Doryx

This page contains recent news articles, when available, and an overview of Doryx but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Doryx (when available)

Pharmacology and use:
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis. For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve

Mechanism Of Action:
Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis.

News Articles on Doxycycline

Warner Chilcott's Shrewd Drug Gamble  -  ‎Aug 24, 2009‎
The company has a record of extending patents on drugs, including acne-treatment Doryx, by tweaking the formula or form of dosage. Wall Street Journal

Warner Chilcott Q2 Profit Up 66%; Lifts FY09 EPS Outlook - Update  -  ‎Aug 7, 2009‎
Dermatology product Doryx generated $44.9 million revenues, up 41.6% from the year-ago period. Hormone therapy product Estrace cream recorded revenues of RTT News

BUYINS.NET: EIX, WCRX, SNH, ARD, MCCC, LNG Expected To Be Higher ...  -  ‎Aug 4, 2009‎
It also offers various dermatology products, such as TACLONEX and DOVONEX for the topical treatment of psoriasis; and DORYX, an oral adjunctive therapy for TMC Net

Warner Chilcott拟31亿收购�?�?处方�?�业务  -  ‎Aug 24, 2009‎
Warner-Chilcott总部�?于爱尔兰的阿耳第(Ardee)，其产�?包括�?�孕�?�Estrostep Fe和用于治疗痤疮的�?�物Doryx等。在纳斯达克市场的早盘交易中，Warner-Chilcott股价新浪网

Warner Chilcott调高盈馀目标  -  ‎Aug 7, 2009‎
...�?�收增长，主�?是因DORYX丶LOESTRIN 24 FE与ESTRACE�?��?贡献2800万美元的净销售�?长金哦。 �?责声明：本文仅代表作者个人观点，与凤凰网无关。凤凰网

Community-acquired MRSA: Oral doxycycline highly effective  -  ‎Jun 29, 2009‎
In this area, he says a doxycycline formulation that uses enteric-coated pellets (Doryx, Warner Chilcott) produces far fewer gastrointestinal side effects Modern Medicine

Daiichi Sankyo files patent lawsuit against 11 generics companies  -  ‎Apr 14, 2009‎
Dispute over abbreviated new drug application to the FDA for generic version of Doryx 150mg ... The Parenteral Drug Association (PDA) is the leadi . Pharmaceutical Business Review

Mylan confirms four first-to-file ANDA lawsuits  -  ‎Mar 31, 2009‎
By Datamonitor staff writer Dispute over abbreviated new drug application to the FDA for generic version of Doryx 150mg ... The Parenteral Drug Association Pharmaceutical Business Review

Research Oracle roundup for 01 April 2009  -  ‎Apr 1, 2009‎
If generics of DORYX 100 mg and 75 mg or DORYX 150 mg delayed release tablets are launched, we expect sales growth to be negatively impacted. Research Oracle

Warner Chilcott Limited (NASDAQ:WCRX) - Threat of generics to key ...  -  ‎Apr 1, 2009‎
If generics of DORYX 100 mg and 75 mg or DORYX 150 mg delayed release tablets are launched, we expect sales growth to be negatively impacted. Research Oracle

Warner Chilcott denied stay on 2 Doryx doses  -  18 Mar 2009
Warner Chilcott (nasdaq: WCRX - news - people ) had asked the FDA not to approve generic versions of Doryx in 75 mg or 100 mg doses for up to 30 months, Forbes

Merck donates experimental malaria drug; AstraZeneca cuts 120 ...  -  18 Mar 2009
Report > Drugmaker Warner Chilcott said the FDA will not delay rulings on two generic versions of the antibiotic Doryx. Report > Abbott Laboratories accused FiercePharma

Warner Chilcott收到美国FDA回函  -  18 Mar 2009
...(WCRX) 9.99 : Warner Chilcott宣布，收到美国FDA对公民请愿书的回应，在DORYX专利�?�挂牌以�?，�?求FDA对延迟释�?�DORYX 100上市申请施以30个月�??置期。凤凰网

BRIEF-Warner Chilcott says Impax filed generic Doryx ANDA  -  ‎Mar 17, 2009‎
Neither the Subscriber nor Thomson Reuters warrants the completeness or accuracy of the Service or the suitability of the Service as a trading aid and Forbes

Warner Chilcott Ltd. Q4 2008 Earnings Call Transcript  -  ‎Feb 27, 2009‎
The increases in both periods were led by increased sales DORYX, Taclonex, Loestrin 24, and Femcon. Sales of our OCs increased 6.3% this quarter versus the Seeking Alpha

10-K: WARNER CHILCOTT LTD  -  ‎Feb 27, 2009‎
The primary drivers of the increase in revenue were the net sales of our promoted products LOESTRIN 24 FE, DORYX, TACLONEX and FEMCON FE, which together MarketWatch (press release)

Market Report -- Short Stories (WCRX)  -  ‎Mar 2, 2009‎
Roth Capital upgrades WCRX to Buy from Hold following the co's successful transition of more than half of the Doryx franchise to the 150mg strength and a MSN Money

Sanofi taps Chew as chief science/medical officer; Pfizer gets ...  -  ‎Mar 17, 2009‎
...a Paragraph IV notice from Impax, advising that Impax filed for FDA approval for a copycat version of Warner's tetracycline-class antibiotic Doryx. FiercePharma

Research Oracle roundup for 02 March 2009  -  ‎Mar 2, 2009‎
We believe the company will continue to report strong top-line growth, going forward, driven by strong demand for Taclonex, Doryx, Leostrin 24 FE and Femcon Research Oracle

Warner Chilcott Files New Lawsuit for Infringement of DORYX(R) Patent  -  Feb 1, 2009
6958161 (the "'161 Patent") which covers DORYX, a tetracycline-class oral antibiotic. Warner Chilcott markets and sells DORYX delayed-release tablets in 150 PR-USA.net (press release),

Warner Chilcott files suit to protect Doryx patent  -  Jan 16, 2009
The FDA approved 75 mg and 100 mg Doryx in 2005, and the 150 mg version reached the market in 2008. When a generic drugmaker asks for approval of a new Forbes,

Market Report -- In Play ()  -  Feb 2, 2009
6958161 which covers DORYX, a tetracycline-class oral antibiotic. Briefing.com is the leading Internet provider of live market analysis for US Stock, MSN Money

Warner Chilcott Unit, Mayne Sue Over Generic Doryx  -  Jan 12, 2009
In the case filed late last month, the plaintiffs allege the defendants have infringed on the ’161 patent covering Doryx (doxycycline hyclate). FDA news (subscription),

Warner Chilcott Limited 2009 Financial Guidance Call Transcript  -  Jan 27, 2009
Let me now turn to our dermatology franchise and our expectations for DORYX, Taclonex and Dovonex in 2009. We've been extremely pleased with the growth Seeking Alpha,

IMPAX Sued Based on ANDA for Generic Doryx®  -  Jan 9, 2009
Doryx® is a tetracycline-class antibacterial indicated for rickettsial infections, sexually transmitted infections, respiratory tract infections, PR-Inside.com (Pressemitteilung),

Warner Chilcott and Mayne file patent infringement lawsuit against ...  -  Jan 19, 2009
Warner Chilcott markets and sells Doryx delayed-release tablets in 150, 100 and 75mg strengths under a licensing agreement with Mayne. Trading Markets (press release),

Sanofi horsetrading with EU on Zentiva; J&J wins round in stent case;  -  Jan 16, 2009
Chilcott and Mayne Pharma filed suit against Sandoz, the generics arm of Novartis, alleging patent infringement involving Mayne's antibiotic Doryx. FiercePharma,

Movers: Yahoo, Boeing, AT&T, SAP, Wells Fargo  -  Jan 29, 2009
Warner Chilcott Limited (WCRX) sees 2009 revenue of $1.015-$1.025 billion, primarily driven by Loestrin 24 FE, Doryx, and Taclonex, cash EPS of $1.55-$1.60. MSNBC

サンド�?抗生物質�?�後発薬�?�よる特許侵害�?��??訴�?�れる  -  Jan 19, 2009
...特殊医薬�?�?�米ワーナー・�?ルコット（Warner Chilcott）�?�16日�?�?会社�?�Mayne Pharma International�?��?テトラサイクリン系抗生物質「Doryx�?�?�関�?�る特許侵害�?�後発 IP NEXT ニュース,

Warner Chilcott sues generic drug developers  -  25 Dec 2008
08:51 AM EST Warner Chilcott Ltd. said Tuesday it filed lawsuits against several drug developers for patent infringement of its antibiotic Doryx. Forbes,

BRIEF-Warner Chilcott files lawsuits for infringement of Doryx patent  -  Dec 23, 2008
The copying, republication or redistribution of Reuters News Content, including by framing or similar means, is expressly prohibited without the prior Forbes,

Warner Chilcott Announces Receipt of Paragraph IV Certification ...  -  Dec 8, 2008
DORYX, which the Company markets and sells in 150, 100 and 75 mg strengths in the United States under a license agreement with Hospira's subsidiary, MarketWatch

Warner Chilcott Limited Q3 2008 Earnings Call Transcript  -  Nov 10, 2008
This increase was led by the sales of our key promoted products; DORYX, Loestrin 24, Taclonex, and Femcon, which continued to deliver year-over-year growth. Seeking Alpha,

Warner Chilcott Limited (WCRX)  -  Nov 13, 2008
In the dermatology category, the company manufactures Dovonex and Taclonex, external creams and ointments for treatment of psoriasis, and Doryx, Zacks.com,

UPDATE 1-Warner Chilcott Q3 profit tops estimates, ups '08 view  -  Nov 10, 2008
Sales of Doryx acne treatment soared 53 percent. Shares of the company closed at $13.40 Friday on Nasdaq. For the press release, please click Reuters

Warner Chilcott Limited (NASDAQ:WCRX) - 3Q 08 revenues and ...  -  Nov 11, 2008
We believe the company will continue to report strong top-line growth, going forward, driven by strong demand for Taclonex, Doryx, Leostrin 24 FE and Femcon Research Oracle,

Warner Chilcott Ltd - Premium Company Profile - New Research ...  -  Nov 14, 2008
Ovcon 35 and Ovcon 50, Femcon FE, Estrostep FE, Femhrt and Estrace Cream and Dermatology related products include Taclonex, Dovonex and Doryx. Live-PR.com (Pressemitteilung),

Research Oracle roundup for 11 November 2008  -  Nov 11, 2008
We believe the company will continue to report strong top-line growth, going forward, driven by strong demand for Taclonex, Doryx, Leostrin 24 FE and Femcon Research Oracle,

Warner Chilcott Ltd (NASDAQ:WCRX) - Significant decline in common ...  -  Oct 13, 2008
...unchanged as we believe the company will post strong growth in revenues driven by products such as Leostrin 24 FE, Femcon FE, Doryx and Taclonex. Research Oracle,

Research Oracle roundup for 13 October 2008  -  Oct 13, 2008
...unchanged as we believe the company will post strong growth in revenues driven by products such as Leostrin 24 FE, Femcon FE, Doryx and Taclonex. Research Oracle,

Warner Chilcott Limited (NASDAQ:WCRX) - Oral Contraceptives and ...  -  Sep 12, 2008
Going forward, we remain optimistic for the company’s performance driven by sales of promoted products such as Leostrin 24 FE, Femcon FE, Taclonex, Doryx Research Oracle,

Research Oracle roundup for 12 September 2008  -  Sep 12, 2008
Going forward, we remain optimistic for the company’s performance driven by sales of promoted products such as Leostrin 24 FE, Femcon FE, Taclonex, Doryx Research Oracle,

Warner Chilcott Limited (NASDAQ:WCRX) - Leostrin FE, Doryx and ...  -  Jul 8, 2008
Warner Chilcott Ltd. (Warner Chilcott), a leading specialty pharmaceutical company focused on women’s healthcare and dermatology in the US reported healthy Research Oracle,

FDA Safety Changes: Serevent Diskus, Letairis, Antibiotics  -  Jul 16, 2008
...doxycycline hyclate capsules (Doryx; Warner Chilcott); doxycycline hyclate film-coated tablets (Vibra-Tabs; Pfizer); and doxycycline hyclate capsules, Medscape (subscription)

2008-07-02 19:47:18 - www.companiesandmarkets.com adds new report ...  -  03 Jul 2008
Ovcon 35 and Ovcon 50, Femcon FE, Estrostep FE, Femhrt and Estrace Cream and Dermatology related products include Taclonex, Dovonex and Doryx. PR-Inside.com (Pressemitteilung),

FDA Approves 150-mg Doryx Tabs  -  Jul 1, 2008
The FDA has approved Warner Chilcott’s 150-mg strength Doryx delayed-release tablets to treat acne. The company already offers Doryx (doxycycline hyclate), FDA news (subscription),

UPDATE 1-Warner Chilcott gets FDA nod for Doryx 150mg tablets  -  Jun 23, 2008
O: Quote, Profile, Research) said it received approval from the US Food and Drug Administration for the 150mg dosage of its Doryx Delayed-Release tablets Reuters

Warner Chilcott Limited receives FDA approval for DORYX Delayed ...  -  Jun 24, 2008
DORYX Delayed-Release Tablets are a tetracycline-class oral antibiotic indicated for adjunctive treatment of severe acne. The company stated that the 150mg Trading Markets (press release),

Warner Chilcott granted approval for acne drug  -  Jun 24, 2008
By Staff Writer Warner Chilcott's Doryx delayed-release tablets are a tetracycline-class oral antibiotic indicated for adjunctive treatment of severe acne. Pharmaceutical Business Review

Research and Markets: Warner Chilcott Ltd has a Strong Portfolio ...  -  Jun 9, 2008
Ovcon 35 and Ovcon 50, Femcon FE, Estrostep FE, Femhrt and Estrace Cream and Dermatology related products include Taclonex, Dovonex and Doryx. istockAnalyst.com,

Warner Chilcott Limited Q1 2008 Earnings Call Transcript  -  May 9, 2008
The increase was primarily led by the sales of our key promoted products for LOESTRIN 24, DORYX, TACLONEX and FEMCON. LOESTRIN 24 generated revenues of Seeking Alpha,

Warner Chilcott Limited (NASDAQ:WCRX) – Company news alert for 1Q ...  -  May 9, 2008
...likely to experience strong top-line growth, going forward, primarily associated with healthy performance of Leostrin FE, Femcon FE, Taclonex and Doryx. Research Oracle,

EARNINGS WATCH Updates, advisories and surprises  -  May 9, 2008
...profit of $33.7 million, or 13 cents a share, with revenue up 5% to $229.5 million, on increased sales of Loestrin 24 FE, Doryx, Taclonex and Femcon FE. MarketWatch

FDA Safety Changes: Aredia, Avalide, Biaxin, Doryx, Monodox  -  Apr 16, 2008
Inc), doxycycline hyclate capsules (Doryx, Warner Chilcott, Inc), and doxycycline monohydrate capsules (Monodox, Watson Laboratories, Inc). Medscape (subscription)

Warner Chilcott Ltd. Q4 2007 Earnings Call Transcript  -  Feb 29, 2008
Also in Dermatology net sales of Doryx were $31.6 million in the fourth quarter of ’07 representing a 16.4% increase compared to the prior year quarter. Seeking Alpha,

Antibiotics and alcohol: Should I avoid mixing them?  -  Mar 5, 2008
Rarely, alcohol can reduce the effectiveness of certain antibiotics — such as doxycycline (Vibramycin, Doryx) — which means a higher dose may be required to MayoClinic.com

Warner Chilcott Reports Operating Results for the Quarter and Year ...  -  Feb 29, 2008
Sales of DORYX increased $4.5 million, or 16.4%, in the quarter ended December 31, 2007, compared with the prior year quarter due to increased demand and MSN Money

Warner Chilcott Issues 2008 Outlook  -  Jan 28, 2008
Warner projects 2008 revenue of $935 million to $945 million, primarily driven by oral contraceptive Loestrin 24 FE, acne drug Doryx, oral contraceptive Houston Chronicle,

Warner Chilcott Announces 2008 Financial Guidance  -  Jan 28, 2008
Total revenues for 2008 are expected to be in the range of $935 to $945 million, with the growth primarily being driven by LOESTRIN 24 FE, DORYX, FEMCON FE, CNNMoney.com

Warner Chilcott Limited Q3 2007 Earnings Call Transcript  -  Nov 10, 2007
Also in dermatology we saw an improvement in the prescription trends for Doryx. Total filled prescriptions in the quarter were up 2.2%, compared with the Seeking Alpha,

Warner Chilcott Reports Operating Results for the Quarter Ended ...  -  Nov 9, 2007
Net sales of DORYX increased $4.6 million, or 18.7%, in the quarter ended September 30, 2007 compared with the prior year quarter due to increased demand CNNMoney.com

Warner Chilcott Reports Operating Results for the Quarter Ended ...  -  Aug 10, 2007
Net sales of DORYX increased $2.9 million, or 11.4% in the quarter ended June 30, 2007 compared with the prior year quarter. DORYX prescriptions, which had CNNMoney.com

IAS: Live Virus Vaccines Touted for HIV  -  Jul 23, 2007
MedPage Today,Dr. Berkhout described a technique of creating a form of HIV that can only replicate in the presence of the antibiotic doxycycline (Doryx).

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Brand Names/Synonyms:
Doryx is also known by the following brand names and/or synonymsAlti-Doxycycline; Apo-Doxy; Atridox; DOXCYCLINE ANHYDROUS; Doryx; Doxy 100; Doxy-Caps; Doxy-Lemmon; Doxychel; Doxychel Hyclate; Doxycin; Doxycycline; Doxycycline Hyclate; Doxycycline Monohydrate; Doxylin; Doxytec; Doxytetracycline; GS-3065; Jenacyclin; Monodox; Novo-Doxylin; Nu-Doxycycline; Periostat; Supracyclin; Vibra-Tabs; Vibramycin

Drug Category:
Doryx is categorized under the following by the FDA: Antimalarials; Anti-bacterial Agents; Tetracyclines; ATC:A01AB22; ATC:J01AA02

Dosage Forms:
Tablet; Capsule; Gel; Liquid; Powder; Powder for Solution

Absorption:
completely absorbed after oral administration

Interactions:
-->Interactions for Doxycycline:

Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin.

Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations.

Absorption of tetracycline is impaired by bismuth subsalicylate.

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity.

Concurrent use of tetracycline may render oral contraceptives less effective.

Drug/Laboratory Test Interactions

False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.

Chemical IUPAC Name:
2-(amino-hydroxy-methylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

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