Darvocet

This page contains recent news articles, when available, and an overview of Darvocet but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Darvocet (when available)

Pharmacology and use:
Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone. The analgesic effect of propoxyphene is due to the d-isomer, dextropropoxyphene. It binds to the opiate receptors and leads to a decrease of the perception of pain stimuli. For pain relief

Mechanism Of Action:
Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Propoxyphene

Officials: Prescription drug abuse is rising  -  May 28, 2008
Kyle S. Leddick of Utica is accused of selling more than 20 pills of the prescription drug Darvocet around May 13 while he was a student at the Middle Utica Observer Dispatch,

Police seize 1000 pills, guns in raid  -  May 30, 2008
Members of the St. Clair County Sheriff Office Drug Task Force seized Vicodin, Darvocet, Lortab, Valium, Methylin and Xanax from the home in the 1600 block Port Huron Times Herald,

Shingles: Treatment and prevention  -  May 23, 2008
This usually involves some form of a narcotic, such as Darvocet, Vicodin or codeine. Also sometimes helpful in more severe cases of shingles is the Scotts Valley/San Lorenzo Valley Press-Banner,

MORNING UPDATE -- Four people charged in shoplifting case  -  May 7, 2008
...with the handgun and seventh-degree criminal possession of a controlled substance for allegedly having the painkiller Darvocet without a prescription. Glens Falls Post-Star,

Police Blotter for May 9  -  May 8, 2008
He is alleged to have possessed darvocet, a controlled substance. Waldron is scheduled to appear in Oneida City Court May 16. * Brandy L. Pallotta, 17, Oneida Dispatch,

Cocaine dealer gets 20 years of probation  -  May 23, 2008
According to the criminal complaint, Gilow sold six tablets of generic Darvocet and four tablets of Vicodin to a police informant Jan. 18, 2007. Winona Daily News,

Circuit court May 23, 2008  -  May 22, 2008
44, at 8:30 am in Division 4 after preliminary hearing waived on a felony charge of fraudulently attempting to obtain a controlled substance, Darvocet. St. Joseph News-Press,

Lock up medicine cabinets  -  May 18, 2008
It wasn't common practice for doctors to prescribe strong medicines such as OxyContin or Darvocet. But today, there's a pill for everything; TMCnet

Collier County Police Briefs: May 12, 2008  -  May 11, 2008
Naples, was arrested Saturday at 3701 US 41 E. He was charged with possession of a controlled substance, a generic form of the painkiller Darvocet, Marconews (subscription),

Thousands in medication, firearms, seized from Randolph County home  -  May 7, 2008
Authorities also recovered 2475 doses of Schedule IV drugs, including Alprazolam (Xanax), Diazepam (valium), Ambien and Darvocet, in addition to several Greensboro News Record,

Barnstable District Court  -  May 6, 2008
GIFFORD, Ellen L., 45, 151 Chuckles Way, Marstons Mills; possession of oxycodone, possession of Vicodin, possession of Darvocet, possession of marijuana, Cape Cod Times,

Atwater: Meds cabinet a danger zone  -  May 25, 2008
Some of the favorite abusables are pain medication – especially opiate-based, such like Vicodin, Norco, Percocet, Darvocet, and even ibuprofen with codeine. Northwest Herald,

Akron crime sweep fruitful  -  Apr 21, 2008
They confiscated 99.2 grams of crack, 5.4 grams of cocaine, 224 grams of marijuana, .3 grams of heroin and pills, including 1 Darvocet, 9 Oxycodone, The Plain Dealer - cleveland.com,

177 People Arrested In 4-Day Sweep Of Area Bars  -  Apr 22, 2008
The detail seized $3542 in cash, 199.2 grams of crack/cocaine, 5.4 grams of powdered cocaine, 224 grams of marijuana, .3 grams of heroin, one Darvocet pill, NewsNet5.com,

Deputies: This growhouse was also a home  -  Apr 5, 2008
Detectives also found baggies of marijuana in a bedroom weighing 19.5 grams, plus various quantities of pills identified as Darvocet, Serex, Neurontin, Winknews.com,

Karen’s Tummy Tuck Marvel  -  Apr 4, 2008
Despite a reaction to Darvocet that landed her in the emergency room, Karen is recovering beautifully after her surgery. Karen is happy that she has met her Make Me Heal,

Top 10 Deadliest Drugs  -  Apr 8, 2008
Some drugs, like Darvon and Darvocet have been found to be no more effective than aspirin, and they may cause heart damage. InjuryBoard.com,

Queen City man arrested on drug charges after traffic stop  -  Apr 6, 2008
Steger was given consent to search the vehicle and found a pill bottle of prescription narcotic medicines darvocet and talacen, Fitzgerald said. Texarkana Gazette,

Musician Zollo pleads not guilty to drug charges  -  Apr 4, 2008
Police say they found cocaine and Darvocet, a prescription pain medication, during a search of Zollo's vehicle. The drug solicitation charge is a Class D Gazette Online,

BLOTTER: Police reports published April 16  -  Apr 15, 2008
Officers also found a Darvocet pill on Westfield. • THEFT: A 39-year-old Augustus Place resident told police that sometime between 12:30 and 2:45 pm Tuesday Niagara Gazette,

The end for ‘blockbuster’drugs  -  Apr 1, 2008
The company’s top-selling drugs include Prozac, Cialis, Evista and Darvocet. But the new business model for companies like Eli Lilly will likely move away Emirates Business 24/7,

10 Deadliest Drugs  -  Mar 27, 2008
For example, the mild opioid drugs Darvon and Darvocet have been found to be no more effective than aspirin—and they can cause heart damage. WXii 12.com,

Port Charlotte couple jailed on drug charges  -  Apr 6, 2008
Detectives also reportedly found plastic bags of marijuana in a bedroom, as well as pills identified as Darvocet, Serex, Neurontin, Carisoprodal and Sarasota Herald-Tribune,

Remember Back in the Old America, When It Was Just Syringes and ...  -  11 Mar 2008
I was holding out for higher-than-trace levels of Oxycontin and Darvocet, but no such luck: -Officials in Philadelphia said testing there discovered 56 Reason Online,

South Berwick man charged in New Durham after traffic stop to be ...  -  Mar 1, 2008
Hillsgrove had in his possession one pill of a generic form of Darvocet, a Schedule IV drug. According to a court clerk, the charge was amended to Class A Foster's Daily Democrat,

Rochester man faces three felonies after traffic stop  -  Feb 22, 2008
Hillsgrove allegedly had on him one pill of a generic form of Darvocet, a Schedule IV drug. No pleas were entered during his video arraignment Thursday Foster's Daily Democrat,

13 arrested in Operation Oxy-Clean  -  Feb 21, 2008
The suspects were buying and selling Oxycontin, Darvocet, Vicodin, Endocet, Carisoprodol and other drugs, Sgt. Perry Tabak said. Those arrested are Akron The Plain Dealer - cleveland.com,

Charges refiled in case involving former sheriff's deputy  -  Feb 12, 2008
The case involves prescriptions for Propoxy or Darvocet that were filled at CVS and the Medicine Shoppe in Clarion through several local doctors. Oil City Derrick,

Musician Zollo faces 3 charges linked to drugs  -  Feb 12, 2008
Zollo allowed officers to search his car, where they found cocaine behind the driver's seat and four Darvocet pills, for which Zollo said he had no DesMoinesRegister.com,

Musician David Zollo arrested on drug charges  -  Feb 11, 2008
Officers also found four pills of Darvocet, a prescription pain medication, and Zollo said he didn't have a prescription, according to the police report. Gazette Online,

Police, fire and courts  -  Mar 4, 2008
Charges include a felony count of possession of a controlled substance called Darvocet, a prescription painkiller. A Blandinsville officer stopped Ferch at Peoria Journal Star,

Kentucky Briefs - March 3, 2008  -  Mar 3, 2008
Ellis found three yellow round pills of Flexiril, a pain management drug, and a pink oblong capsule, Darvocet, also a pain management prescription drug, Madison Courier,

Magistrate Reports for 02-28-08  -  Feb 27, 2008
Police found 22 pills of suspected Darvocet, a narcotic pain reliever, a large box of unused syringes, six clear capsules and a white powdery tablet in a Daily American Online (subscription),

Rutland man faces federal weapons charge  -  Feb 26, 2008
...oxycodone, methadone, Xanax and Darvocet (a painkiller). Those charges also stem from a search at the time of Aitchison's arrest, court records stated. Rutland Herald,

Pushing 60 with Pot  -  Feb 22, 2008
You are dosed with oxycodone, oxycontin, percocet, darvocet, percodan, cortisone, prednisone, hydrocodone, and all or any combination or concoction of CounterPunch,

Understand drugs, save your life  -  Feb 15, 2008
...which when taken in high doses or when combined with prescription medication that also includes acetaminophen (such as Darvocet or Vicodin), Albany Times Union,

Trusted Care: Allegations of Drug Use Inside a Durant Nursing Home  -  Feb 12, 2008
..."In that one week period, a total of four cards of medicine were missing; three of them being Lortab and one Darvocet." A troubling allegation that our KTEN,

Bradford County Court News  -  Feb 24, 2008
Barber was arrested by Athens Township police officer Roger Clink after she attempted to pick up a prescription for Darvocet, a controlled substance under Towanda Daily Review,

Plea of innocent Shooting suspect denies drug charges  -  06 Feb 2008
...oxycodone, methadone, Xanax and Darvocet (a painkiller). The 42-year-old was already facing a potential maximum of 15 years in prison and a $10000 fine. Rutland Herald,

How The FDA Has Done Nothing About An Unsafe Drug  -  Jan 15, 2008
I'm talking about a combination of propoxyphene and acetaminophen, also sold under the brand name Darvocet. It is a pain reliever related to Darvon Evening Bulletin,

Student arrested at Leon High on drug charges  -  Jan 31, 2008
They arrested him on charges of possessing Oxycodone and a generic version of Darvocet with the intent to sell within 1000 feet of a school. Tallahassee.com,

Police, fire and courts  -  Jan 29, 2008
A Blandinsville officer stopped Thomas at about 10 pm Saturday for a traffic violation. Police said the officer found several Darvocet tablets, Peoria Journal Star,

Local Woman Arrested For Forged Prescriptions  -  Jan 22, 2008
According to Officer Anthony Leonard, “Donna Wright, age 53, presented a prescription for Darvocet which had been altered. The prescription was written with UC Daily News,

Deputy sheriff dismissed as investigation continues  -  Jan 10, 2008
Police also said Hilborn obtained three prescriptions from Freenock for Darvocet. Each prescription was for 100 tablets and was filled between Sept. Clarion News,

Painkillers take 'vicious' hold on users  -  Jan 9, 2008
Then someone turned him on to painkillers like Vicodin and Darvocet, which he thought led to freedom from drinking. But that feeling wouldn't last for long. The County Press,

Man arrested for possessing pain pills  -  Jan 21, 2008
According to Watertown PD, Alberry was found with 25 darvocet pills with a total weight of 23.7 grams. Investigators believe Alberry intended to give the Newswatch 50,

Police: Pharmacy worker arrested for theft of pills  -  Jan 17, 2008
Police estimate Mosher took up to 4800 tablets of hydrocodone, Darvocet, Fexiril, and other medications. The stolen pills are valued at about $3000, Glens Falls Post-Star,

Wal Mart Employee Jailed In Drug Theft  -  Jan 17, 2008
Police said Mosher took as many as 4800 tablets consisting of Hydrocodone, Darvocet, Flexiril, and various other medications. North Country Gazette,

Court hearing in deputy sheriff's case delayed  -  Jan 8, 2008
The case involves prescriptions for Propoxy or Darvocet that were filled at CVS and the Medicine Shoppe in Clarion through three local doctors. Oil City Derrick,

Police calls: Housemate vanishes along with woman's car  -  Feb 2, 2008
She had four Darvocet pills that she said did not belong to her in her purse, police said. Madison Comprehensive High School, 600 Esley Lane -- A Mansfield News Journal,

Sentenced to rehab, addicts find freedom  -  Feb 1, 2008
Those first ones were Darvocet. Then it became a combination of Vicodin and Soma, prescribed at 180 pills a month. Those pills not only took away the pain, St. Petersburg Times,

Mobile Meth Lab  -  Jan 31, 2008
Possession of Listed Chemical Ephedrine, Possession of Darvocet, Possession of Ambien, Possession of MDMA, Possession of Soma, Possession of Xanax, WMBB-TV,

Nurse accused of stealing pills from patients  -  Jan 31, 2008
Tablets of Ativan, Darvocet, Endocet - a mixture of oxycodone and acetaminophen - and 20 milligrams of morphine sulfate were missing, Begley said. News-Herald.com,

Three charged for snow blower theft  -  Jan 30, 2008
...of Criminal Possession of a Controlled Substance when, according to Watertown PD, he was found with 25 darvocet pills with a total weight of 23.7 grams. Newswatch 50,

Police, fire and courts  -  Jan 24, 2008
Police said a drug dog later alerted to the presence of drugs in the vehicle, and officers found 2.6 grams of marijuana, a pipe and a Darvocet pill, Peoria Journal Star,

$15000 in heroin seized  -  Jan 18, 2008
Officers also seized a quantity of various prescription medications including Darvocet, Seroquel, Xanax, Neorontin and Lyrica, along with a quantity of Republican & Herald,

ORLEANS COUNTY COURT: Child molester sentenced  -  Jan 16, 2008
She pled guilty to fifth- and seventh-degree criminal possession of a controlled substance, admitting she was in the process of selling Darvocet at the time Journal-Register,

Police Beat  -  Jan 10, 2008
Missing from a drug cabinet were 59 OxyContin tablets, 29 Percocet tablets, 18 Darvocet tablets, 40 Vicodin tablets, 10 vials of Fentanyl, two suppositories Springfield State Journal Register,

Repeat offender convicted of third DUI  -  Jan 9, 2008
Hudler admitted both to taking the pills and to fraudulent use of the prescription, telling police that she had become addicted to the painkiller Darvocet. Powhatan Today,

Crime Stoppers Corner  -  Dec 16, 2007
Wanted on a charge of failure to appear (possession of paraphernalia and possession of Darvocet). Big Bend Crime Stoppers telephones are not recorded and do Tallahassee Democrat,

Operation Puts Bull's Eye on Gang, Drug Crimes  -  Dec 12, 2007
Investigators confiscated marijuana, powdered cocaine, crack cocaine, heroin, Darvocet and cash. Among those arrested on drug charges are Eugene Straiter, WRAL.com,

Police arrest woman with fake prescription  -  Nov 26, 2007
The prescription was for Darvocet, a painkiller. Sheridan later told police she was taking between 20 to 30 Darvocet pills daily, according to the police NewsOK.com (subscription),

Prescription forgery caught at Walgreen's  -  Nov 21, 2007
According to his police report, Sheridan allegedly said she was taking 20 to 30 Darvocet pills a day. Sheridan told Box she has had a drug problem for 14 Edmond Sun,

Downe Township woman gets five years for killing corrections ...  -  Dec 18, 2007
...a drug cocktail that included alcohol and opiates, of which two distinct types - one being the painkiller Darvocet - were detected in her bloodstream. Press of Atlantic City,

Porter County crimetimes  -  Nov 20, 2007
...a controlled substance charge after police said he was caught with 43 pills that were determined to be the generic version of the painkiller Darvocet. nwitimes.com,

Local pharmacist admits theft for addiction  -  Nov 29, 2007
...allegedly walked into a McMartin Street home and scoured the residence until he found bottles of Darvocet and Ketorolac in a bedroom dresser drawer. Plattsburgh Press Republican,

Region 8 Pharmacy Robbed Three Times in Four Months  -  Nov 12, 2007
..."They took Hydrocodone, Xanax, Darvocet and Viagra. So quiet a selection of medication," said Eddington. All drugs with a high street value, but it comes as KAIT,

West Lafayette woman sells child's prescription  -  Nov 16, 2007
Burnett sold Darvocet and Vicodin during two separate controlled drug transactions in May, Batchelor said. Burnett's driver's license was also suspended for Coshocton Tribune,

3 arrested on drug charges after traffic stops  -  Nov 7, 2007
Combined, the two occupants had a total of 25.3 grams of suspected crack cocaine in their possession, along with the bags of cocaine and some Darvocet The News Journal,

Sheriff's Beat  -  Oct 25, 2007
When asked what the pills were Alan stated, that they were Darvocet. Officer Limbaugh asked Alan if he had a prescription for the pills and he stated he did Baker County Standard,

Brand Names/Synonyms:
Darvocet is also known by the following brand names and/or synonymsAlgafan; Antalvic; D-Propoxyphene; Darvocet; Darvon; Darvon-N; Deprancol; Depromic; Dextropropoxyphene; Dextropropoxyphene-M; Dextroproxifeno; Dolene; Dolocap; Doloxen; Doloxene; Erantin; Femadol; Harmar; Kesso-Gesic; Propacet; Prophene 65; Propoxychel; Propoxyphene; Propoxyphene Hcl; Propoxyphene Hcl 65; Proxagesic; SK 65

Drug Category:
Darvocet is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; ATC:N02AC04; ATC:N02AC54; ATC:N02AC74

Dosage Forms:
Tablets

Absorption:
Not Available

Interactions:
Interactions for Propoxyphene:

The CNS-depressant effect of propoxyphene is additive with that of other CNS depressants, including alcohol.

As is the case with many medicinal agents, propoxyphene may slow the metabolism of a concomitantly administered drug. Should this occur, the higher serum concentrations of that drug may result in increased pharmacologic or adverse effects of that drug. Such occurrences have been reported when propoxyphene was administered to patients on antidepressants, anticonvulsants, or warfarin-like drugs. Sever neurologic signs, including coma, have occurred with concurrent use of carbamazepine.

Chemical IUPAC Name:
(4-dimethylamino-3-methyl-1,2-diphenyl-butan-2-yl) propanoate

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