Depo-Provera

This page contains recent news articles, when available, and an overview of Depo-Provera but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Depo-Provera
(when available)

Pharmacology and use:
Progesterone is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Progesterone tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries. For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.

Mechanism Of Action:
Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

News Articles on Progesterone

Learn the truth about birth control  -  ‎Apr 17, 2009‎
First, any hormonal birth control, such as birth-control pills, Depo-provera injections and Norplant implants, work primarily by causing temporary DesMoinesRegister.com

Were You Hurt By Hormone Replacement Therapy (HRT)?  -  ‎Apr 6, 2009‎
Doctors believed until recently that long-term use of hormone replacement therapy (HRT) drugs such as Premarin, Depo Provera, and Prempro were safe. InjuryBoard.com

How Savvy Are Girls About Pregnancy and STDs?  -  ‎Apr 18, 2009‎
I knew one girl in high school, and now one in college, on Depo-Provera (the birth control shot), but that's the only exception. The Santa Barbara Independent

Your Life: Dizzying Heights Left Me Feeling Peaky  -  ‎Mar 28, 2009‎
A Depo Provera, the contraceptive injection, is given every 12 weeks to ensure you are protected. The average time to start ovulating again (producing eggs) Glasgow Sunday Mail

Just think-you might not need to have a period ever again!  -  ‎Apr 11, 2009‎
Depo-Provera, a contraceptive injection that lasts for 12 weeks, stops you having a period. And a type of contraceptive called Seasonale, available in Vanguard

What are the birth control alternatives for women who don't want ...  -  ‎Mar 30, 2009‎
Depo Provera shots are another option and require a visit to the doctor's office every 12 weeks for a shot. An even simpler option is Implanon, Asheville Citizen-Times

What's new in osteoporosis: report of the 8th International ...  -  ‎Apr 9, 2009‎
Medroxyprogesterone acetate (Depo-Provera, DMPA; Pharmacia & Upjohn) is also associated with bone loss and carries an FDA “black box� warning label to that Endocrine Today

On World Health Day, ADRA Recognizes Pivotal Role of Health in ...  -  ‎Apr 7, 2009‎
After taking part in the project, he and his wife chose to adopt usage of Depo-Provera, a commonly used contraceptive. "Now, I don't have any fear of Reuters AlertNet

FSRH Response To Introduction Of Pilot Scheme,Oxfordshire, England ...  -  ‎Mar 30, 2009‎
LARCS include copper and hormonal devices worn within the womb ('coils'), the implant ('Implanon') and injectables (the most commonly used is Depo Provera). Medical News Today (press release)

Is Your Depo-Provera Causing Weight Gain?  -  ‎Mar 4, 2009‎
Depo-Provera, the progesterone-only birth control shot, has a lot of advantages: It's given once every three months in your doctor's office, U.S. News & World Report

Talking about contraceptives  -  ‎Mar 11, 2009‎
Birth control measures aren’t just limited to condoms and the pill: recent developments such as the NuvaRing and Depo-Provera injections are also available. NYU Washington Square News

Which Birth Control Is the Most Effective?  -  ‎Mar 14, 2009‎
Other hormone-related options, including birth control pills, the OrthoEvra patch, the NuvaRing vaginal ring and progestin injections like Depo-Provera, EmpowHer

Study: Birth-control shot causes weight gain, body fat  -  ‎Mar 6, 2009‎
The contraceptive, also known by the brand name Depo-Provera, is used by about 2 million American women, including 400000 teenagers. Newsday

Injectable Contraceptive Linked to Weight Gain  -  ‎Mar 6, 2009‎
Explain to interested patients that while many women use the injectable contraceptive depot medroxyprogesterone acetate (Depo-Provera), there are concerns MedPage Today

Chronic Pelvic Pain: Diagnosis and Treatment  -  ‎Mar 10, 2009‎
The primary options are medical: nonsteroidal anti-inflammatory drugs (NSAIDs) for the pain, continuous oral contraceptives or a shot of Depo-Provera, EmpowHer

The Naked Truth: A long explanation of female birth control  -  ‎Mar 5, 2009‎
Hormonal birth-control methods such as the pill, patch, vaginal ring, Depo-Provera shot or Implanon stop the woman’s ovaries from releasing an egg each JackCentral

Be the first to rate this article:  -  ‎Mar 5, 2009‎
...birth control pills or other types of birth control, such as intrauterine devices (IUDs), Depo-Provera, or tubal ligation will NOT protect you from HIV Great Dad

Lifestyle: Three things you can do to reduce your chances of cancer  -  ‎Mar 4, 2009‎
Contraceptive has high cancer risk - Depo-Provera, the long-lasting contraceptive that can be injected, doubles the risk of breast cancer among women who What Doctors Don't Tell You

Health Buzz: Supreme Court Phenergan Ruling and Other Health News  -  ‎Mar 5, 2009‎
Depo-Provera, the progesterone-only birth control shot, has a lot of advantages, but there's one big drawback: weight gain, enough to make you go up one or U.S. News & World Report

Given A Choice  -  ‎Mar 2, 2009‎
Gruia shrank from the idea of sterilization, so she welcomed the suggestion that she use Depo-Provera, an injectable contraceptive. Transitions Online

Family planning may suffer as economy declines  -  ‎Mar 9, 2009‎
Many are looking for longer-acting contraceptives, such as Depo-Provera, a three-month shot, so they don't have to worry about paying for more frequent Chicago Tribune

Cross Atlantic Commodities Inc. Signs LOI to Acquire Million ...  -  ‎Mar 10, 2009‎
The advisory panel consists of pharmaceutical experts who have launched products producing billions of dollars in revenue including Xanax, Depo Provera, MSNBC

Court stops Teva's launch of Evista copycat; Forest wins patent ...  -  ‎Mar 10, 2009‎
Women using depot medroxyprogesterone acetate (DMPA), a birth control shot sold by Pfizer under the name Depo-Provera, gained an average of 11 pounds and FiercePharma

Pfizer, Aurobindo in deal to sell generic drugs  -  ‎Mar 3, 2009‎
Last year, Medrol, anti-anxiety drug Xanax, injectable contraceptive Depo-Provera and two other medicines marketed by the Greenstone subsidiary got The Associated Press

Studies Find Contraception Makes Women Obese and Newborns Too Thin  -  ‎Mar 9, 2009‎
...commercially known as Depo-Provera, which is delivered in the form of a shot, and found that DMPA users were more than twice as likely to become obese Lifesite

Playing It Safe Down Under  -  ‎Mar 2, 2009‎
The first type is a shot of Depo-Provera, which will last three months, or Lunelle, which will last one month. Another form is the contraceptive patch, New University Online

Juan Pedro Oriol  -  ‎Mar 8, 2009‎
No se les facilitará dinero en lĂ­quido, más bien decenas de millones de pĂ­ldoras abortivas, condones, Norplant, NorLevo y Depo-Provera irán directo a grupos Mural (Suscripción)

Contraccezione: Medrossiprogesterone depot associato a riduzione ...  -  ‎Mar 4, 2009‎
...riguardo agli effetti del Medrossiprogesterone acetato depot ( DMPA, Depo-Provera ), un contraccettivo per via iniettiva, sulla densitĂ  minerale ossea. XagenaSalute

La Ortiga: Peruanadas a pasto (I)  -  ‎Feb 28, 2009‎
...como el laboratorio farmacĂ©utico Pfizer, fabricantes de Viagra (pa que se le pare a uno) y nada menos que varios anticonceptivos, como el Depo-Provera. Correo (Perú)

Post abortion care gets some valuable attention  -  04 Feb 2009
To this end, after women are counselled they may choose a family planning method, which can range from Depo-Provera injections to the birth control pill to DailyNewsOnline,

Diary of a nameless, faceless egg donor, Jennifer Lahl interviews ...  -  04 Feb 2009
I also know of people who had bad reactions to Depo-Provera which acts by similar principles. Though these reactions may be considered “rare� to the medical Proud Parenting

Young: Back to bake sales for abstinence-only cause  -  Feb 2, 2009
...at age-appropriate levels, inform youngsters about contraception -- how the birth-control pill works, or the IUD, or injections of Depo-Provera. Seattle Post Intelligencer

Birth control a friendly but risky alternative to condoms  -  Jan 28, 2009
A prime example is the Depo-Provera birth control shot, which protects against pregnancy for 11-14 weeks. Also, with Depo-Provera there is a black box Tiger Weekly,

Types of hormone treatment  -  Jan 21, 2009
You can take medroxyprogesterone as a pill (called Provera) or as an injection (called Depo-Provera). If you have the injections, you'll need them every two guardian.co.uk,

Knowledge: The Noninvasive Birth Control  -  Jan 26, 2009
The pill has been linked to higher breast cancer risk, the Depo Provera shot to infertility and osteoporosis, and the Mirena IUD to spontaneous abortions Natural News.com,

Risk factors for fibroids  -  Jan 21, 2009
...to get fibroids[5] You've had injections of a contraceptive called medroxyprogesterone (brand names include Depo-Provera) at a dose of 150 milligrams. guardian.co.uk,

Manhattan Research Releases Top Pharma Brand Product Sites by ...  -  Feb 3, 2009
Botox, Caduet, Chantix, Cialis, Concerta, Crestor, Cymbalta, Depakote, Depo-Provera, Detrol LA, Effexor XR, Enbrel, Flomax, Flonase, Flovent, Fosamax, PR Web (press release),

It's time to think again about your choice of contraception  -  Jan 25, 2009
The long-acting injection (eg, Depo-Provera) contains progestogen (as found in the mini-Pill) and is given into the buttock every 8-12 weeks. Times Online,

Should You Stop Taking Birth Control Pills if You're Over 35?  -  Jan 13, 2009
If you're not a good candidate for the pill, safe alternatives include progestin-only contraception like the Depo Provera injection, the Implanon implant, U.S. News & World Report,

Are we seeing bright light?  -  Jan 26, 2009
...in Mkanda are also responsible for referring women who would like to use other family planning methods such as intra-uterine device and depo-provera. Malawi's Daily Times,

Etonogestrel Implant as a Contraceptive Choice; Patient ...  -  Jan 29, 2009
Relative cost effectiveness of Depo-Provera, Implanon, and Mirena in reversible long-term hormonal contraception in the UK. Pharmacoeconomics. Irish Medical Journal,

La menstruaciĂłn: Reconocer las anormalidades  -  Jan 13, 2009
...hipoglucemia, ejercicio excesivo, exceso de estrés, algunos medicamentos como la píldora o anticonceptivos como Norplant o Depo-Provera. Correo del Caroní,

Reviven la castraciĂłn quĂ­mica a violadores  -  Jan 12, 2009
La castración química consiste en inyectar a los violadores un fármaco elaborado con hormonas como es la Depo Provera, para disminuirles la intensidad y Milenio,

Contraindications, Intramuscular to Subcutaneous Depo-Provera  -  Dec 16, 2008
The case of Depo Provera. Contraception. 2007;76:18-22. Abstract World Health Organization WHO statement on hormonal contraception and bone health. 2005. Medscape

Get Real! Did My Stepmother Lie to Me About My Right to Birth Control?  -  Dec 11, 2008
For instance, Depo-Provera isn't always a good choice for very young women because of bone mass concerns. IUDs often aren't comfortable for women who have RH Reality Check,

Teens need sex education  -  Dec 8, 2008
Also, it’s not like they’re running around, capturing 13-year-olds and forcefully injecting them with Depo-Provera, the contraceptive being used for the Metro Canada - Calgary,

Cash offered to addicts, alcoholics who agree to long-term birth ...  -  Dec 17, 2008
Acceptable long-term birth control includes tubal ligation, Depo Provera shots and IUDs for women, or a vasectomy for men. The group verifies that the Tucson Citizen,

Lewa antykoncepcja  -  Dec 9, 2008
Wszystkie ostrzegają: depo-provera niesie szereg skutków ubocznych. Trzech siedleckich lekarzy ginekologów (chcą pozostać anonimowi) nawet nie chce Tygodnik Siedlecki,

Tulsa Woman On Birth Control Having Triplets  -  21 Nov 2008
Doctors tell us the most effective contraception is male sterilization, then the IUD, followed by the Depo-Provera shot. KTUL,

Contraception help available to cash-strapped  -  Nov 18, 2008
Health Quarters offers birth control pills, the patch, NuvaRing and Depo-Provera shots. After the three months free, the contraceptive is usually available The Salem News,

Five Things You'd Never Think Would Make You Fat (But Guess What?)  -  Nov 20, 2008
Depo-Provera. The birth control shot may be convenient, but it delivers a high dose of progesterone, which can cause appetite to increase. Oprah.com,

Women urged to ditch the pill  -  Nov 8, 2008
The contraceptives concerned include Depo Provera, a hormone injection which offers three months of protection; Implanon, a small rod implanted into the arm Scotland on Sunday,

Various treatments take care of uterine fibroids  -  Oct 28, 2008
Danazol (a synthetic male hormone), birth-control pills and Depo-Provera control excessive menstrual bleeding due to fibroids. Sometimes doctors can remove South Coast Today,

Vital: Why The Government Want Us To Ditch The Pill  -  Nov 9, 2008
Long-term contraceptives which could be encouraged include Depo Provera, a hormone injection which lasts for three months, and Implanon, Glasgow Daily Record,

“You have helped us to save the vocations of manyâ€?  -  Nov 20, 2008
The clinic was at the forefront in prescribing Depo-Provera, a birth control drug, which inhibits sexual arousal in men. A brief biography of Msgr. Rossetti California Catholic Daily,

Student Health offers STD tests  -  Nov 10, 2008
...pregnancy testing and contraceptive management, which includes birth control pills, the Depo Provera injection, and emergency contraception for females, UTM Pacer,

It's Not Safe. Period!  -  Oct 27, 2008
Required to be administered after every one to three months, injectable contraceptives, such as Net-En (Norethisterone Enanthate), DMPA or Depo Provera NewsBlaze,

Herpes Often Unknowingly Spread  -  Oct 30, 2008
Nine of the 16 women were using hormonal contraception: Seven were on the pill, one used injectable Depo-Provera, and one the vaginal ring NuvaRing. WebMD

Servant Leader: Strong points—Part II  -  Nov 13, 2008
We know that IUDs, pills, the morning-after pill, Norplant and Depo-Provera are not only contraceptives but are also abortifacients, since they not only Business Mirror,

SPECIAL: Interview with AUL Action's Charmaine Yoest on 'Open ...  -  Oct 30, 2008
They turned a blind eye when he claimed to be a family member, and gave her an abortion, a Depo-Provera shot and a bag of condoms. Catholic Online,

Sex report card  -  Nov 5, 2008
Contraceptives such as condoms, birth control pills, emergency contraception pills, Depo Provera injections, and the contraceptive path Ortho Evra are all Royal Purple News,

La menstruaciĂłn  -  Oct 28, 2008
...hipoglucemia, ejercicio excesivo, exceso de estrés, algunos medicamentos como la píldora o anticonceptivos como Norplant o Depo-Provera. DERF,

Brand Names/Synonyms:
Depo-Provera is also known by the following brand names and/or synonymsAgolutin; Amen; Bio-Luton; CCRIS 533; Colprosterone; Corlutin; Corlutina; Corluvite; Corporin; Corpus Luteum Hormone; Crinone; Crinone Progesterone Gel; Curretab; Cyclogest; Cyclogesterin; Cycrin; Delalutin; Depo-Provera; Depo-Subq Provera 104; Flavolutan; Fologenon; Gesterol; Gesterol 100; Gesterol 50; Gestiron; Gestone; Gestormone; Gestron; Glanducorpin; Gynlutin; Gynoluton; Gynolutone; HSDB 3389; Hormoflaveine; Hormoluton; Hydroxyprogesterone Caproate; Lingusorbs; Lipo-Lutin; Lucorteum; Lucorteum Sol; Luteal Hormone; Luteine; Luteinique; Luteocrin Normale; Luteodyn; Luteogan; Luteohormone; Luteol; Luteopur; Luteosan; Luteostab; Luteovis; Lutex; Lutidon; Lutin; Lutociclina; Lutocuclin M; Lutocyclin; Lutocyclin M; Lutocylin; Lutocylol; Lutoform; Lutogyl; Lutren; Lutromone; MPA; Medroxyprogesterone Acetate; Membrettes; Methylpregnone; NSC 64377; NSC-9704; Nalutron; PROGESTERONE; Percutacrine; Percutacrine Luteinique; Piaponon; Pranone; Pregnenedione; Prempro/Premphase; Primolut; Prochieve; Progekan; Progestasert; Progesterol; Progesterona [Inn-Spanish]; Progesterone; Progesterone [Ban:Inn:Jan]; Progesterone [Progestins]; Progesteronum; Progesteronum [Inn-Latin]; Progestin; Progestogel; Progestol; Progeston; Progestone; Progestosol; Progestron; Progestronol; Projestaject; Prolets; Prolidon; Prolutin; Proluton; Prolutone; Prometrium; Protormone; Provera; Syngesterone; Syngestrets; Synovex S; Syntolutan; Thiuram E; Thiuranide; Utrogestan

Drug Category:
Depo-Provera is categorized under the following by the FDA: Contraceptives; Progestins; ATC:G03AC06; ATC:G03DA02; ATC:G03DA03; ATC:G03DA04; ATC:L02AB02

Dosage Forms:
CAPSULE; GEL; IMPLANT; LIQUID; SOLUTION

Absorption:
Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.

Interactions:
-->Interactions for Progesterone:

Drug/Laboratory Test Interactions

The following laboratory results may be altered by the use of estrogen-progestin combination drugs:

  • Increased sulfobromophthalein retention and other hepatic function tests.
  • Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
  • Metyrapone test.
  • Pregnanediol determination.
  • Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

Fasting and 2-hour plasma insulin and glucose levels following an oral glucose tolerance test (OGTT) and figrinogen levels were measured in patients receiving PROMETRIUM® Capsules at a dose of 200 mg/day for 12 days per 28 day cycle in combination with conjugated estrogens 0.625 mg/day (n-120). Table 6 summarizes this data. Plasma insulin levels 2 hours post-OGTT were decreased from baseline. The fasting plasma glucose and fasting plasma insulin levels were also decreased from baseline. Glucose levels 2 hours post-OGTT were increased slightly. There was no effect on fibrinogen levels.

For information on changes in lipid profile, see the CLINICAL PHARMACOLOGY, Clinical Studies subsection, Table 5.

Table 6

Mean Changes from Baseline in Insulin and Glucose Levels After 36 Months of Treatment

Parameter
Treatment Group Mean
(Mean % Change)

Conjugated Estrogens 0.625 mg + PROMETRIUM 200mg (cyclical)a

Conjugated Estrogens 0. 625 mg (only)

Placebo

N= 173 to 176b N=170 to 172b N=171

mean

mean % change

mean

mean % change

mean

mean % change

OGTT Insulin
(pmol/L)
Fasting
2 hour
-2.2
-45.2
-6.2
 -14.5
-1.1
 -23.9
-3.2
 -7.9
5.1
 -29.7
14.2
 -9.1
Glucose(mg/dL)
 Fasting
2 hour
-3.0
 3.6
-2.9
 5.2
-2.7
5.0
-2.7
7.8
-1.0
2.1
-0.9
3.9

a There are no significant changes (p<0.05) from conjugated estrogens values
b Number of subjects (N) varies by parameter

Also see CLINICAL PHARMACOLOGY.





Chemical IUPAC Name:
17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

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