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DiltiazemThis page contains recent news articles, when available, and an overview of Diltiazem but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Diltiazem (when available) Diltiazem, a benzothiazepine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Diltiazem is similar to other peripheral vasodilators. Diltiazem inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. For the treatment of Hypertension Mechanism Of Action: Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, dilitiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue. News Articles on Diltiazem Dr. Gott: Allergy pills refuse to digest properly - Aug 28, 2008 Dear Dr. Gott: For the past 10 or 12 years, I have been on diltiazem for high blood pressure. I read in a book that this medication can cause liver damage, Northwest Herald, FDA Safety Changes: Evamist, Caduet, Emtriva - Sep 3, 2008 ...and coadministration of atorvastatin 40 mg with diltiazem 240 mg was also associated with higher plasma concentrations of atorvastatin. Medscape (subscription) Drugs Used in Disorders of the Heart - Aug 30, 2008 Do not take verapamil or diltiazem along with these drugs (discussed later). The safety of these drugs has not been established in pregnancy. American Chronicle, FDA Safety Changes: Reyataz and Invanz - Jul 30, 2008 Describe the appropriate use of diltiazem in patients receiving atazanavir therapy. Describe a drug interaction between carbapenems and valproic acid. Medscape (subscription) Time to Buy Elan? - Aug 4, 2008 It reformulated ordinary drugs like calcium channel blockers and naproxen, and extended the patent lives of compounds like Diltiazem, Nifedipine; Seeking Alpha, AHA Releases Guidelines for Hypertension Management in Adults With ... - Jul 16, 2008 Several drugs are contraindicated in patients with heart failure, including verapamil (Calan), diltiazem (Cardizem), clonidine (Catapres), and moxonidine RedOrbit, China Sky One Medical, Inc. Has 11 New Drugs in Clinic Trials - Jul 10, 2008 ...and obstetric hemorrhage; -- Diltiazem Hydrochloride Injection: for treatment of paroxysmal supraventricular tachycardia and unstable angina pectoris. RedOrbit, Take control of your blood pressure - Jul 9, 2008 Calcium channel blockers, such as diltiazem (Cardizem), work by dilating the arteries, he said. ACE inhibitors, such as quinapril (Accupril), LubbockOnline.com, FDA Safety Changes: Ultram ER, Reyataz, Duragesic - Jul 9, 2008 3A4 inhibitors (amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, and verapamil) can increase fentanyl plasma concentrations. Medscape (subscription) Optimizing Pain Control With Fentanyl Patches - Jul 15, 2008 Therefore, potent inhibitors such as azole antifungals, protease inhibitors, diltiazem, and macrolide antibiotics should be used cautiously in patients Medscape (subscription) MI in Pregnancy: Numbers Increasing but Management Improving - Jul 10, 2008 Of calcium-channel blockers (category C), nifedipine appears safe, but diltiazem and verapamil data are limited. ACE inhibitors and angiotensin-receptor Medscape (subscription) Ipertensione resistente: che fare? - Aug 4, 2008 ...oppure associare un calcio-antagonista diidropiridinico a verapamil (o diltiazem), o un aceinibitore con un sartano, oppure aggiungere farmaci oggi meno Pillole.org, Divi`s Labs: In good health - Jun 10, 2008 Divi's is possibly one of the top three global generic suppliers of Naproxen (arthritis), Diltiazem (anti-hypertensive) and Dextromethorphan (medication for Business Standard, Cytokinetics Provides Updates From Phase I Clinical Trials of CK ... - Jun 13, 2008 Diltiazem had no effect on either the Cmax or AUC of CK-1827452 when the two were co-administered to EM subjects, although the half-life increased slightly, CNNMoney.com Blood Pressure Medications Can Multi-Task - Jun 30, 2008 Popular ones include amlodipine (Norvasc), verapamil (Calan), nifedipine (Procardia) and diltiazem (Cardizem). ACE inhibitors: ACE (angiotensin converting Best of Times, Cytokinetics Provides Updates From Phase I Clinical Trials of CK ... - Jun 13, 2008 Diltiazem had no effect on eitherthe Cmax or AUC of CK-1827452 when the two were co-administered to EMsubjects, although the half-life increased slightly, istockAnalyst.com, Is it true that calcium supplements may interfere with blood ... - Jun 13, 2008 When taken intravenously, calcium may decrease the effects of calcium channel blockers such as nifedipine, verapamil, diltiazem and others. MayoClinic.com A 40-Year-Old Woman With Diabetes Contemplating Pregnancy After ... - Jun 3, 2008 ...channel blocker such as diltiazem for hypertensive gravidas with diabetes because of its potential benefit of reducing urinary albumin excretion. Journal of American Medical Association (subscription), Biovail Pleads Out DOJ Charges of Paying Doctors to Write ... - May 19, 2008 Cardizem LA (diltiazem) is a long-acting drug and part of a group of drugs called calcium channel blockers, which work by relaxing the muscles of your heart Patent Baristas, AGS: A Little Anticholinergic Burden Can Be Disabling - May 6, 2008 Using this scoring system, fuorsemide received a 1, as did diltiazem. Cimetidine (Tagamet) was rated 2 and oxybutynin (Ditropan) received a 3. MedPage Today, Biovail to Pay $24.6 Million to Settle Charges, Keep Federal Business - May 21, 2008 ...as much as $1000 each to induce them to prescribe or recommend Cardizem LA (diltiazem HCl) to manage blood pressure and chronic stable angina. FDA news (subscription), Biovail to close Puerto Rican plants - May 13, 2008 Concerns were raised earlier this year about possible contamination of Tiazac (diltiazem) from one of Biovail's Puerto Rico plants, which is now earmarked In-PharmaTechnologist.com, Actavis Purchases Stake in Chinese API Firm - Apr 16, 2008 The company said it is preparing for FDA inspections for the production of gabapentin, etodolac, carbidopa and diltiazem HCl. FDA news (subscription), Statin drugs sometimes cause muscle pain - Mar 26, 2008 These include amiodarone, cyclosporine, clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, nefazodone, protease inhibitors and verapamil. Biloxi Sun Herald, A medicine cabinet runs through it - 11 Mar 2008 ...read like the contents of a medicine cabinet: venlafaxine, fluoxetine, citalopram, diphenhydramine, diltiazem. Some of the compounds have been detected The Oregonian - OregonLive.com, Common Heart Drug May Reduce Cocaine Cravings - Feb 27, 2008 27, 2008) — Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high Science Daily (press release) Amiloride-insensitive Na + and fluid absorption in the mammalian ... - Mar 7, 2008 Using a rat model, it has been demonstrated that a significant portion of the AFC is diltiazem sensitive in terbutaline- or dibutyryl cGMP-stimulated AJP-Lung Physiology (subscription) Drugs Found in Watersheds of 28 Areas - Mar 9, 2008 Arlington, Texas: 5 (unspecified drugs) Atlanta: 10 (including caffeine, sulfamethoxazole, diltiazem, acetaminophen, trimethoprim, cotinine and The Associated Press Common BP drug may help reduce cocaine cravings - Feb 27, 2008 Diltiazem, one of a class of drugs known as calcium channel blockers, interrupts dopamine and glutamate association formed during chronic cocaine use. TopNews, KV Pharmaceutical Reports Record Revenues for Fiscal 2008 Third ... - Feb 27, 2008 ...contribution from the 100 mg and 200 mg strengths of Metoprolol Succinate Extended Release Tablets and our Diltiazem HCl Extended- Release Capsules. Biloxi Sun Herald, Variations in ENaC subunit composition may determine amiloride ... - Mar 7, 2008 Addition of diltiazem, pimozide, and dichlorobenzamil had minimal effects on short-circuit current. These data indicate that, at least under baseline AJP-Lung Physiology (subscription) Treatmenting Lysosomal Storage Diseases - Feb 12, 2008 The study finds two drugs -- diltiazem and verapamil -- could prove to be beneficial to patients. The research was conducted at Scripps Research Institute Ivanhoe, Tainted pills hit US mainland - Feb 19, 2008 After the flecks were spotted again on the capsules, a blood-pressure medication called Diltiazem, the plant began placing covers over drugs in carts in its FinalCall.com, Guggul - Uses and Side Effects - Mar 8, 2008 There is potential reduction in the bioavailability of single doses of diltiazem and propranolol when these drugs are given with guggul. Los Angeles Chronicle, UPI NewsTrack Health and Science News - Feb 28, 2008 28 (UPI) -- A US study suggests diltiazem, used to treat hypertension, can also reduce cocaine cravings in a rat model. Researchers from the Boston United Press International DOV Pharmaceutical, Inc. Announces Successful Restructuring of ... - Mar 3, 2008 ...a Phase IIb trial in patients with diabetic neuropathic pain in the fourth quarter of 2008 -- Partnered DOV diltiazem with Blue Note Pharmaceuticals, CNNMoney.com KV Pharmaceutical Company Completes Unaudited Fiscal 2007 Results ... - Feb 15, 2008 During fiscal 2007, ETHEX Corporation received three approvals from the FDA, including: Diltiazem HCL extended release capsules, Nystatin Topical Powder and PR Newswire (press release), Symptomatic Hyponatremia in Patients Undergoing Total Hip and Knee ... - Mar 1, 2008 Perioperative medications included atenolol, nitroglycerin, losartan, hydrochlorothiazide, diltiazem, and aspirin. The patient weighed 70 kg and was 160 cm Journal of Bone and Joint Surgery (subscription) Where are the Smith Brothers when we need them? - Feb 28, 2008 Let’s take a look at some heart medications (just typing the letters gives me a headache): Verapamil, Nicardipine, Cardizem, Diltiazem, Coreg, Nadolol, Evening Sun (subscription), FDA starts inspecting stalled Watson facility - Feb 18, 2008 ...hyperactivity disorder, and of the antihypertensives Cardizem LA (extended-release diltiazem) and Toprol XL (extended-release metoprolol succinate). OutSourcing-Pharma.com, PUERTO RICO'S DRUG FACTORIES STUMBLE ON QUALITY - Feb 11, 2008 But the company never tried to figure out whether past shipments of the drug, a blood pressure medicine called diltiazem, were contaminated, the AP reports. National Center for Policy Analysis, Elan Reports Fourth Quarter and Full-Year 2007 Financial Results - Feb 12, 2008 6.0 5.4 Focalin® XR / RitalinLA® 22.5 28.4 5.2 3.2 Diltiazem® 19.5 18.7 19.7 24.7 Other 67.9 93.9 67.3 72.8 Total 234.8 271.3 Except as noted above, WELT ONLINE, Full Text - Feb 14, 2008 The proteostasis regulators diltiazem and verapamil appear to function by inhibiting L-type Ca 2+ channels in the plasma membrane, Science Magazine (subscription) Close ended unit trusts to be listed - Feb 23, 2008 Angizem was the first product and the first branded generic of Diltiazem marketed in Sri Lanka. Subsequently many more brands in the "specialities" like Sunday Leader (subscription), News Briefs - 06 Feb 2008 After the flecks were spotted again on the capsules, a blood-pressure medication called Diltiazem, the plant began placing covers over drugs in carts in its Clanton Advertiser, Tainted capsules from Puerto Rico drug plants - 06 Feb 2008 But US regulators say the factory owner, Canadian drug maker Biovail, never tried to find out whether past shipments of the drug (Diltiazem) were WNCT, AP Executive Morning Briefing - 06 Feb 2008 After the flecks were spotted again on the capsules, a blood-pressure medication called Diltiazem, the plant began placing covers over drugs in carts in its The Associated Press Tainted Pills Hit US Mainland - 06 Feb 2008 After the flecks were spotted again on the capsules, a blood-pressure medication called diltiazem, the plant began placing covers over drugs in carts in its The Associated Press Blood pressure drug 'cuts Parkinson's risk' according to new research - 06 Feb 2008 Examples of calcium channel blockers are verapamil and diltiazem. However, other blood pressure medications, such as beta blockers and ACE inhibitors, Daily Mail, Scripps scientists find calcium channel blockers help normalize ... - Feb 4, 2008 The research team found that the hypertension drugs diltiazem and verapamil increased the overall function of mutant lysosomal enzymes associated with the EurekAlert (press release), Biovail Target of Grand Jury Probe Over Cardizem - Feb 4, 2008 The investigation focuses on the Cardizem LA (diltiazem HCl) clinical program, Proving LA through Clinical Experience (PLACE). FDA news (subscription), Federal grand jury investigates Biovail over Cardizem LA - Feb 1, 2008 Toronto, ON - Biovail, the Canadian manufacturer of a long-acting calcium-channel blocker product, Cardizem LA (diltiazem), has announced that it is being TheHeart.Org, Tainted Pills Hit US Mainland - Feb 5, 2008 After the flecks were spotted again on the capsules, a blood-pressure medication called Diltiazem, the plant began placing covers over drugs in carts in its Washington Post, Dr. McGeorge Reports Deadliest Drugs Children Can Swallow - Jan 16, 2008 The most dangerous drugs in this group are a class called calcium channel blockers, such as diltiazem or cardizem. No. 2 on the list is narcotics, WDIV, Too Much of a Good Thing - 20 Dec 2007 And for grapefruit juice lovers, an interaction may increase the potency of certain medications such as atorvastatin (Lipitor) and diltiazem (Cardizem). Gather.com, Watson Settlement Meets Bated Enthusiasm - Dec 4, 2007 ...maker Watson said it will launch a version of Biovail's Cardizem LA and receive a royalty based on sales of Watson's generic Cardizem, called diltiazem. Houston Chronicle, Biovail, Watson Pharma Settle - Dec 4, 2007 ...suit against Watson's subsidiary Andrx Pharmaceuticals over its plans to make a generic formulation of Cardizem LA (a once-daily version of diltiazem), TheStreet.com Watson, Biovail settle patent dispute - Dec 4, 2007 Biovail said it would receive a royalty based on sales of Watson's generic Cardizem, called diltiazem. Biovail had sued Watson's subsidiary Andrx CNNMoney.com Watson and Biovail Settle Lawsuit Over Cardizem(R) LA - Dec 4, 2007 ...against Andrx Pharmaceuticals, Inc., a subsidiary of Watson, related to Andrx's generic version of Cardizem(R) LA (diltiazem extended-release tablets). CNNMoney.com Watson, Biovail Settle Cardizem LA Suit - Dec 11, 2007 ...between Biovail and Andrx Pharmaceuticals, a subsidiary of Watson, related to Andrx’s application for a generic version of Cardizem LA (diltiazem HCl). FDA news (subscription), Biovail Announces Proposed Settlement Of US Securities Class ... - Dec 11, 2007 Biovail's once-daily formulation of Diltiazem last week , announced a proposed settlement of US securities class action suit filed in June 2004. RTT News, Watson Pharma., Biovail Settle Cardizem LA Patent Case - Quick Facts - Dec 4, 2007 ...on Tuesday revealed a settlement on outstanding patent litigation related to the generic version of Cardizem LA or diltiazem extended-release tablets. Trading Markets (press release), History Repeats - Biovail Crafts Deal With Watson Pharma To Keep ... - Dec 4, 2007 The long drawn-out patent suit related to Andrx's attempt to market a generic version of Cardizem LA, Biovail's once-daily formulation of Diltiazem came to RTT News, Prophylactic Migraine Medications - Dec 13, 2007 The CCBs used in preventing migraines are verapamil (Calan, Verelan, Isoptin), diltiazem (Cardizem, Dilacor, Tiazac), and nimodipine. American Chronicle, KV Pharmaceutical Company Reports Record Revenues for Fiscal 2008 ... - Nov 20, 2007 The Company expects increased contribution from both Diltiazem hcl Extended Release Capsules and its two strengths of Metoprolol Succinate Extended Release PR Newswire (press release), Pharmaceutical patent round-up - Dec 13, 2007 The litigation was against Watson's subsidiary Andrx Pharmaceuticals and was in regards to Andrx's generic version of Cardizem LA (diltiazem In-PharmaTechnologist.com, Biovail Announces Settlement - Dec 4, 2007 Inc. related to Andrx?s abbreviated new drug application for a generic version of Cardizem ® LA, Biovail?s once-daily formulation of diltiazem. Ad-Hoc-News (Pressemitteilung), The Ongoing Regulation of Generic Drugs - Nov 14, 2007 Such settlements occurred for K-Dur (potassium chloride), Cardizem (diltiazem), and Nolvadex (tamoxifen), among other drugs. These settlements have been New England Journal of Medicine (subscription), HIV Care is Growing in Complexity - Oct 19, 2007 ...simvastatin, atorvastatin), calcium channel blockers (both dihydropyridine [eg, nifedipine] and nondihydropyridine [eg, verapamil and diltiazem]), Renal and Urology News, Elan Reports Third Quarter 2007 Financial Results - Oct 25, 2007 Tricor(R) 36.0 42.2 10.3 10.6 Skelaxin(R) 24.7 28.1 5.4 7.5 Focalin(R) XR / ritalinla(R) 16.6 23.0 4.4 5.7 Diltiazem(R) 14.3 15.5 7.8 5.2 Verelan(R) American Digital Networks (press release), Brand Names/Synonyms: Diltiazem is also known by the following brand names and/or synonymsAcalix; Anoheal; Adizem; Altiazem; Anginyl; Angizem; Apo-Diltiaz; Britiazim; Bruzem; Calcicard; Cardizem; Cardizem CD; Cardizem SR; Cardizen LA; Cartia XT; Citizem; Cormax; Deltazen; Dilacor; Dilacor-XR; Diladel; Dilcontin; Dilpral; Dilrene; Dilt-cd; Dilta-Hexal; Diltia; Dilticard; Dilzem; Dilzen; Endrydil; Herbesser; Incoril AP; Masdil; Novo-Diltazem; Nu-Diltiaz; Syn-Diltiazem; Tiazac Tildiem; d-cis-Diltiazem Drug Category: Diltiazem is categorized under the following by the FDA: Vasodilator Agents; Cardiovascular Agents; Antihypertensive Agents; Calcium-channel blocking agents; ATC:C08DB01 Dosage Forms: SOLUTION Absorption: Diltiazem is well absorbed from the gastrointestinal tract but undergoes substantial hepatic first-pass effect. Interactions: Interactions for Diltiazem: Due to the potential for additive effects, caution and careful titration are warranted in patients receiving diltiazem hydrochloride concomitantly with other agents known to affect cardiac contractility and/or conduction. Pharmacologic studies indicate that there may be additive effects in prolonging AV conduction when using beta-blockers or digitalis concomitantly with Tiazac. As with all drugs, care should be exercised when treating patients with multiple medications. Diltiazem is both a substrate and an inhibitor of the cytochrome P-450 3A4 enzyme system. Other drugs that are specific substrates, inhibitors, or inducers of the enzyme system may have a significant impact on the efficacy and side effect profile of diltiazem. Patients taking other drugs that are substrates of CYP450 3A4, especially patients with renal and/or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels. Beta Blockers Controlled and uncontrolled domestic studies suggest that concomitant use of diltiazem hydrochloride and beta-blockers is usually well tolerated, but available data are not sufficient to predict the effects of concomitant treatment in patients with left ventricular dysfunction or cardiac conduction abnormalities. Administration of diltiazem hydrochloride concomitantly with propranolol in five normal volunteers resulted in increased propranolol levels in all subjects and bioavailability of propranolol was increased approximately 50%. In vitro, propranolol appears to be displaced from its binding sites by diltiazem. If combination therapy is initiated or withdrawn in conjunction with propranolol, an adjustment in the propranolol dose may be warranted. Cimetidine A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and AUC (53%) after a 1-week course of cimetidine 1200 mg/day and a single dose of diltiazem 60mg. Ranitidine produced smaller, nonsignificant increases. The effect may be mediated by cimetidine's known inhibition of hepatic cytochrome P-450, the enzyme system responsible for the first-pass metabolism of diltiazem. Patients currently receiving diltiazem therapy should be carefully monitored for a change in pharmacological effect when initiating and discontinuing therapy with cimetidine. An adjustment in the diltiazem dose may be warranted. Digitalis Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under-digitalization. Anesthetics The depression of cardiac contractility, conductivity, and automaticity as well as the vascular dilation associated with anesthetics may be potentiated by calcium channel blockers. When used concomitantly, anesthetics and calcium channel blockers should be titrated carefully. Cyclosporine A pharmacokinetic interaction between diltiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of diltiazem. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted, or discontinued. The effect of cyclosporine on diltiazem plasma concentrations has not been evaluated. Carbamazepine Concomitant administration of diltiazem with carbamazepine has been reported to result in elevated serum levels of carbamazepine (40% to 72% increase), resulting in toxicity in some cases. Patients receiving these drugs concurrently should be monitored for a potential drug interaction. Benzodiazepines Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3-4 fold and the Cmax by 2-fold, compared to placebo. The elimination half life of midazolam and triazolam also increased (1.5-2.5 fold) during coadministration with diltiazem. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sodation)of both midazolam and triazolam. Lovastatin In a ten-subject study, coadministration of diltiazem (120 mg bid) with lovastatin resulted in a 3-4 times increase in mean lovastatin AUC and Cmax vs. lovastatin alone; no change in pravastatin AUC and Cmax was observed during diltiazem coadministration. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin. Rifampin Coadministration of rifampin with diltiazem lowered the diltiazem plasma concentrations to undetectable levels. Coadministration of diltiazem with rifampin or any known CYP3A4 inducer should be avoided when possible, and alternative therapy considered. Chemical IUPAC Name: [2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate : |
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