Clavulanate

This page contains recent news articles, when available, and an overview of Clavulanate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Clavulanate (when available)

Pharmacology and use:
Clavulanic acid, produced by the fermentation of Streptomyces Clavuligerus, is a beta-lactam structurally related to the penicillins. Clavulanic acid is used in conjunction with amoxicillin for the treatment of bronchitis and urinary tract, skin, and soft tissue infections caused by beta-lactamase producing organisms. For use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with Staph. aureus and Bacteroides fragilis, or with beta-lactamase producing H. influenzae and E. coli.

Mechanism Of Action:
Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases, commonly found in microorganisms resistant to penicillins and cephalosporins. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent.

News Articles on Clavulanate

His experience: Canadian better  -  ‎Aug 14, 2009‎
There, Dr. Riyaan Hassen saw me immediately, cleaned the wound, sutured it, wrote me a prescription for 14 tablets of Amoxicillin/Clavulanate 875/125MG. Monroe News Star

종근당바�?�오, 160억�? 신규투�? 결정  -  ‎Aug 23, 2009‎
...종근당바�?�오는 주력제품�?� �?�타슘�?��?�블�?�네�?�트(Potassium Clavulanate)�?� �?산 능력�?� �?대하기 위해 160억�?�?� 투�?해 100톤급 발효조 3기를 �?설키로 했다고 24�?� 매일경제

종근당바�?�오 “�?산능력 �?설�? 160억�? 투�?�?  -  ‎Aug 23, 2009‎
...�?�슬기 기�? [헬스코리아뉴스] 종근당바�?�오는 24�?� 주력제품(Potassium Clavulanate)�?� �?산능력�?� 늘리기 위해 발효조(Fermentor) 100톤�?� �?설한다고 �?혔다. 헬스코리아뉴스

The BCA "Plethora of evidence": The Fallon Paper  -  ‎Jul 3, 2009‎
...returns only one article titled "Could one of the most widely prescribed antibiotics amoxicillin/clavulanate "augmentin" be a risk factor for autism?". ScienceBlog.com

Trends in broad-spectrum antibiotic prescribing for children with ...  -  ‎Jun 24, 2009‎
Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones. 7thSpace Interactive (press release)

Cure for extreme TB strain found  -  ‎Apr 7, 2009‎
American scientists have found that a combination of two FDA-approved drugs Clavulanate and Meropenem, meant for fighting other bacterial infections like Times of India

Antibiotic Combination Defeats Extensively Drug-resistant TB  -  ‎Feb 26, 2009‎
The drugs truly work in tandem: one of them (clavulanate) inhibits a bacterial enzyme, β-lactamase, which normally shields TB bacteria from the other Science Daily (press release)

Why Kenya still shoulders high TB burden  -  ‎Mar 13, 2009‎
Net) last month (27 February), showed that a combination of the drugs meropenem and clavulanate inhibited the growth of 13 separate strains of XDR-TB. Africa Science News Service

Full Text (HTML)  -  ‎Feb 26, 2009‎
When meropenem was combined with the β-lactamase inhibitor clavulanate, potent activity against laboratory strains of M. tuberculosis was observed [minimum Science Magazine (subscription)

Ray of hope for drug-resistant TB  -  ‎Mar 6, 2009‎
Laboratory studies, published in Science last week (27 February), showed that a combination of the drugs meropenem and clavulanate inhibited the growth of Reuters AlertNet

An Effective Drug Combination for Resistant TB Discovered  -  ‎Mar 5, 2009‎
The drugs work in tandem: first, Clavulanate (Augmentin) inhibits an enzyme which normally shields TB bacteria from antibiotics; then Meropenem, Africa Science News Service

Combinación de 2 medicinas vence resistencia de bacteria de ...  -  ‎Feb 27, 2009‎
Según los científicos del Instituto Nacional de la Alergia y Enfermedades Infecciosas (NIAD), las medicinas usadas fueron meropenem y clavulanate, Radio Programas del Perú (RPP)

Associação de antibióticos pode curar tuberculose resistente  -  ‎Feb 28, 2009‎
Um destes antibióticos é o clavulanate, já utilizado em coquetéis para combater diferentes infecções, especialmente em crianças, eo outro é o meropenem. AFP

Des antibiotiques combinés prometteurs contre la tuberculose ...  -  ‎Feb 27, 2009‎
L'un d'eux est le clavulanate, déjà utilisé en combinaison pour traiter en particulier différentes infections chez les enfants. AFP

研究：�?�?�兩種抗生素�?�以治抗藥性�?核病  -  ‎Feb 28, 2009‎
...他們所研究的一種藥物Clavulanate，�?�抑制細�?�的酵素乙內醯胺酸（beta-lactamase），這種物質是�?核�?�用來�?護自己�?�?�抗生素的攻擊。目�?Clavulanate在市�?�上沒有商業 yam天空新聞

研究：结�?�两�?抗生素�?�以治抗�?�性结核病  -  ‎Feb 28, 2009‎
...他们所研究的一�?�?�物Clavulanate，�?�抑制细�?�的酵素乙内醯胺酸（beta-lactamase），这�?物质是结核�?�用�?��?护自己�?�?�抗生素的攻击。目�?Clavulanate在市�?�上没有商业大纪元

Nouvel espoir de traitement de la tuberculose  -  ‎Mar 6, 2009‎
Parmi eux, le clavulanate de potassium, que l’on peut retrouver associé à l’amoxicilline, déjà administré aux enfants en combinaison pour traiter d’autres Maxisciences

Cientistas testam com sucesso coquetel de remédios contra tuberculose  -  ‎Feb 26, 2009‎
Os pesquisadores, do Instituto Nacional da Alergia e Doenças Infecciosas (NIAD), informaram que os medicamentos usados foram meropenem e clavulanate, G1.com.br

Veremle Savaşta Yeni Umut  -  ‎Feb 26, 2009‎
...klinik deneylere başlamaya sevketti. Söz konusu ilaçlar verem mikrobunun savunma mekanizmasını kıran clavulanate ve meropenem adlı antibiyotiği içeriyor. VOA News

Scoperto cocktail farmaci efficace contro forma più mortale tbc  -  ‎Feb 26, 2009‎
Continua a leggere questa notizia Il farmaco Merrem IV della AstraZeneca, chiamato anche meropenem, utilizzato insieme al clavulanate, venduto da Yahoo! Italia Notizie

Neue Therapie gegen Tuberkulose  -  ‎Mar 9, 2009‎
Clavulanate werden häufig bei anderen Infektionen zusammen mit dem Antibiotikum Amoxicillin verabreicht und wirken hemmend auf die ß-Lactamase. WELT ONLINE

Un successo nella lotta alla Tbc resistente ai farmaci  -  ‎Feb 28, 2009‎
Secondo quantro riferito sull'ultimo numero della rivista “Science�? nell'articolo Meropenem-clavulanate is effective against extensively drug-resistant L'Espresso

Комбинаци�? двух антибиотиков �?по�?обна преодолеть туберкулез  -  ‎Feb 28, 2009‎
�?ациональном ин�?титуте аллергии и инфекционных заболеваний ученые обнаружили, что комбинаци�? clavulanate и meropenem о�?тановила ро�?т 13 штаммов ШЛУ-ТБ. МЕДСТРИМ.РУ - консультации врачей, новости медицины

Kenya reports a case of XDR-TB, more feared on the way  -  ‎Mar 10, 2009‎
Kenya has so far reported one case of Extremely Drug Resistant TB ( XDR-TB). But low available capacity and lack of equipment and high costs of managing Africa Science News Service

What's the evidence for surgery to make a hole in the eardrum?  -  Jan 21, 2009
Randomised study of myringotomy, amoxycillin/clavulanate, or both for acute otitis media in infants. Lancet. 1989; 2: 141-143. van Buchem FL, Dunk JH, guardian.co.uk,

Treatment options for respiratory infections  -  Jan 27, 2009
For patients with severe symptoms or a history of antibiotic use in the past three months, consider amoxicillin clavulanate (Augmentin), cefpodoxime, Clinical Advisor,

What treatments work for sinusitis?  -  Jan 21, 2009
Randomized double-blind study comparing 3- and 6-day regimens of azithromycin with a 10-day amoxicillin-clavulanate regimen for treatment of acute bacterial guardian.co.uk,

Antibiotics used to treat pneumonia  -  Jan 21, 2009
...group that advises the government on which drugs work and are safe) warns there is a risk of a type of jaundice if you take amoxicillin-clavulanate. guardian.co.uk,

What treatments work for cellulitis and erysipelas?  -  Jan 21, 2009
Tassler H. Comparative efficacy and safety of oral fleroxacin and amoxicillin/clavulanate potassium in skin and soft tissue infections. guardian.co.uk,

BMP Sunstone Takes 50% Stake in Pediatric Drug Maker  -  Dec 23, 2008
They also produce amoxicillin tablets and capsules, as well as clavulanate potassium compounds, often in dispersible tablet form. Seeking Alpha,

Wockhardt climbs 5% on USFDA nod  -  Dec 4, 2008
250 mg/ 5ml of Amoxycillin and 62.5mg/ 5ml of Clavulanate Potassium, which is used for treating several common infections, especially in children. Economic Times,

Wockhardt gets US FDA approval for paediatrics drug  -  Dec 4, 2008
The oral suspension, a combination of amoxycillin and clavulanate potassium is sold in the US by Glaxo SmithKline under the brand name Augmentin 250. domain-B,

Antimicrobials the Leading Cause of Drug-Induced Liver Injury  -  Dec 2, 2008
The most common drugs that created liver injury were amoxicillin/clavulanate (23 cases), nitrofurantoin (13), isoniazid (13), MedPage Today,

Acute and Chronic Rhinosinusitis: Practical Clinical Treatment ...  -  Nov 5, 2008
So if you're treating a typical respiratory bacterium, we recommend amoxicillin clavulanate (Augmentin®, GlaxoSmithKline) or one of the cephalosporins and Medscape (registration)

SK케미칼， 아모�?�닉 �?�장 변경  -  Nov 9, 2008
...[쿠키 건강] SK케미칼(대표�?�사 부회장 김창근)�?� SK 아모�?�닉(성분명: 아목시실린Amoxicillin, �?��?�불란산 칼륨 potassium clavulanate)제품 군(群)�?� �?�장�?� 11월 11 쿠키뉴스,

Antibiotic-Associated Adverse Events Often Require Emergency Care  -  Oct 17, 2008
The rate of visits was significantly higher for penicillin or amoxicillin vs amoxicillin-clavulanate (15.5 vs 7.8 ED visits per 10000 outpatient Medscape (subscription)

Broad Spectrum Antibiotics Suggested for Peritonsillar Abscesses ...  -  Sep 26, 2008
The investigators reported that "the overwhelming majority of cultures contained organisms expected to be sensitive to amoxicillin/clavulanate. DG News

Recommendations Issued for Mastitis in Mothers Breast-Feeding ...  -  Sep 25, 2008
Oral antibiotics typically used for mastitis may include amoxicillin/clavulanate, 875 mg twice daily; cephalexin, 500 mg 4 times daily; ciprofloxacin, Medscape (subscription)

У�?пехи в лечении туберкулеза �? широкой у�?тойчиво�?тью к ...  -  Oct 12, 2008
не отно�?�?щие�?�? непо�?ред�?твенно к противотуберкулезным �?ред�?твам: кларитромицин (clarithromycin), амок�?ициллин/клавуланат (amoxicillin–clavulanate), Medicus Amicus,

ESBLs Detection in Clinical Microbiology: Why & How ?  -  Aug 26, 2008
A difference of >5 mm between the zone diameters of either of the cephalosporin disks and their respective cephalosporin/ clavulanate disk is taken to be RedOrbit,

FDA Safety Changes: Amitiza, Aldurazyme, Most Antibiotics  -  Aug 22, 2008
Demeclocycline, nafcillin, piperacillin, ticarcillin, clavulanate, ampicillin, sulbactam, and tazobactam are antimicrobials indicated for the treatment of Medscape (subscription)

Arthroscopic Treatment of Septic Arthritis of the Shoulder in a 6 ...  -  Aug 19, 2008
Then, the patient was discharged and prescribed oral antibiotics (amoxicillin/clavulanate, 90/6.4 mg/kg/day in 2 divided doses) for 10 days. Ortho SuperSite,

Traitement des tuberculoses résistantes, les antibiotiques utilisés  -  Sep 8, 2008
...non commercialisés en France, données Afssaps), la clofazimine dont l'indication, selon son RCP est la lèpre et l'association amoxicilline-clavulanate. Maroc Info Com,

Phản ứng phụ thư�?ng gặp của thuốc kháng sinh  -  Aug 29, 2008
Trong một số ít trư�?ng hợp, các kháng sinh như erythromycin esters, TMP-SMZ, amoxicillin và clavulanate potassium có thể gây ứ mật. Dân Trí,

FDA Safety Changes: Depakote, Depakote ER, Antibiotics  -  07 Aug 2008
Combining amoxicillin with the β-lactamase inhibitor clavulanate yields an increased spectrum of activity and efficacy against β-lactamase–producing Medscape (subscription)

BMP Sunstones Acquires Pediatric Drug Company  -  Jul 19, 2008
Shengda’s most important products are amoxicillin tablets, capsules and clavulanate potassium compound preparation, which are prepared in dosages and istockAnalyst.com,

Bal Pharma Launches Zefpod in the Indian Market  -  Jul 30, 2008
Zefpod CV - (Cefpodoxime 200mg+Potassium Clavulanate 125mg). The Cefpodoxime market size accounts for 150 Cr which is growing at 17% annually. The Open Press (press release)

Diabetic Foot Infection  -  Jul 15, 2008
Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. RedOrbit,

Antimicrobial Resistance in Community and Nosocomial Escherichia ...  -  Jun 18, 2008
Methods: Antimicrobial susceptibility to ampicillin, amoxicillin / clavulanate, cefalexin, ciprofloxacin, gentamicin, nitrofurantoin, trimethoprim and 7thSpace Interactive (press release),

Incidence and impact on clinical outcome of infections with ...  -  May 17, 2008
The increased resistance to fluoroquinolones and amoxicillin/clavulanate of this pathogen mandates the prescription of broad-spectrum antibiotics such as 7thSpace Interactive (press release),

Bird flu drugs 'poured down the drain'  -  May 15, 2008
Health Minister David Cunliffe said in response to written parliamentary questions that the oral liquid antibiotic, Amoxycillin Clavulanate 250mg, Stuff.co.nz,

Antibiotics Modestly Effective in Treating Acute Sinusitis  -  Apr 18, 2008
18 studies compared a cephalosporin or macrolide to amoxicillin-clavulanate. Other antibiotic groups represented included tetracyclines and fluoroquinolones Medscape (subscription)

Additional Evidence Antibiotics Are Not Helpful for Sinusitis  -  Apr 1, 2008
8 One-hundred twenty children were randomized to three weeks of amoxicillin, amoxicillin-clavulanate, trimethoprim-sulfamethoxazole, or placebo. AAP Grand Rounds (subscription),

Polyurethane cuffed endotracheal tubes to prevent early ...  -  Mar 28, 2008
...(INN amoxicilline) and clavulanate, with an antipseudomonal betalactam if pneumonia develops after 7 days or after previous antibiotic exposure. The Journal of Thoracic and Cardiovascular Surgery

Antibiotics Found Ineffective for Middle Ear Effusion  -  Feb 19, 2008
Amoxicillin was the antibiotic used in each of the five trials (amoxicillin-clavulanate in one). Amoxicillin was compared with placebo in four and delayed MedPage Today,

How Several Drugs can Destroy the Defenses of Tuberculosis  -  Oct 25, 2007
Their experiments showed that a medication called clavulanate works best. Unlike the other two drugs, it permanently inactivates the antibiotic-destroying Wired News

Using Old Medications to Defeat Tuberculosis  -  Oct 26, 2007
Meanwhile, two scientists at the Albert Einstein College of Medicine have learned how the drug clavulanate can destroy the defenses of tuberculosis, Slashdot

Journal of the American Podiatric Medical Association  -  Nov 16, 2007
The patient was given a prescription for amoxicillin-clavulanate potassium (Augmentin; glaxosmithkline, Research Triangle Park, NC), which he took for 1 Journal of the American Podiatric Medical Association (subscription)

Primary Care Practice for Acute Otitis Media May Differ From ...  -  Aug 10, 2007
High-dose amoxicillin is recommended at the first-line treatment for routine otitis media, whereas amoxicillin-clavulanate is recommended for severe Medscape (subscription)

MDs too hasty with ear infection Rx  -  Aug 23, 2007
Amoxicillin clavulanate is an alternative if tympanocentesis isn't practical. Don't go overboard Middle ear effusion can persist for months. National Review of Medicine,

ViroPharma Announces Key Additions to European Management  -  Jul 10, 2007
CNNMoney.com...therapeutic unit, where he developed, licensed and launched products including Famciclovir and Augmentin(R) (amoxicillin/clavulanate potassium) BID.

Antibiotic use sparks fears of 'superbug'  -  Jun 29, 2007
MyTown Bay of Plenty,Figures from Pharmac show 295 prescriptions for the antibiotic amoxycillin clavulanate (also known as Augmentin) were given out for every 1000 people in the

GlaxoSmithKline Announces Altargo® Approved In Europe For ...  -  Jun 4, 2007
Medical News Today (press release),These products include the topical antibacterial agent Bactroban® (mupirocin) as well as the oral agent Augmentin® (amoxicillin/clavulanate potassium).

Robert G. Pietrusko Joins ViroPharma as Vice President of Global ...  -  May 2, 2007
PharmaLive.com (press release),During his tenure at GlaxoSmithKline, he was instrumental in approvals for products including Havrix, Augmentin(R) XR and ES (amoxicillin/clavulanate

Brand Names/Synonyms:
Clavulanate is also known by the following brand names and/or synonymsClavulanate; Clavulanic Acid

Drug Category:
Clavulanate is categorized under the following by the FDA: Anti-bacterial Agents; ATC:J01C

Dosage Forms:
Tablets, ER tablets, suspensions

Absorption:
75%

Interactions:
The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. In controlled clinical trials of AUGMENTIN XR, 22 patients received concomitant allopurinol and AUGMENTIN XR. No rashes were reported in these patients. However, this sample size is too small to allow for any conclusions to be drawn regarding the risk of rashes with concomitant AUGMENTIN XR and allopurinol use. In common with other broad-spectrum antibiotics, AUGMENTIN XR may reduce the efficacy of oral contraceptives

Chemical IUPAC Name:
3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylicacid

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