Darvon-N

This page contains recent news articles, when available, and an overview of Darvon-N but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Darvon-N (when available)

Pharmacology and use:
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. For pain relief

Mechanism Of Action:
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Propoxyphene

Darvon may be a risky painkiller - Jul 1, 2008
Darvon, Darvon-N and Darvocet are prescription narcotic pain medicines that contain propoxyphene and a current law suit claims that they are too risky to Houma Courier,

Public Citizen Petitions FDA to Ban Darvon Products Feb 28, 2006
488 subjects (17.7%) indicated that they had used Darvon or Darvon-N in their lifetimes, making propoxyphene the most frequently mentioned opiate drug. ... - PharmaLive.com,

Brand Names/Synonyms:
Darvon-N is also known by the following brand names and/or synonymsAlgafan; Antalvic; D-Propoxyphene; Darvocet; Darvon; Darvon-N; Deprancol; Depromic; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Dolene; Dolocap; Doloxen; Doloxene; Erantin; Femadol; Harmar; Kesso-Gesic; Propacet; Prophene 65; Propoxychel; Propoxyphene; Propoxyphene Hcl; Propoxyphene Hcl 65; Proxagesic; SK 65

Drug Category:
Darvon-N is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; ATC:N02AC04; ATC:N02AC54; ATC:N02AC74

Dosage Forms:
Tablets

Absorption:
Not Available

Interactions:
Interactions for Propoxyphene:

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

As is the case with many medicinal agents, propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur, the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Sever neurologic signs, including coma, have occurred with concurrent use of carbamazepine.

Chemical IUPAC Name:
(4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl) propanoate

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