Citalopram

This page contains recent news articles, when available, and an overview of Citalopram but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Citalopram (when available)

Pharmacology and use:
Citalopram is one of a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that Citalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Citalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT_1A, 5HT_1B, 5HT₂), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of Citalopram was found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Citalopram does not inhibit monoamine oxidase. For the treatment of depression

Mechanism Of Action:
The antidepressant, antiobsessive-compulsive, and antibulimic actions of Citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

News Articles on Citalopram

El psiquiatra recomienda  -  21 Oct 2008
Para el ataque de pánico, los medicamentos más usados son los famosos inhibidores de la recaptación de serotonina: SERTRALINA, PAROXETINA, CITALOPRAM, El Caribe,

‘Wonder drug’ played a part in man taking his own life – coroner  -  Oct 16, 2008
He had been prescribed the anti-depressant Citalopram for just one month before taking his life and he had expressed a wish to come off it, complaining of Camden New Journal,

City woman's fatal drug OD spurs $3.7M lawsuit  -  Oct 9, 2008
25, 2006, after consuming a fatal dose of the drug citalopram, under the brand name Celexa. Her statement of claim, a copy of which was obtained yesterday Edmonton Sun,

Women respond better than men to antidepressant  -  Oct 11, 2008
Women with major depression are more likely than men to achieve remission during treatment with citalopram, an antidepressant that belongs to a class of The News International,

Court again postpones Barry trial  -  Oct 10, 2008
The state's medical examiner reported the baby died from a lethal dose of crushed Vicodin and the antidepressant citalopram, also called Celexa. EastOregonian.info (subscription),

Back-to-school belly-ache blues may be more than just nerves  -  Sep 30, 2008
So far, a type of SSRI, known as citalopram, has shown promise. The doctors recommend that children with recurrent or persistent abdominal pain should be Thaindian.com,

Treatment in Psychiatry Drug Interactions and Pharmacogenomics in ...  -  Oct 1, 2008
These observations have primarily been made with venlafaxine, paroxetine (continuous release formulation), and citalopram (11, 12, 15, 16). Am J Psychiatry (subscription)

Anti-depressant drugs on the up  -  Oct 15, 2008
The most common anti-depressant drug prescribed in Sunderland in 2007/08 was Citalopram Hydrobromide, with 53282 at a cost of £139727.70. Sunderland Echo,

Escitalopram, Problem-Solving Therapy, and Poststroke Depression  -  Oct 14, 2008
Søndergaard MP, Jarden JO, Martiny K, Andersen G, Bech P. Dose response to adjunctive light therapy in citalopram-treated patients with post-stroke Journal of American Medical Association (subscription),

Heart Patients Should Be Monitored for Depression, Group Says  -  Sep 29, 2008
...such as Pfizer Inc.'s Zoloft, also sold as the generic sertraline, and Forest Laboratories Inc.'s Celexa, also sold as the generic citalopram. Bloomberg

Adheris Study Finds Antidepressant Discontinuation Most Likely at ...  -  Sep 26, 2008
Patients in the study received venlafaxine XR, sertraline, paroxetine CR, fluoxetine, escitalopram, or citalopram prescriptions between October 1, MarketWatch

Anti-depressant drug may affect fertility, says study  -  Sep 24, 2008
Two years ago the same researchers reported that the antidepressants citalopram (Cipramil) and sertraline (Lustral) reduced sperm counts in men, guardian.co.uk,

Is Your Child's Stomach Pain All In His Head?  -  Oct 1, 2008
..."Citalopram Treatment of Pediatric Recurrent Abdominal Pain and Comorbid Internalizing Disorders: An Exploratory Study", Journal of the American Academy of Medical News Today (press release),

Routinely screen for clinical depression in CHD, AHA formally ...  -  Sep 30, 2008
As for treatment, the selective serotonin reuptake inhibitors (SSRIs) sertraline and citalopram "are the first-line antidepressants drugs for patients with TheHeart.Org,

Gevaarlijke medicijnen slingeren rond in Eygelshoven  -  Oct 17, 2008
Het gaat om de medicijnen Zyprexa, Zopiclon en Citalopram. De medicijnen kunnen gevaarlijk zijn voor kinderen. Op de doosjes van de medicijnen staat een Hartvannederland.nl,

A pszichiáter is pánikrohamot kapott  -  Sep 28, 2008
...kezelésének módszerét, amely labilis és magas vérnyomás esetében a citalopram- és S-citalopram-molekulákból kifejlesztett gyógyszereken alapul. 168 Óra,

UN F�?RMACO HABITUAL EN EL TRATAMIENTO DE LA DEPRESIÓN PODR�?A ...  -  Sep 25, 2008
Hace dos años, el equipo de Schlegel descubrió que otros principios activos, como citalopram y sertraline, también utilizados en fármacos antidepresivos, Discapnet (Comunicado de prensa),

Antidepressivi solo nelle forme gravi?  -  Oct 8, 2008
Cinque studi (4 su sertralina e 1 su citalopram) sono stati esclusi perchè non era stato raggiunto un effetto statisticamente significativo del farmaco e Pillole.org,

Mal de Alzheimer, tudo sobre a doença de Alzheimer  -  Oct 16, 2008
Ele aumentou a dosagem do Alois , e cortou o remédio para depressão (citalopram) , que minha mãe tomava a vários anos, e acredite minha mãe melhorou. MAL DE ALZHEIMER,

[혹시 나�?� 우울�??]  -  Oct 2, 2008
...프로작(Fluoxetine), 졸로프트(Sertraline), 세로�?트(Paroxetin), 씨프람(citalopram), 듀미�?스(Fluvoxamine) 등�?� 대표�?�?� 약물�?�다. 우울�? 약물치료�?서 환�?나 매�?�경제,

Genéricos passam a custar menos 30%  -  Sep 30, 2008
...activas em que os medicamentos genéricos representaram mais de 70% das vendas: os antidepressivos Citalopram e Fluxetina estão entre os mais procurados. Jornal de Notícias,

AIDS-Patienten sind schmerztherapeutisch unterversorgt  -  Oct 11, 2008
Günstig seien auch wegen geringer Interaktionen mit HAART die Wirkstoffe Citalopram, Duloxetin und Venlafaxin auf. "Die erheblich verlängerte Überlebenszeit Informationsdienst Wissenschaft (Pressemitteilung),

Samtidig bruk av kvetiapin og escitalopram.  -  Oct 10, 2008
Likevel er det sett at citalopram/escitalopram økte likevektskonsentrasjonen av kvetiapin i plasma (1), men økningen var ikke så stor at forfatterne RELIS,

Switching da inibitori della ricaptazione della serotonina a ...  -  Oct 2, 2008
...etnia caucasica e con precedenti episodi di depressione, in terapia con paroxetina seguita da (in ordine di frequenza) citalopram, fluoxetina, Pillole.org,

Depressie goed te behandelen met Magnetische Hersenstimulatie (rTMS).  -  Oct 1, 2008
Ter vergelijking, Antidepressiva zoals Citalopram laten remissies zien van maximaal 33% (Trivedie et al., 2006; STAR*D trial) en maar 30-50% van de cliënten HotFrog (persbericht),

FANS e SSRI moltiplicano rischio di sanguinamento GI  -  Sep 30, 2008
Inoltre, il rischio di sanguinamento gastrointestinale è riportato solo per paroxetina (molto raro) e citalopram (raro). È stata realizzata ad aprile 2007 Pillole.org,

Zachowania samobójcze u dzieci i młodzieży. Część I: Etiologia i ...  -  Oct 8, 2008
A randomized, double-blind, placebo- controlled study of citalopram in adolescents with major depressive disorder. J. Clin. Psychopharmacol., 2006 Medycyna Praktyczna,

Women With Depression Respond Better to Citalopram Compared With Men  -  Aug 29, 2008
ANN ARBOR, Mich -- August 29, 2008 -- Women with depression may be much more likely than men to get relief from citalopram (Celexa), although both sexes may DG News

Women benefit more from antidepressants  -  Aug 31, 2008
Women with depression are more likely than men to benefit from antidepressant drug citalopram (Celexa), according to a new study, which suggests a Times of India,

Theresa teen arrested for passing drugs on school bus  -  Sep 12, 2008
They allege Titch passed three pills of the drug Citalopram, which is an antidepressant drug that affects neurotransmitters, to 16-year-old Patrick J. Smith Newswatch 50,

Selective Serotonin Reuptake Inhibitor Induced Neonatal Abstinence ...  -  Sep 11, 2008
Of the SSRI half-lives, fluoxetine, sertraline and citalopram have a long one with fluoxetine having the longest, paroxetine and fluvoxamine have an RedOrbit,

Older People in Danger from Common Drugs  -  Aug 28, 2008
Shorter-acting citalopram (Celexa) paroxetine (Paxil) and sertraline (Zoloft) could be possible alternatives. • Fluoxetine (Prozac) causes agitation and NewsMax.com,

Ask more questions about medications  -  Aug 18, 2008
For instance the anti-depressant drug Citalopram may not mix well with the anti-psychotic drug Risperidone slowing its metabolism through the liver and North Island Midweek,

The Drug Gap  -  Sep 8, 2008
All participants were treated for 12 to 14 weeks with citalopram (popularly known as Celexa), a selective serotonin reuptake inhibitor (SSRI), currently the Newsweek

Learn about the World CNS Therapeutics Market  -  Sep 4, 2008
Paxil, Cipralex, Wellbutrin, Citalopram, Prozac, Remeron and Others (includes corresponding Graph/Chart) II-5 Attention Deficit Hyperactivity Disorder MarketWatch

Suicide Trends Among Youths Aged 10 to 19 Years in the United ...  -  Sep 2, 2008
Financial Disclosures: Dr Bridge reported that from 2001 to 2004, he participated as a coinvestigator of an open-label trial of citalopram for treatment of Journal of American Medical Association (subscription),

Raltegravir may cause temporary worsening of pre-existing depression  -  Sep 2, 2008
Two of the patients were taking citalopram and three were taking bupoprion; apart from these overlapping drugs the four patients were taking a wide variety Aidsmap,

Body Dysmorphic Disorder: Treating an Underrecognized Disorder  -  Sep 2, 2008
Symptoms significantly improved in open-label studies of fluvoxamine, citalopram, and escitalopram (Ns ranging from 15 to 30) (32–35), and response rates Am J Psychiatry (subscription)

Raskaus ja citalopram?  -  Sep 3, 2008
Olen syönyt citalopram 40mg lääkettä muutamien vuosien ajan pakko-oireisen häiriön hoitoon. En ole käynyt kontrollissa pitkään aikaan, mutta sairauteni on Verkkoklinikka,

Chatt med Yngve Gustafson 080911  -  Sep 11, 2008
SSRI kan vara t ex Citalopram, Cipramil, Cipralex eller Zoloft. Även dessa preparat bör inledas med en låg dos och alltid följas upp med avseende på Dagens Nyheter,

Notícias On-Line  -  Sep 13, 2008
Mulheres com depressão maior são mais propensas do que os homens a terem melhora na doença durante o tratamento com o antidepressivo citalopram, O Pantaneiro,

Trattamento della depressione: le donne rispondono meglio  -  Sep 4, 2008
Il citalopram è una molecola che fa parte della famiglia degli inibitori selettivi del reuptake della serotonina ed è comunemente prescritta nei casi di Yahoo! Italia Notizie,

En el Posadas se recibieron medicamentos oncológicos  -  Aug 25, 2008
...recibido en donación aproximadamente cien mil comprimidos de Cyclobenzaprine ClH, cien mil de Citalopram 40 mg y otros cien mil de Citalopram de 20 mg. Diario El Sol de Quilmes,

Hommes et femmes inégaux devant l'efficacité d'un antidépresseur  -  Sep 1, 2008
Un antidépresseur utilisé en France nommé Citalopram serait moins efficace sur les hommes que sur les femmes, même si pour les deux sexes, une amélioration CommentCaMarche.net,

Sex en drugs  -  Sep 1, 2008
Het jongste voorbeeld betreft de antidepressiva Citalopram, ook bekend onder het merk Celexa. Vrouwen hebben daar een stuk meer baat bij dan mannen. Teleac Radio,

Enfants et antidépresseurs: les six questions essentielles  -  Sep 11, 2008
Parmi ces médicaments, les plus prescrits sont la fluoxétine (Prozac), la paroxétine (Déroxat) et le citalopram (Seropram). L'Express,

Wenn Kaufen zur Sucht wird  -  Sep 1, 2008
Wer zugleich depressiv ist, dem kann auch eine Pille mit dem Wirkstoff Citalopram helfen, die an der Stanford University (Kalifornien) erfolgreich getestet Tages-Anzeiger Online,

Antidepresivos, el atajo equivocado ante los problemas  -  Aug 29, 2008
Sertralina (11%), citalopram (10%), mirtazapina (6%), duloxetina (6%), fluoxamina (2%) que proceden del sistema ?Depression Monitor? de la Compañía TNS. La Razón Digital,

Brand Names/Synonyms:
Citalopram is also known by the following brand names and/or synonymsCHEMBANK1660; Celexa; Cipram; Citalopram; Citalopram Hydrobromide; Citalopram [Ban:Inn]; Citalopramum [Inn-Latin]; Lexapro; Nitalapram

Drug Category:
Citalopram is categorized under the following by the FDA: Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB04; ATC:N06AB10

Dosage Forms:
Oral solution and tablets

Absorption:
80%

Interactions:
Central nervous system depressant (CNS) drugs including alcohol, antidepressants, antihistamines, antipsychotics, blood pressure medications (reserpine, methyldopa, beta-blockers), motion sickness medications, muscle relaxants, narcotics, sedatives, sleeping pills and tranquilizers

Chemical IUPAC Name:
1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile

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