Clonazepam

This page contains recent news articles, when available, and an overview of Clonazepam but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Clonazepam
(when available)

Pharmacology and use:
Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus. Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures.

Mechanism Of Action:
Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

News Articles on Clonazepam

Havelock man arrested by Jacksonville police  -  20 Apr 2009
He is also accused of growing marijuana and possessing more than one-half ounce of marijuana, clonazepam and xanax, according to warrants. New Bern Sun Journal

Burlington woman pleads guilty to delivering marijuana, pills  -  ‎Apr 14, 2009‎
Clonazepam is used to control certain types of seizures in the treatment of epilepsy and for the treatment of panic disorders. Burlington Hawk Eye

Black Mountain man charged with credit card theft and fraud  -  ‎Apr 17, 2009‎
...took a credit card belonging to Jeffrey Lee Johnson. Donato also was charged with misdemeanor larceny and simple possession of three tablets of Clonazepam. Asheville Citizen-Times

Homicide charges possible in Bay teen's death  -  ‎Apr 2, 2009‎
The other drug reportedly found in Kiefer's body, clonazepam, is used to treat certain types of seizures and panic disorders. Court records show that police Milwaukee Journal Sentinel

Accused burglar gets additional drug charges  -  ‎Apr 15, 2009‎
Tyler Weaver, 1153 S. Tyler, was charged with possession of methamphetamine, Clonazepam and THC in Lincoln County Court Wednesday. North Platte Bulletin

Victim’s alcohol intake becomes focus of trial  -  ‎Apr 14, 2009‎
He also had traces of the anti-anxiety drug clonazepam in his blood. Mayhers agreed with defence lawyer Gary Barnes that Kennedy had enough alcohol in his Ottawa Citizen

Olmsted District Court  -  ‎Apr 13, 2009‎
A 16-year-old Rochester boy is charged with fifth-degree controlled substance crime for allegedly being in possession of clonazepam in January. Post-Bulletin

Kiefer's Death Officially Ruled Overdose  -  ‎Apr 3, 2009‎
It lists Clonazepam and Buprenophine. The manner of death is considered an accident. Kiefer was found dead in the driveway of a friend's home on March 1st. Today's TMJ4

Chill Pills: Overview of Medications  -  ‎Apr 2, 2009‎
Klonopin (generic name: clonazepam): Lasts longer in the body and is therefore more sedating than Xanax or Ativan. Users may feel groggy that day, Oprah.com

Spencer teen faces drug distribution charge  -  ‎Apr 3, 2009‎
Investigators think the teenager had 13 pills of clonazepam, also called Klonopin, at the time of the arrest. Some of the pills were apparently acquired by Spencer Daily Reporter

Spencer teen faces drug distribution charge  -  ‎Mar 31, 2009‎
Spencer Police Chief Mark Lawson said the teenager was selling the prescription drug clonazepam, which is also known under the brand name Klonopin. Spencer Daily Reporter

Police Briefs  -  ‎Apr 2, 2009‎
An unknown amount of prescription pills, which police identified as Clonazepam/Percocet’s, were stolen from the first residence at approximately 8 am on Towanda Daily Review

Huntsville police blotter: Thief stiffs restaurant  -  ‎Apr 2, 2009‎
University Drive: One person was charged with illegal possession of drugs after officers found 42 Clonazepam tablets and a bag of marijuana in a vehicle The Huntsville Times - al.com

Pleas taken in Morgan Superior Court  -  ‎Apr 17, 2009‎
Zachary Johnson, 22, Watkinsville, pled guilty to one count possession of Clonazepam, one count possession of Alprazolam, one count possession of marijuana, Morgan County Citizen

Alleged killer had bullets at DUI stop  -  ‎Apr 15, 2009‎
Horner also had marijuana and Clonazepam, a prescribed drug used to treat panic disorders and seizures, in his system, Turek wrote. Decort set Horner's bond Altoona Mirror

Calvert County Sheriff's Reports  -  ‎Apr 14, 2009‎
Barry Leonard Hunnicutt, 23 of Lusby, was charged with possession of marijuana, possession of Percocet, possession of Clonazepam, possession of heroin, Southern Maryland Online

police logs  -  ‎Apr 17, 2009‎
Newburyport, was arrested yesterday at 2:14 pm and charged with possession of class B drugs (Methadone) and possession of class C drugs (Clonazepam). The Daily News of Newburyport

Observe and Report  -  ‎Apr 10, 2009‎
It isn't all meant to be funny; yes, Ronnie's clonazepam is played for jokes, but it also looks eerily like psycho-pharmaceutical product placement. Houston Chronicle

Two Bridgeton men face several drug charges following arrests ...  -  ‎Apr 13, 2009‎
Police recovered roughly 14 grams of crack cocaine, 21 grams of marijuana, 14 Diazepam pills, 14 Clonazepam pills, 12 Oxycontin pills and a scale while NJ.com

Police seek medical records of Whitefish Bay man in drug death  -  ‎Apr 8, 2009‎
...died of an overdose of Suboxone, a prescription drug used to wean heroin addicts off their dependency, and Clonazepam, another prescription medication Milwaukee Journal Sentinel

Attorney: Howard K. Stern Innocent of 'Baseless' Allegations  -  ‎Apr 7, 2009‎
...were charged last month with conspiring to use fake names to prescribe vast amounts of potent prescription drugs, including methadone, clonazepam and People Magazine

St. Landry Parish - The St. Landry Parish Sheriff's Office ...  -  ‎Apr 10, 2009‎
Opelousas, charged with possession of Schedule I drugs (marijuana), possession of Schedule IV drugs (clonazepam), and possession of drug paraphernalia. Opelousas Daily World

Hatchet, Screwdriver Threats  -  ‎Apr 9, 2009‎
Sharp consented to a search of his vehicle, where police found clonazepam pills and a marijuana joint in a backpack in the rear passenger seat of the The Dispatch

Father charged in child's death  -  ‎Apr 1, 2009‎
...a glass smoking pipe, Clonazepam, Fluoxetine, Cephalexin, Levaquin, Loestrin and several unknown pills in the bedroom that Kohn and his son shared. Phoenixville News

Grand jury hands down indictments  -  ‎Apr 2, 2009‎
...possession of Schedule IV Controlled Substance, clonazepam (2 counts); possession of Schedule VI Controlled Substance, tizanidine. Kirby Kyle Shupe, 22, Southwest Virginia Today

Police Blotter  -  ‎Mar 31, 2009‎
...to affix a tax stamp, possession of codeine, possession of clonazepam, possession of diazepam, possession of lorazepam, and possession of phenobarbital. UI The Daily Iowan

Remedio para la crisis: subió 25 por ciento el consumo de ...  -  ‎Apr 15, 2009‎
Esta última cifra referida a drogas puntuales como lorazepam, clonazepam y alprazolam, entre otras, guarda relación con los períodos de crisis en que los Rosario3

Dos cadáveres fueron encontrados en límites de Durango  -  ‎Apr 4, 2009‎
...durante una revisión efectuada en el municipio de Jerez, portaba un kilo 175 gramos con 500 miligramos de marihuana así como 7 pastillas de clonazepam. El Universal (México)

Tres exitosos operativos realizó el OS7 de Carabineros de San Antonio.  -  ‎Apr 12, 2009‎
GOO, de 47 años, con domicilio en el sector alto de Llolleo, ocultaba en su vágina 16 envoltorios de marihuana, 31 gramos, y 60 dosis de clonazepam, Proa Regional

Consignan a narcomenudista  -  ‎Apr 4, 2009‎
Al realizarle una revisión se le encontró un kilo 175 gramos con 500 miligramos de marihuana, así como siete pastillas de clonazepam. El Sol de Zacatecas

Preso por vender droga a menor hermosillense  -  ‎Apr 6, 2009‎
...de 29 años, tras ejecutársele un cateo domici-liario en su vivienda, dentro de la cual se le encontró marihuana y pastillas de Clonazepam, se informó. El Nuevo Día (Mexico)

Ejercitan acción penal contra presuntos narcomenudistas  -  ‎Apr 6, 2009‎
...una bolsa de plástico transparente con marihuana-cuyo peso bruto fue de 167 gramos 100 miligramos-, 12 tabletas psicotrópicas de clonazepam, Diario de Querétaro

Emergencias: ya hay pánico febril y aumentan los heridos con motos  -  ‎Apr 4, 2009‎
Y siguen sumándose los intoxicados con vino y clonazepam. “Es que los consultorios externos también están saturados, por eso muchos son derivados a TerritorioDigital.com

<28> Klonopin 웨하스  -  ‎Apr 14, 2009‎
...미스 골드만ì?´ 신경안정제 Klonopin(성분명 clonazepam) 처방전ì?„ 들고 오셨다. 약ì?„ 조제하다가 처방전ì?„ 다시 확ì?¸ 하니 Klonopin regular tabletì?´ 아니ë?¼ Klonopin 약업신문

Onrustige benen onbekende ziekte  -  ‎Apr 8, 2009‎
Mijn huisarts heeft mij Rivotril (clonazepam) voorgesvhreven eerst een dosis van een halve miligram, maar ik zit nu op 2 mg. Het helpt gelukkig wel, De Telegraaf

Colusión en farmacias: ¿Las instituciones funcionan?  -  ‎Apr 6, 2009‎
O el clonazepam, que en Cenabast figura a $191, mientras que Cruz Verde la comercializa a $6.490: Un 3.297% de diferencia. También el Ravotril tiene un El Ciudadano (Chile)

Man gets 8 1/2 years for fatal DUI crash  -  18 Mar 2009
A subsequent blood test showed Waldron had alcohol, marijuana and two relaxants - Clonazepam and Nordiazepam - in his system, according to investigators. Gainesville Sun

Police: woman drove drunk to pick up arrested drunk driver  -  ‎Mar 16, 2009‎
Police said Campbell also had four pills of Clonazepam, a narcotic, on her, and also charged her with criminal possession of a controlled substance, Times Herald-Record

Three Charged In Connection With Anna Nicole’s Death  -  ‎Mar 13, 2009‎
Some of the prescription drugs which prosecutors say were prescribed illegally were Ambien, Hydromorphone, Clonazepam, Methadone and Xanax. TheCelebrityCafe.com

DA warns McDonald's about Pittsburgh drug activity  -  ‎Mar 10, 2009‎
24, police say Eckard sold 11 Clonazepam pills for $20 to a confidential informant in the restaurant's restroom, according to a criminal complaint. On Feb. BusinessWeek

Detective struck while investigating shoplifting  -  ‎Mar 11, 2009‎
Canine Officer Lorri Landrigan and her dog Audi discovered a cigarette pack with dozens of prescription Clonazepam pills. Fuller said that during booking, Holbrook Sun

Ware detectives investigating death of man found in car  -  ‎Mar 12, 2009‎
Deputies recovered a variety of drugs including methadone and clonazepam, an anti-convulsant and muscle relaxant, from the car, Royal said. Florida Times-Union

Man arrested on drug charges  -  ‎Mar 5, 2009‎
...without headlights, driving under suspension, failure to appear charges, resisting arrest and possession of Clonazepam with intent to distribute. Monroe News Star

New charges facing suspect in Salem trailer theft  -  ‎Mar 9, 2009‎
...indicating Dussault is facing three more felonies, alleging that a woman mailed a package to him in jail that had Clonazepam and Buprenorphine inside. Eagle Tribune

Laurinburg woman charged with altering a prescription  -  ‎Mar 10, 2009‎
Locklear is accused of trying to get hydrocodone, methadone, and oxycodone, all narcotic painkillers, and clonazepam, an anti-anxiety drug, the release said FayObserver.com

New charges for suspect in overdose death  -  ‎Mar 16, 2009‎
Zubick also faces five felony charges that accuse him of selling clonazepam to police informants in June, July and November last year. Winona Daily News

Weymouth police arrest man wanted on drug warrants  -  ‎Feb 26, 2009‎
Braintree police also said they found 20 clonazepam pills hidden under a chair in the apartment, as well as two burnt marijuana cigarettes and nine 9-mm The Patriot Ledger

Man charged with identity theft, passing bad checks  -  ‎Feb 23, 2009‎
...was charged with possession with intent to sell or deliver 90 tablets of Lorazepam, possession with intent to sell or deliver 180 tablets of Clonazepam, Asheville Citizen-Times

Battery suspect might face drug charges  -  ‎Feb 24, 2009‎
After the teen's mother consented to a search, deputies allegedly found marijuana, OxyContin, Clonazepam and other substances in the suspect's bedroom, Muncie Star Press

Two More Arrests in Avery County Valentine’s Day Drug Roundup  -  ‎Mar 3, 2009‎
...seized drugs including LSD, ecstasy, heroin, cocaine and pills including Percocet, Hydrocodone, Xanax and Clonazepam with the original arrests. Go Blue Ridge

Brother, sister accused of drug possession  -  ‎Feb 22, 2009‎
Robinson’s sister, Brittany, 19, a passenger, admitted to having hypodermic needles as well as 103 tablets of Clonazepam, a muscle relaxant. Buffalo News

Anna Nicole Smith's Psychiatrist Booked on Felony Charges  -  ‎Mar 16, 2009‎
...former Playmate with toxic drugs – including methadone, chloral hydrate and clonazepam – often by using fake names or by prescribing the drugs to Stern. People Magazine

Water leak led to grow-op find  -  ‎Mar 5, 2009‎
...for the purpose of trafficking, possession of oxycodone for the purpose of trafficking and possession of clonazepam for the purpose of trafficking. London Free Press

Prescriptions written for Anna Nicole Smith  -  ‎Mar 12, 2009‎
..._ clonazepam, an anticonvulsant, muscle relaxant. _ chloral hydrate, a hypnotic sedative used to treat insomnia. _ carisoprodol, a muscle relaxant. The Associated Press

Belknap County Indictments  -  ‎Mar 6, 2009‎
...one count of possession of amphetamine, one count of possession of clonazepam, and one count of possession of marijuana with the intent to distribute. Laconia Citizen

March 2009 Mayo Clinic Health Letter Highlights Knee Repair ...  -  ‎Mar 10, 2009‎
Drugs in this category include alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), diazepam (Valium) and lorazepam (Ativan). PR Newswire (press release)

For the record  -  ‎Mar 4, 2009‎
...intent to distribute, possession of a controlled substance (clonazepam) with intent to distribute and possession of a firearm by a convicted felon; Jan. Augusta Chronicle

Treatment of restless legs syndrome with iron infusion therapy  -  ‎Mar 9, 2009‎
Clonazepam and temazepam are preferred over the shortacting benzodiazepines.1,10 Initially, the patient in this case received CPAP for sleep apnea and Journal of the American Academy of Physician Assistants

Best Practices: An Intervention to Promote Evidence-Based ...  -  ‎Feb 27, 2009‎
...in quetiapine use, including chlorpromazine, clonazepam, diphenhydramine, haloperidol, hydroxyzine, lorazepam, temazepam, trazodone, and zaleplon. Psychiatric Services (subscription)

Withdrawal symptoms can vary  -  ‎Mar 3, 2009‎
Other drugs in this class are clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan) and chlordiazepoxide (Librium). I'm not sure I would use the word Times Daily

Thefts lead indictments  -  ‎Feb 26, 2009‎
Presley sold or offered to sell Clonazepam, a Schedule IV controlled substance, and marijuana, in the vicinity of a juvenile, according to the indictment. Coshocton Tribune

A Hard Habit To Break: The Quietus' Lent Themed Spotify Playlist  -  ‎Feb 20, 2009‎
They need anti-spasmodic medication like diazepam or clonazepam to stop a potentially fatal fit or heart attack. It happened in Manchester. The Quietus

Multiple Sclerosis In Children  -  ‎Mar 11, 2009‎
Clonazepam (Rivotril®) is one of the most effective treatments for MS intention tremor. Primidone can also be considered. Urologic and bowel disorders. Medical News Today (press release)

Police Blotter  -  ‎Feb 26, 2009‎
While officers were investigating a suspicious car, the juvenile admitted to being in possession of ecstasy, clonazepam and marijuana. Vernon Hills Review

Diagnosis and Treatment of Sleep Disorders in Older Adults  -  ‎Feb 25, 2009‎
RBD is generally treated with clonazepam, which acts by inhibiting nighttime motoric movements without directly affecting muscle tone (50). Focus (subscription)

Bea Suárez  -  ‎Mar 5, 2009‎
En el laguito del parque Independencia danza jarabe de Clonazepam. Toman los colectiveros, las mamás, los niños hiperactivos, ancianos perdidos, Página 12

Cuatro años a un guardiacárcel  -  ‎Mar 13, 2009‎
Agregó que las pastillas eran de clonazepam, una sustancia no prohibida, pero de extendido uso carcelario. En cambio, el defensor José Alberto Ontivero se La Voz del Interior

La Ventana recomienda  -  ‎Mar 10, 2009‎
Un dolor de amor en la yema de los dedos, dos mujeres internadas, compañeras de cuarto, anestesiadas por el clonazepam y los cócteles de pastillas. La Ventana

Aseguran más de 172 mil pastillas de medicamentos controlados en ...  -  ‎Feb 25, 2009‎
60 mil 480 tabletas de Metilifenidato, 14 mil 250 tabletas de Axium, 17 mil 990 tabletas de Diazepam, y 43 mil 320 tabletas de Clonazepam. Milenio

Brynebu mottok narkotiske brev  -  ‎Feb 24, 2009‎
Clonazepamun-tabletter inneholder imidlertid det narkotiske stoffet clonazepam og er ulovlige i Norge. Dette var også grunnen til at Postens Godssenter i Aftenbladet.no

Apuñaló a profe de inglés y antes planeó matar a la de matemáticas  -  ‎Mar 3, 2009‎
El tratamiento para mantener los síntomas a raya consistía en dosis de "Valpax", medicamento cuyo componente principal es el ansiolítico "Clonazepam". La Cuarta

Brand Names/Synonyms:
Clonazepam is also known by the following brand names and/or synonymsAntelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril

Drug Category:
Clonazepam is categorized under the following by the FDA: Anticonvulsants; Benzodiazepines; ATC:N03AE01

Dosage Forms:
Tablets - scored and unscored

Absorption:
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%.

Interactions:
Interactions for Clonazepam:

Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.





Chemical IUPAC Name:
6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

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