Depo-Provera

This page contains recent news articles, when available, and an overview of Depo-Provera but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Depo-Provera (when available)

Pharmacology and use:
Progesterone is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Progesterone tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries. For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.

Mechanism Of Action:
Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

News Articles on Progesterone

'MJ took Depo Provera jabs to curb sex urges'  -  ‎Aug 8, 2009‎
A highly-respected doctor named Alimorad Farshchian claims that he prescribed the powerful drug Depo Provera, which is often given to sex offenders, Times of India

'Early gainers' using Depo more prone to long-term weight gain: study  -  ‎Aug 5, 2009‎
Women whose weight increased by 5 percent or more within the first six months of taking the injected contraceptive Depo Provera gained an average of 24 Chicago Sun-Times

Frosh 2009: How to keep the bun out of your oven  -  ‎Aug 25, 2009‎
Another offering is the Depo-Provera injection which provides 12 weeks of pregnancy protection with each shot. The clinic also supplies the contraceptive The Eyeopener

Long-Term Weight Gain When Using Birth Control Shot?  -  ‎Aug 13, 2009‎
A small study has found women receiving the birth control drug, Depo Provera (depot medroxyprogesterone - DMPA), may see lasting unwanted weight Diet Blog

Could Birth-Control Shot Weight Gain Last?  -  ‎Aug 7, 2009‎
The birth control shot, better known by the brand name Depo Provera, is given by injection once every three months. Researchers discovered that women who Citizens Report

New methods of contraception mean women must weigh choices  -  ‎Aug 9, 2009‎
Depo-Provera is a progestin shot given once every three months, so there's no need to remember to take a pill. Its slow release of progestin suppresses Detroit Free Press

Women who use depot medroxyprogesterone acetate at increased risk ...  -  ‎Aug 10, 2009‎
Researchers assessed the women before initiation of depot medroxyprogesterone acetate (Depo-Provera) and then every three months until 36 months. Endocrine Today

Family planning and nutrition program for IDPs in Vanni welfare camps  -  ‎Aug 8, 2009‎
The Bureau was instructed to attend to their requests for Tubectomy operations, administration of the Depo-Provera vaccines and handing out birth control Lanka Times

Godfather of Michael Jackson's kids claims paternity of Paris  -  ‎Aug 9, 2009‎
The Daily Mail speculates Jackson may have been unable to use his own sperm because he was taking a 'chemical castration' drug Depo Provera, to suppress his ChattahBox

A proactive stance against illnesses  -  ‎Aug 25, 2009‎
Oral contraceptives and the Depo Provera contraceptive shot may also be given to students who have a prescription for them. “It's not overwhelming (the Wilkes Barre Times-Leader

Is it time to stop taking the Pill? A new book asks whether the ...  -  ‎Aug 23, 2009‎
One of the methods being trialled, which may be available on the NHS by next summer, is a self-injection called Depo-Provera, even though a significant risk Daily Mail

Young moms hope to break cycle of teen pregnancy  -  ‎Aug 22, 2009‎
She was on birth control but had missed her last Depo Provera shot, she said. When she got pregnant, Tylisha said her mother wasn't too mad because she knew PennLive.com

Looking for a baby on the other side of 35  -  ‎Aug 21, 2009‎
Injections like Depo-Provera, he says, do not have any such risk. For oral pills and injections, you only stop using it a couple of months before conception Standard

Are You Risking Getting Knocked Up?  -  ‎Aug 20, 2009‎
...you insert near your cervix each month) or the Depo-Provera shot (which delivers a dose of progesterone that leaves you protected for three months). Cosmopolitan

Letters | It's time for a veterans highway or a memorial drive  -  ‎Aug 25, 2009‎
Birth control pills, depo-provera, IUD, diaphragm, spermicide or condoms? Should one go out tonight or stay at home? Should one engage in unprotected sex or Daily Gleaner

Roundup: Medical Abortion, Now an Option in Australia  -  ‎Aug 10, 2009‎
...women by giving them tubectomy operations if the request it, offering them birth control pills and administering Depo-Provera shots, the article said. RH Reality Check

Brosnan urges officials in Japan to end slaughter of dolphins ...  -  ‎Aug 12, 2009‎
A highly-respected doctor named Alimorad Farshchian claims that he prescribed the powerful drug Depo Provera, which is often given to sex offenders, Gaea Times

Inyectaban Depo Provera a Michael Jackson para frenar sus apetitos ...  -  ‎Aug 9, 2009‎
El doctor Alimorad Farshchian inyectó Depo Provera a Michael Jackson para enfriar sus impulsos sexuales con niños. El médico ha admitido cómo le recetaba La Voz Libre

MICHAEL JACKSON: MIRROR, PRESE FARMACO CASTRAZIONE CHIMICA  -  ‎Aug 10, 2009‎
Depo Provera è solitamente usata come anticoncezionale, ma inibisce anche la produzione di testosterone negli uomini, spiega il giornale. ANSA

'Dokter castreerde Michael Jackson'  -  ‎Aug 9, 2009‎
Hij gaf Jackson het medicijn depo provera, dat een zogenoemde chemische castratie bewerkstelligt, meldt de Britse krant The Daily Mirror. Trouw

Aumento de peso tras inyecciones anticonceptivas sería duradero  -  ‎Aug 6, 2009‎
...no saludables con el uso del anticonceptivo medroxiprogesterona de depósito (DMPA, por sus siglas en inglés) o Depo Provera, según su nombre comercial. Buena Salud

Michael Jackson podría haberse sometido a un proceso de ...  -  ‎Aug 11, 2009‎
El periódico británico explica que el 'Depo Provera' es un fármaco que limita la producción de testosterona y que normalmente se utiliza para el control de Qué.es

莱斯特声称是�?�克逊女儿生父自爆曾�??精给MJ  -  ‎Aug 10, 2009‎
...�?�?父亲乔(Joe)和他诉苦，但最终佣人�?�络�?上他。�?�一�??医生就�?�《星期日镜报》表示曾为迈克尔注射一�?�??为Depo Provera的压制性欲�?�物，希望能治疗迈克尔的娈童癖。 TOM

MJ食化學自宮藥抑制�?兒童性慾  -  ‎Aug 9, 2009‎
...法爾希基安雖然�?�?為米高侵犯那些孩�?，但擔心他「�?孩�?有�?�?�當的感覺�?，於是給他處方�??為Depo Provera的藥物。這種原本是�?�孕藥，用在男性身上，�?�抑制分泌�?�丸素蘋果日報

Tylko u nas  -  ‎Aug 10, 2009‎
Alimorad Farshchian ujawnił, że podawał Jacksonowi lekarstwo o nazwie Depo Provera. Lekarza niepokoiło bowiem zachowanie piosenkarz wobec młodych chłopców. Interia

米高�?�?�自稱帕里斯生父  -  ‎Aug 9, 2009‎
Farshchian）醫生求診，但當醫生得悉他因為戀童罪險�?階下囚後，立�?�處方注射型�?�孕劑Depo Provera給米高�?用，目的在削減其性慾，�?��?他�?與男童大被�?�眠。香港新浪網

Skal ha blitt "kjemisk kastrert"  -  ‎Aug 9, 2009‎
Jacko - som har blitt tiltalt for å ha seksuell omgang med barn, men senere frikjent på samtlige punkter - skal ha fått medisinen Depo Provera. Seher

Michael Jackson… Addirittura siamo arrivati alla castrazione!  -  ‎Aug 15, 2009‎
...il Depo Provera, adatto a limitare gli stimoli sessuali nei confronti di ragazzini durante il periodo del tour della popstar tra il 2002 e il 2003. MondoRaro.com

為抑制�?兒童性欲麥�?��?�化學自宮藥？  -  ‎Aug 10, 2009‎
Alimorad �?�?�發言人，承�?曾經幫助麥�?�抑制性欲，但�?肯�?露為他注射了多少次Depo Provera。 �?�一方�?�，他好�?�馬克�?�斯特（Mark Lester）昨爆料，麥�?�13年�?表明想當新浪網

為抑制对儿童性欲麦�?��?�化学自宫�?�？  -  ‎Aug 10, 2009‎
Alimorad �?过�?�言人，承认曾�?帮助麦�?�抑制性欲，但�?肯�?露为他注射了多少次Depo Provera。 �?�一方�?�，他好�?�马克莱斯特（Mark Lester）昨爆料，麦�?�13年�?表明想当光华日报

MJ teria tomado remédios para barrar desejo  -  ‎Aug 9, 2009‎
A droga (Depo Provera), espécie de castração química, serviria para esfriar o apetite do cantor. O profissional em questão, Alimorad Farshchian, MSN

Jackov boj s túžbou po malých chlapcoch: Lekár ho dal vykastrovať!  -  ‎Aug 9, 2009‎
Liek Depo Provera Jackovi predpísal lekár Alimorad Farshchian (47). Znepokojovalo ho, že na Jackovom ran�?i Neverland prespávajú chlapci, ktorým dával piť CAS.sk

Michael Jackson a luat medicamente prescrise pedofililor  -  ‎Aug 10, 2009‎
Medicamentul Depo Provera este de obicei dat pedofililor si violatorilor. Medicamentul ia fost recomandat artistului de catre doctorul Alimorad Farshchian, Ziare.com

國際新�?�簡訊  -  ‎Aug 10, 2009‎
...米高�?�?�生�?�?時跟孩�?�?�床而�?�，惹來詬病。最新消�?�指，他一�??醫生朋�?�法爾希基安稱，曾經處方強力「化學自宮藥�?（Depo Provera）給米高，抑制他�?兒童的性冲動。香港商报

Ngừa thai dạng chích  -  ‎Aug 16, 2009‎
Depo- provera là medroxyprogeterone acetate,150 mg được tiêm bắp mỗi 3 tháng. Nếu dùng đ�?u đặn trong 1 năm thì tỉ lệ có thai là 0,3%. Tuổi Trẻ

Flicka fick en tio gånger så hög insulindos  -  ‎Aug 6, 2009‎
I ett liknande fall i Karlskrona fick en patient en injektion av kortisonläkemedlet Depo-Medrol istället för preventivläkemedlet Depo-Provera. Helsingborgs Dagblad

Michael Jackson a fost înmormântat, la şapte săptămâni de la ...  -  ‎Aug 10, 2009‎
Medicamentul Depo Provera este de obicei dat pedofililor si violatorilor şi ia fost recomandat artistului de către doctorul Alimorad Farshchian, Antena 3

Filhos de Michael Jackson com vários pretendentes a pais  -  ‎Aug 10, 2009‎
Oferecendo mais pormenores, Mark Lester confirmou que o cantor tomava Depo Provera, um medicamento que induz um efeito de castração mental e que é usado Expresso

Caru cu vedete  -  ‎Aug 9, 2009‎
Doctorul Alimorad Farshchian a explicat ca, ingrijorat fiind de comportamentul lui Michael, ia oferit acestuia o reteta pentru medicamentul Depo Provera, HotNews

Michael Jackson. I dollari e la castrazione chimica  -  ‎Aug 11, 2009‎
Il medicinale sarebbe il Depo Provera, solitamente usato come anticoncezionale, farmaco che ha potere di inibire la produzione di testosterone negli uomini. Dazebao l'informazione on line

Michael Jackson, de perpetua actualidad  -  ‎Aug 11, 2009‎
Un médico, el Doctor Alimorad Farshchian, afirma haber dado Depo Provera al difunto Rey del Pop. Esta sustancia se utiliza generalmente para el control de 40 Principales Radio

Jacko castrato chimicamente  -  ‎Aug 10, 2009‎
Ha prescritto al Re del Pop il “Depo Provera�?, un farmaco che limita il flusso di testosterone. «Lo voleva soltanto aiutare» ha spiegato un portavoce del Libero News

Anti-abortion hardliners see criminalization of birth-control as ...  -  13 Jul 2009
...one particular undisputable effect of the amendment; banning all hormonal birth-control pills, Depo Provera, Norplant, IUDs and the morning after pill. Examiner.com

Effects of Depo Provera family planning method  -  ‎Jun 17, 2009‎
Dear doctor, I am on a three-month Depo Provera family planning method. However, I got my period last month (around May 13). I'm still bleeding (though Daily Monitor

The causes of painful postpartum sex  -  ‎Jul 9, 2009‎
Estrogen levels are often low after a delivery, especially if a Mom is breastfeeding or using a progesterone-only type of contraception (like Depo Provera Examiner.com

Starting all over again..  -  ‎Jul 10, 2009‎
I'm a sobbing mess thinking the Depo Provera bum injection my Doctor gave me has my hormones out of whack. I listen outside; it seems to have stopped Waikato Times

Birth control methods and effectiveness -- Part II  -  ‎Jun 23, 2009‎
In part two, I will discuss hormonal methods including the pill, vaginal ring, skin patch, Depo-Provera, and progesterone IUDs. Examiner.com

The cause of changes in the menstrual cycle  -  ‎Jul 12, 2009‎
Contraceptives. The combined low-dose oral contraceptive pill and other hormonal contraceptives, including depo provera can also cause a change in the cycle. Jamaica Observer

Family planning clinic slated  -  ‎Jul 9, 2009‎
...contraceptive patch, depo provera injection, diaphragm, natural family planning instruction, condoms, IUDs, vaginal ring and emergency contraception. Defiance Crescent News

SHRUM PATIENT CONCERNED ABOUT SAFETY, EFFECTIVENESS OF UNAPPROVED IUD  -  ‎Jun 27, 2009‎
The woman said she had used Depo-Provera, a form of birth control administered as a shot in the arm, before Shrum suggested Mirena. Pine Bluff Commercial

Ex-sex offender hopeful after residency ruling  -  ‎Jul 7, 2009‎
...treatment center for drug and sex addicts. And since March 2000, he has gotten weekly Depo-Provera contraceptive injections to lower his sex drive. Journal and Courier

Six Contraception and Birth Control Stocks  -  ‎Jun 29, 2009‎
Pfizer Incorporated (PFE) makes Depo-Provera Contraceptive Injection which is injected every 3 months. They also market birth control pills. Seeking Alpha

¿Te estás arriesgando a quedar embarazada?  -  ‎Jul 1, 2009‎
...inserta cerca del cuello del útero cada mes) o las inyecciones de Depo-Provera (que brindan una dosis de progesterona que protege durante tres meses). El Mañana de Nuevo Laredo

Một số loại thuốc gây suy giảm tình dục  -  ‎Jul 4, 2009‎
Các loại thuốc tránh thai hormnone - Gồm một số loại thuốc như The Pill, Depo Provera và viên progesterone mini - Phản ứng phụ: Ức chế việc kích thích, 24 giờ

Brand Names/Synonyms:
Depo-Provera is also known by the following brand names and/or synonymsAgolutin; Amen; Bio-Luton; CCRIS 533; Colprosterone; Corlutin; Corlutina; Corluvite; Corporin; Corpus Luteum Hormone; Crinone; Crinone Progesterone Gel; Curretab; Cyclogest; Cyclogesterin; Cycrin; Delalutin; Depo-Provera; Depo-Subq Provera 104; Flavolutan; Fologenon; Gesterol; Gesterol 100; Gesterol 50; Gestiron; Gestone; Gestormone; Gestron; Glanducorpin; Gynlutin; Gynoluton; Gynolutone; HSDB 3389; Hormoflaveine; Hormoluton; Hydroxyprogesterone Caproate; Lingusorbs; Lipo-Lutin; Lucorteum; Lucorteum Sol; Luteal Hormone; Luteine; Luteinique; Luteocrin Normale; Luteodyn; Luteogan; Luteohormone; Luteol; Luteopur; Luteosan; Luteostab; Luteovis; Lutex; Lutidon; Lutin; Lutociclina; Lutocuclin M; Lutocyclin; Lutocyclin M; Lutocylin; Lutocylol; Lutoform; Lutogyl; Lutren; Lutromone; MPA; Medroxyprogesterone Acetate; Membrettes; Methylpregnone; NSC 64377; NSC-9704; Nalutron; PROGESTERONE; Percutacrine; Percutacrine Luteinique; Piaponon; Pranone; Pregnenedione; Prempro/Premphase; Primolut; Prochieve; Progekan; Progestasert; Progesterol; Progesterona [Inn-Spanish]; Progesterone; Progesterone [Ban:Inn:Jan]; Progesterone [Progestins]; Progesteronum; Progesteronum [Inn-Latin]; Progestin; Progestogel; Progestol; Progeston; Progestone; Progestosol; Progestron; Progestronol; Projestaject; Prolets; Prolidon; Prolutin; Proluton; Prolutone; Prometrium; Protormone; Provera; Syngesterone; Syngestrets; Synovex S; Syntolutan; Thiuram E; Thiuranide; Utrogestan

Drug Category:
Depo-Provera is categorized under the following by the FDA: Contraceptives; Progestins; ATC:G03AC06; ATC:G03DA02; ATC:G03DA03; ATC:G03DA04; ATC:L02AB02

Dosage Forms:
CAPSULE; GEL; IMPLANT; LIQUID; SOLUTION

Absorption:
Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.

Interactions:
-->Interactions for Progesterone:

Drug/Laboratory Test Interactions

The following laboratory results may be altered by the use of estrogen-progestin combination drugs:

Increased sulfobromophthalein retention and other hepatic function tests.
Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.
Metyrapone test.
Pregnanediol determination.
Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

Fasting and 2-hour plasma insulin and glucose levels following an oral glucose tolerance test (OGTT) and figrinogen levels were measured in patients receiving PROMETRIUM® Capsules at a dose of 200 mg/day for 12 days per 28 day cycle in combination with conjugated estrogens 0.625 mg/day (n-120). Table 6 summarizes this data. Plasma insulin levels 2 hours post-OGTT were decreased from baseline. The fasting plasma glucose and fasting plasma insulin levels were also decreased from baseline. Glucose levels 2 hours post-OGTT were increased slightly. There was no effect on fibrinogen levels.

For information on changes in lipid profile, see the CLINICAL PHARMACOLOGY, Clinical Studies subsection, Table 5.

Table 6

Mean Changes from Baseline in Insulin and Glucose Levels After 36 Months of Treatment
Parameter	Treatment Group Mean (Mean % Change)
	Conjugated Estrogens 0.625 mg + PROMETRIUM 200mg (cyclical)^a		Conjugated Estrogens 0. 625 mg (only)		Placebo
	N= 173 to 176^b		N=170 to 172^b		N=171
	mean	mean % change	mean	mean % change	mean	mean % change
OGTT Insulin (pmol/L) Fasting 2 hour	-2.2 -45.2	-6.2 -14.5	-1.1 -23.9	-3.2 -7.9	5.1 -29.7	14.2 -9.1
Glucose(mg/dL) Fasting 2 hour	-3.0 3.6	-2.9 5.2	-2.7 5.0	-2.7 7.8	-1.0 2.1	-0.9 3.9

^a There are no significant changes (p<0.05) from conjugated estrogens values

^b Number of subjects (N) varies by parameter

Also see CLINICAL PHARMACOLOGY.

Chemical IUPAC Name:
17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

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