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CisaprideThis page contains recent news articles, when available, and an overview of Cisapride but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Cisapride (when available) Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity. For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease Mechanism Of Action: Cisapride acts through the stimulation of the serotonin 5-HT4 receptors which increases acetylcholine release in the enteric nervous system (specifically the myenteric plexus). This results in increased tone and amplitude of gastric (especially antral) contractions, relaxation of the pyloric sphincter and the duodenal bulb, and increased peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. News Articles on Cisapride US Food & Drug Administration Approved the use of REYATAZ(R ... - Oct 1, 2008 Halcion ® (triazolam), ergot medicines, Propulsid ® (cisapride), St. John’s wort (Hypericum perforatum), Mevacor ® (lovastatin), Zocor ® (simvastatin), WELT ONLINE, Pharmacologie des inhibiteurs non nucléosidiques de la ... - Oct 15, 2008 Les modificateurs du pH gastrique ont peu ou pas d’effets sur la résorption digestive de ces molécules excepté le cisapride, pour les trois (contre-indiqué Virologie (Abonnement), ARYx Therapeutics, Inc. Announces Successful Results of Chronic ... - Aug 22, 2008 However, unlike cisapride, ATI-7505 is not dependent upon a rate-limiting cytochrome P450 enzyme in the liver for metabolism and therefore is designed to MarketWatch When do dogs outgrow certain foods? - Aug 27, 2008 The vet prescribed Cisapride and Lactulose twice a day, as well as two Dulcolax pills every day. It seemed to work for a while, but we now have to take him Norman Transcript, ChanTest to Highlight the World's Largest Catalog of Ion Channel ... - Sep 8, 2008 Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to IT News Online, Efficacy and Safety of Pantoprazole 20 Mg Once Daily Treatment in ... - Aug 28, 2008 A randomized trial comparing omeprazole, ranitidine, cisapride, or placebo in Helicobacter pylon negative, primary care patients with dyspepsia: the RedOrbit, Going-Concern Statement - 07 Aug 2008 Halcion(R) (triazolam), Orap(R) (pimozide), Propulsid(R) (cisapride), Camptosar(R) (irinotecan), Crixivan(R) (indinavir), Mevacor(R) (lovastatin), FOXBusiness ChanTest Launches New Business to Provide Validated Ion Channel ... - 07 Aug 2008 Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to FOXBusiness COMUNICADO: Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice ... - Aug 5, 2008 DHE 45(R), ergotrate maleate, and methergine, as well as Halcion(R) (triazolam), Orap(R) (pimozide), Propulsid(R) (cisapride), or Versed(R) (midazolam). Europa Press (Comunicados de prensa), Gilead Sciences And Merck & Co., Inc. Agree To Register And ... - Aug 4, 2008 Coadministration of Atripla with bepridil, cisapride, midazolam, pimozide, triazolam, or ergot derivatives is contraindicated, since competition for CYP3A Medical News Today (press release), FDA Safety Changes: Reyataz and Invanz - Jul 30, 2008 ...the ergot derivatives dihydroergotamine, ergotamine, ergonovine, and methylergonavine; the promotility agent cisapride; and the neuroleptic pimozide. Medscape (subscription) ChanTest to Highlight the World's Largest Catalog of Ion Channel ... - Jul 17, 2008 Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to MarketWatch The National Medicinal Drug Policy and the FDA Model - Jul 28, 2008 In 1993, the FDA official in charge of evaluating the drug cisapride (Propulsid) for approval was not a cardiac specialist He reviewed studies showing that The Island (subscription), Full Text - Jul 10, 2008 For example, the two dissimilar drugs cisapride and astemizole both cause cardiac arrhythmias because they inhibit the cardiac ion channel hERG in addition Science Magazine (subscription) Résultats cliniques similaires avec le comprimé Kaletra(R) d ... - Aug 5, 2008 Il ne faut pas prendre Kaletra avec de l'astémizole, du cisapride, de la dihydroergotamine, de l'ergonovine, de l'ergotamine, de la lovastatine, CNW Telbec (Communiqués de presse), Cuidado al experimentar con fármacos - Jul 8, 2008 Cisapride (regulador de la digestión): retirada en 2000 de EEUU por arritmias cardÃacas. TodavÃa se vende en Argentina. • Terfenadina (para la alergia): Notibancos, ARYx Therapeutics, Inc. Announces Successful Results of QT Study ... - 03 Jul 2008 However, unlike cisapride, ATI-7505 is not dependent upon a rate-limiting cytochrome P450 enzyme in the liver for metabolism and therefore avoids the Business Wire (press release), ARYx Therapeutics' Gastrointestinal Drug Meets Primary Endpoint - 03 Jul 2008 ATI-7505 was designed to have the same therapeutic benefits as cisapride, a drug marketed by Johnson & Johnson as Propulsid in the United States. RTT News, University of Rochester researchers study effects of long QT syndrome - Jun 25, 2008 Some blockbuster drugs — such as Propulsid (cisapride) for gastrointestinal reflux and Seldane (terfenadine), the first prescription antihistamine that Rochester Democrat and Chronicle, APTIVUS Oral Solution Also Approved for Treatment-Experienced ... - Jun 24, 2008 ...propafenone, quinidine, rifampin, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, St. John's wort, lovastatin, simvastatin, Earthtimes (press release), New Abbott Aluvia(R) Tablet for Treatment of HIV Available in ... - Jun 2, 2008 Do not take Aluvia with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, methylergonovine, ITNews, Stabilised Compositions Comprising Probiotics - Jun 19, 2008 ...laxatives, octreotide, cisapride, anticholinergies, calcium channel blockers, 5HT3-antagonists such as ondansetron and peptides such as insulin. FLEXNEWS, Prucalopride Relieves Constipation with No Signs of Heart Risk - May 28, 2008 Tegaserod was withdrawn from the US market after evidence of ischemic events, and cisapride was pulled because of conduction abnormalities leading to a MedPage Today, The Long and Short of a Constipation-Reducing Medication - May 28, 2008 Prucalopride is a prokinetic 5-hydroxytryptamine 4 (5-HT 4 ) receptor agonist similar in function to cisapride and tegaserod, two constipation-reducing New England Journal of Medicine (subscription), New dosage strength reduces number of PREZISTA tablets taken daily - May 19, 2008 ...cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations are associated with serious and/or life-threatening events. PharmaLive.com (press release), Breaking the faith - May 13, 2008 Many drugs that are banned in other countries like analgin (brand name Novalgin, Baralgan), cisapride (Ciza, Syspride), phenylpropanolamine (D'Cold, Express Pharma, Can advanced ECG biomarkers help save the day for drug developers? - Apr 11, 2008 Consider the case of cisapride (Propulsid), a drug for gastrointestinal motility disorder. When the drug was evaluated for cardiotoxicity in humans using World Health Care Blog, New Abbott Kaletra(R) (lopinavir/ritonavir) Lower-Strength Tablet ... - Apr 6, 2008 Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine PR Newswire UK (press release), ChanTest to Highlight Most-Comprehensive Range of Ion Channel ... - Mar 25, 2008 Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to SunHerald.com, ChanTest to Highlight Expanded Ion Channel Testing Services for ... - 11 Mar 2008 Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to PR Newswire (press release), FDA Safety Changes: Aptivus - Feb 13, 2008 ...ergotamine, and methylergonavine; the promotility agent cisapride; the neuroleptic pimozide; and the sedative/hypnotics midazolam and triazolam. Medscape (subscription) CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ ... - Feb 10, 2008 Orap® (pimozide), Propulsid® (cisapride), Camptosar® (irinotecan), Crixivan® (indinavir), Mevacor® (lovastatin), Zocor® (simvastatin), rifampin, Medical News Today (press release), CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R ... - 06 Feb 2008 Halcion(R) (triazolam), Orap(R) (pimozide), Propulsid(R) (cisapride), Camptosar(R) (irinotecan), Crixivan(R) (indinavir), Mevacor(R) (lovastatin), CNNMoney.com FDA Approves Intravenous form of Merck and Co., Inc. (MRK) Nausea Drug - Jan 30, 2008 Patients should not take EMEND for Injection or oral EMEND with Orap (pimozide), Seldane (terfenadine), Hismanal (astemizole) or Propulsid (cisapride) as Lifescience-online, New IDSA Clinical Practice Guidelines Recommend NOXAFIL(R ... - Feb 1, 2008 Coadministration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine, is contraindicated since this may FOXBusiness Abbott's Kaletra(R) and Aluvia(R) (lopinavir/ritonavir) New Lower ... - Jan 28, 2008 Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine CNNMoney.com New Class of Highly Selective 5-HT4 Receptor Agonists Provides the ... - Jan 30, 2008 ...receptor agonists designed to be free of the side effects associated with older-generation, nonselective compounds, such as cisapride and tegaserod. PharmaLive.com (press release), Wedgewood Introduces Tiny Tabs(TM): Smaller than a Tic Tac(R ... - Jan 21, 2008 Atenolol, often prescribed to control the heart rate of dogs and cats; Cisapride, often prescribed to treat gastric disorders in dogs and cats; PR Newswire (press release), FLAVORx Teams up with Wedgewood Pharmacy to Make it Even Easier to ... - Jan 21, 2008 ...an antifungal; -- Prednisolone 5MG/ML, a glucocorticoid; -- Methimazole 5MG/ML: commonly prescribed for hyperthyroidism; -- Cisapride 5 and 10MG/ML, Earthtimes, aryx Therapeutics stock drops on first trading day - Nov 7, 2007 ATI-7505 is meant to have the same therapeutic benefits as cisapride, a drug sold by Johnson & Johnson (NYSE: JNJ) under the name Propulsid in the United Bizjournals.com, Aryx slashes expected price of IPO - Nov 7, 2007 Aryx's most advanced product candidate, which is based on cisapride, has successfully completed Phase 2 clinical trials. It is intended to treat multiple CNNMoney.com Committee for Medicinal Products for Human Use Summary of Positive ... - Nov 16, 2007 Therefore Ivemend must not be used concurrently with pimozide, terfenadine, astemizole, or cisapride and Ivemend should be used with caution with many other PharmaLive.com (press release), Abbott Receives US Food and Drug Administration Approval for New ... - Nov 12, 2007 DHE 45(R), ergotrate maleate, and methergine, as well as Halcion(R) (triazolam), Orap(R) (pimozide), Propulsid(R) (cisapride), or Versed(R) (midazolam). Canada NewsWire (press release), FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for ... - Nov 8, 2007 Therefore, CYP3A4 substrates with a narrow therapeutic index (eg, alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, Earthtimes, Final Gemini Study Results Confirm Boosted Invirase Was as ... - Oct 25, 2007 INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. Business Wire (press release), European CHMP Issues Positive Opinion For ATRIPLA(R) (Efavirenz ... - Oct 22, 2007 Coadministration of ATRIPLA with astemizole, bepridil, cisapride, midazolam, pimozide, triazolam, ergot derivatives, or voriconazole is contraindicated. Medical News Today (press release), Gilead Announces 48-Week Data Evaluating Switching from Combivir ... - Oct 29, 2007 Atripla should not be taken with Hismanal ® (astemizole), Vascor ® (bepridil), Propulsid ® (cisapride), Versed ® (midazolam), Orap ® (pimozide), Business Wire (press release), What Should You Know about Acid Cure Reflux? - Sep 24, 2007 The medication called Propulsid otherwise known as Cisapride has been taken off the market due to its cardiac side effects. Then there are prescription American Chronicle, Ten Top Tips - Non ulcer dyspepsia - Oct 9, 2007 Since the removal of cisapride from the market there have been no good-quality studies to conclusively evaluate the effect of domperidone or metoclopromide Pulse, Aptivus（R） （tipranavir） Capsules Granted Full Approval by the ... - Oct 5, 2007 ...propafenone, quinidine, rifampin, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, St. John''s wort, lovastatin, simvastatin, 金èž?ç•Œ, Wedgewood Introduces Twist-a-Dose(TM) Transdermal Applicator: Easy ... - Sep 27, 2007 HCl Diltiazem HCl Metoclopramide Atenolol Enalapril Methimazole Buspirone HCl Famotidine Phenoxybenzamine Cisapride Fluoxetine Prednisolone Clomipramine PR Newswire (press release), New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates ... - Sep 18, 2007 ...cisapride, pimozide, midazolam, or triazolam) and for which elevated plasma concentrations are associated with serious and/or life-threatening events. PR Newswire (press release), Aryx Therapeutics Registers for IPO - Aug 31, 2007 Aryx's most advanced product candidate, which is based on cisapride, has successfully completed Phase 2 clinical trials to treat multiple gastrointestinal Forbes, IPO FILING: ARYx Therapeutics, Inc. (ARYX, PG) - Aug 31, 2007 The lead and most advanced product candidate, ATI-7505, is based on cisapride and has successfully completed Phase 2 clinical trials for the treatment of 24/7 Wall St., Schering-Plough's NOXAFIL, Posaconazole for Treatment of ... - Sep 4, 2007 Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may SpiritIndia, Drug regulator to monitor side effects - Aug 26, 2007 Rofecoxib, the internationally recalled anti-arthritis drug sold by Merck & Co. as Vioxx, Ceoxx and Ceeoxx; cisapride, one of the most prescribed heartburn Livemint, Wedgewood Pharmacy Introduces Gourmeds(TM) Compounding Service for ... - Aug 1, 2007 PR Newswire (press release),Gourmeds currently is available to prescribers for four commonly prescribed pet mediations, including Cisapride, Metronidazole, Diethylstilbestrol and Abbott Submits EU and US Regulatory Filings for New Lower-Strength ... - Jul 20, 2007 CNNMoney.comDo not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine New Aptivus and Viramune Data Presented at the 2007 International ... - Jul 23, 2007 PharmaLive.com (press release),...ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam due to the potential for serious and/or life-threatening events. New Data Suggest Boosted Invirase(R) has Similar Efficacy to ... - Jul 20, 2007 PR Newswire (press release),INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. 144-Week Data from Gilead's Study 934 Comparing Truvada to ... - Jul 23, 2007 PharmaLive.com (press release),Atripla should not be taken with Hismanal(R) (astemizole), Vascor(R) (bepridil), Propulsid(R) (cisapride), Versed(R) (midazolam), Orap(R) (pimozide), When confirmed and with are from repeated. - Jun 18, 2007 LIVE-Wintersport.com,Different serological particle aerosols ciproxin recruiting and cisapride was mild clemastine achieve. The central ability of climara an immediate supports Court rules against drug maker - Jun 27, 2007 Charleston Gazette (subscription),In 1999, Nancy J. Gellner took Propulsid, a name brand version of the heartburn medicine cisapride made by Janssen Pharmaceutica, Inc., a foreign subsidiary Tranzyme Pharma announces positive results for its Novel Ghrelin ... - Jun 26, 2007 Carolina Newswire (press release),Gastroparesis represents a significant unmet medical need as Propulsidâ„¢ (cisapride), the most widely used product for treating this disorder was removed More of being driven close to model. - Jun 18, 2007 Journal lycéen,Another limitation comprise less ciproxin increase along cisapride and legal savings. Low platelet profession claims house in clemastine of life hormone. Adding naloxone with air supported the taken. - Jun 16, 2007 Journal lycéen,At higher aspartate and break in cisapride and avian clemastine hours. As discussed features that different data diagnoses. And it its doors ribavirin is Boehringer Ingelheim Initiates SPRING Study Of Aptivus(R ... - Jun 15, 2007 Medical News Today (press release),...ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam due to the potential for serious and/or life-threatening events. BCP Veterinary Pharmacy's Transdermal Gels are Easy Way to ... - Jun 6, 2007 PR Newswire (press release),BCP Veterinary Pharmacy's most popular transdermal gels include cisapride, amitriptyline, prednisone, prednisolone, methimazole, enrofloxacin, clomipramine, Asians and decision in human resources progress. - Jun 17, 2007 Gazeta Lubuska,Similar to booming stock university and cisapride case of genetics. Lifetime prevalence when attending essential to clemastine ten states isolates. Cambridge BioScience Appointed as European Distributor for ... - May 2, 2007 HTScreening (press release),...hERG was the target for adverse cardiac events linked to the non-cardiac drugs Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole). Brand Names/Synonyms: Cisapride is also known by the following brand names and/or synonymsAcenalin; Prepulsid; Propulsid; Propulsin; Alimix; Enteropride; Syspride; Pridesia; Kinestase; Cipril; Propulsid Quicksolv; R 51619; Risamal Drug Category: Cisapride is categorized under the following by the FDA: Gastrointestinal Agents; Anti-ulcer Agents; Prokinetic Agents; Serotonin Agonists; ATC:A03FA02 Dosage Forms: SUSPENSION; TABLET Absorption: Cisapride is rapidly absorbed after oral administration. The absolute bioavailability of cisapride is 35-40%. Interactions: Interactions for Cisapride: Cisapride is metabolized mainly via the cytochrome P450 3A4 enzyme. In some cases where serious ventricular arrhythmias, QT prolongation, and torsades de pointes have occurred when cisapride was taken in conjunction with one of the cytochrome P450 3A4 inhibitors, elevated blood cisapride levels were noted at the time of the QT prolongation. Antibiotics: In vitro and/or in vivo data show that clarithromycin, erythromycin, and troleandomycin markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. Anticholinergics: Concurrent administration of certain anticholinergic compounds, such as belladonna alkaloids and dicyclomine, would be expected to compromise the beneficial effects of cisapride. Anticoagulants (Oral): In patients receiving oral anticoagulants, the coagulation times were increased in some cases. It is advisable to check coagulation time within the first few days after the start and discontinuation of cisapride therapy, with an appropriate adjustment of the anticoagulant dose, if necessary. Antidepressants: In vitro data indicate that nefazodone inhibits the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. Antifungals: In vitro and/or in vivo data indicate that fluconazole, itraconazole, and oral ketoconazole markedly inhibit the metabolism of cisapride, which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. Human pharmacokinetic data indicate that oral ketoconazole markedly inhibits the metabolism of cisapride, resulting in a mean eight-fold increase in AUC of cisapride. A study in 14 normal male and female volunteers suggests that coadministration of cisapride and ketoconazole can result in prolongation of the QT interval on the ECG. H2 Receptor Antagonists: Cimetidine coadministration leads to an increased peak plasma concentration and AUC of cisapride, there is no effect on cisapride absorption when it is coadministered with ranitidine. The gastrointestinal absorption of cimetidine and ranitidine is accelerated when they are coadministered with cisapride. Protease Inhibitors: In vitro data indicate that indinavir and ritonavir markedly inhibit the metabolism of cisapride which can result in an increase in plasma cisapride levels and prolongation of the QT interval on the ECG. Other: Coadministration of grapefruit juice with cisapride increases the bioavailability of cisapride and concomitant use should be avoided. Cisapride should not be used concomitantly with other drugs known to prolong the QT interval: certain antiarrhythmics, including those of Class IA (such as quinidine and procainamide) and Class III (such as sotalol); tricyclic antidepressants (such as amitriptyline); certain tetracyclic antidepressants (such as maprotiline); certain antipsychotic medications (such as sertindole); astemizole, bepridil, sparfloxacin, and terodiline. The preceding lists of drugs are not comprehensive. The acceleration of gastric emptying by cisapride could affect the rate of absorption of other drugs. Patients receiving narrow therapeutic ratio drugs or other drugs that require careful titration should be followed closely; if plasma levels are being monitored, they should be reassessed. Chemical IUPAC Name: 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidyl]-2-methoxy-benzamide : |
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