Esomeprazole

This page contains recent news articles, when available, and an overview of Esomeprazole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Esomeprazole (when available)

Pharmacology and use:
Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and H. pylori eradication to reduce the risk of duodenal ulcer recurrence. Esomeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H⁺/K⁺ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Esomeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. For the treatment of acid-reflux disorders (GERD) and peptic ulcer disease

Mechanism Of Action:
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H⁺/K⁺-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity.

News Articles on Esomeprazole

Heartburn Medications Do Not Ease Asthma Symptoms, Study Shows  -  ‎Apr 9, 2009‎
Half took daily doses of the most commonly used proton pump inhibitor -- 80 milligrams of esomeprazole (Nexium) -- while the rest received a placebo. Science Daily (press release)

Esomeprazole treatment does not improve poorly controlled asthma  -  ‎Apr 14, 2009‎
A randomized, placebo-controlled, double-blind trial published in the New England Journal of Medicine demonstrated no beneficial effect of esomeprazole for Modern Medicine

Acid Reflux Treatment Does Not Improve Asthma  -  ‎Apr 12, 2009‎
Participants took either 40 milligrams of the drug esomeprazole or a placebo. Esomeprazole is a key ingredient in common GERD drugs including Prilosec and Ivanhoe

Pozen Forecasts Updated  -  ‎Apr 15, 2009‎
In early December 2008, Pozen released positive top-line data from its 400-301/-302 phase III program testing PN-400 (20mg esomeprazole / 500mg naproxen) vs Zacks.com

Platelet-function test finds fault with omeprazole/clopidogrel ...  -  ‎Apr 10, 2009‎
The study, published in the April issue of Thrombosis and Haemostasis, hints that other PPIs tested—pantoprazole and esomeprazole—might be a safer bet for TheHeart.Org

FDA Safety Changes: Tracleer, Nexium, Nexium IV, Tygacil  -  ‎Apr 1, 2009‎
On January 15, the FDA approved safety labeling revisions for esomeprazole sodium injection (Nexium IV, AstraZeneca) and esomeprazole magnesium Medscape

Your sweet tooth may get taxed  -  ‎Apr 9, 2009‎
Half the patients were given a heart-burn medication called esomeprazole, while the others received a placebo. All the patients continued to take their Globe and Mail

The drug–drug interaction between proton pump inhibitors and ...  -  ‎Mar 30, 2009‎
Juurlink and colleagues speculate as to why: unlike the other proton pump inhibitors (omeprazole, lansoprazole, rabeprazole and esomeprazole), CMAJ

This Week in Health  -  ‎Apr 10, 2009‎
One group was given esomeprazole (Nexium). This is a type of heartburn drug called a proton pump inhibitor. The other group got dummy pills (placebos). Intelihealth.com

Medicines turn off acid pump  -  ‎Mar 30, 2009‎
Nexium (esomeprazole) belongs to the family of drugs called proton pump inhibitors, the most potent suppressors of stomach acid production. South Coast Today

US prescription growth stalls in 2008  -  ‎Apr 2, 2009‎
They were followed by proton pump inhibitors at $13.9bn, down 2.1%, and driven by a solid 7.3% sales increase for AstraZeneca's PPI Nexium (esomeprazole) to Pharmafocus

השפעת ניטרול חומציות הקיבה על המהלך והטיפול ב�?סתמה  -  ‎Apr 12, 2009‎
...קבוצת הטיפול קבלה תכשיר PPI) ESOMEPRAZOLE ) משך 24 שבועות, כ�?שר קבוצת הבקרה טופלה ל�?ותו פרק זמן בפלצבו. כושר הנשיפה וחומציות הושט נבדקו בשתי הקבוצות בצורה מרכז הרופאים המומחים

Health in the News -- And Your Life The Checkup Health in the News ...  -  ‎Apr 13, 2009‎
By Adapted from voices.washpost.com/checkup In the new Dunkin' Donuts TV ad, three kids (and a dog) are in a darkened room, watching television. Washington Post

Acid reflux disease  -  18 Mar 2009
Proton pump inhibitors like esomeprazole (Nexium), lansoprazole (Ogastro, Lanzap), omeprazole (Losec), pantoprazole (Pantecta), and rabeprazole (Pariet) are Jamaica Gleaner

High-Dose Esomeprazole May Reduce Recurrent Peptic Ulcer Bleeding  -  ‎Mar 2, 2009‎
March 2, 2009 — High-dose intravenous esomeprazole given after successful endoscopic therapy may reduce recurrent bleeding in high-risk patients with peptic Medscape

Is Esomeprazole The Best Choice For Reflux Esophagitis Patients?  -  ‎Mar 4, 2009‎
In patients with gastroesophageal reflux disease (GERD), esomeprazole, has demonstrated pharmacological and clinical benefits beyond those seen with the Medical News Today (press release)

Alternative vs. conventional treatment given on-demand for ...  -  ‎Feb 24, 2009‎
The aim of this trial was to compare on-demand treatment with a pectin-based, raft-forming, natural, anti-reflux agent (PRA) with that of esomeprazole 20 mg 7thSpace Interactive (press release)

POZEN to Present at the Cowen and Company 29th Annual Healthcare ...  -  ‎Mar 4, 2009‎
...in adults, and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single MarketWatch (press release)

Generics at fraction of the cost. Digestive! Gener  -  ‎Feb 21, 2009‎
Esomeprazole or you may have. Find the stories you you are taking any prescription or crush the capsule can be added to GERD and the pellets should be Divadlo.cz

Alphabet Shuffle  -  ‎Feb 23, 2009‎
Abstract of USP 7227024 (1) is " A process for the manufacture of omeprazole or esomeprazole from pyrmethyl alcohol via pyrmethyl chloride and pyrmetazole Pharmaceutical Processing

More Concern About Plavix and Proton-Pump-Inhibitors  -  ‎Mar 9, 2009‎
...prescription include omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), and esomeprazole (Nexium). About - News & Issues

Genzyme Corp.: Chronic Kidney Disease Patients on Dialysis Must ...  -  ‎Mar 2, 2009‎
...of AstraZeneca's stomach acid drug Nexium (esomeprazole magnesium), which many experts say has the exact same clinical effect as Prilosec (omeprazole). Atlantic Information Services, Inc.

10-K: POZEN INC /NC  -  ‎Mar 6, 2009‎
...to co-develop and commercialize proprietary fixed dose combinations of the PPI esomeprazole magnesium with the NSAID naproxen in a single tablet using MarketWatch (press release)

POZEN Reports Fourth Quarter and Year End 2008 Results  -  ‎Feb 25, 2009‎
...in adults, and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single MarketWatch (press release)

高劑�?�?�脈注射Esomeprazole�?�能�?低復發消化性潰�?出血  -  ‎Mar 7, 2009‎
March 2, 2009 — 根據2月17日內科醫學檔案期刊發表的一篇隨機控制試驗�?果，�?功內視�?�治療後，使用�?�脈注射高劑�?esomeprazole，�?�以�?低消化性潰�?病患的出血風險。臺灣新浪網

احتواء نزي�? القرحة بدواء Esomeprazole  -  ‎Mar 1, 2009‎
توصلت دراسة موسعة - شملت 91 مستش�?ى (قسم الطوارئ) �?ي 16 دولة – إلى أن العلاج بجرعة عالية من دواء الـ (إسوميبرازول - esomeprazole ) عن طريق الوريد بعد العلاج باب

'그것�?� 알고 싶다'…녹십�? 등 무�?�기 행정처분  -  ‎Mar 10, 2009‎
...팜플렛�?� 제작함�? 있어 �?기제품�?� 주성분�?� 'esomeprazole strontium' �?� 논문�?료가 아닌 'esomeprazole Mg'�?� 논문�?료를 �?�용했으나 �?� �?료�? 'esomeprazole 메디컬헤럴드

'�?소메졸캡�?' 논문�?�용 조작 처분  -  ‎Mar 9, 2009‎
...한미약품�?� '넥시움' 염 변경 개량신약 '�?소메졸캡�?(esomeprazole strontium)'�?� 광고위반으로 해당품목 광고업무정지 1개월�?� 처분�?� 받�?� 것�?� 뒤늦게 드러났다. 디지틀보사

Nicox : Credit Suisse doute d'un partenariat avec une "big pharma ...  -  ‎Mar 10, 2009‎
...est l'association de deux molécules existantes, l'anti-inflammatoire non stéroïdien naproxène et l'esomeprazole, qui est l'anti-ulcéreux d'Astrazeneca. La Vie Financière

Risk of heart attack from drug combination  -  04 Feb 2009
Names for proton pump inhibitors include omeprazole (brand name Losec), lansoprazole (Zoton), rabeprazole (Pariet), pantoprazole (Protium) and esomeprazole guardian.co.uk,

Pozen: Finally Some Good News  -  Jan 29, 2009
The discussion relates to Pozen's PN-400 product, a fixed dose combination of enteric-coated naproxen and immediate release esomeprazole for the treatment Zacks.com,

What's the evidence for taking three drugs?  -  Jan 21, 2009
Esomeprazole-based therapy in Helicobacter pylori eradication: a meta-analysis. Digestive and Liver Diseases. 2004; 36: 843-849. Gisbert JP, Khorami S, guardian.co.uk,

New Questions About Plavix  -  Feb 2, 2009
...pantoprazole (Protonix), rabeprazole (Aciphex), and esomeprazole (Nexium). Prilosec is also sold over-the-counter for heartburn. Plavix is a "pro-drug. About - News & Issues,

Other News To Note  -  Jan 30, 2009
...which is partnered with London-based AstraZeneca plc and is a fixed-dose combination of enteric-coated naproxen with immediate-release esomeprazole in TMCnet

Zacks Analyst Blog Highlights: Pozen Inc., The Boeing Company, HCP ...  -  Jan 31, 2009
The discussion relates to Pozen's PN-400 product, a fixed dose combination of enteric-coated naproxen and immediate release esomeprazole for the treatment istockAnalyst.com (press release),

People's Pharmacy: Medicines pay for medical breakthroughs  -  Jan 18, 2009
Facing a huge loss in revenue due to generic competition, the company brought out a chemical cousin, esomeprazole. It was (and still is) sold under the name Houston Chronicle,

AstraZeneca 4Q Net Profit $1.25 Billion, Targets $5.15-$5.45 '09 ...  -  Jan 29, 2009
...the combination of enteric coated naproxen and immediate release esomeprazole for the treatment of arthritic pain in patients at risk of developing EasyBourse.com,

BREAKING NEWS: Sales rise but more job cuts at AstraZeneca  -  Jan 29, 2009
Sales reached $8.19 billion and the company’s biggest earner was the antiulcerant blockbuster Nexium (esomeprazole) which rose 6% to $1.32 billion, Pharma Times,

Stomach ulcers  -  Jan 21, 2009
Some examples of proton pump inhibitors are esomeprazole (brand name Nexium), pantoprazole (Protium) and rabeprazole (Pariet). guardian.co.uk,

Aspirin and other antiplatelet drugs  -  Jan 21, 2009
...[2] [4] For people who get stomach problems when they take aspirin, taking a drug called esomeprazole as well as aspirin may help. guardian.co.uk,

What treatments work for GORD?  -  Jan 21, 2009
Some common names (and brand names) are omeprazole (Losec), lansoprazole, rabeprazole (Pariet), pantoprazole (Protium) and esomeprazole (Nexium). More. guardian.co.uk,

Taking Indigestion Medication May Increase Risk of Osteoporosis  -  Jan 20, 2009
Varieties include esomeprazole (marketed as Nexium), lansoprazole (marketed as Inhibitol, Prevacid and Zoton), omeprazole (marketed as Losec, Prilosec and Natural News.com,

Is new drug prescribing in primary care specialist induced?  -  Jan 11, 2009
The proportion of GPs prescribing new drugs before waiting for prescriptions from medical specialists ranged from 21.1% in the case of esomeprazole to 32.9% 7thSpace Interactive (press release),

FDA Issues an Early Communication about an Ongoing Safety Review ...  -  Jan 27, 2009
PPIs include omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), and esomeprazole (Nexium), PharmaLive.com (press release),

Ranbaxy Lab swings to loss for FY 08  -  Jan 22, 2009
Ranbaxy reached several agreements with AstraZeneca settling patent infringement litigation for Nexium® (Esomeprazole Magnesium). Myiris.com,

AstraZeneca Submits sNDA for NEXIUM(R) for the Short-Term ...  -  Dec 19, 2008
The formulation contains esomeprazole magnesium, the same active ingredient used in NEXIUM Delayed-Release Capsules. The sNDA submission for NEXIUM in PR Newswire (press release),

Pozen drug clears one hurdle, but another remains  -  Dec 3, 2008
The drug is a combination of naproxen, the painkiller, and esomeprazole, an AstraZeneca drug that helps inhibit the production of stomach acid. Bizjournals.com,

POZEN To Participate in The RBC Capital Markets 2008 Healthcare ...  -  Dec 2, 2008
...and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single tablet for Trading Markets (press release),

Pozen eyes $54M stock placement  -  Dec 14, 2008
The drug combines the painkiller naproxen with esomeprazole, an AstraZeneca drug that helps inhibit the production of stomach acid. Triangle Business Journal,

Esophageal erosions tend to recur  -  Dec 4, 2008
Nexium (esomeprazole) is one of the proton pump inhibitors, the most powerful suppressors of stomach acid production. With two months of Nexium treatment, Kilgore News Herald,

Poor Pay the Most for Prescription Drugs Independent retailers in ...  -  Dec 5, 2008
When the researchers compared the prices of a one-month supply of esomeprazole for peptic ulcer disease, fluticasone/salmeterol for asthma, clopidogrel for Drug Topics Magazine,

ASTRAZENECA:FAS III-STUDIER PN 400 NÅR PRIMÄR MÅLSÄTTNING (NY)  -  Dec 3, 2008
...som är en kombination av det smärtstillande preparatet Naproxen och magsyresubstansen esomeprazole, har nått den primära målsättningen. Dagens Nyheter,

Nicox : "Nous ralentissons un peu les discussions, volontairement"  -  Dec 8, 2008
Le PN 400 est l'association de deux molécules existantes, l'anti-inflammatoire non stéroïdien naproxène et l'esomeprazole, qui est l'anti-ulcéreux Trading Sat,

Esomeprazole helps prevent aspirin-related ulcers  -  Oct 27, 2008
Treatment with the proton pump inhibitor esomeprazole is useful in preventing gastric and duodenal ulcers in patients receiving continuous, low-dose aspirin Medicexchange,

Nexium Helps Prevent Aspirin-Related Ulcers  -  Oct 27, 2008
Esomeprazole is a proton pump inhibitor, meaning that it suppresses gastric acid. The authors note that no studies until now have measured how often NewsMax.com,

AstraZeneca Appoints Rich Fante as President of its US Business  -  Nov 18, 2008
...including Vice President-Primary Care for the gastrointestinal and respiratory franchises, including NEXIUM(R) (esomeprazole magnesium) and PULMICORT SYS-CON Media,

XplosiveStocks.com: AstraZeneca (NYSE: AZN) Hot Stock on the Move!  -  Nov 19, 2008
...the gastrointestinal and respiratory franchises, including NEXIUM (esomeprazole magnesium) and PULMICORT RESPULES (budesonide inhalation suspension). Trading Markets (press release),

POZEN'S PA32520 Study Data Demonstrated Better Upper ...  -  Nov 11, 2008
...and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single tablet for MarketWatch

POZEN Reports Third Quarter 2008 Results  -  Oct 29, 2008
...in adults, and with AstraZeneca for proprietary fixed dose combinations of naproxen with the proton pump inhibitor esomeprazole magnesium in a single MarketWatch

Pipeline Insight - Upper GI Disorders - Generics will limit ...  -  Nov 17, 2008
The inclusion of Nexium (esomeprazole) as a comparator in clinical trials is essential to ensure market success for pipeline products. Live-PR.com (Pressemitteilung),

Nexium added to daily aspirin helps prevent stomach ulcers  -  Oct 29, 2008
A study found that patients who take low-dose aspirin daily to help prevent heart attacks can reduce the risk of stomach ulcers by adding esomeprazole or SmartBrief,

Emerging markets push up AstraZeneca's earnings  -  Oct 31, 2008
The antiulcerant blockbuster Nexium (esomeprazole) slipped 2% to $1.32 billion, though sales were down 12% to $2.27 million in the USA which AstraZeneca Pharma Times (registration),

Data continue to show differences in gastrointestinal and lipid ...  -  Oct 27, 2008
Vfend® (voriconazole), AcipHex® (rabeprazole), Nexium® (esomeprazole), Prevacid® (lansoprazole), Prilosec® (omeprazole), Protonix® (pantoprazole), PipelineReview.com (press release),

Taking Plavix with Popular GI Medications Increases Risk for ...  -  Nov 11, 2008
PPIs include omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), and esomeprazole (Nexium), SeniorJournal.com,

ESOMEPRAZOLE מפחית מסיכוני הטיפול היומי ב�?ספירין  -  Oct 26, 2008
...מדובר בתרופת ה - ESOMEPRAZOLE ששיכת לקבוצת מעכבי מש�?בת המימן בדומה לLOSEC,כלומר �?ותן תרופות המדכ�?ות הפרשת יתר של יוני מימן ( חומצה) לקיבה. מרכז הרופ�?י�? המומחי�?,

Brand Names/Synonyms:
Esomeprazole is also known by the following brand names and/or synonymsAntra; Antra Mups; Audazol; Aulcer; Belmazol; CCRIS 7099; Ceprandal; Danlox; Demeprazol; Desec; Dizprazol; Dudencer; Elgam; Emeproton; Epirazole; Erbolin; Esomeprazole; Esomeprazole Magnesium; Exter; Gasec; Gastrimut; Gastroloc; Gibancer; H 168/68; HSDB 3575; Indurgan; Inhibitron; Inhipump; Lensor; Logastric; Lomac; Losec; Mepral; Miol; Miracid; Mopral; Morecon; Nexium; Nexium Iv; Nilsec; Nopramin; OMEP; OMEPRAZOLE; OMP; OMZ; Ocid; Olexin; Omapren; Omebeta 20; Omed; Omegast; Omepral; Omeprazol [Inn-Spanish]; Omeprazole; Omeprazole [Usan:Ban:Inn:Jan]; Omeprazolum [Inn-Latin]; Omeprazon; Omeprol; Omesek; Omezol; Omezolan; Omid; Omisec; Omizac; Ompanyt; Ortanol; Osiren; Ozoken; Paprazol; Parizac; Pepticum; Pepticus; Peptilcer; Prazentol; Prazidec; Prazolit; Prilosec; Prilosec Otc; Procelac; Proclor; Prysma; Ramezol; Regulacid; Result; Sanamidol; Secrepina; Tedec Ulceral; Ulceral; Ulcesep; Ulcometion; Ulcozol; Ulcsep; Ulsen; Ultop; Ulzol; Victrix; Zefxon; Zegerid; Zepral; Zimor; Zoltum

Drug Category:
Esomeprazole is categorized under the following by the FDA: Anti-ulcer Agents; Proton-pump Inhibitors; ATC:A02BC01; ATC:A02BC05

Dosage Forms:
Oral tablets

Absorption:
Absorption is rapid, Absolute bioavailability (compared to intravenous administration) is about 30-40% at doses of 20-40 mg

Interactions:
-->Interactions for Omeprazole:

Other

Omeprazole can prolong the elimination of diazepam, warfarin and phenytoin, drugs that are metabolized by oxidation in the liver. Although in normal subjects no interaction with theophylline or propranolol was found, there have been clinical reports of interaction with other drugs metabolized via the cytochrome P-450 system (e.g., cyclosporine, disulfiram, benzodiazepines). Patients should be monitored to determine if it is necessary to adjust the dosage of these drugs when taken concomitantly with omeprazole.

Because of its profound and long lasting inhibition of gastric acid secretion, it is theoretically possible that omeprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (e.g., ketoconazole, ampicillin esters, and iron salts). In the clinical trials, antacids were used concomitantly with the administration of omeprazole.

Combination Therapy with Clarithromycin

Co-administration of omeprazole and clarithromycin may result in increases in plasma levels of ompeprazole, clarithromycin, and 14-hydroxy-clarithromycin.

Concomitant administration of clarithromycin with cisapride, pimozide, or terfenadine is contraindicated.

There have been reports of an intereaction between erythromycin and astemizole resulting in QT prolongation and torsades de points. Concomitant administration of erythromycin and astemizole is contraindicated. Because clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with astemizole is not recommended.

Chemical IUPAC Name:
5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3H-benzoimidazole

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