Darvon

This page contains recent news articles, when available, and an overview of Darvon but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Darvon (when available)

Pharmacology and use:
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. For pain relief

Mechanism Of Action:
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Propoxyphene

Youth prescription drug abuse on the rise in Vt  -  ‎Aug 21, 2009‎
The Times Argus reports Cimaglio said the prescription drugs involved usually are prescribed for pain, including OxyContin, Percocet, Vicodin and Darvon. Newsday

New Warnings Required on Possible Overdose in using Darvon and ...  -  ‎Aug 11, 2009‎
On July 7, 2009, the Food and Drug Administration (FDA) requested the manufacturers of pain relievers that contain propoxyphene, such as Darvon and Darvocet InjuryBoard.com

Crime report for Thursday, August 20, 2009  -  ‎Aug 19, 2009‎
At 1:23 pm Kevin Darvon Allen, 24, was charged with synthetic narcotic possession, prescription forgery and obstructing a law enforcement officer following Valdosta Daily Times

Windward Oahu Gets Afternoon Drenching  -  ‎Aug 13, 2009‎
...“It was crazy last few hours,�? added Kahaluu resident Darvon Silveira. Silveira said he couldn't leave his home Wednesday night after police shut down KHON2

Coach: Talent, depth mark Avon football team  -  ‎Aug 12, 2009‎
...and a host of other talented players -- including prolific quarterback Jake Harris and standout wide receiver Darvon Blackmon -- also are gone, Indianapolis Star

Methadone treatments can help opiate-addicted people  -  ‎Aug 10, 2009‎
Commonly abused prescription opiates include brands such as Vicodin, OxyContin, Percocet, Percodan, Darvon, Demerol and Dilaudid. Lexington Dispatch

Suozzi: Clear Heroin Problem Exists  -  ‎Aug 6, 2009‎
These drugs include OxyContin, Percocet, Vicodin, Codein and Darvon. “Over the course of the last three months, we've seen a huge upswing both in kids Mineola American

Sát thủ si tình (Kỳ 4)  -  ‎Aug 24, 2009‎
Sau đó, hắn cũng cố gắng tự tử bằng nhi�?u cách, uống số lượng lớn thuốc Darvon, chứ không phải chất độc xyanua và rạch nhi�?u nhát trên cánh tay. 24 giờ

FDA Slaps Strong Warning on Darvon, Darvocet  -  ‎Jul 8, 2009‎
The US Food and Drug Administration has called for a boxed warning of overdose risk on packages of Darvon, Darvocet and other painkillers ABC News

Dr. Gott: Riboflavin may help migraine sufferers  -  ‎Jul 11, 2009‎
I finally went to another doctor, who suggested that I try a Darvon compound and avoid bright lights and sun, MSG, tobacco, alcohol, chocolate, Northwest Herald

Clem's Chronicles: Michael Jackson Memorial/US-Russia/Sarah Palin  -  ‎Jul 7, 2009‎
...--PAINKILLER WARNING- The government is letting the painkillers Darvocet, Darvon and their generic cousins stay on the market but ordered stronger warnings ABC News

FDA Tightens Overdose Warnings for Propoxyphene Pain Drugs  -  ‎Jul 10, 2009‎
The FDA is requiring manufacturers of Darvon, Darvocet and other propoxyphene-containing drugs to strengthen the labeling information on the drugs' overdose FDA news (subscription)

Over-the-counter doesn't equal harmless  -  ‎Jul 7, 2009‎
Another drug, Darvon, along with the Darvon-acetaminophen combination Darvocet, will come with a pamphlet describing the dangers of overdose. Norman Transcript

Treating pain can be a tricky business  -  ‎Jul 9, 2009‎
4, Oxycontin, Percoset, Percodan, Darvon, Oxycodone and Tramadol. These drugs are addictive and will result in dependence with overuse. Ventura County Star

Europe Regulator Advises Ban on Painkiller  -  ‎Jun 25, 2009‎
It was first introduced in the US in 1957 by Eli Lilly & Co., under the brand name Darvon. Today it is marketed by a variety of generic-drug makers. Wall Street Journal

European Regulator Wants Painkiller Off Market  -  ‎Jun 26, 2009‎
It was first introduced in the United States in 1957 under the brand name Darvon and is marketed today by a wide number of generic drug makers. EmpowHer

This Week in Health  -  ‎Jul 10, 2009‎
Darvocet, Darvon and their generic clones will remain legal in the United States -- for now. The US Food and Drug Administration (FDA) said this week that Intelihealth.com

J&J Acts Fast on Tylenol  -  ‎Jul 8, 2009‎
On Tuesday, the agency said it would require two painkillers, Darvon and Darvocet, which contain acetaminophen and another ingredient, to carry a boxed Wall Street Journal

Setback for health-care bill  -  ‎Jul 8, 2009‎
Painkiller warnings: The Food and Drug Administration is letting the painkillers Darvocet, Darvon and their generic cousins, which consumer-health advocates Seattle Times

Prescription for abuse  -  ‎Jul 11, 2009‎
In comparison, medical examiners in Florida said 55 deaths were caused by propoxyphene -- a synthetic narcotic marketed under the trade name Darvon or Sarasota Herald-Tribune

Health Buzz: Painkillers Get Warning and Other Health News  -  ‎Jul 8, 2009‎
Xanodyne Pharmaceuticals Inc.'s Darvon and Darvocet, which both contain propoxyphene, and similar generic drugs are the medicines targeted by the FDA; U.S. News & World Report

A daughter's tears...New food safety rules...Health care talks  -  ‎Jul 7, 2009‎
WASHINGTON (AP) — The government is letting the painkillers Darvocet, Darvon and their generic cousins stay on the market. But the FDA has ordered stronger 9&10 News

Will the death of Michael Jackson finally get parents to safeguard ...  -  ‎Jun 28, 2009‎
Examples include oxycodone (Oxycontin), propoxyphene (Darvon), hydrocodone (Vicodin), hydromorphan (Dilaudid), and meperidine (Demerol). Examiner.com

Charges against Fulton County ambulance driver tossed  -  ‎Jun 23, 2009‎
Police said he removed a prescription bottle of Darvon while on a call to the woman's home in Gloversville. But Smrtic said his client did not take the Schenectady Gazette

With daughter's death, Waycross mom joins call for drug monitoring  -  ‎Jun 20, 2009‎
An autopsy revealed a lethal combination of prescription drugs including the painkillers methadone, Darvon and its metabolite norproxyphene; Florida Times-Union

The Consumer Memo, 7/7: New food safety standards  -  ‎Jul 7, 2009‎
The government is letting the painkillers Darvocet, Darvon and their generic cousins stay on the market but ordered stronger warnings against deadly Kansas City Star

My doctor the pusher  -  ‎Jun 30, 2009‎
Opioids include: oxycodone (OxyContin), propoxyphene (Darvon), hydrocodone (Vicodin), hydromorphone (Dilaudid), meperidine (Demerol), and diphenoxylate Manila Times

UPI NewsTrack Health and Science News  -  ‎Jul 7, 2009‎
WASHINGTON, July 7 (UPI) -- The US Food and Drug Administration says it has ordered strengthened warnings for drugs, such as Darvon and Darvocet, Times of the Internet

止痛藥Darvocet�?Darvon �?�准續售  -  ‎Jul 8, 2009‎
...美國食�?暨藥物管�?�局（FDA）7日決定，止痛藥Darvocet�?Darvon�?�其學�??藥�?�以繼續銷售，但必須在藥盒上明顯標明，這種藥�?用�?��?�?�能致死。 FDA的決定與�?洲國家構�? 世界日報

美�?�管局�?求丙氧芬类镇痛�?�强化用�?�风险�??示  -  ‎Jul 7, 2009‎
...新�?�网�?�盛顿７月７日电（记者任海军）美国食�?和�?�物管�?�局７日表示，该局目�?�?�?许达尔丰（Ｄ�?ｒｖ�?ｎ）等丙氧芬类镇痛�?�上市销售，但此类�?�物的生产商必须在�?��? 新华网

EE UU advierte del peligro para la salud que supone consumir ...  -  ‎Jul 9, 2009‎
La muerte de Michael Jackson los ha colocado en primer plano porque los forenses estiman que el consumo de altas dosis de Darvon y Darvocet, dos productos El Correo Digital (Vizcaya)

Preocupan propuestas para limitar el consumo de analgésicos  -  ‎Jul 7, 2009‎
También vendido como Darvon y en una combinación de acetaminofeno llamada Darvocet, ha sido vinculado con sobredosis accidentales y suicidios. El Nuevo Herald

진통제 '다본' 안정성 논란, 퇴출�?� 모면  -  ‎Jul 7, 2009‎
...［메디컬투�?��?� 권선미 기�?］ 진통약 다르본(Darvon)과 다르보셋(Darvocet)가 과용량 사용시 치명�?�?� 수 있다는 경고문구는 강화�?�는 대신 시장�?서 퇴출�?� 모면할 Medical Today

止痛藥紛紛出�?題患者迷惘無所�?�從  -  ‎Jul 8, 2009‎
...�?題，�?�有乙醯胺酚(Acetaminophen) 的Tylenol會引起�?衰竭將被�?�?，�?�有�?�樣�?分的Percocet和Vicodin將被�?止，而�?�有Propoxyphene的Darvon則會致死和引起自殺。新浪網

美藥管局�?求丙氧芬類鎮痛藥強化用藥風險�??示  -  ‎Jul 7, 2009‎
...美國食�?和藥物管�?�局7日表示，該局目�?�?�?許�?�爾�?(Darvon)等丙氧芬類鎮痛藥上市銷售，但此類藥物的生產商必須在藥�?標簽�?�加框警告中強化措辭，�??示消費者�?��?�?用中國經濟網

美FDA�?制止痛�?�剂�? 患者心慌慌  -  ‎Jul 11, 2009‎
...这一�?��?也作为止痛�?�达尔丰（Darvon）出售，还有与乙醯胺酚混和�?被称为Darvocet的�?�物。丙氧芬�?�能导致事故性过�?�?用�?�自�?�，现在这一处方�?�出售时必须包括一本�? 大纪元

Homicidio o sobredosis  -  ‎Jul 10, 2009‎
Este caso se ha colocado en primer plano porque los forenses estiman que el consumo de altas dosis de 'Darvon' y 'Darvocet', dos productos muy usados en El Norte de Castilla

진통제 안전성 �?�마�?… 용량·용법 지키면 "걱정 NO"  -  ‎Jul 1, 2009‎
...�?미와 유럽�?서 50년간 사용�?��?� 아스피린과 프로�?�시펜(약한 마약성 진통제�?� �?�종) 복합제�?� 다본(Darvon)�?� �?�연사를 유발해 전문�?�약품으로 전환�?� 것�?� 대표�? 한국일보

Send tips til Dagbladet.no MMS/SMS: 2400 Tlf: 2400 0000 e-post ...  -  ‎Jun 29, 2009‎
Som for eksempel: Placidyl, Valmid, Dalmane, Valium, Mandrax, Hycomine, Kodein, Darvon, Dilaudid, Demerol, Meperidine, Dexdrine, Dexamil, Eskotrol, Dagbladet.no

Edwards leads Edgewood boys to triangular victory  -  ‎Apr 14, 2009‎
Darvon Hill nipped teammate Dylan Anderson in the 100 as both finished in 11.5. Max Tuttle lost to the state indoor 55-hurdles champ in the 110 but came The Herald-Times (subscription)

North glad Winningham joined team  -  ‎Mar 31, 2009‎
...high jump (5-6) and Justin Crohn in the shot (44-0), and so did two sophomores, Dan Varns in the 800 (2:10.3) and rookie Darvon Hill in the 100 (11.0). The Herald-Times (subscription)

Mass Torts Inevitable In Wake Of FDA Urged To Pull Popular ...  -  ‎Mar 6, 2009‎
Darvon and Darvocet, which have been on the market for over fifty years, have already been banned in the UK The FDA was first pressured to closely Justice News Flash

Man arrested with hundreds of prescription pills at border  -  ‎Feb 24, 2009‎
Officers arrested Hofer with 255 Xanax tablets and 321 Darvon pills on his possession. He didn’t have a prescription for the pills, customs agents said. Helena Independent Record

Regis Philbin's reality nightmare family life  -  ‎Mar 5, 2009‎
He has lots of pills, including the narcotic pain medication Darvon and also Xanax. Police told me he took a massive overdose. Monsters and Critics.com

Inquiry uncaps a multitude of pills  -  ‎Mar 6, 2009‎
...of prescription drugs, including 510 tablets of addictive and pain-killing compounds typically sold as Vicodin, Darvon and Valium, NTSB documents show. The San Francisco Examiner

ACROSS the BIG SKY  -  ‎Feb 24, 2009‎
He was carrying 255 Xanax and 321 Darvon pills without a prescription. The driver and another man riding in the cab of the truck failed to tell the CBP Great Falls Tribune

Brand Names/Synonyms:
Darvon is also known by the following brand names and/or synonymsAlgafan; Antalvic; D-Propoxyphene; Darvocet; Darvon; Darvon-N; Deprancol; Depromic; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Dolene; Dolocap; Doloxen; Doloxene; Erantin; Femadol; Harmar; Kesso-Gesic; Propacet; Prophene 65; Propoxychel; Propoxyphene; Propoxyphene Hcl; Propoxyphene Hcl 65; Proxagesic; SK 65

Drug Category:
Darvon is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; ATC:N02AC04; ATC:N02AC54; ATC:N02AC74

Dosage Forms:
Tablets

Absorption:
Not Available

Interactions:
Interactions for Propoxyphene:

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

As is the case with many medicinal agents, propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur, the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Sever neurologic signs, including coma, have occurred with concurrent use of carbamazepine.

Chemical IUPAC Name:
(4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl) propanoate

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