Clonazepam

This page contains recent news articles, when available, and an overview of Clonazepam but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Clonazepam
(when available)

Pharmacology and use:
Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus. Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures.

Mechanism Of Action:
Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

News Articles on Clonazepam

Dimond: The Addict, the Enabler and Us  -  ‎Aug 29, 2009‎
But there they were: bottles of Valium, Tamsulosin, Lorazepam, Temazepam, Clonazepam, Trazodone and Tizanidine. Drugs used as hypnotic sedatives, INDenverTimes.com

Police waiting on toxocology for cause of man's death  -  ‎Aug 28, 2009‎
Police found medication at his residence, including clonazepam and oxycontin for pain and citalopram, which is an antidepressant. The oxycontin bottle was Burlington Times News

Crash driver arraigned on probation violation  -  ‎Aug 26, 2009‎
10 that she had "consumed four clonazepam, some suboxone pills and then drove." The complaint said Cook did not have a prescription for either medication. Rutland Herald

Four indicted in pill trafficking scheme at Volunteer High School  -  ‎Aug 25, 2009‎
Benjamin Smith allegedly brought about 50 Clonazepam pills to school that day and “fronted� the pills to Blizzard for the purpose of selling them. Kingsport Times News

Jackson Died from Lethal Levels of Propofol  -  ‎Aug 24, 2009‎
Cops also found Valium, Tamsulosin, Lorazepam, Temazepam, Clonazepam, Trazodone and Tizanidine, along with the Propofol. The various drugs were prescribed TMZ.com

Combined drug danger action call  -  ‎Aug 28, 2009‎
Morphine and clonazepam, which were not recorded as being prescribed to him, were also detected. The report from crown research institute Environmental Otago Daily Times

News | in brief  -  ‎Aug 29, 2009‎
A search of a residence and property on Penniac Road in Penniac resulted in the seizure of thousands of prescription pills, including oxycodone, clonazepam, Daily Gleaner

Judge urges suspect in fatal crash to get treatment  -  ‎Aug 20, 2009‎
The indictment states Brown was under the influence of mirtazapine, normally prescribed for depression; clonazepam, for seizure disorders and panic attacks; Huntington Herald Dispatch

Police say Waltham hotel worker stole guest's prescription drugs  -  ‎Aug 17, 2009‎
The guest discovered his medications, oxycodone and clonazepam, were missing and called 911, according to the report. Oxycodone is a prescription painkiller Daily News Tribune

Vero Beach woman returns home to 2 men ransacking her place  -  ‎Aug 11, 2009‎
Inside, the woman said several pieces of jewelry, including a diamond ring, were missing from her bedroom, as well as several Oxycodone and Clonazepam pills TCPalm

Braintree woman arrested on drug/alcohol charges  -  ‎Aug 21, 2009‎
Charges of drinking alcohol from an open container and possession of twelve Clonazepam pills were added after officers found the alcohol and pills inside Braintree Forum

Merrimack County Indictments  -  ‎Aug 29, 2009‎
...was indicted on three Class B felonies for allegedly possessing the drugs Lorazepam, Adderall and Clonazepam while at 24 West High St., Franklin. Laconia Citizen

Entrepreneur arrested again, faces drug charges  -  ‎Aug 10, 2009‎
In the truck was a defaced pill bottle with 58 yellow pills, later identified as clonazepam – an anti-anxiety, anti-seizure medication sometimes abused on Times Herald-Record

Police: Man Planned To Sell Drugs Near Playground  -  ‎Aug 11, 2009‎
The arresting officers found 23 Clonazepam pills, 1.5 Alprazolam pills and 7 hydrocodone pills in Logan's left pocket, according to a news release from the WYFF4.com

Trio faces drug charges in Milford  -  ‎Aug 6, 2009‎
Crosby is charged with possession of heroin and the narcotic drug Clonazepam, both felony crimes, and two misdemeanor counts of unlawful dealing of Cabinet.com

Police arrest man in pizza driver robbery  -  ‎Aug 18, 2009‎
After the officer took the man and woman into custody, 17 oxycodone pills and eight clonazepam pills were found in the man's possession, while the woman had Richmond Register

Dr. Conrad Murray: Investigating Michael Jackson's Personal Doctor  -  ‎Aug 13, 2009‎
...a vial containing a tablet of the muscle relaxant clonazepam, a photocopy picture of Murray, Rolodex cards, public storage receipts and a receipt for a ABC News

Stoddard County woman arrested for alleged drug possession ...  -  ‎Aug 26, 2009‎
Among the pills were Cyclobenzaprine (Flexeril), Alprazolam (Xanax), Clonazepam (Klonopin) and Skelaxin. After being transported to the Stoddard County Jail Southeast Missourian

Northampton police arrest 4 picnickers, 3 from Springfield and 1 ...  -  ‎Aug 26, 2009‎
Further investigation yielded a large quantity of pills including oxycodone, clonazepam, morphine sulfate and Viagra, Patenaude said. The Republican - MassLive.com

Winona man pleads guilty to drug charges  -  ‎Aug 24, 2009‎
Matthew John Polus, 24, was convicted of four felonies, including third-degree sale of hydrocodone and two fifth-degree counts of selling clonazepam. Winona Daily News

POLICE NEWS: Trial scheduled for man charged in fatal accident ...  -  ‎Aug 25, 2009‎
Also found in her jacket were five Clonazepam pills and a black flashlight containing a bag of marijuana in the battery compartment, according to the report Bowling Green Daily News

Man charged in fatal collision  -  ‎Aug 21, 2009‎
Strassburg tested positive for marijuana and the prescription drug Clonazepam, an anti-anxiety drug, in tests taken immediately following the accident. phillyBurbs.com

St. Lucie Crime Blotter Aug. 21  -  ‎Aug 21, 2009‎
Ky, possession of controlled substance (clorazopate), possession of controlled substance (alprazolam), possession of controlled substance (clonazepam). TCPalm

What Was Confiscated from Dr. Murray's Office?  -  ‎Aug 14, 2009‎
According to the Los Angeles Times this is what was taken: 27 tablets of phentermine, a prescription appetite suppressant; and one tablet of clonazepam, TheInsider.com

Endless War: The Suicide of the United States  -  ‎Aug 20, 2009‎
...and the military doctor he consulted sent him back into the field with the antidepressant Zoloft and an anti-anxiety drug called clonazepam. eNews Park Forest

Man faces up to 22 years in prison for drug charges  -  ‎Aug 20, 2009‎
...possession of clonazepam with priors and a forfeiture specification, aggravated possession of oxycodone hydrochloride with a forfeiture specification, Zanesville Times Recorder

Health checkup: Generalized Anxiety Disorder  -  ‎Aug 19, 2009‎
If symptoms are severe and debilitating, medications such as benzodiazepines, lorazepam and clonazepam, may be considered for short-term use. Rochester Democrat and Chronicle

Arrests: Man charged with returning stolen goods for gift cards  -  ‎Aug 18, 2009‎
Asheville, charged with possession with intent to sell and deliver marijuana, simple possession of clonazepam and possession of drug paraphernalia. Asheville Citizen-Times

Traffic stop leads to issue of arrest warrant on drug charge  -  ‎Aug 7, 2009‎
...nothing was found in the vehicle, Bellamy was asked to turn her pants pockets out and did so, revealing the presence of the schedule IV drug clonazepam. The Marshall Democrat-News

Orleans District Court  -  ‎Aug 15, 2009‎
HUFNAGEL, Nathan, 27, 24 Mitchell Lane, Brewster; possession of Clonazepam, July 14 in Brewster, dismissed on payment of $100; possession of Suboxone same Cape Cod Times

Daily Record, August 6, 2009  -  ‎Aug 6, 2009‎
412 S. 3rd St. Apt. #4, was arrested for public intoxication and possession of a Schedule IV Controlled substance without prescription (clonazepam). Marshalltown Times Republican

Michael Jackson: Uri Geller says he was 'killing himself slowly ...  -  ‎Aug 25, 2009‎
Following Jackson's death other drugs reportedly confiscated in the search at the star's residence included tamsulosin, temazepam, clonazepam, trazodone and Telegraph.co.uk

Charles Bonnet syndrome: visual loss and hallucinations  -  ‎Aug 3, 2009‎
...carbamazepine, clonazepam, selective serotonin reuptake inhibitors, gabapentin and olanzapine. 9 – 15 The evidence for treatment remains limited. CMAJ

08-25-09 EUR ALL ON ONE PAGE  -  ‎Aug 25, 2009‎
Other drugs that were confiscated in the search included valium, tamsulosin, lorazepam, temazepam, clonazepam, trazodone and tizanidine. Eurweb.com

Mi Clonazepam  -  ‎Aug 29, 2009‎
...narcóticos que nos tornan insensibles. Desde esta premisa cobran vida los protagonistas de “Mi Clonazepam (k)�, un tragicómico de 500 mg. Alternativa Teatral

Michael Jackson est décédé d'une dose mortelle de Propofol  -  ‎Aug 24, 2009‎
Selon le rapport, les policiers ont trouvé du Valium, du Tamsulosin, du Lorazepam, du Temazepam, du Clonazepam, du Trazodone, du Tizanidine et plusieurs Showbizz.net

Descubren que dependencia a ciertos fármacos produce daños a la ...  -  ‎Aug 26, 2009‎
...como estudiantes y ejecutivos, principalmente por el efecto depresor que producen los fármacos como Clonazepam y �cido Valproico. El Dr. Héctor Burgos, universia.cl

El CEETA advierte sobre los riesgos de la automedicación de ...  -  ‎Aug 16, 2009‎
...“Hoy día hay muchas personas que se auto medican, los nombres Clonazepam o Rivotril se han hecho comunes. También están quienes mezclan fármacos con otras Web Pilar

Denuncian robos en la farmacia del hospital  -  ‎Aug 11, 2009‎
El encargado de seguridad, admitió que “se detectó que ingresaron dos veces� y “faltaron derivados del Clonazepam y un equipito de música de una de las Radio FM Lider 97.7

Ante el dolor de los neuróticos globales  -  ‎Aug 22, 2009‎
Por momentos, Carlos vacila, y es justo al despertarse de su siesta de clonazepam. ¿Tiene sentido dar continuidad a sus citas en el consultorio Clarín.com

Contraloría revela graves irregularidades sanitarias en la Cenabast  -  ‎Aug 27, 2009‎
También se observaron cajas de clonazepam rotas y húmedas, y una caja de diazepam vencidas que no habían sido dadas de baja". Las bodegas no cuentan con El Mercurio OnLine (Chile)

Quentin Tarantino tem melhor estreia de sua carreira  -  ‎Aug 24, 2009‎
Na mansão onde ele morreu, a polícia encontrou Propofol, Valium, Tamsulosin, Lorazepam, Temazepam, Clonazepam, Trazodone e Tizanidine. (Planet Pop) Abril

"Mi ex pareja me quiere matar"  -  ‎Aug 21, 2009‎
Tomo cuatro pastillas clonazepam para dormir, además de otros medicamentos e inyecciones para la infección y el dolor. Estoy muerta en vida, lo que me está Ajá

Académico de la Universidad Autónoma de Chile obtiene importante ...  -  ‎Aug 21, 2009‎
...investigación en el área clínica titulada "La administración crónica de acido valproico y clonazepam deprime el desempeño visuo-espacial en la rata". universia.cl

Conférence de 13 heures du Mardi, 25 Août 2009  -  ‎Aug 25, 2009‎
Craignant une addiction, il avait diminué les doses à 25 mg par jour, combinées à d'autres sédatifs : Valium, Tamsulosin, Lorazepam, Temazepam, Clonazepam, MediaPart

尸检结果:æ?°å…‹é€Šæ­»äºŽä»–æ?€(组图)  -  ‎Aug 25, 2009‎
...å?¦æ´›æ–°èƒ¶å›Šï¼ˆTamsulosin):治疗å‰?列腺增生。 æ°¯ç¡?安定(Clonazepam):长效肌肉放æ?¾å‰‚。 氯哌三唑酮(Trazodone):抗抑éƒ?è?¯ã€‚ 替扎尼定(Tizanidine):治疗肌肉痉挛。 和讯网

Michael Jackson morto per una dose letale di Propofol  -  ‎Aug 24, 2009‎
Tra i farmaci sequestrati dalla polizia ci sono: il valium, il tamsulosin, il lorazepam, il temazepam, il clonazepam, il trazodone e il tizanidine. In dies

Brand Names/Synonyms:
Clonazepam is also known by the following brand names and/or synonymsAntelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril

Drug Category:
Clonazepam is categorized under the following by the FDA: Anticonvulsants; Benzodiazepines; ATC:N03AE01

Dosage Forms:
Tablets - scored and unscored

Absorption:
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%.

Interactions:
Interactions for Clonazepam:

Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the Cmax of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.





Chemical IUPAC Name:
6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

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