Cozaar

This page contains recent news articles, when available, and an overview of Cozaar but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cozaar
(when available)

Pharmacology and use:
Losartan is the first of a class of antihypertensive agents called angiotensin II (AG II) receptor antagonists. It is, along with its longer acting active metabolite (E-3174), a specific and selective AT1 receptor antagonist. Losartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). For the treatment of hypertension

Mechanism Of Action:
Losartan and its longer acting active metabolite (E-3174) interfere with the binding of angiotensin II to the angiotensin II AT1-receptor by, themselves, binding reversibly to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Neither Losartan or its metabolite inhibit the angiotensin converting enzyme, other hormone receptors, or ion channels.

News Articles on Losartan

About this author:  -  20 Apr 2009
Negative factors this quarter could come from currency headwinds and lower sales from Cozaar/Hyzaar and Gardasil lines. The joint marketing with Seeking Alpha

Fitch Affirms DuPont's IDR at 'A'; Outlook Revised to Negative  -  ‎Mar 31, 2009‎
...the anticipated loss of more than $1 billion in pharmaceutical royalties from the hypertension drug Cozaar/Hyzaar after patent expiry in April 2010. FOXBusiness

Fitch cuts ratings outlook on DuPont to negative  -  ‎Mar 31, 2009‎
DuPont likely will also be affected by an expected loss of $1 billion in pharmaceutical royalties when the patent expires for hypertension drug Cozaar, Forbes

Author, Creator of The 50 Million Pound Challenge  -  ‎Apr 2, 2009‎
My doctor switched me from Hyzaar, to Cozaar (sp?) to avoid further problems with low Potassium. Doctors I've seen are not sure why my Potassium is so low Washington Post

Generic Version of Topamax® Will Save Upstate New Yorkers Millions  -  ‎Apr 7, 2009‎
Other drugs whose patents are scheduled to expire in 2009 and 2010 include Prevacid®, Hyzaar®, Cozaar® and Flomax®. The patent for Prevacid is expected to ReadMedia (press release)

2-in-1: Merck and Schering-Plough  -  ‎Apr 8, 2009‎
Most notable of these is Cozaar. The high blood pressure treatment which is expected to earn at least $3.4 billion this year is due to lose its US market Pharmafocus

To drug firms, UPS a cure for logistics  -  ‎Mar 30, 2009‎
With 36-foot-high ceilings, about six stories of crates filled with drugs can be stacked in dry conditions, such as Singulair for allergies or Cozaar for Atlanta Journal Constitution

Schering-Plough, Merck set $41.1B merger  -  ‎Apr 7, 2009‎
Other key products include: Cozaar, Hyzaar, Gardasil, Januvia, Vytorin and Zetia. Schering-Plough was established in the late 1800s as the US subsidiary of IndUS Business Journal

Gilead: Helping Investors Cope With the Market  -  ‎Apr 3, 2009‎
...reduce their blood pressure with other medications like AstraZeneca's (NYSE: AZN) Zestril, Merck's (NYSE: MRK) Cozaar, or Pfizer's (NYSE: PFE) Norvasc. Motley Fool

The growth potion  -  ‎Apr 4, 2009‎
Four of its brands (Singulair, Cozaar/Hyzaar, Fosamax and Zocor) were slated to take on generic competition post-expiry. Pfizer estimates the off-patent Hindu Business Line

惠誉将æ?œé‚¦å‰?景评级é™?至负é?¢  -  ‎Mar 31, 2009‎
...惠誉还称,预计æ?œé‚¦å°†æ?Ÿå¤±10亿美元的è?¯ç‰©ä¸“利收益,原因是高血压è?¯ç‰©Cozaar(亦å??Hyzaar)的专利æ?ƒå°†äºŽæ˜Žå¹´åˆ°æœŸã€‚æ?œé‚¦å’Œé»˜æ²™ä¸œå…¬å?¸(Merck & Co.)签有分享这ç§?è?¯ç‰©ç›ˆåˆ©çš„ 新浪网

惠譽將æ?œé‚¦å‰?景評級é™?至負é?¢  -  ‎Mar 31, 2009‎
...惠譽還稱,é ?計æ?œé‚¦å°‡æ??失10億美元的藥物專利收益,原因是高血壓藥物Cozaar(亦å??Hyzaar)的專利權將於明年到期。æ?œé‚¦å’Œé»˜æ²™æ?±å…¬å?¸(Merck & Co.)簽有分享這種藥物盈利的 新浪網

专利å?±æœºï¼šè¾‰ç‘žæ€¥è¿›ä»¿åˆ¶è?¯ç½—æ°?对仿制è?¯è¯´"ä¸?"  -  ‎Apr 9, 2009‎
...默沙东的状况也很ä¸?妙,其两大é‡?磅è?¯Cozaarå’ŒSingulair将分别于2010å¹´å’Œ2012年失去专利ä¿?护,这两ç§?è?¯æ¶‰å?Šè¿‘80亿美元的销售é¢?,相当于2009年预计销售é¢?32%的产å“?。 搜狐

Single bid for Lipitor · Cozaar…competition for domestic companies  -  ‎Mar 8, 2009‎
Most doses of ‘Cozaar’ of MSD Pharmaceutical were designated as single items, but 50mg will compete with ‘Coska’ of SK. However, Cozaar and Coska have been 디지틀보사

Merck & Schering-Plough: Analysts See a Win-Win Deal for Holders  -  ‎Mar 9, 2009‎
Our model indicates that the deal is accretive after the 1st year of the merger, better positions Merck to navigate its patent expirations (Cozaar/Hyzaar Wall Street Journal Blogs

South Korea Pharmaceuticals and Healthcare Report Q1 2009 ...  -  ‎Mar 13, 2009‎
Dong- A, Hanmi and Yuhan were planning to launch their generic versions of Cozaar, while Daewoong and MSD Korea intend to launch their generic Januvia PR-Inside.com (Pressemitteilung)

Blood pressure drug may help brain tumor patients  -  ‎Feb 28, 2009‎
...researchers tested in rats a compound similar to the anti-hypertensive drug losartan (Cozaar®) to see if it might prevent the cognition loss that has Cancerfacts.com

Merck and Schering-Plough mega-merger will create a company ...  -  ‎Mar 13, 2009‎
The key factor driving this decline is generic competition against patent expired major products out to 2013, including Singulair, Cozaar/Hyzaar, Trading Markets (press release)

About this author:  -  ‎Mar 9, 2009‎
Merck, which will see patents on blockbusters Cozaar and Singulair expire in 2010 and 2012, respectively, will have almost $8 billion (about 32% of Seeking Alpha

WHO angry at seizure by Dutch of HIV drug shipment  -  ‎Mar 12, 2009‎
...request of Merck & Co, which holds the patent for the branded version Cozaar, so that it could be inspected for a possible violation of patent rights. Pharma Times

For Big Pharma, the playfield's here  -  ‎Mar 8, 2009‎
It is projected that another $44 billion worth of drugs will go off patent in 2010, including leading ones like Lipitor (for cholesterol), Cozaar (blood Daily News & Analysis

Piribo: New Report Provides Guidance to Pre-Launch Planning in the ...  -  ‎Mar 11, 2009‎
With so many revenue-producing drugs going off patent shortly (Lipitor, Cozaar, Fosamax, Singulair, etc.), companies are facing sales that are increasingly Live-PR.com (Pressemitteilung)

Generic drugs' war hotting up  -  ‎Feb 26, 2009‎
However, the US-based DuPont holds the patent for branded losartan in the Netherlands which is sold as the brand name Cozaar brand. Central Chronicle

EU anti-counterfeiting rules “being misused by pharma corporate ...  -  ‎Feb 24, 2009‎
...bulk losartan (Merck & Co’s antihypertension drug Cozaar) manufactured by Indian firm Dr Reddy’s, as it passed through Rotterdam on its way to Brazil. Pharma Times

EU, States Clash Over Generic Drug Swoop  -  ‎Mar 3, 2009‎
...under the name Merck Sharp & Dohme. Losartan is the generic name for the drug Cozaar developed jointly by Merck and EI du Pont de Nemours & Co (Dupont). Javno.hr

Grandes manoeuvres dans la pharmacie américaine  -  ‎Mar 10, 2009‎
Le Cozaar (hypertension) tombera dans le domaine public en 2010 et le Singulair (asthme) en 2012. Ensemble, ces deux médicaments ont généré environ 8 Le Monde

Todas las secciones  -  ‎Mar 9, 2009‎
Medicamento COZAAR (Losartán) de 100 mg, es para la presión arterial alta, si sabes de alguien que necesite tomarlo, yo vendo varias cajas porque por Mi Morelia.com

焦点:默克制è?¯å¼€ä»·411亿美元收购先ç?µè‘†é›…  -  ‎Mar 9, 2009‎
...默克用于治疗哮喘的è?¯ç‰©Singulair的专利将于2012年到期,而用于控制血压的è?¯ç‰©Cozaar专利将于明年到期. 由于Vytorin是默克和先ç?µè‘†é›…çš„å?ˆä½œäº§ç‰©,多年æ?¥ä¸€ç›´æœ‰åˆ†æž?师预期 路透社

Massiver Stellenabbau bei Cytos  -  ‎Mar 17, 2009‎
...rund 40 Mrd. Dollar geschätzten Marktsegment tummeln sich Milliarden-Medikamente wie Diovan von Novartis , Norvasc von Pfizer oder Cozaar von Merck. 20minuten

Fusionskarussell in der Pharmaindustrie dreht sich immer schneller  -  ‎Mar 9, 2009‎
Auch Merck & Co muss in absehbarer Zeit den Patentablauf zweier Erfolgsmedikamente, des Blutdrucksenkers Cozaar und des Asthma-Medikaments Singulair, Epoch Times Deutschland

Hastaneler bir aydır ilaçsız  -  ‎Feb 26, 2009‎
Norflex ampul, Muscoril ampul, Buscopan ampul, Genta 80 ampul, Diazem ampul, Beloc 50 tablet, Citalopram tablet, Cozaar 50 tablet, Cardura 2 tablet, Kıbrıs Gazetesi

Merck beats fourth-quarter projections  -  04 Feb 2009
Sales of blood-pressure medicines Cozaar and Hyzaar dipped 1 percent, to $881 million, and revenue for Gardasil, a vaccine to prevent cervical cancer, Philadelphia Inquirer,

Merck & Co chief does not rule out big deals as earnings climb  -  04 Feb 2009
Revenues from the anti-hypertensives, Cozaar (losartan) and Hyzaar (losartan plus hydrochlorothiazide) were down 1% to $881 million, while sales of the Pharma Times,

Zacks Analyst Blog Highlights: Motorola, Merck & Co., Canadian ...  -  04 Feb 2009
Sales of Singulair and Gardasil continue to show significant softening, and Cozaar/Hyzaar sales in the most recent quarter were significantly weaker than Business Wire (press release),

Zacks Analyst Blog Highlights: Motorola, Merck & Co., Canadian ...  -  04 Feb 2009
Sales of Singulair and Gardasil continue to show significant softening, and Cozaar/Hyzaar sales in the most recent quarter were significantly weaker than PR-Inside.com (Pressemitteilung),

Merck, Schering Earnings Are Better Than Expected  -  Feb 3, 2009
Next year, it faces the loss of US patent protection for anti-hypertension drugs Cozaar and Hyzaar. On Tuesday, Merck said 2009 sales were likely to come in CNNMoney.com

Merck Posts In-Line 4th Quarter  -  Feb 3, 2009
Sales of Singulair and Gardasil continue to show significant softening, and Cozaar/Hyzaar sales in the most recent quarter were significantly weaker than Zacks.com,

Chinese herb may help treat a cold  -  Feb 2, 2009
Finally, I saw an allergist, who took me off lisinopril and replaced it with Cozaar. Cough gone! Lisinopril is an ACE inhibitor. Los Angeles Times,

Merck Announces Fourth-Quarter and Full-Year 2008 Financial Results  -  Feb 3, 2009
2 COZAAR and HYZAAR are registered trademarks of EI duPont de Nemours and Company, Wilmington, Del. Worldwide sales of Merck's other viral vaccines, WELT ONLINE,

Brazil to object to Dutch seizure of generic drug  -  Jan 22, 2009
Losartan is the generic name for the drug Cozaar that was co-developed by Merck & Co and DuPont Co. (Reporting by Pedro Fonseca; writing by Reese Ewing) Reuters

Merck reassigns Gardasil exec  -  Jan 13, 2009
As you know, Merck's latest foray into that field, the cholesterol med Cordaptive, is on the back burner till 2013, and its blood pressure drug Cozaar could FiercePharma,

Analyst: Contract sales reps rule  -  Jan 22, 2009
Some companies are already doing this; for instance, Merck inked a deal with InVentiv Health for marketing Cozaar and Hyzaar--right after it laid off 1200 FiercePharma,

Lowering blood pressure  -  Jan 21, 2009
Angiotensin II receptor antagonists: Drugs in this group include losartan (Cozaar), valsartan (Diovan) and candesartan (Amias). There are other drugs that guardian.co.uk,

Drug Makers Take Varying M&A Tacks In Wake Of Pfizer's Move  -  Feb 3, 2009
Hypertension drugs Cozaar and Hyzaar face patent expirations next year, while the Singulair allergy and asthma medication is set to lose protection in 2012. CNNMoney.com

People's Pharmacy: A cure for doctors' illegible scrawl  -  Feb 1, 2009
Finally, I saw an allergist, who immediately took me off lisinopril and replaced it with Cozaar. Cough gone! A. Lisinopril is an ACE inhibitor. Houston Chronicle,

Reportlinker: Forecast Performance For Merck & Co. Inc ...  -  Jan 22, 2009
122 Overview 122 Sales forecast 123 Cardiovascular 125 Zetia/Vytorin 125 Overview 126 Sales forecast 128 Cozaar/Hyzaar 133 Overview 134 Sales forecast MarketWatch (press release)

DuPont Has $629 Million Loss as Global Demand Drops  -  Jan 27, 2009
Hypertension drugs Cozaar and Hyzaar contributed $265 million to earnings, a 7.7 percent increase. US patents for the medicines, marketed through Merck Bloomberg

Developing states attack EU on generic drug seizure  -  Feb 3, 2009
Losartan is the generic name for the drug Cozaar developed jointly by Merck (nyse: MRK - news - people ) & Co and Dupont (nyse: DD - news - people ) Co. Forbes,

High blood pressure  -  Jan 21, 2009
Angiotensin II receptor blockers (ARBs): candesartan (Amias), losartan (Cozaar) and valsartan (Diovan). Beta-blockers: atenolol (Tenormin), guardian.co.uk,

What treatments work for heart failure?  -  Jan 21, 2009
Examples of these drugs include candesartan (Amias), eprosartan (Teveten) and losartan (Cozaar). More... Beta-blockers: These drugs slow your heart rate, guardian.co.uk,

Dr Reddy’s consignment of drugs to Brazil seized  -  Jan 14, 2009
The patent for losartan in the Netherlands is held by US-based DuPont under the Cozaar brand. Commerce secretary GK Pillai said the department has taken up Livemint,

A taste of dysglycemia  -  Jan 9, 2009
Medications included lisinopril, carvedilol, duloxetine (Cymbalta, Eli Lilly), pramlintide (Symlin, Amylin) 12 U with meals, losartan (Cozaar, Merck), Endocrine Today,

Brazil, India denounce Dutch generic drug seizure  -  Jan 30, 2009
Losartan is the generic name for the drug Cozaar developed jointly by Merck & Co and Dupont Co. (Reporting by Jonathan Lynn; editing by Erica Billingham) Reuters

India plans to move WTO as EU confiscates drugs in transit  -  Jan 16, 2009
US-based DuPont holds the patent for branded losartan in the Netherlands which is sold as the brand name Cozaar brand. Losartan is used to lower blood domain-B,

BUYINS.NET: Market Maker Surveillance Report. Top 6 Highest Net ...  -  Jan 30, 2009
Its products comprise Singulair, a leukotriene receptor antagonist for the treatment of asthma and allergic rhinitis; Cozaar, Hyzaar, Vasotec, and Vaseretic Trading Markets (press release),

Brasil ataca UE na OMC por apreensão de genéricos  -  Feb 3, 2009
Trata-se da versão genérica do medicamento Cozaar, desenvolvido conjuntamente pela Merck e pela Dupont. Fontes comerciais dizem que a Merck é a detentora da Invertia (Brasil),

DAVOS-Brasil e Ã?ndia denunciam apreensão de genéricos na Holanda  -  Jan 30, 2009
...sido fabricado pelo laboratório Dr. Reddy's. Losartan é o nome genérico do medicamento Cozaar, desenvolvido conjuntamente pelas empresas Merck e Dupont. Estadão,

Medicamentos aumentan más del 30% en un año  -  Jan 13, 2009
Otro medicamento de marca que subió de precio es la Cozaar (para la hipertensión), el precio mediano 2007 era de $1.86 y, en 2008, fue de $2.23, El Diario CoLatino,

盲目跟进代价高  -  Jan 20, 2009
...目��邦对制�业务仅�留两项��Cozaar 金�界,

Brand Names/Synonyms:
Cozaar is also known by the following brand names and/or synonymsCHEMBANK1667; Cozaar; DUP 89; Hyzaar; Lacidipine; Lortaan; Losartan

Drug Category:
Cozaar is categorized under the following by the FDA: Antihypertensive Agents; Antiarrhythmic Agents; Angiotensin II Receptor Antagonists; ATC:C09CA01

Dosage Forms:
Tablets

Absorption:
Well absorbed, the systemic bioavailability of losartan is approximately 33%

Interactions:
-->Interactions for Losartan:

No significant drug-drug pharmacokinetic interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital. Rifampin, an inducer of drug metabolism, decreased the concentrations of losartan and its active metabolite. In humans, two inhibitors of P450 3A4 have been studied. Ketoconazole did not affect the conversion of losartan to the active metabolite after intravenous administration of losartan, and erythromycin had no clinically significant effect after oral administration. Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration. The pharmacodynamic consequences of concomitant use of losartan and inhibitors of P450 2C9 have not been examined. Subjects who do not metabolize losartan to active metabolite have been shown to have a specific, rare defect in cytochrome P450 2C9. These data suggest that the conversion of losartan to its active metabolite is mediated primarily by P450 2C9 and not P450 3A4.

As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium.

As with other antihypertensive agents, the antihypertensive effect of losartan may be blunted by the non-steroidal anti-inflammatory drug indomethacin.

 





Chemical IUPAC Name:
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-imidazol-4-yl]methanol

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