Cipro

This page contains recent news articles, when available, and an overview of Cipro but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Cipro (when available)

Pharmacology and use:
Ciprofloxacin, a broad-spectrum antiinfective agent of the fluoroquinolone class, is used to treat gram-negative infections, sexually transmitted diseases, mycobacterial infections, corneal ulcers, and bacterial conjunctivitis. For the treatment of Bacterial infection of Respiratory tract, UTI, Uncomplicated Cystitis in females, GI, Chronic Bacterial Prostatitis, CNS, Immuno compromised patients, Skin, Bone and Joint Infections, Uncomplicated cervical and urethral gonorrhea

Mechanism Of Action:
Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive organisms. Ciprofloxacin inhibits bacterial DNA gyrase, an enzyme responsible for counteracting excessive supercoiling of DNA during replication or transcription. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials.

News Articles on Ciprofloxacin

Antibiotics Can Disrupt Digestive Tract  -  21 Nov 2008
This time, a newly released study is indicating that not only does the antibiotic commonly known as Cipro upset the bacterial balance in the digestive Newsinferno.com,

Motlanthe enters COPE fray  -  21 Nov 2008
..."Although COPE has registered as a company with (the companies' register) Cipro, the ANC has a year in which they can still object to it. Independent Online,

RELIGIONE. Pace. De Clermont a Cipro per l'incontro di Sant'Egidio  -  21 Nov 2008
...uno dei 21 dibattiti proposti a Cipro - ha notato come l'Europa si stia ponendo "sulla difensiva verso le migrazioni invece di farne uno strumento di ICN News,

I Sondaggi di Goal.com: Vi piace la nuova Italia di Marcello Lippi?  -  21 Nov 2008
Questa Nazionale però non convince tutti le stentate vittorie con Cipro e Montenegro condite dallo scialbo pareggio in Bulgaria hanno fatto storcere il naso Goal.com,

In distribuzione i cataloghi Atitur  -  21 Nov 2008
Si tratta di Marocco, Portogallo, Kenya e Zanzibar e Mauritius, Seychelles & Dubai, oltre a Cipro che però è solo on line. Per quanto riguarda il Marocco, GuidaViaggi,

This is your stomach on drugs: Study shows antibiotics disrupt gut ...  -  Nov 18, 2008
While all antibiotics will knock out a range of bacteria, cipro is believed to be among the least disruptive of the drugs. In fact, thousands of US postal The Canadian Press,

Clerk helps Stanley Police make prescription drug arrest  -  Nov 19, 2008
7 and handed in two prescriptions, one for Cipro, an antibacterial, and another for Percocet, a controlled substance, according to warrants. Gaston Gazette,

Antibiotics May Kill Off Healthy Bacteria in the Gut  -  Nov 17, 2008
But several types are wiped out by a course of Cipro, or they survive only in much smaller numbers, reports Stanford University’s Les Dethlefsen, PhD, Health.com,

Celebrity traveler: Bill Kurtis  -  Nov 16, 2008
And Cipro [the antibiotic]. I was in Mombasa [Kenya] and flew to Kigali after the massacre in Rwanda, and we stopped in Uganda, and there were some US Chicago Tribune,

New Antibiotic Beats Traveler's Diarrhea  -  Oct 29, 2008
Mary MacGregor, DO, of The Travel Medicine Source in Morton Grove, Ill., says the antibiotic Cipro is often used to treat travelers' diarrhea. WebMD

Fines proposed over MPs’ undeclared interests  -  Nov 17, 2008
...auditor-general Terence Nombembe compared the declarations with the companies records in the Companies and Intellectual Property Rights (Cipro) database Business Day,

Turkey dinner: Not as healthy as you think  -  Nov 17, 2008
The antibiotic, Cipro, is a good example. In spite of this drug-feeding regimen, supermarket poultry is loaded with bacteria. While proper cooking and Examiner.com

Seven ANC MPs fined for breach of ethics  -  Nov 17, 2008
Cape Town – Seven MPs have been fined sums varying from R500 to R3500 for breaching the members‘ code of ethics by not disclosing their interests in various The Herald Eastern Cape,

Paying Off Your Generic Drug Competition? No Problem.  -  Oct 31, 2008
Specifically, it covers ciprofloxacin hydrochloride, the active ingredient in Cipro®. The patent expired on December 9, 2003 but the FDA granted Bayer an Patent Baristas,

Connecting the dots: Reasons why fluoroquinolones such as Levaquin ...  -  Nov 14, 2008
The medications involved in this action are: Cipro and generic ciprofloxacin, Cipro XR and Proquin XR (ciprofloxacin extended release), InjuryBoard.com,

Nektar Therapeutics Q3 2008 Earnings Call Transcript  -  Nov 20, 2008
Additionally, we retained our rights to royalties on sales of inherited Cipro, which is also partnered with Bayer. These anti-infective programs represent Seeking Alpha,

US Court Of Appeals Upholds Validity Of "Reverse Payment" Patent ...  -  Oct 30, 2008
After the settlement with Barr, Bayer had the Cipro patent successfully reexamined by the PTO, and then litigated the validity of the patent against three Mondaq News Alerts (registration),

A look at big drug mistakes you can avoid  -  Nov 5, 2008
Dairy products: Avoid if you're taking antibiotics (such as Cipro, Levaquin and tetracycline). Why: Dairy foods can interfere with their absorption, Press & Sun-Bulletin,

Gut Check Reveals Vast Multicultural Community of Bugs in Bowels ...  -  Nov 17, 2008
...at various intervals over an eight-month time course that included a five-day oral regimen of the broad-spectrum antibiotic ciprofloxacin, or Cipro. MarketWatch

Don't dose friendly bacteria with antibiotics  -  Nov 19, 2008
Yet none of the subjects reported any gut-related problems -- probably because other types of bacteria unfazed by Cipro took up the digestive slack. Scripps News,

FDA cracks down on labeling, initiates trial result reporting  -  Nov 14, 2008
The drug family includes Leverkusen, Germany–based Bayer's Cipro (ciprofloxacin), Cipro XR and Avelox (moxifloxacin HCL); Raritan, New Jersey–based Nature.com (subscription),

COPE court battle looms  -  Nov 17, 2008
COPE has registered its name with the companies' register, Cipro, and has applied to the Independent Electoral Commission for formal registration as a Independent Online,

Shikota group comes up with a name  -  Nov 5, 2008
According to movement insiders, the name will not be published until after it has been registered at Cipro, the IEC and as an Internet domain name. Legalbrief (subscription),

Daiichi completes Ranbaxy buy, seeks "to realize sustainable growth"  -  Nov 8, 2008
...antibiotic Cipro and the cholesterol pill Zocor - over concerns about alleged "deficiencies in manufacturing processes" at two of its Indian plants. IBTimes India,

11 items that should be in every tourist's first-aid kit  -  Nov 5, 2008
...antibiotic is the most effective diarrhea cure—especially in places like India and Thailand where bacteria are becoming more resistant to Cipro. MSNBC

Birth of the Bailout State  -  Oct 25, 2008
...than it was back in the good old days when all you had to say was 'Cipro' and 'duct tape' and the electorate would reach for its GOP security blanket. OpEdNews,

Depth shown in Lions top performers  -  Nov 7, 2008
...who was Penn State's front runner last year, can be back and help the Lions in the future along with Sam Borchers, Chris Cipro, Owen Dawson. The Daily Collegian Online,

Plain, spicy or sweet, try your hand at making some Vietnamese cuisine  -  Oct 26, 2008
Perhaps it was a false sense of complacency, because I traveled with Cipro, an antibiotic that can cure diarrhea quickly. And since I felt like a humongous Detroit Free Press,

Don Wilson, CEO of Endacea, To Lead Regional Innovation Economic ...  -  Oct 29, 2008
...the bacteria responsible for pneumonic plague, provides statistically significant improvement in survival and lung pathology versus cipro alone. dBusinessNews Dallas (press release),

Mourinho Eyes Anorthosis Win And Qualification  -  Nov 4, 2008
I can easily see us winning in Cipro,keep the top of the table in CL and concentrate our strenghts on the Serie A race 19:03 03 Nov 08 Dzole Skopje Goal.com,

Is your medication really safe?  -  Nov 3, 2008
Examples include: Remicade, used to treat rheumatoid arthritis and the digestive disease called Crohn's; the antibiotics Cipro and Levaquin; News Sentinel,

ICAAC-IDSA: Investigational Antibiotic Slows Traveler's Diarrhea  -  Oct 28, 2008
Referring to ciprofloxacin (Cipro), she said "we [already] have a fairly effective drug for traveler's diarrhea." Dr. MacGregor said that many clinicians MedPage Today,

Bayer earnings slip but firm says future looks bright  -  Oct 29, 2008
The antibiotic Cipro/Ciprobay (ciprofloxacin) fell 12.5% to 84 million euros as a result of generic competition. Future growth at healthcare is expected to Pharma Times (registration),

New SA party hits name snag  -  Nov 3, 2008
Former defence minister Mosiuoa Lekota told the Cape Argus today that the new party would first be registered with the companies register, Cipro, The Zimbabwean,

Ranbaxy reports $96m quarterly loss  -  Oct 31, 2008
In September, the FDA banned the import of more than 30 of Ranbaxy's generic drugs, including generic versions of the popular antibiotic Cipro and the Times of India,

CIPRO: ATTERRAGGIO EMERGENZA PER AEREO MINISTRO DANESE, NESSUN FERITO  -  Nov 20, 2008
...(ASCA-AFP) - Nicosia, 20 nov - Un aereo militare danese, con a bordo il ministro degli Esteri, Per Stig Moller, e' stato costretto ad effettuare un ASCA - Agenzia Stampa Quotidiana Nazionale,

Avandia Recall Urged by Consumer Group  -  Oct 31, 2008
In previous petitions, Public Citizen asked the FDA to add a black box warning about the risk of tendon ruptures with Levaquin, Cipro and other AboutLawsuits.com

ECUMENISMO: DA INCONTRO SANT'EGIDIO A CIPRO APPELLO PER GIUSTIZIA ...  -  Nov 18, 2008
Religioni e culture in dialogo'', organizzato dalla Comunita' di sant'Egidio e che si e' svolto quest'anno sull'isola di Cipro. ASCA - Agenzia Stampa Quotidiana Nazionale,

Search this blog  -  Oct 29, 2008
C. diff is resistant to many commonly used antibiotics, so when, for example, I give you cipro for your severe urinary tract infection, many colonic E. coli ScienceBlogs

Cipro, la processione contro l’ultimo muro  -  Nov 16, 2008
L’ultimo muro che in Europa divide ancora una città, Nicosia, capitale di Cipro, è stato oggi simbolicamente abbattuto da 40 leader religiosi che, Il Secolo XIX,

Russia-Ue/ Cipro: sì a proposta Mosca trattato sicurezza europeo  -  Nov 19, 2008
...(Apcom-Nuova Europa) - Cipro è il primo paese dell'Unione europea (Ue) che ha ufficialmente sottoscritto il sostegno all'iniziativa del presidente russo, Virgilio Notizie,

Obama per Cipro  -  Nov 17, 2008
Il neoeletto presidente americano Barack Obama ha espresso più di un parere sull’annosa questione di Cipro. Ancora prima che venisse eletto aveva dichiarato Portalino,

Azienda Agricola D’Alessandro: International Mediterranean Food ...  -  Nov 19, 2008
...nati con l’obiettivo di esprimere la tradizione el’innovazione che questa terra racchiude, non potevano mancare proprio a Cipro, per dimensioni terza Wine Community,

Campagna di comunicazione per un uso corretto degli antibiotici  -  Nov 18, 2008
L’Italia, nell’ambito dell’UE, nel 2007 è stato uno dei paesi con il consumo più elevato di farmaci antibiotici, preceduto solo da Francia, Grecia e Cipro. MELITO online,

Cipro, le religioni parlano di Giovanni Paolo II  -  Nov 17, 2008
Il Meeting delle religioni, organizzato dalla Comunità di Sant’Egidio a Cipro, ha dedicato una sessione speciale a papa Giovanni Paolo II. korazym.org,

Cipro/ Presidente greco-cipriota: Lavoriamo a uno stato federale  -  Nov 16, 2008
...(Apcom) - La soluzione per Cipro allo studio di greco-ciprioti e turco-ciprioti è l'evoluzione dell'isola, divisa dal 1974, "in uno stato federale con una Virgilio Notizie,

Sant'Egidio/ Dziwisz candida Cracovia per Summit Religioni 2009  -  Nov 17, 2008
..."L'anno prossimo venite a Cracovia, la città che tanto Giovanni Paolo II ha amato", ha esortato nel suo intervento a Cipro l'Arcivescovo polacco, Virgilio Notizie,

Cipro vince la corsa dentro l’Arsenale  -  Nov 9, 2008
Il primo ad alzare le braccia al cielo è stato Sergio Cipro, atleta dell’Arci Favaro che ha chiuso i circa 9 km di corsa con un ottimo 33’ e 44�?; Il Secolo XIX,

¡Buen viaje!  -  Nov 20, 2008
...prendre à tous les jours pendant le voyage pour ne pas être infectée par le paludisme, ainsi que trois pilules de Cipro XL en cas de diarrhée grave. Trait d'Union,

Champions: Cruz salva l`Inter a Cipro  -  Nov 4, 2008
...(AGM-DS) - 04/11/2008 22.46.34 - (AGM-DS) - Milano, 4 novembre - Sofferto pareggio dei nerazzurri a Cipro contro l’Anorthosis, qualificazione agli ottavi DataSport.it,

Brand Names/Synonyms:
Cipro is also known by the following brand names and/or synonymsBacquinor; Baycip; Bernoflox; CIPROFLOXACIN HCL; Ciflox; Cifloxin; Ciloxan; Ciprinol; Cipro; Cipro I.V.; Cipro Xl; Cipro Xr; Ciprobay; Ciprocinol; Ciprodar; Ciprofloxacin; Ciprofloxacin Base; Ciprofloxacin Dihydrochloride; Ciprofloxacin Hydrochloride; Ciprofloxacin Monohydrochloride; Ciprofloxacina; Cipromycin; Ciproquinol; Ciproxan; Ciproxin; Flociprin; Floxin; Floxin Otic; Floxin in Dextrose 5%; Ocuflox; Ofloxacin; Proquin Xr; Septicide; Velomonit

Drug Category:
Cipro is categorized under the following by the FDA: Anti-Infectives; Quinolones; ATC:J01MA02; ATC:S01AX13; ATC:S03AA07

Dosage Forms:
LIQUID; OINTMENT; SOLUTION; SUSPENSION; TABLET; TABLET (COMBINED RELEASE); TABLET (EXTENDED-RELEASE)

Absorption:
70-80%

Interactions:
-->Interactions for Ciprofloxacin:

Caffeine

Some quinolones, including ciprofloxacin, have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of its serum half-life.

Cyclosporine

Some quinolones, including ciprofloxacin, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.

Glyburide

The concomitant administration of ciprofloxacin with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.

Histamine H2-receptor antagonists

Histamine H₂-receptor antagonists appear to have no significant effect on the bioavailability of ciprofloxacin.

Methotrexate

Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate. This might increase the risk of methotrexate toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.

Multivalent Cation-Containing Products

Concurrent administration of a quinolone, including ciprofloxacin, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of ciprofloxacin, resulting in serum and urine levels considerably lower than desired. Proquin XR should be administered at least 4 hours before or 2 hours after these products. This time window is different than for other oral formulations of ciprofloxacin, which are usually administered 2 hours before or 6 hours after antacids.

Non-steroidal anti-inflammatory drugs (but not aspirin)

These drugs in combination with very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies.

Omeprazole

The rate and extent of absorption of ciprofloxacin was bioequivalent when Proquin XR was given alone or when Proquin XR was given 2 hours after omeprazole at the dose that maximally suppresses gastric acid secretion. Omeprazole should be taken as directed and Proquin XR should be taken with a main meal of the day, preferably the evening meal..

Phenytoin

Altered serum levels of phenytoin (increased and decreased) have been reported in patients receiving concomitant ciprofloxacin.

Probenecid

Probenecid interferes with renal tubular secretion of ciprofloxacin and produces an increase in the level of ciprofloxacin in serum.

Theophylline

As with some other quinolones, concurrent administration of ciprofloxacin with theophylline may lead to elevated serum concentrations of theophylline and prolongation of its elimination half-life. This may result in increased risk of theophylline-related adverse reactions. If concomitant use cannot be avoided, serum levels of theophylline should be monitored and dosage adjustments made as appropriate.

Warfarin

Quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be monitored.

Chemical IUPAC Name:
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carboxylicacid

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