Cyclobenzaprine

This page contains recent news articles, when available, and an overview of Cyclobenzaprine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cyclobenzaprine
(when available)

Pharmacology and use:
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness to and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease. For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions

Mechanism Of Action:
Like the tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.

News Articles on Cyclobenzaprine

Man injured fighting burglars  -  ‎Apr 13, 2009‎
There were 18 Alprazalom pills, 11 methocarbanol pills, 45 acetaminophen-oxycodone hydrochloride, 3 diazepam pills, 51 cyclobenzaprine HCl, 5 clarinex pills WBBH

Cephalon Announces Positive Results from a Phase Three Study of ...  -  ‎Apr 6, 2009‎
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), PR Newswire (press release)

Acupuncturist FAIL  -  ‎Apr 9, 2009‎
Hoyt allegedly obtained Cyclobenzaprine, a muscle relaxer; Rozerem, Lorazepam and Phenobarbital, all sedatives; Nandrolone, an anabolic steroid; Sermorelin, ScienceBlogs

“서방형 본레스ER캡ìŠ?, ì†?효성제제와 효과 ë?™ë“±â€?  -  ‎Mar 30, 2009‎
...서울ì?˜ëŒ€ 재활ì?˜í•™ê³¼ ì •ì„ ê·¼ êµ?수는 ‘근골격계 ìƒ?태ì—? 따른 시í?´ë¡œë²¤ìž?프린 서방형 캡ìŠ?ì?˜ ìž„ìƒ?ì ? 가치 (Clinical values of Cyclobenzaprine ER in musculoskeletal 헬스코리아뉴스

심í?‰ì›?, '리리카캡ìŠ?' 요양급여 완전코드로 청구  -  ‎Apr 5, 2009‎
...ì—? 수반하는 ë?™í†µì?˜ ì¦?ìƒ?완화ì—? 사용할 수 있는 ê·¼ì?´ì™„ì œ(cyclobenzaprine 등)를 ì ?ì–´ë?„ 1달 ì?´ìƒ? 사용했ì?Œì—?ë?„ 효과가 불충분한 경우 요양급여를 ì?¸ì •한다"ê³  ë§?했다. e-헬스 통신

Eurand Announces International Agreements for Once-Daily Extended ...  -  18 Mar 2009
..."These agreements represent important milestones in expanding Eurand's cyclobenzaprine ER franchise into new territories," said John Fraher, Eurand's Chief MSNBC

תרופה חדשנית להרפיית שרירי×? ×¢×? שחרור מושהה  -  18 Mar 2009
..."הסכמי×? ×?לה ×”×? ציון דרך חשוב בהתרחבות של הענקת הזיכיונות ל-cyclobenzaprine ER על-ידי יור×?נד ל×?זורי×? חדשי×?", ×?מר ×’'ון פרייהר, הסמנכ"ל המסחרי של יור×?נד. News1 מחלקה ראשונה

Cephalon Announces Positive Results From a Phase Two Study of ...  -  ‎Mar 17, 2009‎
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), PR Newswire (press release)

Durant Police Department Media Report for 3/16/2009  -  ‎Mar 16, 2009‎
Inside the bottle I located 1 blue pill (Alprazolam), 1 large oval pill (Acetaminophen-hydrocodone), and 2 small round white pills (Cyclobenzaprine). KTEN

Eurand NV Q4 2008 Earnings Call Transcript  -  ‎Mar 5, 2009‎
We hold the worldwide rights to cyclobenzaprine’s extended release outside North America. In August 2008, we entered into an exclusive license and supply Seeking Alpha

Cephalon Launches Takeover Offer for Australian Biotechnology ...  -  ‎Feb 26, 2009‎
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), PR Newswire (press release)

La Asociación Argentina de Farmacéuticos de Hospital y la ...  -  ‎Mar 6, 2009‎
En el Hospital Posadas se recibió en donación aproximadamente cien mil comprimidos de Cyclobenzaprine ClH, cien mil de Citalopram 40 mg y otros cien mil de Diario El Sol de Quilmes

Cephalon Appoints Sarma P. Duddu as General Manager and Vice ...  -  04 Feb 2009
The company's proprietary products in the US include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), TREANDA(R) (bendamustine PR Newswire (press release),

Tasered by deputies, man died from combination of factors, ME reports  -  04 Feb 2009
He had a small amount of alcohol in his blood, as well as prescription anti-depressants Cyclobenzaprine, Doxapine and Mitrazapine. Tampabay.com,

Buy cyclobenzaprine  -  Jan 17, 2009
Watch 5 buy cyclobenzaprine from people the give much home without mail to from particular buy cyclobenzaprine work Dizziness internet adipex adipex not Griggs County Courier,

Cephalon Exercises Option to License Worldwide Rights to ...  -  Feb 2, 2009
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), PR Newswire (press release),

Impax confirms patent challenge of muscle spasm drug  -  Jan 9, 2009
...submission of abbreviated new drug application for cyclobenzaprine hydrochloride extended release capsules 15 and 30mg, generic of Amrix, to the FDA. Trading Markets (press release),

What is fibromyalgia and what causes it?  -  Jan 28, 2009
Muscle relaxants such as cyclobenzaprine are also sometimes useful. Cymbalta is the trade name for the drug duloxetine, a serotonin-norepinephrine reuptake CNN

How to take strain off back pain  -  Jan 14, 2009
Narcotic analgesics can be used as well as skeletal muscle relaxants such as cyclobenzaprine for spasms. Local and epidural injections may relieve chronic Chicago Tribune,

What treatments work for neck pain?  -  Jan 21, 2009
Basmajian J. Cyclobenzaprine hydrochloride effect on skeletal muscle spasm in the lumbar region and neck: two double-blind controlled clinical and guardian.co.uk,

Cephalon Signs Option Agreement to Acquire Ception Therapeutics  -  Jan 13, 2009
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), PR Newswire (press release),

What's the evidence for muscle relaxants for long-term back pain?  -  Jan 21, 2009
Basmajian J. Cyclobenzaprine hydrochloride effect on skeletal muscle spasm in the lumbar region and neck: two double-blind controlled clinical and guardian.co.uk,

An Appraisal of Potential Drug Interactions in Cigarette Smokers ...  -  Jan 13, 2009
13 – 15 Other common drugs metabolized by CYP1A2 are cyclobenzaprine, duloxetine, lidocaine, melatonin, mirtazapine, ondansetron, ramelteon, ropinirole, Journal of the American Podiatric Medical Association (subscription)

Companies sue Mylan over generic version of Amrix  -  Dec 1, 2008
Cephalon Inc., Eurand Inc. and Anesta AG all have sued over the abbreviated new drug application to make cyclobenzaprine hydrochloride extended-release CNNMoney.com

Mylan Confirms First-to-File Patent Challenge Relating to AMRIX(R)  -  Dec 1, 2008
Cyclobenzaprine HCl ER Capsules, a muscle relaxant introduced to the market in October 2007 , had approximately $53 million in sales for the twelve months SYS-CON Media,

Jim Devereaux Pill mania  -  Dec 1, 2008
I have to take baby aspirin now that I'm 76, and too many pills have names I can't remember, like Cyclobenzaprine. I think every pill should have a simple Frederick News Post (subscription),

Difficult-to-treat chronic pain syndromes  -  Dec 16, 2008
13 Recommended treatment options include amitriptyline, cyclobenzaprine, cardiovascular exercise, cognitive behavior therapy, patient education, Clinical Advisor,

Primary Care Management of Nonmalignant Pain Reviewed  -  Dec 2, 2008
...atypical antidepressants (duloxetine, venlafaxine), topical lidocaine, and others (topical capsaicin, cyclobenzaprine, lidocaine patches). Medscape

Mylan reaches Femara settlement with Novartis  -  Dec 3, 2008
The legal action relates to the filing of an abbreviated new drug application for Cyclobenzaprine Hydrochloride Extended-release Capsules 15 mg and 30 mg, Hays Pharma,

Cephalon and Eurand file lawsuit against Mylan and Barr ...  -  Nov 28, 2008
By Staff Writer This patent claims extended-release formulations containing the muscle relaxant cyclobenzaprine, including Amrix and expires February 26, Pharmaceutical Business Review

Market Report -- In Play ()  -  Dec 1, 2008
...an Abbreviated New Drug Application for Cyclobenzaprine Hydrochloride Extended-release Capsules, 15 mg and 30 mg, the generic version of AMRIX Capsules. MSN Money

Cephalon, Eurand Sue Generic Drug Developers Over Patent ...  -  Nov 28, 2008
The companies said that their versions of cyclobenzaprine hydrochloride would not infringe on the Amrix patents. Cephalon claimed otherwise and that patents Trading Markets (press release),

Police: Drug dealer had five types of illegal prescriptions  -  Nov 14, 2008
Police found 20 tablets of Cyclobenzaprine, 14 tablets of Clonazepam, 20 oxycodone pills, 19 Suboxone pills and four Percocet tablets, along with 28.7 grams Enterprise News,

Cephalon Added to S&P 500 Today  -  Nov 14, 2008
The company's proprietary products in the United States include: TREANDA(R) (bendamustine hydrochloride) for Injection, AMRIX(R) (cyclobenzaprine MarketWatch

Eurand Reports Recent Developments and Third Quarter and Year-to ...  -  Nov 7, 2008
Faherty noted that revenues grew in part due to the strong growth in sales of AMRIX(r) (Cyclobenzaprine Hydrochloride Extended-Release Capsules) by Eurand's MarketWatch

Cephalon Receives FDA Approval for TREANDA to Treat Patients with ...  -  Oct 31, 2008
TREANDA, AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), VIVITROL(R) (naltrexone for extended-release injectable suspension), MarketWatch

Cephalon Inc. Q3 2008 Earnings Conference Call Transcript  -  Oct 28, 2008
Once a day dosing and low rates of some one from a molecule cyclobenzaprine which is the market leader. We believe AMRIX will continue to grow into a very Seeking Alpha,

Cephalon Reports Another Strong Quarter  -  Oct 28, 2008
AMRIX(R) (cyclobenzaprine hydrochloride extended- release capsules) sales increased 20 percent over the second quarter 2008. Oncology franchise sales were MarketWatch

Cephalon Receives FDA Approval for TREANDA to Treat Patients with ...  -  Nov 3, 2008
TREANDA, AMRIX ® (cyclobenzaprine hydrochloride extended-release capsules), VIVITROL ® (naltrexone for extended-release injectable suspension), PR Newswire (press release),

Aurobindo gets FDA nod for Cyclobenzaprine  -  Sep 29, 2008
US Food and Drug Administration (USFDA) approval for marketing Cyclobenzaprine hydrochloride tablets, most widely prescribed as a muscle relaxant. Economic Times,

Aurobindo Pharma receives final approval for Cyclobenzaprine ...  -  Oct 10, 2008
Cyclobenzaprine Hydrochloride Tablets is the generic version of MCNEIL-PPC's Flexeril tablets 5mg and 10mg and is indicated as an adjunct for relief of Equity Bulls,

Convicted Murder's Death Ruled Suicide  -  Oct 14, 2008
...which is used to treat moderate to severe pain; cyclobenzaprine, which is a muscle relaxer; and doxepin, which is used to treat depression or anxiety. WCAV,

Aurobindo Pharma gets USFDA nod for Fluconazole drug  -  Oct 11, 2008
Recently, Aurobindo Pharma has got US Food and Drug Administration (USFDA) nod to sell Cyclobenzaprine hydrochloride tablets of 10 mg and 5 mg. Stock Watch,

Weaver arraigned in deaths of 2 people  -  Oct 1, 2008
He is accused of being under the influence of the muscle relaxant cyclobenzaprine when his 1999 Jeep Cherokee crossed into the opposite lane about 8 pm Oct. WatertownDailyTimes.com,

Two drug busts, one town, one night  -  Oct 2, 2008
Seized evidence includes Cocaine, Oxycontin, Dilaudid (Hydromorphone), Ritalin and Cyclobenzaprine. Both males will attend provincial court on Nov. 10. Pictou Country Nova Scotia News,

Market Live  -  Oct 10, 2008
12:10 pm: Aurobindo Pharma has received final approval from the US Food & Drug Administration to manufacture and market cyclobenzaprine hydrochloride Economic Times,

Teva Neuroscience Launches Spanish Parkinson's Disease Patient and ...  -  Sep 29, 2008
Patients should not take AZILECT with tramadol, methadone, propoxyphene, dextromethorphan, St. John's wort, mirtazapine, or cyclobenzaprine. MarketWatch

Authorities rule death of Holton teen accidental  -  Sep 29, 2008
...levothyroxine, a thyroid hormone synthetic; cyclobenzaprine, a muscle relaxant; hydroxyzine, an antihistamine; plus hydrocodone (Vicodin) and methadone. Muskegon Chronicle - MLive.com,

Cephalon Launches National Consumer Awareness Initiative on ...  -  Oct 14, 2008
The company's proprietary products in the United States include: TREANDA(R) (bendamustine hydrochloride) for Injection, AMRIX(R) (cyclobenzaprine PR Newswire (press release),

Wockhardt gets nod for Promethazine hydrochloride injection  -  Sep 26, 2008
Wockhardt has received final approval from the US Food and Drug Administration (USFDA) to make and sell Promethazine hydrochloride injection, Myiris.com,

Gouverneur teen indicted in fatal crash  -  15 Sep 2008
The indictment accuses Weaver of being under the influence of the muscle relaxant cyclobenzaprine at the time of the accident. Newswatch 50,

Cephalon Receives Complete Response Letter Regarding Request for ...  -  15 Sep 2008
The company's proprietary products in the United States include: TREANDA(R) (bendamustine hydrochloride) for Injection, AMRIX(R) (cyclobenzaprine Earthtimes (press release),

Carlisle police chief’s son faces charges  -  Aug 28, 2008
A third held hydrocodone and cyclobenzaprine tablets. Troopers Michael Brandtonies and Scott Masci went to the home at 5:26 am to take Timothy Margeson into Carlisle Sentinel,

En el Posadas se recibieron medicamentos oncológicos  -  Aug 25, 2008
...recibido en donación aproximadamente cien mil comprimidos de Cyclobenzaprine ClH, cien mil de Citalopram 40 mg y otros cien mil de Citalopram de 20 mg. Diario El Sol de Quilmes,

Eurand Reports Recent Developments and Second Quarter 2008 ...  -  07 Aug 2008
In another noteworthy development, the Company was granted a patent for Amrix(r) (cyclobenzaprine HCl), the first and only once-daily skeletal muscle MarketWatch

Use of Muscle Relaxants for Musculoskeletal Conditions Reviewed  -  Aug 5, 2008
The most commonly prescribed antispasmodic agents are carisoprodol, cyclobenzaprine, metaxalone, and methocarbamol. A meta-analysis of cyclobenzaprine Medscape (subscription)

Eurand Enters Agreement With Daewoong Pharmaceutical Co. Ltd ...  -  Aug 1, 2008
Cyclobenzaprine ER has been developed using Eurand's innovative Diffucaps(r) technology. Financial terms were not disclosed. FOXBusiness

Rookie cop arrested for second time  -  Jul 14, 2008
Marketed under the brand name Flexeril and Fexmid, cyclobenzaprine is commonly prescribed for chronic back and neck pain and is potentially addictive. The Times of Trenton - NJ.com,

Court Briefs  -  Jul 14, 2008
He is accused on June 10 of trying to obtain hydrocodone and cyclobenzaprine using a fake prescription. Selling booze to children Elias Arthuro Cabera, 32, Northwest Arkansas Times,

Valdez's Final Year  -  Aug 1, 2008
He obtains a prescription for the muscle relaxer Flexeril, also known as cyclobenzaprine. It is effective 10 days later because he already had one from Tampa Tribune,

Cephalon Exceeds Both Sales and Earnings Guidance for Second ...  -  Jul 30, 2008
The company's proprietary products in the United States include: AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), TREANDA, PharmaLive.com (press release),

US Patent Disclosures  -  Jul 24, 2008
7387793, titled "Modified Release Dosage Forms of Skeletal Muscle Relaxants," which includes claims covering Amrix (cyclobenzaprine hydrochloride), TMCnet

Journal of Clinical Oncology Publishes Study of Cephalon ...  -  Jul 15, 2008
TREANDA, AMRIX(R) (cyclobenzaprine hydrochloride extended-release capsules), VIVITROL(R) (naltrexone for extended-release injectable suspension), CNNMoney.com (press release)

Market Report -- In Play (EURX)  -  Aug 1, 2008
Cyclobenzaprine ER has been developed using Eurand's innovative Diffucaps technology. Financial terms were not disclosed. Briefing.com is the leading MSN Money

Federal Agents Seize More Than $24 Million In Unapproved New  -  Aug 5, 2008
Representatives of the US Food and Drug Administration and the US Marshals Service recently seized $24.2 million worth of unapproved new drugs from KV Pharmaceutical Online (press release),

Brand Names/Synonyms:
Cyclobenzaprine is also known by the following brand names and/or synonymsCyclobenz; Cyclobenzaprine; Cyclobenzaprine Hcl; Flexeril; Flexiban; MK-130; Proeptatriene; Proheptatriene; RP-9715

Drug Category:
Cyclobenzaprine is categorized under the following by the FDA: Tranquilizing Agents; Muscle Relaxants; Antidepressants; Skeletal Muscle Relaxants; ATC:M03BX08

Dosage Forms:
"D"-shaped, film coated tablets

Absorption:
Well absorbed after oral administration

Interactions:
-->Interactions for Cyclobenzaprine:

FLEXERIL may have life-threatening interactions with MAO inhibitors.

FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.

Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.

Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol.

 




Chemical IUPAC Name:
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine

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