Fexofenadine

This page contains recent news articles, when available, and an overview of Fexofenadine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Fexofenadine (when available)

Pharmacology and use:
Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells. For management of Seasonal allergic rhinitis

Mechanism Of Action:
Like other H1-blockers, Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Fexofenadine exhibits no anticholinergic, alpha1-adrenergic or beta-adrenergic-receptor blocking effects.

News Articles on Fexofenadine

Dr Reddy`s gets tentative nod from USFDA for Ranitidine  -  ‎Apr 16, 2009‎
Ranitidine is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. Recently, the company has Myiris.com

When what's good for us may not be  -  ‎Apr 16, 2009‎
The test involved healthy volunteers taking the antihistamine fexofenadine with either water, water mixed with naringin, or grapefruit juice. Daily Gleaner

10-K: SEPRACOR INC /DE/  -  ‎Feb 27, 2009‎
In July 1993, we licensed to HMR, now sanofi-aventis (formerly Aventis), our US patent rights covering fexofenadine HCl, which is marketed by sanofi-aventis MarketWatch (press release)

How that 'healthy' fruit juice could give you liver failure- or worse  -  ‎Mar 2, 2009‎
While I waited for an appointment for the test, my GP prescribed the non-drowsy antihistamine Fexofenadine hydrochloride and told me, in a casual way, Daily Mail

Wockhardt gets USFDA nod for Ranitidine syrup  -  ‎Feb 23, 2009‎
It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. Recently, the company had received final Myiris.com

Case Study: Adjuvant chemotherapy and radiation following PDD for ...  -  ‎Mar 13, 2009‎
His medications at presentation included fexofenadine, simvastatin, and metformin. His past medical history was significant for a 10-year history of American Journal of Hemotology and Oncology

�?�语阅读：�?��?�的时候�?�万�?�?�?果�?  -  ‎Mar 10, 2009‎
Healthy volunteers took fexofenadine, an antihistamine used to fight allergies, along with either a glass of grapefruit juice, a glass of water with 互联星空

10 bivirkninger du ikke vil ha  -  ‎Mar 11, 2009‎
Allegra (= fexofenadine) er et eksempel. Denne medisinen skal motvirke høy feber og allergiske reaksjoner (som blant annet kløe i øynene), men brukerne DinSide

Antihistamine tablets  -  Jan 21, 2009
But some research suggests that an antihistamine called fexofenadine (Telfast) can help people breathe more easily through their nose. guardian.co.uk,

Student says she took drugs from parents  -  Jan 24, 2009
Deputies said the girl had a bottle of pills, which were identified as Xanax, Fexofenadine and Methadone. She told officers she got the Methadone from her Tampabay.com,

Sepracor Reports Fourth Quarter and Full-Year 2008 Operating Results  -  Jan 28, 2009
Schering-Plough's CLARINEX(R) brand desloratadine, sanofi-aventis' ALLEGRA(R) brand fexofenadine HCl and UCB's XYZAL(R)/XUSAL(TM) brand levocetirizine. Trading Markets (press release),

What treatments work for hay fever?  -  Jan 21, 2009
Boots Hayfever and Allergy Relief All Day), cetirizine (Zirtek) and fexofenadine (Telfast). You can get some antihistamines as syrups. More. guardian.co.uk,

Fruit juices react with common medicines  -  Jan 21, 2009
Researchers looked at healthy volunteers who took a drug called fexofenadine. It's an antihistamine that's used to treat allergies like hay fever. guardian.co.uk,

Treating colds: What works, what doesn't  -  Jan 12, 2009
Newer, non-sedating antihistamine like fexofenadine (Telfast, Allergan in the US) and loratidine (Claritin) don’t appear to be as effective. 3. Philippine Star,

BUYINS.NET: Market Maker Surveillance Report. Top 6 Highest Net ...  -  Jan 30, 2009
Sepracors out-licensing agreements include Schering-Plough for CLARINEX (desloratadine); sanofi-aventis for ALLEGRA (fexofenadine HCl); and UCB SA for Trading Markets (press release),

Company and People Notes: Lilly Completes Acquisition of ImClone ...  -  Dec 4, 2008
SA will also provide royalties to AMRI on the sale of products containing fexofenadine HCl and products containing fexofenadine HCl and pseudoephedrine HCl Pharmaceutical Technology Magazine,

AMRI to receive payment, royalties  -  21 Nov 2008
AMRI joined Aventis Pharmaceuticals in filing lawsuits in March 2004 pertaining to its fexofenadine-related patents. Fexofenadine is the active ingredient Albany Times Union,

Barr Announces Agreements on Nasacort(R) AQ, Allegra(R) D-12 and ...  -  Nov 18, 2008
...pay Aventis approximately $30 million to settle the patent litigation with Aventis regarding Teva's fexofenadine 30mg, 60mg and 180mg tablets product. MarketWatch

Fluticasone Provides Better Relief Than Fexofenadine for Nighttime ...  -  Nov 11, 2008
Data showed that fluticasone was more effective than fexofenadine at reducing nighttime symptoms, with a significant difference of -0.9 (P < 0.001). DG News

Fruit juices can block drug absorption  -  Oct 30, 2008
Healthy volunteers took fexofenadine, an antihistamine used to fight allergies, along with either a glass of grapefruit juice, a glass of water with The Sun Daily,

Teva Announces Agreement on Allegra® Patent Challenge  -  Nov 18, 2008
Allegra® (fexofenadine) 30mg, 60mg and 180mg tablets including all claims for patent infringement and damages. After entering into a separate agreement with Ad-Hoc-News (Pressemitteilung),

New reasons to avoid grapefruit and other juices when taking ...  -  Nov 4, 2008
In the most recent research, Bailey’s group had healthy volunteers take fexofenadine, an antihistamine used to fight allergies. The volunteers consumed the Hospital News,

Market Report -- In Play (AMRI)  -  Nov 19, 2008
Sanofi-aventis US LLC will also provide royalties to AMRI on the sale of products containing fexofenadine hydrochloride and products containing fexofenadine MSN Money

Barr Reports Third Quarter 2008 GAAP Earnings of $0.28 Per Share ...  -  Nov 6, 2008
...plc which more than offset decreased royalties earned from the Company's agreement with Teva Pharmaceuticals on fexofenadine hydrochloride tablets, SYS-CON Media,

Sepracor Inc. Reports 9.6% Increase in Revenue for Third Quarter ...  -  Oct 28, 2008
...which include Schering-Plough's CLARINEX(R) brand desloratadine, sanofi-aventis' ALLEGRA(R) brand fexofenadine HCl and UCB's XYZAL(R)/XUSAL(TM) brand MarketWatch

Sanofi-Aventis Ups EPS Forecast for 2008 on Slight Improvement in ...  -  Oct 31, 2008
...(docetaxel) is being muted by losses for the likes of Eloxatin, Stilnox/Ambien (zolpidem), Allegra (fexofenadine hydrochloride) and Tritace (ramipril). PharmaLive.com (press release),

טבע וב�?ר מתפשרות: ישלמו לס�?נופי �?וונטיס 30 מיליון דולר כל �?חת בגין ...  -  Nov 19, 2008
...מדובר ביישוב המחלוקת המשפטית בין החברות, הנוגעת להפרת זכויות הפטנט על התרופה ההיסטמינית Allegra (התרופה הגנרית Fexofenadine) המיועדת לטיפול בקדחת השחת גלובס,

חודש לפני רכישת ב�?ר: החברות מסיימות �?ת הסכסוך המשפטי ע�? �?וונטיס ...  -  Nov 18, 2008
...בשנת 2005 ל�?חר שטבע הגיעה להסכ�? נפרד ע�? חברת ב�?ר, טבע השיקה בהצלחה �?ת הגרסה הגנרית לתרופה בש�? Fexofenadine בחודש ספטמבר 2005. תחת פרטי ההסכ�?, טבע וב�?ר ישלמו Bizportal,

החוזי�? על המדדי�? המובילי�? בוול סטריט מ�?ותתי�? על ירידות בפתיחת המסחר  -  Nov 19, 2008
...בתוך כך, טבע הודיעה כי הגיעה להסכ�? פשרה ע�? חברת ס�?נופי �?וונטיס, לגבי שיווקה ב�?רה"ב של ה-fexofenadine - גרסה גנרית של הפטנט של ס�?נופי �?וונטיס, Allegra. גלובס,

果�?，是�?�物的敌人�?�？  -  Sep 30, 2008
...一批�?�康的志愿者进行了一个实验，他们被分为三组�?用�?�索�?�那定（fexofenadine 农产�?加工网,

Jugos y medicinas: ¿Combinación peligrosa?  -  Oct 9, 2008
El componente analizado fue la fexofenadine, una droga antihistamínica presente en algunos de estos medicamentos. "Recientemente descubrimos que el jugo de La Opinión,

Juices may wash out drug effects  -  Aug 20, 2008
The London research involved testing groups of 12 to 15 healthy volunteers with the antihistamine drug fexofenadine, used to fight allergies. London Free Press,

Some fruit juices can harm drug absorption: study  -  Aug 20, 2008
Healthy volunteers took fexofenadine, an antihistamine used to fight allergies, along with either a glass of grapefruit juice, a glass of water with AFP

Fruit juices can handcuff effects of drugs  -  Aug 23, 2008
The researchers administered healthy volunteers with antihistamine and fexofenadine. The drug was given with either a single glass of grapefruit juice, HealthJockey.com,

Ind Swift Laboratories board allots equity shares  -  Aug 31, 2008
The company`s products include Clarithromycin, Fexofenadine, Clarie granules, Pentazocine, Roxithromycin, Clopidogrel, Azithromycin, and Atorvastatin. Myiris.com,

Taking Blood Pressure Meds? Better Lay Off the Juice  -  Aug 22, 2008
Canadian researchers found that only half the allergy drug fexofenadine was absorbed when volunteers drank the pill with juice. A chemical in grapefruit Discover Magazine,

Check the Label: Grapefruit Juice Interacts With a Growing List of ...  -  Sep 1, 2008
In a study of healthy volunteers, the Canadian scientists asked subjects to take fexofenadine, an antihistamine widely used in the treatment of allergies. ParamusPost.com,

News in Brief:  -  Aug 19, 2008
When taken with grapefruit juice, only half as much of the antihistamine fexofenadine was absorbed as it was with water. A British driver was killed by a Times Online,

Older People in Danger from Common Drugs  -  Aug 28, 2008
Consider cetirizine (Zyrtec), fexofenadine (Allegra) and loratadine (Claritin) as alternatives. • Doxazosin (Cardura), prazosin (Vasoflex), and Terazosin NewsMax.com,

Fruit juice interacts with drugs  -  Aug 27, 2008
During the study, healthy volunteers took the allergy-fighting antihistamine fexofenadine. The subjects took the drug with either grapefruit juice, Consult Magazine Online,

'New reasons to avoid mixing juice and medicine'  -  Aug 27, 2008
Scientists gave a healthy group of volunteers the antihistamine drug, fexofenadine, and then asked them to drink either a single glass of grapefruit juice, Nursing Times,

Your health  -  Aug 24, 2008
Canadian researchers found that study participants who took fexofenadine - the generic form of Allegra - with grapefruit juice absorbed only half the drug Chicago Daily Herald,

Guidelines Updated for Diagnosis and Treatment of Rhinitis  -  Aug 18, 2008
At recommended doses, the second-generation oral antihistamines fexofenadine, loratadine, and desloratadine do not cause sedation. Medscape (subscription)

Fruit Juice Can Make Some Drugs Ineffective  -  Aug 25, 2008
Washing medicines down with fruit juice can dramatically reduce their effectiveness, claims a new report. Canadian researchers found that apple, Vhi.ie,

�?些果�?会�?低�?�物疗效  -  Sep 2, 2008
...在这项实验中，�?�与的�?�康志愿者以一�?�葡�?�柚�?�?一�?�加了柚皮的水�?或白开水，�?��?用一�?能抵抗过�?症的�?�物“�?�索�?�那定�?（Fexofenadine �?��?�早报,

果�?，是�?�物的敌人�?�？  -  Aug 27, 2008
...一批�?�康的志愿者进行了一个实验，他们被分为三组�?用�?�索�?�那定(fexofenadine 东北网,

약 먹�?�때 '�?몽·오렌지주스' 같�?� 먹으면 위험  -  Aug 20, 2008
...작용�? 해를 줄 수 있다고 알려진 것�?� 빙산�?� �?��?�? 불과하다"고 �?히며 심지어 알레르기 약물�?� 알레그�?�(Fexofenadine) �?� 효과를 떨어뜨릴 수 있다고 �?혔다. 마�?��?��?�리,

Nước quả: Bạn hay thù?  -  Aug 25, 2008
Các tình nguyện viên kh�?e mạnh đã uống fexofenadine, một loại thuốc antihistamine dùng để đi�?u trị bệnh dị ứng, cùng với nước bưởi chùm hoặc nước hương liệu Dân Trí,

Nước ép trái cây có thể giảm tác dụng của thuốc  -  Aug 22, 2008
Những ngư�?i tình nguyện tham gia cuộc nghiên cứu đã được cho uống fexofenadine, một loại thuốc được dùng để chữa chứng dị ứng cùng với một ly nước nho hoặc �?àn Ông,

研究：部分果�?会影�?�?�?��?�效  -  Aug 20, 2008
...�?�康的�?�试者分别以一�?�葡�?��?�?一�?�柚皮甘水和一�?�普通水，�?用一�?抗组织胺的过�?�?�物「�?�索那锭（Fexofenadine 大纪元时报-澳洲版,

Nước trái cây làm giảm tác dụng của thuốc  -  Aug 21, 2008
Một nhóm chuyên gia của �?ại h�?c Western Ontario tìm hiểu tác dụng của nước bưởi đối với fexofenadine, một loại thuốc chống dị ứng, ở một số bệnh nhân tình VNExpress,

果�?�?藥會影響藥效需�?心  -  Aug 20, 2008
...在實驗中，�?�康的志願�?�試者分別以一�?�葡�?��?�?一�?��?�有柚皮甙（Naringin）的水和一�?�普通水，�?用一種抗組織胺藥物「�?�索那錠（Fexofenadine 大公報,

Jugos de frutas y medicamentos: ¿combinación peligrosa?  -  Sep 9, 2008
El componente analizado fue la fexofenadine, una droga antihistamínica presente en algunos de estos medicamentos. “Recientemente descubrimos que el jugo de El Periódico,

Π�?οσοχή στη λήψη χαπιών με χυμο�?ς  -  Sep 6, 2008
Για πα�?άδειγμα, υγιείς εθελοντές έλαβαν μια δόση του αντιαλλε�?γικο�? φα�?μάκου fexofenadine, με νε�?ό ή χυμό. Oταν το φά�?μακο ελήφθη με χυμό γκ�?έιπφ�?ουτ, Η Καθημε�?ινή,

I farmaci inattivati dalla frutta  -  Sep 4, 2008
..."Abbiamo fatto assumere a tre gruppi di volontari", continua Bailey, "fexofenadine e antistamine, due farmaci antiallergici, con un bicchiere di succo di La Repubblica,

Употребление �?ока может нейтрализовать лекар�?тва  -  Aug 21, 2008
В ходе нового и�?�?ледовани�? группе здоровых добровольцев было предложено принимать �?ред�?тво против аллергии (М�?�? fexofenadine) и одновременно один из трёх Мембрана.ру,

Nước hoa quả có thể giảm hiệu quả thuốc chữa bệnh  -  Aug 21, 2008
H�? phát hiện ra nước nho đã đảo ngược tác dụng của fexofenadine, một loại thuốc chống dị ứng, làm cho nó kém hiệu lực đi. Những ngư�?i tình nguyện được cho Nhân Dân,

Succhi di frutta, alcuni interferiscono con i farmaci  -  Aug 20, 2008
In una, per esempio, sono stati somministrati dei farmaci antiallergici (fexofenadine e antistamine) a tre gruppi di volontari divisi in base al tipo di Universonline,

Self-medicating at Olympus  -  Aug 4, 2008
Also in my bag are bottles of Omeprazole and Lansoprazole for acid reflux, Fexofenadine for allergies, a handful of tablets of Oxycodone, Hydrocodone and Boston Globe,

PHARMA MARKET: Merck Asthma Drug Gets Wind Knocked Out Of It  -  Aug 5, 2008
Several generics are among the most prescribed, including fluticasone, albuterol and fexofenadine. THE MARKETING: Merck said in June it extended its CNNMoney.com

READERS RESPOND  -  Aug 3, 2008
...and fexofenadine, 60 mg twice daily as needed. In addition to the adverse drug reactions listed above, he has a history of hives due to penicillin. Journal of American Medical Association (subscription),

Sepracor Inc. Reports Second Quarter 2008 Results  -  Jul 29, 2008
Schering-Plough’s CLARINEX ® brand desloratadine, sanofi-aventis’ ALLEGRA ® brand fexofenadine HCl and UCB’s XYZAL ® /XUSAL ™ brand levocetirizine. Business Wire (press release),

A Bit of Summertime Drug Advise  -  Jul 23, 2008
For instance fexofenadine (Allegra) is considerably less expensive than desloratidne (Clarinex). Both are about equally effective. Liberty County Times,

טבע וב�?ר - הרומן  -  Jul 17, 2008
...טבע וב�?ר חתמו בספטמבר 2005 על הסכ�? לשיתוף פעולה בשיווק Fexofenadine, גרסה גנרית לתרופה Allegra D לטיפול בתסמיני�? של �?לרגיה עונתית ומחלות עור כרוניות. ה�?רץ,

Realtor slaying suspect's assets frozen  -  Jul 22, 2008
Nexium for heartburn; and Fexofenadine, an antihistamine. As supporting documents, Justian attached prescription labels for Johnson, all dated Feb. The Grand Rapids Press - MLive.com,

Brand Names/Synonyms:
Fexofenadine is also known by the following brand names and/or synonymsAllegra; Allegra-D; CHEMBANK1622; Carboxyterfenadine; FEXOFENADINE HYDROCHLORIDE; Fexofenadine; Fexofendine; Terfenadine Acid Metabolite; Terfenadine Carboxylate; Terfenadine-Cooh

Drug Category:
Fexofenadine is categorized under the following by the FDA: Antihistamines; Antihistamines; ATC:R06AX26

Dosage Forms:
Oral tablets and capsules

Absorption:
33%

Interactions:
-->Interactions for Fexofenadine:

Drug Interaction with Erythromycin and Ketoconazole

Fexofenadine has been shown to exhibit minimal (ca. 5%) metabolism. However, coñ administration of fexofenadine hydrochloride with either ketoconazole or erythromycin led to increased plasma concentrations of fexofenadine. Fexofenadine had no effect on the pharmacokinetics of either erythromycin or ketoconazole. In 2 separate studies, fexofenadine hydrochloride 120 mg twice daily (240 mg total daily dose) was co-administered with either erythromycin 500 mg every 8 hours or ketoconazole 400 mg once daily under steady-state conditions to healthy volunteers (n=24, each study). No differences in adverse events or QTc interval were observed when subjects were administered fexofenadine hydrochloride alone or in combination with either erythromycin or ketoconazole. The findings of these studies are summarized in the following table:

Effects on steady-state fexofenadine pharmacokinetics after 7 days of
co-administration with fexofenadine hydrochloride 120 mg every 12 hours
(two times the recommended twice daily dose) in healthy volunteers (n=24)

Concomitant Drug	c_maxSS (Peak plasma concentration)	AUC_ss(0-12h) (Extent of systemic exposure)
Erythromycin (500 mg every 8 hrs)	+82%	+109%
Ketoconazole (400 mg once daily)	+135%	+164%

The changes in plasma levels were within the range of plasma levels achieved in adequate and well-controlled clinical trials.

The mechanism of these interactions has been evaluated in in vitro, in situ, and in vivo animal models. These studies indicate that ketoconazole or erythromycin co-administration enhances fexofenadine gastrointestinal absorption. This observed increase in the bioavailability of fexofenadine may be due to transport-related effects, such as p-glycoprotein. in vivo animal studies also suggest that in addition to enhancing absorption, ketoconazole decreases fexofenadine gastrointestinal secretion, while erythromycin may also decrease biliary excretion.

Drug Interactions with Antacids

Administration of 120 mg of fexofenadine hydrochloride (2 x 60 mg capsule) within 15 minutes of an aluminum and magnesium containing antacid (Maalox®) decreased fexofenadine AUC by 41% and c_max by 43%. ALLEGRA should not be taken closely in time with aluminum and magnesium containing antacids.

Interactions with Fruit Juices

Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of fexofenadine. This is based on the results from 3 clinical studies using histamine induced skin wheals and flares coupled with population pharmacokinetic analysis. The size of wheal and flare were significantly larger when fexofenadine hydrochloride was administered with either grapefruit or orange juices compared to water. Based on the literature reports, the same effects may be extrapolated to other fruit juices such as apple juice. The clinical significance of these observations is unknown. In addition, based on the population pharmacokinetics analysis of the combined data from grapefruit and orange juices studies with the data from a bioequivalence study, the bioavailability of fexofenadine was reduced by 36%. Therefore, to maximize the effects of fexofenadine, it is recommended that ALLEGRA should be taken with water.

Chemical IUPAC Name:
2-[4-[1-hydroxy-4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-butyl]phenyl]-2-methyl-propanoicacid

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