Clonazepam

This page contains recent news articles, when available, and an overview of Clonazepam but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Clonazepam (when available)

Pharmacology and use:
Clonazepam, a benzodiazepine, is used primarily as an anticonvulsant in the treatment of absence seizures, petit mal variant seizures (Lennox-Gastaut syndrome), akinetic and myoclonic seizures, and nocturnal myoclonus. Used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures.

Mechanism Of Action:
Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

News Articles on Clonazepam

Drug pipes found in woman's purse  -  Sep 11, 2008
Those drugs were later identified as hydrocodone, clonazepam, Adderall and Ambien, the complaint said. Landers was charged with misdemeanor possession of a Daily Mail - Charleston,

5 things you didn't know about burning mouth syndrome  -  Sep 9, 2008
She had been taking the drug alprazolam for anxiety, but was switched to clonazepam because of increased anxiety. Clonazepam relieved her symptoms, MiamiHerald.com,

Two arrested on drug charges  -  Sep 9, 2008
Russel Pack, 24, of Myrtle Beach was charged with unlawful possession of clonazepam. Tegel reportedly went into an apartment at the Blossom Inn at about 3 Myrtle Beach Sun News,

Dangerous prescription error led to senior's traffic accident  -  Aug 23, 2008
DeRoy had unknowingly been taking a daily dose of one milligram of Clonazepam, a sedative used to treat anxiety and seizure disorders, in place of HCTZ, Vancouver Sun,

Three Mount Holly men charged with having stolen gun  -  Sep 8, 2008
Crack cocaine, hydrocodone and the prescription drug Clonazepam were also allegedly found in the car. James Edward McDowell, 30, of the 600 block of Gaston Gazette,

Arrests: Man charged with possessing drugs in jail  -  Sep 4, 2008
Vincent O’Dell Lee, 43, of Lake Eden Road, had eight dosage units of clonazepam in his shoe while in custody, according to the arrest warrant. Asheville Citizen-Times,

2 men indicted in sale of drugs  -  Aug 25, 2008
MacLeod was charged with sale of a controlled drug, in that he "knowingly sold 10 pills containing clonazepam in exchange for money" to a cooperating member Nashua Telegraph,

Report: Mom gave daughter drugs to sell  -  Aug 25, 2008
Julie Ann Vines, 48, of 305 Angus Road, Ouachita Parish, was charged with possession with intent to distribute methadone, oxycontin and clonazepam. Monroe News Star,

Man faced with third DWI  -  Aug 30, 2008
Rodgers performed poorly on a subsequent field sobriety test and told officers he had drunk two glasses of wine and taken "a few" pills of Clonazepam and Monroe News Star,

Woman: Man stole purse inside Wal-Mart  -  Aug 25, 2008
She and a Wal-Mart employee chased Langley and caught him inside the store with the purse. Officers found two clonazepam tablets inside his front right Monroe News Star,

Wrong meds blamed for crash  -  Aug 26, 2008
...prescription for "hydrochlorothiazide," which helps treat her high blood pressure, and that's when she found out she was given Clonazepam, a sedative. Surrey Now,

Police arrest three after following car  -  Aug 18, 2008
Officers searched a 16-year-old Athens boy and found he had 16 pills of Clonazepam, a prescription medication used to treat a panic disorder, according to Online Athens,

Three arrested in Knox County drug bust  -  Sep 13, 2008
Overlock was arrested for possession of Aterol, Flexiral, and Clonazepam and for violating conditions of release on a prior domestic assault charge. Bangor Daily News,

Three arrested after drug raids  -  Sep 12, 2008
She was charged with possession of Aterol, possession of Flexiral, possession of clonazepam and violating conditions of release for a prior domestic assault MaineToday.com,

Police report  -  Sep 12, 2008
A 44-year-old Hurst woman was arrested on suspicion of possession of 1.8 grams of Clonazepam and 7.8 grams of Etodolac. She was stopped at 1:25 am Sept. Keller Citizen,

Local news in brief  -  Sep 9, 2008
...possession of prescription drugs without a prescription after police reported finding a bag with a number of Xanax and Clonazepam pills, police report. Aiken Standard (subscription),

Lawyers criticize filings made in Smith appeal  -  Sep 8, 2008
...the likelihood that Mr. Smith’s death was the result of a tragic accident,�? due to his mixture of alcohol and the antidepressants Zoloft and Clonazepam. Greenwich Post,

What to do about painful erections  -  Aug 22, 2008
Expert opinion says that clozapine, an antipsychotic medication used in the treatment of schizophrenia, clonazepam, a potent anticonvulsant, and baclofen, Times Online,

More secret indictments handed down  -  Sep 5, 2008
The sentence was the result of charges for trafficking in prescription drugs, Clonazepam and OxyContin, fourth- and fifth-degree felonies. Coshocton Tribune,

Illinois residents face drug charges  -  Sep 4, 2008
Natschke was charged with Possession of Controlled Substance-Clonazepam, a Schedule IV prescription medication, serious misdemeanor. Spencer Daily Reporter,

Strafford County indictments vary from felony drug to criminal ...  -  Sep 2, 2008
One count alleges Perkins had in his possession clonazepam, while the other alleges he had in his possession methadone. Perkins is currently being held at Foster's Daily Democrat,

USP announces new tool to help prevent medication mix-ups due to ...  -  Aug 25, 2008
...including Colchicine (used for gout), Cetirizine (an antihistamine), and Clonazepam and its brand name, Klonopin (used for anxiety and seizures). EurekAlert (press release),

Circuit court pleas heard  -  Aug 23, 2008
Janice Greenfield, 47, of Van Buren pleaded not guilty to delivery of lorcet and delivery of clonazepam. Greenfield is accused of selling the controlled Van Buren Press Argus-Courier,

Bipolar disorder: What you need to know  -  Sep 3, 2008
18 If insomnia is a problem, a high-potency benzodiazepine medication such as clonazepam (Klonopin ® ) or lorazepam (Ativan ® ) may be helpful to promote Food Consumer,

Piden cuatro años de prisión para la anciana  -  Aug 31, 2008
...identificada como María Luisa RP, trató en julio de 2007 de introducir en el citado centro penitenciario 46 comprimidos de clonazepam y alprazolam, Ideal Digital,

Mendoza, segunda en el ránking de consumo de tranquilizantes  -  Sep 13, 2008
Entre las drogas derivadas de las benzodiazepinas figuran alprazolam, clonazepam, bromazepam y lorazepam; cada una indicada según el tratamiento que cada Los Andes (Argentina),

Drogan y asaltan jóvenes en discotecas  -  Aug 29, 2008
Otra sustancia también utilizada para abusar sexualmente de la víctima es el Clonazepam, que se vende con el nombre de Klonopin y Rivotril. elPeriódico (Guatemala),

Epilepsie bei Kindern Steiniger Weg zur Anfallsfreiheit  -  Sep 2, 2008
So verringert Carbamazepin beispielsweise als Enzyminduktor von CYP3A4 die Wirkungen verschiedener oxidativ metabolisierter Stoffe wie Clonazepam, pharmazeutische-zeitung.de,

El psiquiatra recomienda  -  Sep 8, 2008
Dentro de las benzodiacepinas más usadas en nuestro país están: Diazepam, clonazepam, lorazepam, bromazepam, alprazolam, midazolam. El Caribe,

Fernández dijo que "no hay un control sobre la efedrina"  -  Aug 22, 2008
..."No necesariamente tiene que tener droga ilegal – continuó – Puede tener medicamentos, como clonazepam, por decir algo. También se habla de drogas anti InfoBAE.com,

Arrestan 12 presuntos sicarios  -  Sep 5, 2008
10 (diez) pastillas psicotrópicas con la leyenda Rivotril Clonazepam, más 37 kilogramos de marihuana, 3 gramos de heroína y 10 pastillas psicotrópicas. El Mexicano,

Remedios sanan achaques, pero también bajan el deseo sexual  -  Aug 30, 2008
El clordiazepóxido, clonazepam y diazepam reportan disminución de la libido, disfunción eréctil y anorgasmia, posiblemente por una relajación muscular La Cuarta,

Ningún medicamento puede ser vendido sin la respectiva receta  -  Aug 27, 2008
Midazolam, Butalbital, Zolpidem, Bromazepam, Clobazam, Clonazepam, Brotizolam, Clorazepato, Fenobarbital, Triazolam, Ketazolam, Lorazepam, Tetrazepam. El Mercurio (Manta),

Cuáles son los medicamentos que atentan con una vida sexual plena  -  Aug 25, 2008
El CLORDIAZEPOXIDO, CLONAZEPAM y DIAZEPAM, reportan una disminución de la libido, disfunción eréctil y anorgasmia, posiblemente por una relajación muscular La Segunda,

Temen que los carteles de droga usen al país "como una fábrica"  -  Aug 22, 2008
..."No necesariamente tiene que tener droga ilegal, puede tener medicamentos, como clonazepam, por decir algo. También se habla de drogas antiparkinson. MDZol,

LA PUBLICIDAD POTENCIA LA AUTOMEDICACIÓN  -  Aug 17, 2008
...peligroso psicofármaco anticonvulsivante: el clonazepam Se verificó que en una oportunidad, fue tomado como ansiolítico, por indicación de familiares. De Riojanos,

Drogas: temen que se tome al país como lugar de fabricación  -  Aug 22, 2008
...“No necesariamente tiene que tener droga ilegal, puede tener medicamentos, como clonazepam, por decir algo. También se habla de drogas antiparkinson. Ciudadano,

Brand Names/Synonyms:
Clonazepam is also known by the following brand names and/or synonymsAntelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepam; Clonazepamum; Clonopin; Iktorivil; Klonopin; Klonopin Rapidly Disintegrating; Landsen; RO4023; Rivotril

Drug Category:
Clonazepam is categorized under the following by the FDA: Anticonvulsants; Benzodiazepines; ATC:N03AE01

Dosage Forms:
Tablets - scored and unscored

Absorption:
Clonazepam is rapidly and completely absorbed after oral administration. The absolute bioavailability of clonazepam is about 90%.

Interactions:
Interactions for Clonazepam:

Effect of Clonazepam on the Pharmacokinetics of Other Drugs: Clonazepam does not appear to alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect of clonazepam on the metabolism of other drugs has not been investigated.

Effect of Other Drugs on the Pharmacokinetics of Clonazepam: Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.

In a study in which the 2 mg clonazepam orally disintegrating tablet was administered with and without propantheline (an anticholinergic agent with multiple effects on the GI tract) to healthy volunteers, the AUC of clonazepam was 10% lower and the C_max of clonazepam was 20% lower when the orally disintegrating tablet was given with propantheline compared to when it was given alone.

Fluoxetine does not affect the pharmacokinetics of clonazepam. Cytochrome P-450 inducers, such as phenytoin, carbamazepine and phenobarbital, induce clonazepam metabolism, causing an approximately 30% decrease in plasma clonazepam levels. Although clinical studies have not been performed, based on the involvement of the cytochrome P-450 3A family in clonazepam metabolism, inhibitors of this enzyme system, notably oral antifungal agents, should be used cautiously in patients receiving clonazepam.

Pharmacodynamic Interactions: The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.

Chemical IUPAC Name:
6-(2-chlorophenyl)-9-nitro-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

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