Ciprofloxacin

This page contains recent news articles, when available, and an overview of Ciprofloxacin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Ciprofloxacin
(when available)

Pharmacology and use:
Ciprofloxacin, a broad-spectrum antiinfective agent of the fluoroquinolone class, is used to treat gram-negative infections, sexually transmitted diseases, mycobacterial infections, corneal ulcers, and bacterial conjunctivitis. For the treatment of Bacterial infection of Respiratory tract, UTI, Uncomplicated Cystitis in females, GI, Chronic Bacterial Prostatitis, CNS, Immuno compromised patients, Skin, Bone and Joint Infections, Uncomplicated cervical and urethral gonorrhea

Mechanism Of Action:
Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. Ciprofloxacin inhibits bacterial DNA gyrase, an enzyme responsible for counteracting excessive supercoiling of DNA during replication or transcription. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials.

News Articles on Ciprofloxacin

Aradigm cystic fibrosis treatment wins 'orphan' status  -  ‎Aug 5, 2009‎
Ciprofloxacin is a widely prescribed antibiotic in oral and intravenous forms to treat acute lung infections in CF patients. Aradigm's formulation, besides Bizjournals.com

Mad rantings about politics, evolution, and microbiology  -  ‎Aug 26, 2009‎
But quinolone antibiotics such as ciprofloxacin ("Cipro"), which are used to treat many different diseases including urinary tract infections, are different ScienceBlogs

Typhoid Fever Cases In US Linked To Foreign Travel  -  ‎Aug 25, 2009‎
...resistant to ciprofloxacin from typhoid-endemic areas have generated concern that strains resistant to fluroquinolones may become more prevalent. Science Daily (press release)

Health Advice from the Frugal Traveler's Doctor  -  ‎Aug 26, 2009‎
...basics: sunblock, an analgesic, decongestant, tweezers and an antidiarrheal agent, plus a broad-spectrum antibiotic like ciprofloxacin or azithromycin. New York Times

An Unforgettable Salmonella Illness  -  ‎Aug 7, 2009‎
He was discharged several hours later with a prescription for Ciprofloxacin, an antibiotic. Ron's course over the next two months is one that defies clever Food Poison Journal

Drug makers face penalty for overcharging  -  ‎Aug 20, 2009‎
...such as salbutamal, prescribed for treatment of asthma and antibiotics such as cloxacillin and ciprofloxacin used to treat a wide variety of infections. Economic Times

4 drugstores ordered to comply with price cap  -  ‎Aug 26, 2009‎
...the anti-diabetic drug gliclazide; the antibiotic drugs piperacillin + tazobactam, ciprofloxacin, metronidazole and co-amoxiclave; and bleomycin, Inquirer.net

HobNobMurfreesboro Raises Awareness to Free Prescriptions at ...  -  ‎Aug 13, 2009‎
These medicines include the following: Amoxicillin, Cephalexin, Sulfamethoxazole/Trimethoprim (SMZ-TMP), Ciprofloxacin (excluding ciprofloxacin XR), PR-USA.net (press release)

Cheaper medicines act lists medicines at reduced prices  -  ‎Aug 28, 2009‎
Gliclazide for anti-diabetic/antihypoglycemic; Piperacillin plus Tazobactam and all its salt form; Metronidazole and all its salt form, Ciprofloxacin, Philippine Information Agency

Diversity and Complexity of Urinary Tract Infection in Diabetes ...  -  ‎Aug 20, 2009‎
Comparison of ciprofloxacin (7 days) and trimethoprim-sulfamethoxazole (14 days) for acute uncomplicated pyelonephritis in women: a randomized trial. Medscape

In Katine, a Coke is easy to buy. Medicine isn't  -  ‎Aug 19, 2009‎
..."Paracetamol, aspirin, diclofenac, ciprofloxacin are all here." But will they get to the health centres? Even when the money is found, there is another guardian.co.uk

Cheap medicines law registers 90% compliance  -  ‎Aug 19, 2009‎
...drug clopidogrel; the anti-diabetic drug gliclazide; and the antibiotic drugs piperacillin + tazobactam, ciprofloxacin, metronidazole and coamoxiclave. Inquirer.net

Consequences of the "Chileno Miracle": The Salmon Farms and the ...  -  ‎Aug 21, 2009‎
In the first city, between 1999 and 2003, the resistance to ciprofloxacin increased from 2.6% to 9% and in Castro, it surpassed 4.4% to 8.3%.10 The decision IRC's Americas Program

Another 'paracetamol victim' hospitalised  -  ‎Aug 24, 2009‎
Resectil 20 (omiprazol capsule), Citapen Cafil (paracetamol tablet), Ridocin (ciprofloxacin tablet), Doxipac (doxicilin capsule), Ridzol (metronidazol The Daily Star

Take drug price plaints to health centers  -  ‎Aug 16, 2009‎
...the antibiotics piperacillin and tazobactam, ciprofloxacin, metronidazole and co-amoxiclave; anticancer drugs such as bleomycin, carboplatin, cisplatin, Inquirer.net

Mucous Membrane Ulcers in an Immunocompromised Patient—Quiz Case  -  ‎Aug 17, 2009‎
Antibiotic therapy with ciprofloxacin and metronidazole was unable to improve the clinical lesions, which enlarged after a few days. Archives of Dermatology

BiomedReports: News and FDA Updates for XenoPort (Nasdaq:XNPT ...  -  ‎Aug 6, 2009‎
...to the Company's inhaled liposomal ciprofloxacin drug product candidate for the treatment of lung infections associated with cystic fibrosis ("CF"). Trading Markets (press release)

Drug-Dispensing Contact Lenses: Coming Soon to an Eye Near You?  -  ‎Aug 5, 2009‎
The new lenses now being developed have been proven effective at dispensing typical doses of the antibiotic ciprofloxacin into the eye for between 30 and Attorney at Law

www.PicksThatMove.com: "Picks that move" Alerts, August 10, 2009 ...  -  ‎Aug 10, 2009‎
Proquin(R) XR (ciprofloxacin hydrochloride) is approved in the United States for the once-daily treatment of uncomplicated urinary tract infections. TMCnet

MHRA recalls more than one hundred batches of drugs  -  ‎Aug 19, 2009‎
The medicines, manufactured by Karib Kemi Pharm Ltd, include batches of amoxicillin, atenolol, ciprofloxacin and ranitidine tablets that were shipped to the Nursing Times

Contact Lenses May Replace Eye Drops  -  ‎Aug 5, 2009‎
Kohane said that the contact lens his team has developed dispenses the appropriate amounts of ciprofloxacin for 30 days, and, in some tests, even as long as RedOrbit

Hospitals and pharmacies won't go bankrupt with cheaper meds law - CHO  -  ‎Aug 17, 2009‎
...the antibiotic piperacillin and tazobactam, ciprofloxacin, metronidazole and co-amoxiclave; anti-cancer drugs such as bleomycin, carboplatin, cisplatin, Philippine Information Agency

In vitro antimicrobial effects of aztreonam, colistin, and the 3 ...  -  ‎Aug 10, 2009‎
...imipenem, meropenem, aztreonam, ceftazidime, amikacin, tobramycin, arbekacin, ciprofloxacin and colistin) were determined using the agar dilution test. 7thSpace Interactive (press release)

Superbug battle goes on  -  ‎Aug 14, 2009‎
Three antibiotics - cefuroxime, cefalexin and ciprofloxacin - are no longer recommended for general use following an increase in C difficile cases, South Wales Argus

Depomed to Present at Canaccord Adams' 29th Annual Global Growth ...  -  ‎Aug 11, 2009‎
Proquin ® XR (ciprofloxacin hydrochloride) is approved in the United States for the once-daily treatment of uncomplicated urinary tract infections. PharmaLive.com (press release)

Werden die Mediziner entmündigt?  -  ‎Aug 20, 2009‎
Mit Folgen, deren gravierendste sich auf dem Sektor der Antibiotika mit dem Paradebeispiel Ciprofloxacin abzeichnet. Ciprofloxacin war vormals ein Wiener Zeitung

'ì?¸ë?„·파키스탄·방글ë?¼ë?°ì‹œ' 여행ìž? '장티푸스' 주ì?˜ë³´  -  ‎Aug 25, 2009‎
...는 날리딕스산(Nalidixic acid) ì?´ë?¼ëŠ” 구형 í•­ìƒ?ì œì—? 내성ì?„ 보였고 대부분ì?€ 시프로플ë¡?사신(Ciprofloxacin) ì?´ë?¼ëŠ” í•­ìƒ?ì œì—? ë°˜ì?‘ì?„ 하지 않았다ë?¼ê³  ë°?혔다. 메디컬투데이

베타ë?½íƒ? 저항균 위험요ì?¸ '세계공통'  -  ‎Aug 23, 2009‎
...아울러, 대부분 ESBL ìƒ?성 장내세균ì?€ 페니실린과 세팔로스í?¬ë¦°(cephalosporins) 외ì—? 다른 계열 í•­ìƒ?ì œì—?ë?„ 저항ì?„ 보였는ë?°, 특히 '시프로플ë¡?사신'(ciprofloxacin) 디지틀보사

*vwd/BUSINESS WIRE: Inhalatives liposomales Ciprofloxacin von ...  -  ‎Aug 6, 2009‎
...„Es freut uns sehr, dass die EMEA unserem liposomalen Ciprofloxacin zur Behandlung von zystischer Fibrose die Bezeichnung als Arzneimittel für seltene Vereinigte Wirtschaftsdienste

Mga 'di magbababa sa presyo ng gamot dapat daw parusahan  -  ‎Aug 21, 2009‎
...ang anti-diabetic drug na gliclazide; at antibiotic drugs na piperacillin + tazobactam, ciprofloxacin, metronidazole at coamoxiclave. GMA news.tv

РиÑ?кови фактори за инфекциÑ? Ñ? бета-лактам резиÑ?тентни организми 20 ...  -  ‎Aug 24, 2009‎
Ð?вторите докладват за изолати от повечето региони Ñ? голÑ?ма чеÑ?тота на резиÑ?тентноÑ?Ñ‚ към ciprofloxacin (>70%), което Ñ?очи, че резиÑ?тентноÑ?тта към DoctorBG.com

Infektionsrisiko: Wie bedrohlich ist Lungenpest?  -  ‎Aug 4, 2009‎
Wer einem Lungenpest-Erkrankten näher als 2 Meter kommt, sollte für sieben Tage eine Antibiotika-Prophylaxe mit Ciprofloxacin oder Doxycyclin erhalten. FOCUS Online

è?¯ç‰©æœ?用与è?¯é£Ÿå¹¶ç”¨ç¦?忌  -  ‎Aug 12, 2009‎
...陈美玉è?¯å¸ˆæŒ‡å‡ºï¼Œå’–啡具有利尿的效果,对于部分抗生素(如:ciprofloxacin)ã€?胃肠è?¯ï¼ˆå¦‚:cimetidine)ã€?å?£æœ?é?¿å­•è?¯ï¼Œå?¯èƒ½ä¼šä½¿å’–啡因代谢å‡?缓而在体内浓度增高,导致 大纪元

护士内科护ç?†å­¦è¾…导:éœ?  -  ‎Aug 19, 2009‎
...诺佛沙星(norfloxacin)æˆ?人æ¯?次200mg,æ¯?æ—¥3次或环丙沙星(ciprofloxacin)æˆ?人æ¯?次250~500mg,æ¯?æ—¥2次å?£æœ?。以上è?¯ç‰©ä»»é€‰ä¸€ç§?,连æœ?3日。ä¸?能å?£æœ?者å?¯åº”用氨苄西林 青年人

[중국리í?¬íЏ] 주요 ì›?료ì?˜ì•½í’ˆ 수출입 현황-2  -  ‎Aug 9, 2009‎
Macrolide와 Cephemsì?„ 제외한 모든 í•­ê°?염제 수출ì?€ ê°?소했으며 Ciprofloxacinì?€ ìƒ?ì‚° 한계로 ì?¸í•´ 약 50% ì •ë?„ 떨어졌고 í?‰ê·  가격ì?€ 약 24.7% ìƒ?승했다. 디지틀보사

Penyakit Perjalanan dan Pencegahannya  -  ‎Aug 5, 2009‎
Obat antibiotika golongan ciprofloxacin dan sejenisnya, serta co-trimoxazole dan obat antidiare sering dibekalkan dokter kepada mereka yang hendak melakukan Suara Merdeka CyberNews

ë°”ì?´ì—˜, 2Q실ì ? 제약부문 9%ì?´ìƒ? ê³ ë?„ 성장  -  ‎Aug 3, 2009‎
...발기부전 치료제 레비트ë?¼(vardenafil)는 7.1% ì¦?가한 90M 유로, í•­ìƒ?ì œ Cipro/Ciprobay(ciprofloxacin)ì?€ 16.9% ì¦?가한 90M 유로로 ê°?ê°? ë°?혀졌다. 메디포뉴스

Første omfattende risikovurdering av avløpsslam i Norge  -  ‎Aug 21, 2009‎
Et unntak kan være mulig utvikling av resistens til fluorokinolonene ciprofloxacin i jord på grunn av langtidspersistens og begrenset mobilitet av disse VKM (Vitenskapskomiteen for mattrygghet)

Brand Names/Synonyms:
Ciprofloxacin is also known by the following brand names and/or synonymsBacquinor; Baycip; Bernoflox; CIPROFLOXACIN HCL; Ciflox; Cifloxin; Ciloxan; Ciprinol; Cipro; Cipro I.V.; Cipro Xl; Cipro Xr; Ciprobay; Ciprocinol; Ciprodar; Ciprofloxacin; Ciprofloxacin Base; Ciprofloxacin Dihydrochloride; Ciprofloxacin Hydrochloride; Ciprofloxacin Monohydrochloride; Ciprofloxacina; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Flociprin; Floxin; Floxin Otic; Floxin in Dextrose 5%; Ocuflox; Ofloxacin; Proquin Xr; Septicide; Velomonit

Drug Category:
Ciprofloxacin is categorized under the following by the FDA: Anti-Infectives; Quinolones; ATC:J01MA02; ATC:S01AX13; ATC:S03AA07

Dosage Forms:
LIQUID; OINTMENT; SOLUTION; SUSPENSION; TABLET; TABLET (COMBINED RELEASE); TABLET (EXTENDED-RELEASE)

Absorption:
70-80%

Interactions:
-->Interactions for Ciprofloxacin:

Caffeine

Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of its serum half-life.

Cyclosporine

Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Glyburide

The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.

Histamine H2-receptor antagonists

Histamine H2-receptor antagonists appear to have no significant effect on the bioavailability of ciprofloxacin.

Methotrexate

Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate. This might increase the risk of methotrexate toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.

Multivalent Cation-Containing Products

Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired. Proquin XR should be administered at least 4 hours before or 2 hours after these products. This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.

Non-steroidal anti-inflammatory drugs (but not aspirin)

These drugs in combination with very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies.

Omeprazole

The rate and extent of absorption of ciprofloxacin was bioequivalent when Proquin XR was given alone or when Proquin XR was given 2 hours after omeprazole at the dose that maximally suppresses gastric acid secretion. Omeprazole should be taken as directed and Proquin XR should be taken with a main meal of the day, preferably the evening meal..

Phenytoin

Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.

Probenecid

Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.

Theophylline

As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life. This may result in increased risk of theophylline-related adverse reactions. If concomitant use cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments made as appropriate.

Warfarin

Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be monitored.





Chemical IUPAC Name:
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylicacid

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