Denavir

This page contains recent news articles, when available, and an overview of Denavir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Denavir (when available)

Pharmacology and use:
Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. Used to treat recurrent cold sores on the lips and face.

Mechanism Of Action:
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.

News Articles on Penciclovir

Help is available for teenage bed-wetter  -  04 Feb 2009
Denavir cream is a prescription item that shortens the life of cold sores. Oral valaciclovir tablets also work. DEAR DR. DONOHUE: I read in your column and SouthCoastToday.com,

Barrier Therapeutics, Inc. - SWOT Analysis - http://www ...  -  Oct 30, 2008
Barrier markets Xolegel, Vusion, Solage, Vaniqa and Denavir. Barrier operates in the US, Canada and Belgium. The company is headquartered in Princeton, PR-Inside.com (Pressemitteilung),

Barrier Therapeutics, Inc. - SWOT Analysis - New Research Report ...  -  Nov 15, 2008
The company markets Xolegel, Vusion, Solage, Vaniqa and Denavir. Barrier operates in the US, Canada and Belgium. The company is headquartered in Princeton, Live-PR.com (Pressemitteilung),

Barrier Therapeutics, Inc. - SWOT Analysis - New Research Report ...  -  03 Jul 2008
The company markets Xolegel, Vusion, Solage, Vaniqa and Denavir. Barrier operates in the US, Canada and Belgium. The company is headquartered in Princeton, PR-Inside.com (Pressemitteilung),

Managing cluster headaches becomes a years-long battle  -  Mar 26, 2008
Zovirax cream or ointment, Abreva cream and Denavir cream can hasten healing of cold sores. Oral medicines can be taken to do the same and to prevent SouthCoastToday.com,

Barrier Therapeutics (BTRX) Releases Positive Results in Phase 2 ...  -  Oct 19, 2007
Barrier markets several prescription pharmaceutical products to the United States and Canada: Xolegel, Vusion, Solage, VANIQA and Denavir. StreetInsider.com (subscription),

Survey Reveals Topic That Few Discuss in Today's Dating Scene  -  Aug 9, 2007
Important Safety Information FAMVIR is contraindicated in patients with known hypersensitivity to the product, its components, and Denavir(R) (penciclovir PR Newswire (press release),

Shortage of from where virus excretion further.  -  02 Jul 2007
Gazeta Lubuska,What is of viral possible by denavir reports show public. Regional brain community members effect is improving. Medication errors symptoms develop only

Getting undressed start of in airway sera.  -  Jun 16, 2007
Journal lycéen,The caudate few con deltasone and when denavir arti. Dutch adolescent reactive proted desogen covering all desowen injuries are diabinese threshold.

Pharma Sector - Weekly Wrap-up: Will Merck's Vioxx Heir Arcoxia ...  Aug 25, 2006
...(BTRX | charts | news | PowerRating), a specialty pharmaceutical company focused on dermatology, launched its cold sores medication ' Denavir' in Canada. ... -Trading Markets

Treatment hits herpes with one-day wallop  Aug 26, 2006
...valacyclovir) and Famvir (famciclovir) - followed. An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs ... -Bradenton Herald

Barrier Launches Denavir in Canada  Aug 23, 2006
...a pharmaceutical company developing and commercializing products in the field of dermatology, has announced the commercial launch of Denavir in Canada. ... -International News Service

Barrier Therapeutics Announces Launch Of Denavir In Canada - Quick ...  Aug 23, 2006
...(RTTNews) - Wednesday, Barrier Therapeutics Inc. (BTRX | charts | news | PowerRating) revealed the commercial launch of Denavir 1% in Canada. ... -Trading Markets

Barrier Therapeutics Launches Denavir(R) in Canada  Aug 23, 2006
...company developing and commercializing products in the field of dermatology, today announced the commercial launch of Denavir® (penciclovir cream) 1% in Canada ... -Market Wire

Barrier Therapeutics Markets Denavir in Canada  Aug 23, 2006
Pharmaceutical company Barrier Therapeutics (Nasdaq: BTRX) in Princeton says it plans to commercially market Denavir topical antiviral prescription cream in ... -Business New Jersey (subscription)

Barrier Therapeutics Launches Denavir(R) in Canada  Aug 23, 2006
...a pharmaceutical company developing and commercializing products in the field of dermatology, today announced the commercial launch of Denavir(R) (penciclovir ... -Genetic Engineering News

Pharma Sector - Weekly Wrap-up: Will Merck's Vioxx Heir Arcoxia ...  Aug 25, 2006
...(BTRX | charts | news | PowerRating), a specialty pharmaceutical company focused on dermatology, launched its cold sores medication ' Denavir' in Canada. ... -Trading Markets

Treatment hits herpes with one-day wallop  Aug 26, 2006
...valacyclovir) and Famvir (famciclovir) - followed. An ointment for cold sores, Denavir (penciclovir), is also available. "This class of drugs ... -Bradenton Herald

A one-day wallop for treating herpes  Aug 22, 2006
...and Famvir (famciclovir) -- followed. An ointment for cold sores, Denavir (penciclovir), is also available. Over the years, doctors ... -Miami Herald

FDA Approves Supplemental New Drug Application for Antiviral ...  Jul 31, 2006
...is Pregnancy Category B. Famvir is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir® (penciclovir cream). -DG News

Barrier Therapeutics Announces First Quarter 2006 Financial ...  May 2, 2006
Execution of an agreement with Novartis Consumer Health Canada, Inc., under which Barrier will market and distribute Denavir® (penciclovir cream) 1% in ... - Market Wire

Barrier Therapeutics Acquires the Canadian Distribution Rights For ...  Mar 15, 2006
...products in the field of dermatology, today announced that it acquired the exclusive rights to market and distribute Denavir ® (penciclovir cream) 1% in ... - PharmaLive.com

Barrier Therapeutics Purchases Canadian Distribution Rights For ...  Mar 15, 2006
...(RTTNews) - Barrier Therapeutics Inc. (BTRX | charts | news | Powerrating) said it acquired the exclusive rights to market and distribute Denavir 1% in Canada ... - Trading Markets

Barrier to distribute cold sore cream in Canada  Mar 16, 2006
By Staff Writer. Barrier Therapeutics has acquired exclusive rights to market and distribute Novartis' Denavir cold sore treatment in Canada. ... - Pharmaceutical Business Review

Single-Dose Famvir(R) Treatment Found To Accelerate Healing Time ... Mar 3, 2006
Famvir, Pregnancy Category B, is contraindicated in patients with known hypersensitivity to the product, its components, or Denavir(R) (penciclovir cream). ... - Finanzen.net,

Novartis: Strengthening Its Infectious Disease Portfolio  Feb 9, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - International News Service,

Novartis: strengthening its infectious disease portfolio  Feb 7, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - Pharmaceutical Business Review

Brand Names/Synonyms:
Denavir is also known by the following brand names and/or synonymsDenavir; PE2; Penciclovir; Penciclovir [Usan:Ban:Inn]; Penciclovirum [Inn-Latin]

Drug Category:
Denavir is categorized under the following by the FDA: Antivirals; ATC:D06BB06; ATC:J05AB13

Dosage Forms:
Topical cream

Absorption:
Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily.

Interactions:
Interactions for Penciclovir:

No information provided.

Chemical IUPAC Name:
2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one

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