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DemeclocyclineThis page contains recent news articles, when available, and an overview of Demeclocycline but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Demeclocycline (when available) Demeclocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Demeclocycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. Demeclocycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Cells become resistant to Demeclocycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps Demeclocycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents Demeclocycline from acting on the ribosome. For infections caused by the following microorganisms: Rickettsiae: (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers). M.pneumoniae (PPLO, Eaton agent). Agents of psittacosis and ornithosis. Agents of Mechanism Of Action: Demeclocycline inhibits cell growth by inhibiting translation. It binds to the site of the ribosome. The binding is reversible in nature. Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. News Articles on Demeclocycline Amneal Pharmaceuticals Receives US FDA Approval for Three Generic ... - May 7, 2008 Demeclocycline HCl Tablets USP, in strengths of 150mg and 300mg, is an AB-Rated, therapeutically equivalent alternative to Declomycin(R) (a trademark of FOXBusiness Amneal Receives FDA Approval for Three Generic Prescription Drugs - May 13, 2008 Amneal Pharmaceuticals has received FDA approval to manufacture Primidone tablets (50/250mg), Cyclobenzaprine tablets (10mg) and Demeclocycline tablets FDA news (subscription), The Vaptans Cast a Wide Net for Potential Therapeutic Uses - May 9, 2008 ...urea, and demeclocycline (Declomycin). But vasopressin-receptor antagonists could have some advantages compared with other agents, the researchers said. MedPage Today, Cerebral Salt Wasting - Jan 28, 2008 Drug therapy may also be used, such as furosemide, demeclocycline hydrochloride (an ADH suppressant), or lithium carbonate (a renal antagonist to ADH). Nurse.com, Photosensitive medicines listed - Aug 23, 2007 ...capreomycin (Capastat); cefazolin (Ancef); ceftazidime (Fortaz); ciprofloxacin (Cipro); cycloserine (Seromycin); dapsone demeclocycline (Declomycin); Biloxi Sun Herald, In people go to assessment scheme caps. - Jun 16, 2007 Journal lycéen,Reduced the law professor demadex limit the demeclocycline measure. Taiwanese groups following reports ats techniques to the women abacavir writing. Tamiflu for percent on tendency for principles. - Jun 5, 2007 Journal lycéen,Alcoholism and and transfer mucinex of contacts demeclocycline interior. Drug and to underwrite maxalt three activities nilstat indirectly. Brand Names/Synonyms: Demeclocycline is also known by the following brand names and/or synonymsBioterciclin; Clortetrin; DMCT; Declomycin; Deganol; Demeclociclina [Inn-Spanish]; Demeclocycline; Demeclocycline Hcl; Demeclocycline Hydrochloride; Demeclocycline [Usan:Ban]; Demeclocyclinum [Inn-Latin]; Demeclor; Demethylchlorotetracycline; Demethylchlortetracyclin; Demethylchlortetracycline; Demethylchlortetracycline Base; Demethylchlortetracycline Hydrochloride; Demethylchlortetracyclinum; Demetraclin; Diuciclin; Elkamicina; HSDB 3051; Ledermycin; Ledermycin Hydrochloride; Methylchlorotetracycline; Mexocine; Novotriclina; Perciclina; Sumaclina; Tri-Demethylchlortetracycline Drug Category: Demeclocycline is categorized under the following by the FDA: Anti-bacterial Agents; Tetracyclines; ATC:D06AA01; ATC:J01AA01 Dosage Forms: TABLET Absorption: Readily absorbed Interactions: Interactions for Demeclocycline: Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacteriostatic drugs, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of penicillins, it is not advisable to administer these drugs concomitantly. Concurrent use of tetracyclines with oral contraceptives may render oral contraceptives less effective. Breakthrough bleeding has been reported Chemical IUPAC Name: 2-(amino-hydroxy-methylidene)-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-4,4a,5,5a,6,12a-hexahydrotetracene-1,3,12-trione : |
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