Fenfluramine

This page contains recent news articles, when available, and an overview of Fenfluramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Fenfluramine (when available)

Pharmacology and use:
Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.

Mechanism Of Action:
Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.

News Articles on Fenfluramine

Napoli Bern Ripka & Associates, LLP Announces Lawsuits Continue to ...  -  20 Apr 2009
The firm has successfully litigated claims of thousands of persons injured by the diet drugs Fenfluramine and dexfenfluramine (Reduxtm), Rezulin, Trading Markets (press release)

Research and Markets: China Pharmaceuticals and Healthcare Report ...  -  ‎Apr 16, 2009‎
The State Food and Drug Administration (SFDA) has finally banned a dangerous weight loss drug (fenfluramine), and a delegation of regulators took the Business Wire (press release)

Arena Defends Obesity Drug as Stock Plunges  -  ‎Mar 30, 2009‎
Lorcaserin has been under close scrutiny for heart valve damage because the drug is a close chemical cousin to fenfluramine, or the "fen" in the effective TheStreet.com

On Speed: The Many Lives of Amphetamine  -  ‎Mar 31, 2009‎
...which, with its numerous sister compounds, including methamphetamine, MDMA (ecstasy), methylphenidate and fenfluramine, are pivotal in the history of British Journal of Psychiatry

Politie houdt grote controle op traditionele Chinese medicijnen  -  ‎Apr 15, 2009‎
Vaak gaat het hierbij om verouderde, gevaarlijke middelen, zoals fenfluramine, al jaren verboden in de meeste Westerse landen. Medical facts

Courtroom View Network to Webcast Diet Drug Trial  -  ‎Mar 2, 2009‎
The case involves the diet drugs fenfluramine, phentermine, and dexfenfluramine, commonly known as Fen-Phen. The Food and Drug Administration asked drug dBusinessNews Atlanta (press release)

Don't count on pill to lose weight  -  ‎Mar 3, 2009‎
One of the most high-profile was Fen-phen, a cocktail of fenfluramine and phentermine, which was taken off the market in 1997 after it was linked to Stuff.co.nz

Weight loss centres cop a pounding from consumer group  -  ‎Feb 25, 2009‎
Most doctor prescribed phentermine, an appetite suppressant to held reduce weight and control appetite, and fenfluramine, which gives a feeling of fullness เดอะ เนชั่น

Other diet pills  -  Jan 21, 2009
Fenfluramine is an appetite suppressant. It is no longer available in the UK. Fenfluramine helped people lose weight by making them feel less hungry. guardian.co.uk,

China bans diet drug, says it can harm heart  -  Jan 9, 2009
BEIJING (AP) — China's top food and drug regulator has ordered a halt to the sale and production of the weight-loss drug fenfluramine hydrochloride, The Associated Press

Arena CEO expects to partner obesity drug  -  Jan 12, 2009
The drug, lorcaserin, is a serotonin activator like fenfluramine, half of the infamous fen-phen diet pill that was recalled a decade ago after being linked guardian.co.uk,

What treatments work for obesity?  -  Jan 21, 2009
They include fenfluramine, phenylpropanolamine and phentermine. More... National Institute for Health and Clinical Excellence. Understanding NICE guidance: guardian.co.uk,

Verizonwireless ringtones  -  Jan 17, 2009
...medication verizonwireless ringtones description the brain investigate. verizonwireless ringtones phone fenfluramine verizonwireless ringtones help you Griggs County Courier,

Multi-billion dollar industry Don't count on pills to lose weight  -  Jan 22, 2009
One of the most high-profile was Fen-phen, a cocktail of fenfluramine and phentermine, which was taken off the market in 1997 after it was linked to WELT ONLINE,

Weight-Loss Potions Have Hidden Surprises  -  Dec 23, 2008
...fail miserably when used on a chronic basis—like the notorious combination of two FDA-approved drugs called "fen-pfen" (fenfluramine and phentermine), U.S. News & World Report,

Researchers Seek Safer Obesity Drug  -  Dec 1, 2008
25 issue of Neuron, the researchers define a circuit in the brain that explains the ways fenfluramine, a component of Fen-phen, suppresses appetite. Consumer Affairs

Despite failures, search for obesity drugs still looks golden  -  Dec 9, 2008
Eleven years ago, the search for an obesity drug ran into controversy when fenfluramine, an appetite suppressant, was banned in the United States over fears Macau Daily Times,

Study: New Diet Drug Shows Promise  -  Dec 12, 2008
The Food and Drug Administration recalled Fen-phen because of reports that the other half of the drug’s component, fenfluramine, caused heart damage. FOXNews

Experimental Weight-Loss Pill Passes Early Test  -  Dec 12, 2008
The drug Fen-phen, a combination of fenfluramine and dexfenfluramine, worked for many but was withdrawn from the market in 1997 when it was linked with Washington Post,

Drug trial success a boost for Arena  -  Dec 9, 2008
But one of the two components of that drug made by Wyeth, fenfluramine, also hit a second target in the heart, which was linked to heart valve problems. San Diego Union Tribune,

Vivus to Roll Out Key Obesity Drug Data  -  Dec 3, 2008
...(And yes, it's the "phen" in fen-phen but it was "fen" or fenfluramine and not phentermine that was later discovered to be toxic drug in the combination. TheStreet.com

Mechanism Behind Regulation of Food Intake Identified  -  Nov 29, 2008
Further, 5-HT2CRs are known to contribute to the appetite suppressant effects of d-fenfluramine, a drug widely prescribed to combat obesity in the 1990s MedIndia,

Diet pills a dangerous way to lose  -  21 Nov 2008
The product was a mix of two other diet drugs, fenfluramine and phentermine. It was pulled from the market after otherwise healthy users began developing MSU The Trail Blazer Online,

Valvular regurgitation and surgery associated with fenfluramine ...  -  Nov 6, 2008
Valve surgery was performed on 38 patients (0.66% of 5743), 25 (0.44%) with clear evidence of fenfluramine-related etiology. 7thSpace Interactive (press release),

Lasting Damage From Fen-Phen Drug?  -  Nov 5, 2008
The study shows that heart valve problems linked to the banned obesity drugs fenfluramine and/or dexfenfluramine typically last years after stopping those WebMD

Diet Drug Fen/Phen Still Causing Damage  -  Nov 6, 2008
Fenfluramine, part of the fen/phen obesity drug that was banned in the US in 1997 after it was linked to heart problems, is still causing damage, FoxReno.com,

Banned Obesity Drug Tied to Heart Risks Long After Use  -  Nov 7, 2008
The appetite suppressant fenfluramine has been banned in the United States since 1997, because of its links to heart damage. Thousands of lawsuits have been Washington Post,

Despite failures, search for obesity drugs still looks golden  -  Nov 15, 2008
Eleven years ago, the search for an obesity drug ran into controversy when fenfluramine, an appetite suppressant, was banned in the United States over fears AFP

Valve Problems from Banned Diet Drug Persist  -  Nov 5, 2008
5 -- Heart valve damage from the banned diet drugs fenfluramine and dexfenfluramine can persist for many years, researchers here said. MedPage Today,

Fen-Phen Left Long-Lasting Damage to the Heart  -  Nov 6, 2008
Problems linked to the banned obesity drugs fenfluramine and dexfenfluramine, which together formed the blockbuster diet drug Fen-Phen, lasted for years Attorney at Law

Fen/phen diet drug now tied to heart valve damage  -  Nov 8, 2008
Banned in the US since 1997, the appetite suppressant fenfluramine was eliminated from the marketplace due to its links to heart damage. CaymanMama.com (press release),

How to Choose the Right Weight Loss Pills For You?  -  Nov 3, 2008
Some ingredients may be very like fen-phen or fenfluramine and phentermine. Studies show that these two affect the heart and nervous system adversely. Best Syndication,

Vicar tells of diet drug hell  -  Nov 5, 2008
By Chris Visser An overweight Lancashire vicar has told how his life was made hell by a banned diet pill linked to suicide. Father Timothy Lipscomb took the Lancashire Evening Post,

Local study explores dangers of fen-phen over time  -  Nov 6, 2008
The appetite suppressant fenfluramine -- the "fen" half of the drug -- was banned by the US Food and Drug Administration in September 1997 over fears it Daily Herald,

Composition Comprising Licorice Polyphenol  -  Nov 20, 2008
...but are not limited to, fenfluramine, fluoxetine, mazindol and the like as pharmaceutical products that suppress appetite, and acarbose, voglibose, FLEXNEWS,

Médicaments amaigrissants retirés il ya 11 ans: séquelles toujours ...  -  Nov 8, 2008
Charles Dahl et ses collègues de la Central Utah Clinic (É.-U.) ont étudié la condition cardiaque de 5743 utilisateurs de la fenfluramine. PsychoMédia,

불법 다�?�어트성분 �?��?� 지 7년 후�?�?� '심장장애' 유발  -  Nov 6, 2008
...국내�?서 다�?�어트 제품�? 불법�?으로 혼입�?�는 대표�? 성분�?� '펜플루�?�민(fenfluramine)'�?��?�는 �?욕억제성분�?� 11년전 중단한 사람�?서�?� 7년�?� 지나서까지 심장 Medical Today,

GAZETA: Pesquisa sobre obesidade pode estar em risco  -  Oct 27, 2008
...fenfluramine e phentermine, prescritas 6 milhões de vezes antes de ser recolhido por causa dos efeitos colaterais fatais há mais de uma década. Gazeta Mercantil,

Health Canada Warns Against ARMA  -  Sep 24, 2008
Fenfluramine was previously used in the treatment of obesity but is currently prohibited for sale in Canada. Use of sibutramine may cause headaches, eMaxHealth.com,

House call with Dr. Andy: Weigh the pros, cons of diet pills  -  Sep 29, 2008
Several years ago the Fen part (Fenfluramine) was pulled from the market due to adverse health risks. Phentermine is a very effective weight loss medication The News-Press,

The Gossip Page  -  Oct 16, 2008
The 21 year old former world champion tested positive for the stimulant fenfluramine, used a weightloss drug, on 5 July at the U23 European championships in Podium Cafe

An Obesity Drug Pipeline Report: The Development of Therapies for ...  -  Oct 6, 2008
...notable safety failures of several late-stage and marketed obesity drugs (such as the notorious case of Fen-Phen [fenfluramine/phentermine]), Business Wire (press release),

Aggression, Suicide, and Lithium Treatment  -  Oct 1, 2008
Actually, positron emission tomography studies have shown reduced response in the prefrontal cortex and anterior cingulate gyrus after fenfluramine Am J Psychiatry (subscription)

Lawsuits Filed in the Wake of Bayer Pulling Trasylol From the ...  -  Sep 25, 2008
The firm has successfully litigated claims of thousands of persons injured by the diet drugs Fenfluramine and dexfenfluramine (Redux(tm)), Rezulin, Trading Markets (press release),

La Psicologia a Tavola. – "Mangio quel che sono" – influenze psico ...  -  Sep 25, 2008
...individuali verso la nutrizione risentono dell'assunzione di 5-idrossitriptofano, fluoxetina e d-fenfluramina, ma non delle altre fenfluramine. Scienza e Psicoanalisi,

{} {On this day in history}  -  Sep 15, 2008
In 1997 two of the nation's most popular diet drugs—dexfenfluramine and fenfluramine—were pulled off the market because of new evidence they could seriously Chicago Tribune,

Health Canada: Avoid Energy II, Apisate, Obat Asam Urat, Asam Urat  -  Aug 22, 2008
Energy ll contained sibutramine and Apisate contained fenfluramine. Obat Asam Urat and Asam Urat both contained dexamethasone, piroxicam and phenylbutazone. eMaxHealth.com,

Warning issued on slimming product  -  Aug 28, 2008
Banned in Hong Kong in 1998, fenfluramine was used as an appetite suppressant for management of obesity but could lead to heart valve disease. News.gov.hk,

Third Circuit upholds denial of diet-drug settlement claim  -  Sep 12, 2008
...which pulled its diet drugs Pondimin (fenfluramine) and Redux (dexfenflura) off the market [FDA press release] in 1997. Earlier that year, a Mayo Clinic JURIST

专家�?�示10�?�?�?��?�的�?肥�?分  -  Sep 7, 2008
2�?Fenfluramine 第一食�?网,

衞生署籲�?��?「新康散�? 減肥藥  -  Aug 28, 2008
...衞生署呼籲市民�?�?購買或�?用「新康散�? ，因該產�?�?�有在香港�?止使用的西藥�?份，包括「西布曲明�? (sibutramine) �?�「氟苯丙胺�? (fenfluramine 蘋果動新�?�,

Drug Makers Seek Antiobesity Blockbuster  -  Jul 28, 2008
Arena's lorcaserin targets a receptor in the brain that is also affected by fenfluramine, a drug withdrawn in 1997 after being linked to heart-valve damage. Wall Street Journal

Alert issued on slimming product  -  Jul 25, 2008
Laboratory results showed the product contains sibutramine and a small amount of fenfluramine. Sibutramine is a Western drug used as appetite suppressant. News.gov.hk,

Extreme Weight Loss Techniques  -  Jul 31, 2008
Fen-Phen is essentially phentermine combined with other appetite suppressants; fenfluramine or dexfenfluramine. After some Fen-Phen users experienced heart AskMen

Are You Familiar With These Stimulants?  -  Jul 20, 2008
Two Schedule IV anorectics often used in combination with phentermine, fenfluramine and dexfenfluramine, were removed from the US market because they were TransWorldNews (press release),

ドーピング疑惑�?��?スティア�?ッリ無実を主張  -  Aug 6, 2008
...陽性�??応�?�出�?��?��?�フェンフルラミン（Fenfluramine）�?��?��?�ダイエット用�?�製�?�?��?�り�?�?スティア�?ッリ�?��?注�?�?�摂�?��?��?��?��?��?��?��?�訴�?��?��?�る。(c)AFP. AFPBB News,

請勿購買或�?用�??為「新康散�?�?�「壯腎之寶�?之產�?  -  Aug 5, 2008
...有關香港衛生署7月25日發布之新�?�，�??為「新康散�?之減肥產�?，經檢出�?�「Sibutramine�?�?�少�?「Fenfluramine 我的E政府,

澳门特区称�?肥产�?“新康散�?�?��?�?�?份  -  Jul 28, 2008
...澳门特区近日�?�布公告说，根�?�香港�?�生署的公告，产�?“新康散�?掺�?�有西�?��?份“西布曲明(sibutramine)�?�?�“氟苯丙胺（fenfluramine 人民网,

衛局籲�?��?�止�?食「新康散�?  -  Jul 25, 2008
...�?本報訊】根據香港衛生署的公告，產�?「新康散�? 摻雜有西藥�?份「西布曲明(sibutramine)�? �?�「氟苯丙胺(fenfluramine 新�?�澳報,

10�?�?�?��?�的�?肥�?分  -  Jul 13, 2008
2�?Fenfluramine 糖酒快讯网,

�?肥�?�几大副作用大盘点  -  Aug 4, 2008
...芬芬也是一�?食欲抑制剂，其主�?�?分之一就是芬弗拉明（fenfluramine 第一食�?网,

�?スティア�?ッリ �?止薬物�?�陽性�??応  -  Jul 28, 2008
...彼女�?�陽性�?��?��?��?��?��?�フェンフルラミン（Fenfluramine）�?ダイエット用�?�製�?�?��?��?��?��?��?�。体�?�?��?��?��?�頭�?��?��?��?��?��?��?サラダ�?��?�食�?��?��?��?��?��?��?��?�?�語�?��?��?�る AFPBB News,

Are obesity pills a good idea?  -  Jun 25, 2008
In 1997, the Food and Drug Administration (FDA), which regulates medicines in the US, ordered the withdrawal of fenfluramine, one of the components of the guardian.co.uk,

Diet pills can be deadly  -  Jun 25, 2008
Fenfluramine intake has been associated with an increase in the number of people who develop a disease called Primary Pulmonary Hypertension (PPH), Health24.com,

Mood hormone may affect fat, US study finds  -  Jun 14, 2008
The diet drug fenfluramine, which has the effect of raising serotonin levels, was pulled off the market in 1997 after it caused sometimes deadly heart valve ABS CBN News,

Arena expects initial obesity drug data in March  -  Jun 18, 2008
The drug, lorcaserin, is a serotonin activator like fenfluramine, half of the infamous fen-phen diet pill that was recalled a decade ago after being Therapeutics Daily (subscription) (press release),

PPH and Fen-Phen: One Plaintiff’s Lawsuit  -  Jul 1, 2008
When reports showed it caused heart damage, the drug fenfluramine, (one half of the fen-phen combination), was voluntarily pulled from the market in Lawyers and Settlements

Beware: Risky diet aids may still be sold online  -  Jun 12, 2008
FENFLURAMINE This chemical appetite suppressant, also known as Fen-Phen, was removed from the market in 1997 after being linked to potentially fatal heart New York Daily News,

Clinical Outcomes of Pulmonary Arterial Hypertension in Carriers ...  -  Jun 17, 2008
BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. Eur Respir J 2002;20:518-523. 13. Koehler R, Grunig E, RedOrbit,

Brand Names/Synonyms:
Fenfluramine is also known by the following brand names and/or synonymsAcino; Adipomin; CHEMBANK1560; Dea No. 1670; F1884; Fenfluramina [Dcit]; Fenfluramine; Fenfluramine Hydrochloride; Fenfluraminum [Inn-Latin]; HSDB 3080; Obedrex; Pesos; Ponderax Pa; Ponderex; Pondimin; Rotondin; S 768

Drug Category:
Fenfluramine is categorized under the following by the FDA: Serotonin reuptake inhibitor; Anorexigenic Agents; Stimulants; ATC:A08AA02; ATC:A08AA04

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
Interactions for Fenfluramine:

Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine.

Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive.

Chemical IUPAC Name:
N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine

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