Dextromethorphan

This page contains recent news articles, when available, and an overview of Dextromethorphan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Dextromethorphan
(when available)

Pharmacology and use:
Suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. For treatment and relief of dry cough

Mechanism Of Action:
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan.

News Articles on Dextromethorphan

NACDS supports congressional crackdown on dextromethorphan  -  ‎Apr 4, 2009‎
HR 1259, the Dextromethorphan (DMX) Distribution Act, passed the House on March 31 with a vote of 407 to eight. The bill amends the Federal Food, Drug, Modern Medicine

House passes bill limiting sale of cough syrup ingredient  -  ‎Mar 31, 2009‎
A non-narcotic cough suppressant used in over-the-counter medicines, dextromethorphan or DMX can produce hallucinations and other effects when taken in Detroit Free Press

Mike McIntyre's Word on Washington  -  ‎Apr 14, 2009‎
Third, I was pleased to support the Dextromethorphan Distribution Act, also known as the cough syrup bill. This measure will crack down on the bulk sale of Lumina News

Recognizing Psychiatric and Cognitive Complications in Parkinson's ...  -  ‎Apr 17, 2009‎
Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Ann Neurol. 2006;59:780-787. Phuong L, Garg S, Medscape

Rehab program in Plano offers performance as part of therapy for teens  -  ‎Mar 30, 2009‎
He had been robo-tripping, a fad among teens in which they consume cough syrups that contain the drug Dextromethorphan, like Robitussin DM, in excess. Pegasus News

House Meets At... 10:30 am: Morning Hour  -  ‎Mar 31, 2009‎
Burgess - Energy and Commerce) 3) HR 1259 - Dextromethorphan Distribution Act of 2009 (Rep. Upton – Energy and Commerce) 4) HR 577 - Vision Care for Kids Congress Matters

AVANIR Provides Clinical and Corporate Updates  -  ‎Apr 1, 2009‎
Zenvia is a combination of two well-characterized compounds: the therapeutically active ingredient dextromethorphan and the enzyme inhibitor quinidine, Business Wire (press release)

1 in 5 teens used prescription drugs illegally  -  ‎Apr 1, 2009‎
The cold remedies are valued for an ingredient called dextromethorphan, which can cause hallucinations. The high school meetings come after the county OCRegister

Medication abuse — ‘legal high’ a danger for teens  -  ‎Apr 1, 2009‎
Dextromethorphan, or DXM, is a narcotic found in over-the-counter cold medicines and there have been reports of it being used as a recreational drug. Fenton Tri County Times

It’s like punk rock, only it’sa pig  -  ‎Apr 3, 2009‎
I pointed at the implements of instruction and jabbered through a mental fog of phenylephrine and dextromethorphan: “What are those for? Brandeis Hoot

Live the dream  -  ‎Apr 3, 2009‎
With Yale’s body overflowing with dextromethorphan, it’s easy to overlook that this sexy Bombay club was a New Haven, vegetarian, Indian restaurant a mere Yale Daily News

Merchants face fines for selling cold medicine to teens  -  ‎Mar 31, 2009‎
In both cases, the clerks sold the medicine in violation of Suffolk County Local Law 15-2007, which prohibits the sale of Dextromethorphan (DXM) to anyone EmpireStateNews.net

Sức Ä‘á»? kháng yếu, cần phòng ho khi thay đổi thá»?i tiết  -  ‎Apr 17, 2009‎
Nhi�u nghiên cứu y dược hiện đại đã chứng minh mật ong có tác dụng giảm ho còn tốt hơn cả Dextromethorphan (một hoạt chất trừ ho được sử dụng phổ biến). VietNamNet

Gesetz für Dextromethorphan  -  ‎Mar 31, 2009‎
Berlin - In den USA könnte der Vertriebsstatus des Hustenstillers Dextromethorphan schon bald beschränkt werden. Dem US-Repräsentantenhaus liegt derzeit der apotheke-adhoc

Dùng thuốc trong thai kỳ  -  ‎Apr 10, 2009‎
Dược chất có tác dụng dập tắt những cÆ¡n ho là dextromethorphan gần đây cÅ©ng bị nhiá»?u tai tiếng. Lý do, có nhiá»?u nghiên cứu cho thấy chất dextromethorphan có Thanh Niên

20 triệu chứng không được bá»? qua (tiếp theo)  -  ‎Apr 14, 2009‎
Nếu bạn bị ho hoặc bị ngứa khó chịu trong cổ khi bị viêm há»?ng, hãy súc miệng vá»›i nước muối và uống thuốc chứa dextromethorphan có công hiệu trong vòng 30 Báo Thể Thao TPHCM

Teens getting high off every day drugs  -  18 Mar 2009
..."The danger of dextromethorphan, which is in those types of drugs, is that it can cause heart arythmias, especially when taken in abnormal doses," family WFIE-TV

Zenvia Phase III PBA Trial Completes Patient Enrollment  -  18 Mar 2009
Zenvia is a combination of two well-characterized compounds: the therapeutically active ingredient dextromethorphan and the enzyme inhibitor quinidine, Medical News Today (press release)

North Carolina mom warns of cough medicine abuse among teens  -  ‎Mar 16, 2009‎
..."Over the counter cough medicines often contain dextromethorphan, which is an excellent cough suppressant and when used appropriately is a great product. WBIR-TV

Concert Pharmaceuticals Announces Positive Results from Phase I ...  -  ‎Mar 16, 2009‎
In this portion of the study, women dosed with CTP-347 substantially retained their ability to metabolize dextromethorphan, suggesting that time-dependent Business Wire (press release)

BONO MACK WORKS TO PREVENT ABUSE OF OVER-THE-COUNTER DRUGS  -  ‎Mar 4, 2009‎
The Dextromethorphan Distribution Act will help curb the alarming increase in DXM abuse – especially among youth – in recent years. California Chronicle

Over-the-counter high destroys young life  -  ‎Feb 20, 2009‎
Allen and his friends turned to Dextromethorphan, an ingredient in over-the-counter medication. “This is an inexpensive way to get high,� he said. Newton Kansan

Danger lurks in medications  -  ‎Mar 13, 2009‎
...“Almost all these contain dextromethorphan,� said Melewsky, pointing to a shelf full of products sold under the brand names of Coricidin, Nyquil, Vicks, Republican & Herald

Reader says milk of magnesia helps skin  -  ‎Feb 23, 2009‎
Dextromethorphan (DM) is the leading ingredient in most over-the-counter cough medicines. Its effectiveness has been controversial, particularly in children Newsday

Abuse of over-the-counter cold medications top methamphetamine ...  -  ‎Mar 8, 2009‎
Beckwith's oldest daughter, Shae, died in 2004 at age 20 of an overdose of dextromethorphan, the active ingredient in many over-the-counter cough Press-Enterprise

Parents told not to give cough and cold remedies  -  ‎Feb 28, 2009‎
...promethazine, triprolidine and doxylamine; the cough suppressants dextromethorphan and pholcodine, and the expectorants guaifenesin and ipecacuanha. Telegraph.co.uk

How is Congress spending its time — and our money? (Part 3)  -  ‎Mar 5, 2009‎
HR1259 - To amend the Federal Food, Drug, and Cosmetic Act with respect to the distribution of the drug dextromethorphan, and for other purposes. Liberty Maven

How to Buy Ourselves Out of a Depression: A Shopping List  -  ‎Mar 4, 2009‎
Dextromethorphan is an active ingredient. The illusion of cherries makes this the most desirable drug for sleep-stimulation. Brazzers.com 12-Month Cornell University The Cornell Daily Sun

Honey Naturals to Unveil ZarBee's All-Natural Children's Cough ...  -  ‎Feb 25, 2009‎
According to a recent Penn State research trial, dark honey has been proven to be safer and more effective than Dextromethorphan, the active ingredient in MarketWatch (press release)

Pet droppings topic of Yongsan griping  -  ‎Feb 24, 2009‎
She said she has seen three cases of adolescents using over-the-counter medicines containing dextromethorphan, which has hallucinogenic properties. Stars and Stripes

Open eyes, dialog best tools against drug abuse and addiction  -  ‎Mar 2, 2009‎
Whether it be scoring over-the-counter cough medicines like Coricidin, which contain dextromethorphan and when taken in large doses produce a Petoskey News-Review

Fact or Urban Legend? Vicks VapoRub on the Feet to Suppress a Cough?  -  ‎Feb 20, 2009‎
I really had my doubts but since I am allergic to dextromethorphan (the "DM" in most over the counter cough suppressants) I decided to give it a try. Tipp City Independent Voice

It's 11 PM: Do You Know If Your Children Are Sniffling?  -  ‎Feb 19, 2009‎
..."But there is some value to using plain cough syrup, such as Delsym for children over 2 and the DM (Dextromethorphan) preparations, such as Robitussin DM. Jewish Exponent

AVNR: Completes Enrollemtn for Ph III Trial of Zenvia(TM)  -  ‎Mar 16, 2009‎
...a confirmatory Phase III trial of Zenvia(TM) (dextromethorphan/quinidine [DM/Q]) in patients exhibiting signs and symptoms of pseudobulbar affect (PBA). Trading Markets (press release)

أدوية نينوى تنتج مستحضرين جديدين Ù?ÙŠ العراق  -  ‎Mar 2, 2009‎
ولÙ?ت إلى انه إنتاج هذا المستحضر الأول من نوعه Ù?ÙŠ العراق كشراب ØŒ وبتركيزml 15 ØŒ للمادة الÙ?عالة dextromethorphan. وأضاÙ? المصدر ان الشركة أنتجت ولأول مرة Ù?ÙŠ أصوات العراق

Erkältungsmittel zurück in die Apotheke  -  ‎Mar 5, 2009‎
Betroffen von der Neuregelung sind unter anderem das Antitussivum Dextromethorphan, die Expektoranzien Guaifenesin und Ipecacuanha, Nasentropfen mit apotheke-adhoc

COLUMN: America's pill-popping problem  -  04 Feb 2009
Many people tell tales of friends who battled addictions to things like caffeine pills, dextromethorphan (the main ingredient in most cough syrups), USD Volante Online,

Concerns raised about cold drugs  -  Feb 2, 2009
...“The active ingredient that actually gets them high is dextromethorphan, and that’s in just about every cough medicine,� Williamson said. Richmond County Daily Journal,

5-year-old dies of drug overdose  -  Jan 27, 2009
Cedrick Smith's test results showed high levels of Oxycodone and Dextromethorphan, Chief Deputy Coroner Jeffrey Wells said. Wells said Tuesday that the Munster Times,

Toxicology tests show Gary tot died of pain pill overdose  -  Jan 27, 2009
A toxicology report revealed lethal doses of oxycodone and dextromethorphan, Lake County Chief Deputy Coroner Jeff Wells said. Gary Post Tribune,

Survey shows prescription drug abuse remains high; marijuana use ...  -  Jan 21, 2009
There was also positive news in the abuse of over-the-counter cough medicines containing dextromethorphan (DXM). There was a decline is use among 8th and White Mountain Independent,

Robotripping: Overdosing on cough syrup on the rise  -  Jan 9, 2009
The ingredient in cough syrup that gives abusers a high is called Dextromethorphan, or DXM. A normal dose contains 20 milligrams and is taken every four NewsChannel 9 WSYR,

Former prosecutor to run for Danville commonwealth's attorney  -  Jan 16, 2009
His accomplishments as a prosecutor include an involuntary manslaughter conviction in the death of a young man from an overdose of dextromethorphan (DXM), Chatham Star Tribune,

The Household Medicine Chest Presents Yet Another Dangerous  -  Jan 16, 2009
If that syrup contains the drug Dextromethorphan and if that syrup is stored in the family medicine chest between uses, it presents yet another threat to TransWorldNews (press release),

Treatment options for respiratory infections  -  Jan 27, 2009
Honey, which was recently shown to be as effective as dextromethorphan for treating cough in children, 21 is another example (for more information, Clinical Advisor,

Can’t cure cold but sure can fight one  -  Jan 16, 2009
Dextromethorphan is America’s cough suppressant, but it will make you feel weird. It is abused as a hallucinogen. It can produce some pretty fascinating Greenwood Commonwealth,

Bee products are generating a lot of buzz  -  Jan 25, 2009
Researchers at Penn State College of Medicine recently compared honey with a cough suppressant called dextromethorphan and found that honey worked better. Chicago Daily Herald,

Reason for GVSU students' deaths called 'undetermined'  -  Jan 15, 2009
...plus five medications -- antidepressants Bupropion, Trazodone and Citalupram; dextromethorphan, a cough suppressant and acetaminophen, a pain reliever. Muskegon Chronicle - MLive.com,

What treatments work for bronchitis?  -  Jan 21, 2009
Overall, the research doesn't show clearly whether cough suppressants work or not. dextromethorphan (one brand is Benylin Dry Coughs Non Drowsy). guardian.co.uk,

Common cold  -  Jan 21, 2009
These often contain the drug dextromethorphan. Other cough medicines aim to help you cough up mucus. These often contain the drug guaifenesin. guardian.co.uk,

Cough/Cold Products and Vapor Rub  -  Jan 22, 2009
Antitussives like dextromethorphan which is in Vicks 44 or Delsym can help stop dry, hacking, nonproductive coughs. You can also use diphenhydramine but it ABC7Chicago.com,

Children's cough and cold medicines: advice for parents  -  Jan 21, 2009
One example is dextromethorphan. Cough expectorants, which aim to help you cough up mucus. One example is guaifenesin. Antihistamines, which aim to reduce guardian.co.uk,

Research and Markets: Top Three Drugs by Sales in Kazakhstan were ...  -  Jan 27, 2009
Novartis' over-the-counter (OTC) flu treatment Theraflu (acetaminophen + chlorpheniramine + dextromethorphan + phenylephrine + pheniramine + MarketWatch (press release)

PHYSICIAN LAUNCHES NATURAL PRODUCT AS ALTERNATIVE TO CONTROVERSIAL ...  -  Jan 26, 2009
A 2007 Penn State study found Buckwheat Honey to be just as effective as treating symptoms as the main cough suppressant drug, Dextromethorphan (DM). Mass Media Distribution LLC (press release),

Join the Fight Against Cough Medicine Abuse  -  Jan 19, 2009
Nicknamed “robotripping� after the cough syrup Robitussin, those abusing these substances are using the main ingredient Dextromethorphan, known as DXM to HealthNews,

Coughing fits  -  Jan 17, 2009
...age 2 through 18 with a tablespoon of buckwheat honey, honey-flavored dextromethorphan (DM), a cough suppressant and no treatment for nocturnal coughs. St. Joseph News-Press,

Cold or flu?  -  Jan 12, 2009
For example, people with chest congestion and coughing should avoid dextromethorphan, a cough suppressant, because they likely will need to cough up mucus. Times Daily,

Slices of living brain tissue are helping scientists identify new ...  -  Jan 21, 2009
He's also studying two sigma receptor ligands, dextromethorphan and carbetapentane. Sigma receptors are ubiquitous in the body, but little is known about PhysOrg.com,

Was verbirgt sich eigentlich hinter einem Husten?  -  Jan 20, 2009
Wirkstoffe sind zum Beispiel Codein, Hydrocodon oder Dextromethorphan. Um die Schleimhautentzündung im Hals und in den Bronchien zu lindern, können außerdem WELT ONLINE,

Brand Names/Synonyms:
Dextromethorphan is also known by the following brand names and/or synonyms&Laquo;Delta&Raquo;-Methorphan; Antussan; Ba 2666; Balminil Dm; Balminil Dm Children; Benylin Adult Formula Cough Suppressant; Benylin Dm; Benylin Dm 12 Hour; Benylin Dm for Children; Benylin Dm for Children 12 Hour; Benylin Pediatric Cough Suppressant; Calmylin #1; Canfodion; Cosylan; Cough-X; Creo-Terpin; D-Methorphan; D-Methorphan Hydrobromide; Dea No. 9210; Delsym; Delsym Cough Formula; Delta-Methorphan; Demorphan; Demorphan Hydrobromide; Demorphine; Destrometerfano [Dcit]; Dextromethorfan; Dextromethorfan [Czech]; Dextromethorphan; Dextromethorphan Bromhydrate; Dextromethorphan Bromide; Dextromethorphan [Ban:Inn]; Dextrometorfano [Inn-Spanish]; Dextrometorphan; Dextromorphan; Dexyromethorphan; Diabe-Tuss Dm Syrup; Dormetan; Dormethan; Hihustan M.; Hold Dm; Koffex Dm; L-Methorphan; Levomethorphan; Levomethorphan [Ban:Dcf:Inn]; Levomethorphane [Inn-French]; Levomethorphanum [Inn-Latin]; Levometorfano [Inn-Spanish]; Medicon; Methorate Hydrobromide; Methorphan; Metrorat; Novahistex Dm; Novahistine Dm; Pertussin Cs Children's Strength; Pertussin Dm Extra Strength; Racemethorphan [As D-Form]; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Romilar; Sucrets 4 Hour Cough Suppressant; Triaminic Dm Long Lasting for Children; Trocal; Tusilan; Tussade; Vicks 44 Cough Relief

Drug Category:
Dextromethorphan is categorized under the following by the FDA: Antitussives; Analgesics; Antitussives; ATC:R05DA09

Dosage Forms:
SYRUP

Absorption:
Not Available

Interactions:
Not Available



Chemical IUPAC Name:
Not Available

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