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Ciprofloxacin HClThis page contains recent news articles, when available, and an overview of Ciprofloxacin HCl but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Ciprofloxacin HCl (when available) Ciprofloxacin, a broad-spectrum antiinfective agent of the fluoroquinolone class, is used to treat gram-negative infections, sexually transmitted diseases, mycobacterial infections, corneal ulcers, and bacterial conjunctivitis. For the treatment of Bacterial infection of Respiratory tract, UTI, Uncomplicated Cystitis in females, GI, Chronic Bacterial Prostatitis, CNS, Immuno compromised patients, Skin, Bone and Joint Infections, Uncomplicated cervical and urethral gonorrhea Mechanism Of Action: Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. Ciprofloxacin inhibits bacterial DNA gyrase, an enzyme responsible for counteracting excessive supercoiling of DNA during replication or transcription. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. News Articles on Ciprofloxacin Wait for the healing power - May 10, 2008 At present, it doesn’t have any formal arrangement for supply of any of its products, except for Ciprofloxacin Hcl, for which they have entered into formal. Financial Express, FTC Has Eye on $400 Million Settlement Agreement - Feb 1, 2008 Plaintiffs consisting of direct and indirect purchasers of Bayer’s antibiotic Cipro (ciprofloxacin HCl) have launched an appeal in the US Court of Appeals FDA news (subscription), Superior Drug Dissolution with ISP Super DisintegrantsDetailed in ... - Dec 21, 2006 PharmaLive.com (press release),...and Venlafaxine HCl), but also for actives with low water solubility (Ciprofloxacin HCl, Fexofenadine HCl, Terbinafine HCl, and Clopidogrel Bisulfate). Superior Drug Dissolution with ISP Super DisintegrantsDetailed in ... - Dec 21, 2006 PharmaLive.com (press release),...and Venlafaxine HCl), but also for actives with low water solubility (Ciprofloxacin HCl, Fexofenadine HCl, Terbinafine HCl, and Clopidogrel Bisulfate). It is a challenge to provide low-cost medicines to consumers Mar 3, 2006 A strip of 10 tablets of 500 mg each of Ciprofloxacin HCL, a widely used antibiotics costs about Rs 29 in India whereas it costs about Rs 2,353 to the consumer ... - Financial Express, Brand Names/Synonyms: Ciprofloxacin HCl is also known by the following brand names and/or synonymsBacquinor; Baycip; Bernoflox; CIPROFLOXACIN HCL; Ciflox; Cifloxin; Ciloxan; Ciprinol; Cipro; Cipro I.V.; Cipro Xl; Cipro Xr; Ciprobay; Ciprocinol; Ciprodar; Ciprofloxacin; Ciprofloxacin Base; Ciprofloxacin Dihydrochloride; Ciprofloxacin Hydrochloride; Ciprofloxacin Monohydrochloride; Ciprofloxacina; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Flociprin; Floxin; Floxin Otic; Floxin in Dextrose 5%; Ocuflox; Ofloxacin; Proquin Xr; Septicide; Velomonit Drug Category: Ciprofloxacin HCl is categorized under the following by the FDA: Anti-Infectives; Quinolones; ATC:J01MA02; ATC:S01AX13; ATC:S03AA07 Dosage Forms: LIQUID; OINTMENT; SOLUTION; SUSPENSION; TABLET; TABLET (COMBINED RELEASE); TABLET (EXTENDED-RELEASE) Absorption: 70-80% Interactions: -->Interactions for Ciprofloxacin: Caffeine Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of its serum half-life. Cyclosporine Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly. Glyburide The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia. Histamine H2-receptor antagonists Histamine H2-receptor antagonists appear to have no significant effect on the bioavailability of ciprofloxacin. Methotrexate Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate. This might increase the risk of methotrexate toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated. Multivalent Cation-Containing Products Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired. Proquin XR should be administered at least 4 hours before or 2 hours after these products. This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids. Non-steroidal anti-inflammatory drugs (but not aspirin) These drugs in combination with very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies. Omeprazole The rate and extent of absorption of ciprofloxacin was bioequivalent when Proquin XR was given alone or when Proquin XR was given 2 hours after omeprazole at the dose that maximally suppresses gastric acid secretion. Omeprazole should be taken as directed and Proquin XR should be taken with a main meal of the day, preferably the evening meal.. Phenytoin Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin. Probenecid Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum. Theophylline As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life. This may result in increased risk of theophylline-related adverse reactions. If concomitant use cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments made as appropriate. Warfarin Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be monitored. Chemical IUPAC Name: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylicacid : |
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