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ClarinexThis page contains recent news articles, when available, and an overview of Clarinex but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Clarinex (when available) Loratadine, a non-sedating H1-blocker similar in structure to cyproheptadine and azatadine, is used to treat seasonal allergic rhinitis. Unlike other H1-blockers, loratidine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors. For the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older Mechanism Of Action: Like other H1-blockers, loratadine competes with free histamine for binding at H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Loratadine also has a weak affinity for acetylcholine and alpha-adrenergic receptors. News Articles on Loratadine Schering-Plough Agreement Allows Generic Clarinex In 2012 - Aug 11, 2009 BY) and Orgenus Pharma Inc. that will allow those companies to sell generic forms of its Clarinex allergy treatment starting in 2012. CNNMoney.com Schering-Plough spent $550K lobbying gov't in 2Q - Aug 21, 2009 That's just over the $530000 the maker of allergy treatments Nasonex and Clarinex spent in the year-ago period. The Kenilworth, NJ-based company is in the Forbes Company and People Notes: Forest Labs and AstraZeneca Form Pact ... - Aug 20, 2009 1, 2012, and Clarinex brand 5 mg tablets to be introduced on July 1, 2012. Schering holds various patents related to Clarinex that extend to 2022. Pharmaceutical Technology Magazine Indian shares fall 1.5 pct; Sun Pharma gains - Aug 11, 2009 N) said on Tuesday it settled a patent litigation with the Indian drugmaker related to generic versions of its allergy medication, Clarinex. Reuters Forget the whales; Save the FSA! - Aug 21, 2009 Many insurance programs won't cover Clarinex because Claritin is available OTC and as a generic. Shouldn't the FSA cover that? What about canes and walkers Examiner.com Orchid Pharma settles patent row, stock up 4% - Aug 12, 2009 The issue was related to generic versions of its allergy medication, Clarinex. The agreement marks the end of all pending lawsuits filed and consolidated Business Standard Stunning recovery for Sensex...Nifty above 50 DMA - Aug 12, 2009 2.5 mg and 5 mg Orally Disintegrating Tablets (ODT), the generic versions of Schering-Plough's Clarinex® and Clarinex® RediTabs® allergy medication. India Infoline.com Zacks Analyst Blog Highlights: Schering-Plough Corp., Caraco ... - Aug 14, 2009 Pursuant to the agreement, Orchid received rights to launch a generic version of the Clarinex brand Reditabs in the US on Jan. 1, 2012 and Clarinex brand 5 Earthtimes (press release) FDA: Antidepressant suicide risk varies with age; Sun Pharma nabs ... - Aug 12, 2009 Report > Schering-Plough settled patent litigation with Orchid Chemicals & Pharmaceuticals related to generic versions of its allergy medication, Clarinex. FiercePharma Closing Bell - Aug 12, 2009 Orchid's products may be the prescription form or over-the-counter version products depending on the status of Clarinet and Clarinex RediTabs at the time. Economic Times Traders Look to Fed Announcement For More Clarity on Economic Outlook - Aug 12, 2009 The agreement allows Orchid to manufacture orally disintegrating RediTabs in the US on January 1st, 2012 and Clarinex 5 mg tablets on July 1st, 2009. RTT News Pill Popping And Flight Hopping: Airport Pharmacies Proliferate - 13 Jul 2009 Until then, feel free to fill your Viagra Clarinex prescriptions with the full-time pharmacist or check your blood pressure; SFO's Harmony Pharmacy is Jaunted October 2005 Pharmaceutical Update - Jun 29, 2009 Clarinex (desloratadine) Syrup by Schering-Plough will be available in a 4 oz. bottle to make it easier for pharmacists to dispense the usual course of ADVANCE for Physician Assistants Five questions about diagnosing and treating allergies - Jul 1, 2009 If these are no help, Clarinex and Xyzal are prescription pills that can be tried but are much more expensive. After that, a steroid nasal spray can be PennLive.com Glaxo's Migraine Pill Spurned by UnitedHealth for Generic Combo - Jun 19, 2009 ...s allergy pill Clarinex, a replacement for Claritin, because there are cheaper alternatives, Heady said. “There are clearly practices that don't add value Bloomberg Switch Hitters - Jun 22, 2009 ...may launch the Clarinex product in the next couple of years to bolster their franchise in allergy and steal some of the newness from Zyrtec,â€? she said. Supermarket News Analyst upgrades, downgrades and initiations: AMZN, RS, JNJ, NFLX ... - 20 Apr 2009 ...based on expectations that Sandoz will settle patent litigation regarding Skelaxin after last weeks settlement of Clarinex with Schering-Plough (SGP). BloggingStocks Sepracor Up As Schering, Mylan Settle Clarinex Patent Dispute - Apr 8, 2009 Under the settlement, Mylan can start marketing a generic version of Clarinex in July 2012. Outstanding litigation between Mylan and Sepracor is also Wall Street Journal Hoffman La Roche sues Mylan over alleged patent violation - Apr 15, 2009 Last week, the company settled patent litigation with Schering-Plough after being accused of breaching intellectual property rules covering Clarinex allergy Hays Pharma Biotech/Pharma Docket - Apr 9, 2009 Mylan announced a settlement of all patent litigation (see "Court Report," March 8, 2009) stemming from its generic version of Schering-Plough's Clarinex® Patent Docs SGP/Merck Merger Makes Sense - Apr 1, 2009 On a stand-alone basis, we expect Schering-Plough's (SGP) sales to increase only 2% in 2009 as increased competition to prescription Claritin/Clarinex comes Zacks.com April Brings Showers, Flowers and ….Allergies - Apr 2, 2009 Treatments include over-the-counter and prescription antihistamines such as Benadryl, Clarinex, Zyrtec, or Allegra; oral decongestants like Sudafed; HealthNews Underinsured can be as bad as uninsured - Apr 18, 2009 To treat her allergies, Carroll's doctor prescribed Clarinex-D and Veramyst, but neither was covered by her plan, and she could not afford the $268 a month Indianapolis Star US HOT STOCKS: Shaw Group, Calif. Pizza Active In Late Trading - Apr 8, 2009 Under the settlement, Mylan can start marketing a generic version of Clarinex in July 2012. Outstanding litigation between Mylan and Sepracor is also Wall Street Journal Man injured fighting burglars - Apr 13, 2009 There were 18 Alprazalom pills, 11 methocarbanol pills, 45 acetaminophen-oxycodone hydrochloride, 3 diazepam pills, 51 cyclobenzaprine HCl, 5 clarinex pills WBBH Adcock wants to buy SA's Cipla for $227M; Solvay shares up on ... - Apr 9, 2009 Laboratories has settled all ongoing Hatch-Waxman litigation over desloratadine tablets, a generic version of Schering-Plough's anti-allergic Clarinex. FiercePharma Allergic rhinitis: market evolution - Apr 3, 2009 Although these figures are far from the multi-billion dollar sales of Claritin in its heyday, Xyzal will continue to challenge desloratadine (Clarinex), Nature.com (subscription) Zacks Analyst Blog Highlights: Schering-Plough, Merck & Co ... - Apr 3, 2009 On a stand-alone basis, we expect Schering-Plough's (NYSE: SGP) sales to increase only 2% in 2009 as increased competition to prescription Claritin/Clarinex FOXBusiness Common drugs can help allergic rhinitis - Mar 29, 2009 Second-generation anti-histamines have been developed such as Xyzal, Zyrtec, Allegra, Claritin, Clarinex, and Alavert that do not cross the Daytona Beach News-Journal Tháng tÆ° và bệnh dị ứng phấn hoa - Apr 16, 2009 Thuốc chống dị ứng bao gồm có các loại thuốc kê Ä‘Æ¡n và không cần kê Ä‘Æ¡n nhÆ° Benadryl, Clarinex, Zyrtec hay Allegra; các loại thuốc giảm xung huyết há»?ng nhÆ° Dân Trí Mylan与先ç?µè‘†é›…了结专利诉讼 - Apr 8, 2009 ...地氯雷他定是Clarinex的活性æˆ?分。 两公å?¸å·²å°±æ‰€æœ‰æœªå†³çš„专利诉讼达æˆ?了和解。 在特定的æ?¡ä»¶ä¸‹ï¼ŒMylan将能够在2012å¹´7月之å‰?推出其仿制版本，并将能够把该è?¯ä½œä¸ºé?žå¤„æ–¹ 新浪网 Mylan與先é?ˆè‘†é›…了çµ?專利訴訟 - Apr 8, 2009 ...新浪財經訊周三，制藥商Mylan Inc(MYL)宣布，已了çµ?了由先é?ˆè‘†é›…å…¬å?¸(SGP)æ??èµ·çš„ä¸€é …å°ˆåˆ©è¨´è¨Ÿï¼Œå¾žè€Œèƒ½å¤ è‡ª2012å¹´7月1日開始出售先é?ˆè‘†é›…的抗é?Žæ•?è—¥Clarinex的一個仿制 新浪網 Schering-Plough May Pay $165 Million to Settle Shareholder Suit - Mar 13, 2009 The company referred to the Clarinex settlement in its 10-K, filed on Feb. 27. But there was no dollar value mentioned there. An FAQ on the company’s Web Wall Street Journal Blogs Merck & SGP Announce Merger - Mar 9, 2009 Other than cholesterol, Schering has a large presence in respiratory therapeutics (Clarinex/OTC, Claritin, Nasonex) and has large consumer and animal health Zacks.com 10-K: SEPRACOR INC /DE/ - Feb 27, 2009 In January 2002, Schering-Plough commercially introduced CLARINEX brand desloratadine 5 mg tablets for the treatment of seasonal allergic rhinitis, MarketWatch (press release) How to avoid spring allergies - Mar 10, 2009 Antihistamines such as Allegra, Claritin, Clarinex, and Zyrtec work by lowering the body's histamine levels, thus reducing allergy symptoms like sneezing, Retriever Another Day, Another Merger, Another Shareholder Lawsuit - Mar 16, 2009 ...a class action that claimed the company defrauded investors by failing to disclose manufacturing flaws blocking approval of the allergy drug Clarinex. Am Law Litigation Daily New Renderings Show Off Interiors for the 1 Hotel Washington DC - 04 Feb 2009 ...during our hotel stays, we do wonder what happens to guests who have bad allergies. Will they offer a free pack of Clarinex with every room? by AndrewC. HotelChatter, SP in "sweet spot on product flow and expected exclusivity" - 04 Feb 2009 ...interferon) decreased 6% to $225 million, due to lower US sales, while revenues from the antihistamine Clarinex (desloratadine) fell 8% to $160 million. Pharma Times, Schering earnings expected to show cost cuts - Feb 2, 2009 OVERVIEW: The maker of hepatitis, respiratory and allergy drugs such as Asmanex and Clarinex has been working since April on cutting 20 percent of its sales Forbes, GeoPharma settles patent suit for generic Clarinex - Jan 20, 2009 O) relating to its generic version of allergy drug Clarinex. Under the settlement, GeoPharma can commercially launch its generic product, with 6 months Reuters BRIEF-GeoPharma announces settlement of Clarinex(R) - Jan 20, 2009 The copying, republication or redistribution of Reuters News Content, including by framing or similar means, is expressly prohibited without the prior Forbes, Perrigo Reports Record Second Quarter Sales - Feb 3, 2009 This product seeks an AB-rating as equivalent to Schering-Plough's Clarinex(R) tablets (5 mg) indicated for the treatment of seasonal allergic rhinitis, PR Newswire (press release), BRIEF-GeoPharma announces settlement of Clarinex(R) - Jan 20, 2009 Interactive Investor Trading Limited, trading as "Interactive Investor", is authorised and regulated by the Financial Services Authority. Interactive Investor, Sepracor Reports Fourth Quarter and Full-Year 2008 Operating Results - Jan 28, 2009 Sepracor continues to earn royalty revenues on sales of out-licensed antihistamine products, which primarily include Schering-Plough's CLARINEX(R) brand Trading Markets (press release), savvy senior - Jan 26, 2009 ...allergy drug Clarinex (desloratadine), the herpes antiviral drug Valtrex (valacyclovir), GERD drugs Prevacid (lansoprazole) and Aciphex (rabeprazole), Seymour Herald, Savvy Senior - Jan 24, 2009 ...allergy drug Clarinex (desloratadine), the herpes antiviral drug Valtrex (valacyclovir), GERD drugs Prevacid (lansoprazole) and Aciphex (rabeprazole), Fergus Falls Daily Journal, Business briefs - Jan 21, 2009 Under the agreement, GeoPharma received a license to sell generic Clarinex tablets. The settlement is one of several agreements reported recently between Worcester Telegram, BUYINS.NET: Market Maker Surveillance Report. Top 6 Highest Net ... - Jan 30, 2009 Sepracors out-licensing agreements include Schering-Plough for CLARINEX (desloratadine); sanofi-aventis for ALLEGRA (fexofenadine HCl); and UCB SA for Trading Markets (press release), Brand Names/Synonyms: Clarinex is also known by the following brand names and/or synonymsAerotina; Alarin; Alavert; Alerpriv; Allertidin; Bedix Loratadina; Biloina; Bonalerg; CHEMBANK1389; Civeran; Claratyne; Claratyne Cold; Claratyne Decongestant; Clarinase; Clarinase Reperabs; Clarinex; Claritin; Claritin Reditab; Claritin Reditabs; Claritin-D; Claritine; Clarityn; Clarityne; Fristamin; Histaloran; Lergy; Lertamine; Lesidas; Lisino; Loracert; Loradex; Loradif; Loranox; Lorantis; Lorastine; Loratadina [Spanish]; Loratadine; Loratadine [Usan:Ban:Inn]; Loratadinum [Latin]; Loratyne; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Polaratyne; Pylor; Restamine; Rhinase; Rinomex; Sanelor; Sensibit; Sinhistan Dy; Sohotin; Tadine; Talorat Dy; Velodan; Versal; Zeos Drug Category: Clarinex is categorized under the following by the FDA: Anti-allergic Agents; Antipruritics; Antihistamines; Histamine H1 Antagonists, Non-Sedating; ATC:R06AX13; ATC:R06AX27 Dosage Forms: Tablet; Syrup Absorption: Loratadine was rapidly absorbed following oral administration (40% bioavailability) Interactions: -->Interactions for Loratadine: Loratadine (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of loratadine and/or descarboethoxyloratadine were observed following coadministration of loratadine with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of loratadine, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.
There does not appear to be an increase in adverse events in subjects who received oral contraceptives and loratadine. Chemical IUPAC Name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester : |
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