MedPage Today, Strategies for Preventing Infection in Cancer Patients with ... - Mar 31, 2008 ...prophylactic antibiotics and colony stimulating factors such as filgrastim or pegfilgrastim for preventing infection in neutropenic cancer patients. Cancer Consultants, Myelosuppression: A Report from the 2007 ONS Annual Congress - Mar 31, 2008 Unlike anemia where prophylaxis is not one of the dosing options, granulocyte-colony stimulating factors (G-CSF), such as filgrastim or pegfilgrastim, Cancer Consultants, Updates in the Management of Gastrointestinal Cancers: A Report ... - Mar 28, 2008 The first examined the use of myeloid growth factors with modern chemotherapy for colorectal cancer.11 The use of filgrastim and pegfilgrastim (Neulasta) Cancer Consultants, Daily Cancer News - Mar 25, 2008 ...[9] Researchers from Japan have also reported that a regimen of carboplatin and irinotecan supported by filgrastim was effective and well tolerated in Cancer Consultants, Arizona RN Saves a Life by Becoming a Patient - Mar 10, 2008 In the donation of peripheral blood stem cells or PBSC, the donor receives filgrastim for five days to increase blood-forming cells. Nurse.com, Teva/Ratiopharm/CT Arzneimittel: EU approval shakes up biosimilar ... - Feb 22, 2008 The European Medicines Agency (EMEA) issued a positive opinion on the first biosimilar of Amgen's Neupogen (filgrastim or granulocyte colony stimulating Trading Markets (press release), UPDATE 1-Teva, others win EU okay for biosmilar Neupogen - Feb 21, 2008 O: Quote, Profile, Research); Ratiograstim and Filgrastim, from ratiopharm; and Biograstim, from CT Arzneimittel. Recommendations for marketing approval by Reuters Teva: EMEA panel grants positive opinion on biosimilar G-CSF product - Feb 21, 2008 The innovator product, Neupogen Filgrastim, had annual sales of approximately $300 million in the European Union for the 12 months ended September 30, 2007, CNNMoney.com Committee for Medicinal Products for Human Use Summary of Positive ... - Feb 21, 2008 The active substance of Ratiograstim is filgrastim, an immunostimulating medicinal product (L03AA02) which regulates the production and release of PharmaLive.com (press release), Teva hopes to double revenues in five years to $20 billion - Feb 25, 2008 This is the first biosimilar G-CSF to receive a positive opinion in the European Union and is a copy of Amgen’s Neupogen (filgrastim). Pharma Times (subscription), Neulasta®/Ciprofloxacin Effective Prophylaxis for TAC Regimen in ... - Feb 27, 2008 European researchers have reported that Neulasta® (pegfilgrastim)/ciprofloxacin was more effective than ciprofloxacin alone, daily Neupogen® (filgrastim) or Cancer Consultants, Teva biosimilar product gets first EU approval - Feb 23, 2008 According to IMS sales data, the innovator product, Neupogen Filgrastim, had $300 million in sales in the EU in the year through September 2007. Globes, EU Panel Backs Pre-Pandemic Vaccine Against H5N1 Flu -2- - Feb 21, 2008 Ratiograstim, or filgrastim, from ratiopharm GmbH, Biograstim from CT Arzneimittel GmbH, Tevagrastim, from Teva Generics GmbH, and Filgrastim ratiopharm, EasyBourse.com, Teva's Developed G-CSF is the First Biosimilar to Receive a ... - Feb 21, 2008 The innovator product, Neupogen(R) Filgrastim, had annual sales of approximately $300 million in the EU for the twelve months ended September 30, 2007, FOXBusiness Child's plight inspires outpouring of help - Feb 26, 2008 In the case ofMarc requiring a stemcell transplant, the donor would be given an injection of filgrastim, which will stimulate the growth of stem cells prior Colts Neck News Transcript, Dr Reddy’s to scale up biologicals operation - Feb 3, 2008 Mumbai: After a shaky opening with cancer-related biosimilar drug Filgrastim in 2001, Dr Reddy’s Laboratories (DRL) seems to have got it’s act together on Sify, Your browser does not support script - Jan 26, 2008 We have a drug called filgrastim (and its long-acting sister, pegylated filgrastim) which is given to prevent WBCs from becoming dangerously low. Malaysia Star, Amgen (AMGN) to Release Q4 2007 Earnings January 24 - Jan 17, 2008 Amgen also produces Aranesp (darbepoetin alfa), Neulasta (pegfilgrastim), Neupogen (Filgrastim), Epogen (Epoetin alfa) and Enbrel (etanercept). TransWorldNews (press release), Midshipman's donation may save man's life - Feb 3, 2008 Each morning for a week, she had to go to the hospital to receive daily injections of filgrastim, a drug that increases the number of blood-forming cells in Annapolis Capital, Denosumbab May Hold Key For an Amgen Recovery? - Feb 2, 2008 ...grow include the chemotherapy-associated infection fighters Neulasta (pegfilgrastim) and Neupogen (filgrastim), which brought in $4.28 billion in 2007. BioWorld Online, Amgen's Fourth Quarter 2007 Adjusted Earnings Per Share (EPS ... - Jan 24, 2008 Combined worldwide sales of Neulasta® (pegfilgrastim) and NEUPOGEN® (Filgrastim), increased 9 percent to $1118 million in the fourth quarter of 2007 versus WELT ONLINE, Amgen Earnings Beat Estimates, But ESA Uncertainty Looms - Jan 25, 2008 Amgen reported increased price and demand that led to higher fourth-quarter and full year sales of Neulasta (pegfilgrastim), Neupogen (filgrastim), BioWorld Online, Amgen impresses with osteoporosis trial, but 2008 outlook disappoints - Jan 25, 2008 On the flip side, combined worldwide turnover of its white blood cell stimulators Neulasta (pegfilgrastim) and Neupogen (filgrastim) climbed 9% to $1.1 Pharma Times (subscription), Side line the side effects - Jan 24, 2008 Examples of this are drugs to counter nausea and vomiting (Ondansetron, Granisetron, Palonosetron, Aprepitant) and decreased blood formation (filgrastim, Express Pharma, Velcade® (Bortezomib) Induction Improves Outcomes of Patients with ... - Jan 15, 2008 Mobilization of peripheral blood stem cells was with Neupogen® (filgrastim) alone. Consolidation with DCEP did not improve outcomes in this study. Cancer Consultants (press release), Technical sergeant in business of saving a life ... twice - Nov 8, 2007 Prior to the donation, Sergeant Navarro receives a series of shots of protein called filgrastim, every day for five days before the donation. Air Force Link, Dr. Reddy's Sales, Profit Decline on US Slowdown (Update2) - Oct 24, 2007 ...rituximab, a monoclonal antibody to treat Non- Hodgkins lymphopma, or a type of blood cancer, and filgrastim, to boost white blood-cell production, Bloomberg Camptosar®-Platinum Regimens Confirmed Effective for Small Cell ... - Nov 5, 2007 ...[1] Researchers from Japan have also reported that a regimen of Paraplatin and Camptosar supported by Neupogen® (filgrastim) was effective and well Cancer Consultants (press release), Amgen cost-cutting is working but Aranesp slumps again - Oct 25, 2007 Combined sales of the white blood cell stimulators Neulasta (pegfilgrastim) and Neupogen (filgrastim) were up 10% to $1.10 billion, while Enbrel Pharma Times (subscription), Amgen's Third Quarter 2007 Adjusted Earnings Per Share Increased 4 ... - Oct 24, 2007 Combined worldwide sales of Neulasta(R) (pegfilgrastim) and NEUPOGEN(R) (Filgrastim), increased 10 percent to $1100 million in the third quarter of 2007 Trading Markets (press release), Brand Names/Synonyms: Filgrastim is also known by the following brand names and/or synonymsGranulocyte colony-stimulating factor precursor;G-CSF;Pluripoietin;Filgrastim;Lenograstim; Neupogen (Amgen Inc.) Drug Category: Filgrastim is categorized under the following by the FDA: Immunomodulatory Agents; Anti-infective Agents; Antineutropenic Agents; hematopoietic agents (20:16.00) Dosage Forms: SOLUTION Absorption: Not Available Interactions: Not Available Chemical IUPAC Name: Human granulocyte colony stimulating factor : |
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