Codeine

This page contains recent news articles, when available, and an overview of Codeine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Codeine (when available)

Pharmacology and use:
Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent. For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.

Mechanism Of Action:
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

News Articles on Codeine

CAA's Bryan Lourd to Carrie Fisher: 'Your Codeine Made Me Gay'  -  21 Oct 2008
Page Six has the excerpt: "He told me later that I had turned him gay . . . by taking codeine again. And I said, 'You know, I never read that warning on the Defamer.com,

Carrie Fisher tells all in memoir  -  21 Oct 2008
She says of Lourd, an executive with the CCA talent agency: "He told me later that I had turned him gay . . . by taking codeine again. First Post,

Carrie Fisher says she did not turn ex-hubby gay  -  21 Oct 2008
In her side-splitting journal, the actress, who was deserted by Lourd for a man, joked that she did not realise that taking codeine would turn her former Thaindian.com,

Carrie Fisher will not turn you gay  -  21 Oct 2008
..."He told me later that I had turned him gay . . . by taking codeine again. And I said, 'You know, I never read that warning on the label. AfterElton.com

After my cancer triathlon, I faced Everest  -  21 Oct 2008
Anne ordered codeine, then stronger narcotics. When the CT scan results came back negative, she said, "I want you to see a physiatrist. Globe and Mail,

Neighbour tells how he pulled firebombed family to safety  -  21 Oct 2008
In mitigation Alex Williams said: "He received scratches (in the road rage incident) and self medicated with codeine and alcohol. Croydon Advertiser,

Health Canada/Advisory: Use of Codeine Products by Nursing Mothers  -  Oct 8, 2008
Once ingested, codeine is converted by the body into morphine. Some people convert codeine into morphine more rapidly and completely than others. MarketWatch

EAST BAY ROUNDUP  -  Oct 18, 2008
While speaking to the teens in the car, the officer spotted five bottles of prescription codeine cough syrup without prescription labels. San Jose Mercury News,

Drug makers to change codeine labels to prevent overdose in babies  -  Oct 9, 2008
Nursing mothers who take codeine medication should be aware that, depending on how quickly they metabolize the drug, their breastfed babies may be at CBC.ca,

Warning Label for Acetaminophen With Codeine to Include Nursing ...  -  Oct 14, 2008
2, 3, 4 and Tylenol with codeine Elixir) in nursing mothers with ultra-rapid metabolisers of codeine. · Some individuals may be ultra-rapid metabolisers of DG News

East Haven pedestrian struck  -  Oct 19, 2008
Gabucci was taken into custody and had Tylenol and Codeine in her possession. Assault 1st Degree, Reckless Endangerment, Possession of Narcotics are just a WTNH,

2 men armed with pistols rob pharmacy in the Crichton area of Mobile  -  Oct 17, 2008
An officer at the scene of the abandoned truck said Lortab, Xanax, OxyContin, and codeine were recovered. Bridgeforth said both robbers were described as Press-Register - al.com,

Confessions of an opiate-eater  -  Sep 25, 2008
I'm talking about codeine linctus, which is sold as a cough suppressant. Many pharmacists no longer sell this product, but all can if they wish. Belfast Telegraph,

LSD Cured My Headache  -  Oct 10, 2008
Aspirin, paracetamol, codeine -- doubling up on the codeine -- taking whatever you're allowed to each day," Flash says. "It took the lining off my stomach, AlterNet,

My fears for baby after drugs error  -  Oct 11, 2008
Crystal, who is six months pregnant with her first child, had been prescribed the codeine-based drug Cocodamol to help ease back pain. Southern Daily Echo,

Demand for addictive drugs testing security  -  Oct 12, 2008
They did, however, make away with 14 bottles of promethazine with codeine, a painkiller that, when mixed with a soft drink, becomes an intoxicating liquid Columbus Dispatch,

Substance Use Problems  -  Oct 19, 2008
...codeine, heroin, and morphine) are the most commonly abused substances. Anabolic steroids are sometimes abused in order to improve athletic performance. Canada.com,

Hospitals urged to standardize wristband colors for safety  -  Oct 18, 2008
The yellow band reminded her colleagues that she's a fall risk, and handwriting on her red bracelet noted that she's allergic to codeine and penicillin. Houston Chronicle,

Overdose theory on death at police HQ  -  Oct 14, 2008
...was revealed at his inquest at Stourport Coroner’s Court yesterday as poisoning from two types of painkillers which contained paracetamol and codeine. expressandstar.com,

Richfield Man Charged in Pharmacy Thefts for 'Purple Drank'  -  Sep 25, 2008
In each case, they targeted prescription cough syrup with codeine. "Their method of operation is to walk into these pharmacies and either jump the counter FOX 9 News,

Redwood man stopped with drugs in Alexandria Bay  -  Oct 12, 2008
...in possession of less than 25 grams of marijuana and several prescription medications consisting of Hydrocodone, Ultracet, and Codeine/ Acetaminophen. Newswatch 50,

Dozens Charged In Major Drug Operation In Clermont Co.  -  Oct 9, 2008
...focused on people who were involved in trafficking and abusing various opiates, including morphine, codeine, oxycontin, percocet, methadone, and heroin. kypost.com,

Commonly Abused Prescription Medications-Painkillers  -  Sep 25, 2008
Morphine and fentanyl are often used to alleviate severe pain, while codeine is used for milder pain. Other examples of opioids that can be prescribed to TransWorldNews (press release),

Weed & Seed patrols net arrests  -  Sep 29, 2008
Police found a quart-sized plastic bag containing 316 Tylenol with codeine pills in Balser's purse, along with marijuana, two pipes with residue and a pipe Journal and Courier,

Jolly case pushed back  -  Sep 30, 2008
Jolly faces felony charges of possessing at least 200 grams of codeine. According to news stories citing the official police report, cups of liquid codeine Milwaukee Journal Sentinel,

Man Shot By Police Under Influence Of Drugs  -  Oct 7, 2008
Cocaine, codeine and heroin were among the drugs detected in the blood of Larry Labensky, 44, of Kettering. Cocaine was also found in his pocket. WHIOtv.com,

Prescription drug drop-off to be held in El Segundo  -  Oct 5, 2008
Do not bring controlled substances such as narcotics, Vicodin, Ritalin, codeine, Oxycodone and Valium. Also not permitted are thermometers, Daily Breeze,

Man died from excessive use of painkillers  -  Sep 26, 2008
Mr Morris also read evidence that Mr Elding was addicted to codeine, which he had taken to crushing and injecting rather than taking it orally as prescribed Leighton Buzzard Today,

Fortunate to have had local ER response  -  Sep 29, 2008
On my own, I decided to take some aspirin and worked my way up to Tylenol with codeine. Thus a bleeding ulcer. I have wondered since what might have Welland Tribune,

Packers lose Jenkins for the season  -  Oct 1, 2008
Jolly was arrested this summer for allegedly possessing at least 200 grams of codeine. Police said he was in a car with several friends and one reportedly New Richmond News,

Couple plan to sue Sheriff's Office  -  Oct 18, 2008
Investigators raided their home, seizing Lorazepom, Hydrocodone, Hydromorphone, Oxycodone, a bottle for Acetaminophen with Codeine and other items. Tallahassee.com,

LSD cured my headache  -  Oct 6, 2008
Aspirin, paracetamol, codeine – doubling up on the codeine – taking whatever you're allowed to each day," Flash says. "It took the lining off my stomach, Independent,

British pair face three months in Dubai jail for drunken sex on ...  -  Oct 16, 2008
Even everyday medicines such as codeine are banned, and carrying poppy seeds or jet-lag medicine can lead to a charge. While alcohol is tolerated, guardian.co.uk,

Extreme rehab: Inside the world's most radical drug clinic  -  Oct 1, 2008
He states: "It doesn't matter whether it is a heroin addict who has been using for 20 years or a businessman who started taking codeine for a back problem Independent,

Marine Corps News, news from Iraq - Marine Corps Times  -  Oct 18, 2008
Mitragyna speciosa korth, a leaf that acts as an opiate, similar to codeine. • Spice gold, a powder that when smoked produces effects similar to marijuana. Marine Corps Times (subscription)

China Aoxing Pharmaceutical Reports Fiscal Year 2008 Financial Results  -  Oct 15, 2008
...as several pipeline products entered clinical trials in 2008, including Tilidine, Codeine phosphate and other narcotics and pain management programs. CNNMoney.com

Autopsy results released in murder of Salisbury dentist  -  Oct 18, 2008
Oxymorphone is a narcotic painkiller; opiates are similar to codeine and morphine, which are also pain relievers; and ethanol is a form of alcohol. Salisbury Post,

Courthouse records  -  Oct 18, 2008
Timothy R. Hammond, 30, of 71 Lyford St., Worcester, charged with possession of heroin and possession of Klonopin and codeine, continued to Nov. 20. Worcester Telegram,

Bureau Of Prisons Worker Indicted For Bribery  -  Oct 17, 2008
During this meeting, the UC said that the inmate was experiencing pain in his/her shoulder and asked Frangiosa if he could smuggle Tylenol with codeine to North Country Gazette,

Sheriff’s office: 5300 pills stolen  -  Oct 17, 2008
Hydrocodone is a habit-forming compound derived from codeine; it's usually used with other drugs as an analgesic or cough sedative, according to Gulf Coast Newspapers,

Covidien launches $100 million plant expansion, adds jobs  -  Oct 17, 2008
Covidien’s pharmaceutical line includes acetaminophen, antidepressants, sleep aids, generic products and controlled substances such as morphine and codeine. St. Louis Business Journal,

Treatment Options For Pain Pill Addiction  -  Oct 17, 2008
Or maybe the person has been feeling down, and notices that the codeine that they took for their wisdom tooth surgery made them feel better, and so makes up Times of the Internet,

11.31pm - Jury retires in Tredworth murder case  -  Oct 17, 2008
He had also suffered liver damage from an overdose of paracetamol and codeine. Bayle, who denies murder, told the jury he could not recollect anything Forester,

WINEHOUSE BLAMES CRACK ADDICTION ON LSD HALLUCINATIONS  -  Oct 17, 2008
..."I’d done Darvon, Lortab, methadone, morphine, Percodan, some Phenaphen with Codeine, Talacen, Tramadol, lots of Tylenol, some Ultram, but never all at the Daily Mash (satire),

'My daughter died because they didn't care'  -  Oct 10, 2008
A toxicology report showed Melanie had traces of the painkiller Tramadol, sedative Promazine and codeine in her system when she died. NEWS.com.au,

The recovery of Agustin Castellanos, doctor and drug addict  -  Oct 5, 2008
He had collapsed from the effects of Fiorinal with codeine, a powerful narcotic pain medication and muscle relaxant. He hadn't meant to overdose. Palm Beach Post,

The devil in Miss Jolie Holland  -  Oct 16, 2008
Holland has no cause to be bummed out by The Living and the Dead, which effortlessly blends whispering-pines Americana, codeine-laced throwback jazz, Georgia Straight,

Oceana County struggles with teen drug problem  -  Oct 11, 2008
The use of prescription drugs, like OxyCotin, Vicodin and Codeine, is increasing, French said, due to "household availability" and the fact the pills are MLive.com,

McLennan County grand jury indictments for Oct. 15  -  Oct 15, 2008
Robert Ray Ruiz, 25, Waco, delivery of a controlled substance: promethazine with codeine. * William Keith Payne, 47, address unavailable, unauthorized use Waco Tribune Herald,

Call for major aged care shakeup  -  Oct 9, 2008
His report found that there had been inadequate documentation over how much of the drug codeine phosphate Peggy was given and there was a need for a more TVNZ,

Brand Names/Synonyms:
Codeine is also known by the following brand names and/or synonymsCCRIS 7555; Codeine; Codeine Anhydrous; Codeine Base [D.D]; Codeine [Anhydrous]; Codicept; Coducept; HSDB 3043; L-Codeine; Methylmorphine; Morphine Monomethyl Ether; Norcodeine, N-Methyl; Norcodine, N-Methyl

Drug Category:
Codeine is categorized under the following by the FDA: Narcotics; Antitussives; Analgesics; Opiate Agonists; ATC:N02AA08; ATC:R05DA04

Dosage Forms:
oral solution, tablets

Absorption:
well absorbed

Interactions:
Interactions for Codeine:

Codeine in combination with other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, or other CNS depressants (including alcohol) has additive depressant effects. When s.c. combination therapy is contemplated, the dosage of one or both agents should be reduced.

Chemical IUPAC Name:
(5(,6()-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol

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