Cimetidine

This page contains recent news articles, when available, and an overview of Cimetidine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Cimetidine
(when available)

Pharmacology and use:
Cimetidine is a histamine H2-receptor antagonist. It reduces basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin. It is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Cimetidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Cimetidine include an increase in gastric bacterial flora such as nitrate-reducing organisms. For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion

Mechanism Of Action:
Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

News Articles on Cimetidine

Medications to avoid when trying to get pregnant  -  ‎Aug 12, 2009‎
For men, the list of potential culprits includes the heartburn medication cimetidine (Tagamet), the rheumatoid arthritis drug (Azulfidine), Examiner.com

The Use of OTC Medications in Older Adults  -  ‎Aug 25, 2009‎
The Beers Criteria focus on prescription medications, with only a few OTC medications being addressed (diphenhydramine, mineral oil, cimetidine). Medscape

Hair Removal  -  ‎Aug 15, 2009‎
...imbalances such as the high testosterone levels seen in polycystic ovarian syndrome (PCOS), drugs like Spironolactone and Cimetidine are prescribed. Vanguard

è?¯ç‰©æœ?用与è?¯é£Ÿå¹¶ç”¨ç¦?忌  -  ‎Aug 12, 2009‎
...陈美玉è?¯å¸ˆæŒ‡å‡ºï¼Œå’–啡具有利尿的效果,对于部分抗生素(如:ciprofloxacin)ã€?胃肠è?¯ï¼ˆå¦‚:cimetidine)ã€?å?£æœ?é?¿å­•è?¯ï¼Œå?¯èƒ½ä¼šä½¿å’–啡因代谢å‡?缓而在体内浓度增高,导致 大纪元

Buy VIAGRA Stimulus Pills With No Prescription Online Viagra Major ...  -  13 Jul 2009
Some of the drugs that can potentially interact with Viagra include cimetidine, ritonavir, and alpha blockers. To reduce your risk of drug interactions with Cleveland Indy Media

Fact and Myths about Generic Drugs  -  ‎Jul 8, 2009‎
...and continued treatment with prescription strength antacids (cimetidine tablets; http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=8131#nlm34067-9). HealthNewsDigest.com

Structure-activity relationship analysis of cytotoxic ...  -  ‎Jun 29, 2009‎
Pinacidil and cimetidine were found to be non-toxic in all ten cell lines. Starting with cyanoguanidine as the crucial core it was shown that 4-pyridyl 7thSpace Interactive (press release)

Viagra - Buy Viagra online Here‎  -  ‎Jul 4, 2009‎
Some of the drugs that can potentially interact with Viagra include cimetidine, ritonavir, and alpha blockers. To reduce your risk of drug interactions with Toute la Poésie

40% men suffering from ED newlywed  -  ‎Jul 5, 2009‎
Many common medicines including blood pressure drugs, antihistamines, antidepressants, tranquilizers, appetite suppressants and cimetidine (an ulcer drug) Times of India

Spurious drugs worth Rs 76 lakh imported from China seized at ...  -  ‎Jun 17, 2009‎
The third interception was consignment containing cimetidine imported by a Mumbai based company, Sheetal Pharma. It was sent by Zhejiang Chemicals Import pharmabiz.com

Vitamin D has many benefits  -  ‎Jun 20, 2009‎
...thiazide diuretics, corticosteroids, nicotine, cimetidine, cholesterol-lowering agents (ezetimibe), heparin, and diet agents (Xenical and Alli). fwdailynews.com

Viagra rivals add hours of hope for men - $1.15 per PILL  -  ‎Jun 30, 2009‎
These drugs would include bosentan, blood thinners, cimetidine, certain antibiotics, doxazosin, prazosin, Terazosin, HIV medicines such as amprenavir Toute la Poésie

FAQ on erectile dysfunction  -  ‎Jun 24, 2009‎
...include drugs taken for high blood pressure, antidepressants, antihistamines, tranquillisers, appetite suppressants, and the ulcer drug cimetidine. Health24.com

ANTI - ANXIETY DRUGS ONLINE WITHOUT PRESCRIPTION  -  ‎Jul 4, 2009‎
Valium Dull Interactions : Admit your doctor of all formula and nonprescription drugs you may say, first of all of: cimetidine, digoxin, disulfiram, Toute la Poésie

PRESS RELEASE: Novartis: Afinitor® And -2-  -  ‎Jun 24, 2009‎
The use of Sandostatin LAR may increase the bioavailability of bromocriptine, impair intestinal absorption of cyclosporin and delay that of cimetidine. Capital.gr (press release)

Extract of wild mango seed shows promise in obesity treatment  -  ‎Apr 8, 2009‎
...po) exhibited dose-dependent inhibition of indomethacin-induced gastric ulceration that seems to be stronger than cimetidine (50 mg/kg). The Guardian - Nigeria

FDA Safety Changes: Combivent, Qualaquin, Sucraid  -  ‎Mar 4, 2009‎
Cimetidine and ranitidine are H 2 -blockers and nonspecific CYP450 inhibitors that inhibit quinine clearance to different degrees. Medscape

Guideline to treat post-burn itching is provided  -  ‎Feb 28, 2009‎
The treatments which these specialists ranked as “good� were cimetidine, a prescription antihistamine pill; colloidal oatmeal bath as a topical treatment; HealthJockey.com

This awful burning sensation  -  ‎Mar 4, 2009‎
Histamine-2 receptor antagonists like ranitidine (Zantac, Apo-Ranitidine), cimetidine, and famotidine (Pepcid) relieve the symptoms of GORD by reducing the Jamaica Gleaner

FDA Safety Changes: Boniva, Emend, Clozaril  -  ‎Feb 26, 2009‎
Drugs in this category include citalopram, cimetidine, caffeine, ciprofloxacin, and erythromycin. Clozapine is an atypical antipsychotic agent indicated for Medscape

The MT Interview: Luke Johnson  -  ‎Feb 27, 2009‎
I've always been a fantastic admirer of a man called Sir James Black, who worked for Glaxo and was responsible for creating beta blockers and cimetidine. Management Today

Buy diclofenac  -  Jan 17, 2009
Sundays episode buy diclofenac associated buy diclofenac hiv. Malaria of bizrate complete taking mexico green. Priapism buy diclofenac and buy diclofenac Griggs County Courier,

A distinguished sceptic about Big Pharma  -  Feb 2, 2009
There is a fascinating interview in the FT today with Sir James Black, the scientist who helped to discover beta blockers and cimetidine, a stomach ulcer Financial Times,

FDA to Study Safety of Clopidogrel  -  Jan 26, 2009
Traditional antacids and H2 blockers such as cimetidine (Tagamet) and ranitidine (Zantac) do not appear to interfere with clopidogrel's anti-platelet MedPage Today,

What treatments work for warts?  -  Jan 21, 2009
...[11] Cimetidine (brand name Tagamet) is a drug that's usually used for people with stomach ulcers. The theory behind this treatment is that it helps your guardian.co.uk,

What's the evidence for antacids?  -  Jan 21, 2009
Low-dose antacids versus 400 mg cimetidine twice daily for reflux oesophagitis: a comparative, placebo-controlled, multicentre study. guardian.co.uk,

What treatments work for GORD?  -  Jan 21, 2009
Some common names (and brand names) are ranitidine (Zantac), nizatidine (Axid), famotidine (Pepcid) and cimetidine (Tagamet). guardian.co.uk,

How common is vitamin B-12 deficiency?  -  Jan 16, 2009
High doses of H 2 -receptor antagonists (eg, >1000 µg/d cimetidine) or proton pump inhibitors (eg, 20–40 mg/d omeprazole) inhibit food cobalamin absorption Am J Clin Nutr (subscription),

أريد علاجا للحموضة المستمرة التي أعاني منها  -  Jan 26, 2009
ولعلاجها يجب تجنب الأسباب التي ذكرتها، وهناك بعض الأدوية التي تعالج الحموضة مثل: ( Famotidine, Rantidine, Cimetidine)ØŒ وهذه تؤخذ مرتين Ù?ÙŠ اليوم، ويستمر الشبكة الإسلامية,

Cimetidine inhibits salivary gland tumor cell adhesion to neural ...  -  Dec 18, 2008
Cimetidine, a histamine type-2 receptor antagonist, has been reported to inhibit the growth of glandular tumors such as colorectal cancer, 7thSpace Interactive (press release),

Use yohimbe under doctor's care  -  Dec 1, 2008
There is also the option of taking over-the-counter cimetidine (Tagamet HB). Although studies of cimetidine have had mixed results, some readers report that Jackson Clarion Ledger,

Management of HIV/AIDS in older adults  -  Dec 15, 2008
Drugs discussed: abacavir, alendronate, atazanavir, atorvastatin, cetirizine, cimetidine, darunavir, didanosine, efavirenz, ezetimibe, fluconazole, Drug Topics Magazine,

Winners Announced at Medical Futures Innovation Awards 2008  -  Dec 8, 2008
His work on cimetidine, an H2 receptor antagonist, has transformed the treatment of stomach ulcers and other gastrointestinal conditions dramatically Pressemeldungen.at (Pressemitteilung),

Gradeons: Prescribing placebos  -  Nov 30, 2008
There is also the option of taking over-the-counter cimetidine (Tagamet HB). Although studies of cimetidine have had mixed results, some readers report that Houston Chronicle,

Analysis Suggests That Improvements In Kidney Function In Patients ...  -  Nov 19, 2008
...spironolactone and cimetidine); interactions with other medicines: inhibitors of cytochrome P450 3A4, other HMG-CoA reductase inhibitors, antacid, Medical News Today (press release),

Treat mouth tenderly to reduce canker sores  -  Nov 10, 2008
The heartburn drug cimetidine (Tagamet) also may help relieve symptoms. For larger, more painful canker sores, there are several prescription medicines that The Star-Ledger - NJ.com,

An Effective Method To Study The Pressure Of The Sphincter Of Oddi  -  Oct 26, 2008
They found that SOBP and SOCA were significantly decreased after Cimetidine administration, and no statistical difference was seen in the Famotidine group. Medical News Today (press release),

Data continue to show differences in gastrointestinal and lipid ...  -  Oct 27, 2008
Prevacid® (lansoprazole), Prilosec® (omeprazole), Protonix® (pantoprazole), Axid® (nizatidine), Pepcid AC® (famotidine), Tagamet® (cimetidine), PipelineReview.com (press release),

Don't Ignore Melanomas  -  Oct 1, 2008
Other therapies used to treat melanomas include cimetidine, cisplatin, frankincense oil, and melanoma vaccines. Cimetidine Opinions are divided on TheHorse.com,

Health Corner  -  Oct 13, 2008
These include: * diuretics ('water tablets'), nifedipine, cimetidine, salbutamol, terbutaline, lithium, clofibrate, penicillamine, morphine (withdrawal), Mmegi Online,

US Food & Drug Administration Approved the use of REYATAZ(R ...  -  Oct 1, 2008
Prevacid ® (lansoprazole), Prilosec ® (omeprazole), Protonix ® (pantoprazole), Axid ® (nizatidine), Pepcid AC ® (famotidine), Tagamet ® (cimetidine), WELT ONLINE,

Hoe kom ik af van die nachtelijke spierkrampen?  -  Oct 1, 2008
...'Is er bij jou geen ziekte in het spel en slik je geen medicijnen die spierkrampen kunnen veroorzaken (zoals cimetidine tegen maagzuur en maagzweren, Het Laatste Nieuws,

FAQ on erectile dysfunction  -  15 Sep 2008
...include drugs taken for high blood pressure, anti-depressants, anti-histamines, tranquillisers, appetite suppressants, and the ulcer drug cimetidine. Health24.com,

Do some foods stop drugs working?  -  Sep 12, 2008
For example, cimetidine (Tagamet and Zantac) helps to treat stomach ulcers and heartburn by lowering the acidity in our stomachs. This can have the knock-on Times Online,

What actually causes man breasts?  -  Aug 22, 2008
Generally, these include certain antipsychotics, spironolactone, finasteride, cimetidine, imatinib mesylate, and omeprazole. Some of these operate directly 3x24 - Your Newspaper and News Magazine,

Listerosis scare in Santiago's top private clinics and hospitals  -  Aug 21, 2008
...the elderly; normal people--some reports suggest that normal, healthy people are at risk, although antacids or cimetidine may predispose. MercoPress,

Cure Gynecomastia By Pills, Supplements or Even Operation  -  Aug 21, 2008
Medicines like omeprazole, finasteride, cimetidine can also cause gynecomastia. Some of the medicines directly harm the chest tissue while others enhance 3x24 - Your Newspaper and News Magazine,

Symptoms, causes and treatment of Gynecomastia  -  Aug 20, 2008
Some of the medicines that may cause this disease are antipsychotics, imatinib mesylate, omeprazole, cimetidine, finasteride and others. 3x24 - Your Newspaper and News Magazine,

Xìu Tại Thuốc  -  Aug 29, 2008
Cimetidine (Tagamet) trị bệnh bao tử. Có thể gây rối loạn cương hoặc làm cho vú nở to ra. - Nhóm thuốc � phiện (Opioids) chống đau nhức có thể làm giảm Take2Tango

Going-Concern Statement  -  07 Aug 2008
Pepcid AC(R) (famotidine), Tagamet(R) (cimetidine), or Zantac(R) (ranitidine), Advair(R) (fluticasone propionate and salmeterol inhalation powder), FOXBusiness

How cocaine abuse during pregnancy damages foetal brains  -  Aug 6, 2008
To confirm the role of cocaine N-oxidative metabolism, we administered the p450 inhibitor cimetidine, both in vitro and in vivo, to see if it would prevent Scientist Live,

Ä?à Nẵng: Giá tân dược tiếp tục leo thang  -  Jul 27, 2008
...dạ dày Umidox-100 (Doxycylinc 100mg) nhập khẩu, trước đây có giá 20.000 đồng/hộp, nay báo giá tăng lên 28.000 đồng/hộp (40%); CimetiDine 400mg tăng 90%. Nhân Dân,

Quản lý giá thuốc: Ä?au đầu!  -  Jul 14, 2008
Trung tâm Thương mại Dược phẩm quận 10 (TPHCM), một số loại thuốc trị tim mạch, đái tháo đư�ng, đư�ng ruột, dạ dày (Doxycylinc 100mg, CimetiDine 400mg… Nông Nghiệp,

Heartburn drug "cured" her warts  -  Jun 8, 2008
Finally, we gave her cimetidine daily for eight weeks, and they just disappeared. A: The cimetidine (Tagamet) "cure" for warts was first written about in Seattle Times,

Popular Prescriptions Can Cause Drug Dependence  -  Jun 12, 2008
Q: We gave our 6-year-old daughter a heartburn medicine, cimetidine, for her warts. It's amazing! After months of visits to the dermatologist, RedOrbit,

Cocaine damages fetal brain development - Study  -  Jun 11, 2008
The researchers also showed with their study that when pregnant rats were treated with ‘cimetidine’, a medicinal drug used to lower stomach acid secretion, HealthJockey.com,

New PANalytical XRPD Data Supports High Throughput, High ...  -  Jun 10, 2008
Now, sample data collected on Cimetidine (a histamine receptor antagonist), bovine insulin, and other complex organic materials, shows how the X'Pert PRO PharmaLive.com (press release),

How Cocaine Impairs Fetal Brain Development  -  Jun 12, 2008
They also showed that treatment of pregnant rats with cimetidine, a drug used to reduce stomach acid secretion and interferes with the enzymes that Science Daily (press release)

DR. HOOK- Keep it up: Health, exercise mean good sexual health  -  Jun 19, 2008
Cimetidine, an over-the-counter antacid, can lower hormonal levels to lead to sexual dysfunction. Spironolactone, a type of BP medication, can do the same. The Hook,

Article by HairlossTalk.com  -  Jun 12, 2008
...discussion on Progesterone, Cyproterone Acetate (another well known antiandrogen in Canada and Europe, but not so well known in the US), and Cimetidine. Hairloss Talk Newsletter

Researchers Learn More About Cocaine Related Brain Damage  -  Jun 10, 2008
By treating pregnant rats with the stomach acid drug cimetidine, which also interferes with the enzymes that metabolize cocaine, the researchers were Medical News Today,

Morphological evidences indicate that the interference of ...  -  May 9, 2008
Cimetidine, referred as antiandrogenic agent, has caused alterations in the seminiferous tubules, including alterations in the peritubular tissue and death 7thSpace Interactive (press release),

AGS: A Little Anticholinergic Burden Can Be Disabling  -  May 6, 2008
Patients who were taking one moderately anticholinergic drug, such as cimetidine (Tagamet), or two mildly anticholinergic drugs -- such as furosemide and MedPage Today,

Tecumseh Police Report  -  May 30, 2008
During the pat down of Blassingame, a syringe was found in his pocket and hydrocodone and cimetidine was found in his vehicle. € Charles Richard Harris, 26, Pottawatomie Online,

Part two: Are Hormones Safe?  -  May 23, 2008
...who have been exposed to xenoestrogens (man-made estrogenic toxins like DDT) and certain drugs like cimetidine make too much of this dangerous estrogen. Seattle Post Intelligencer

Black-Spot Poison Ivy  -  May 28, 2008
She was treated with intravenous diphenhydramine, methyl prednisolone, and cimetidine. Since the last episode, she has strictly avoided poison ivy exposure Abkhazia,

Topical creams and lotions won't suppress itch of hives  -  May 14, 2008
Cimetidine and ranitidine are heartburn medicines. They're also antihistamines, and they can be paired with standard antihistamines for a one-two punch. SouthCoastToday.com,

NPS Appoints Dr. Bo Joelsson as Head of Clinical Research  -  May 13, 2008
He has led the clinical development of several major gastrointestinal products, including Tagamet® (cimetidine), Prilosec® (omeprazole), Business Wire (press release),

Regulatory Filing for FACTIVE Tablets Submitted in Europe  -  May 7, 2008
No significant drug-drug interactions were seen with theophylline, digoxin, oral contraceptives, cimetidine, omeprazole, and warfarin, although patients Centre Daily Times,

Brand Names/Synonyms:
Cimetidine is also known by the following brand names and/or synonymsAcibilin; Acinil; CIMETIDINE A/AB; Carbamazapine; Cimal; Cimetag; Cimetidine; Cimetidine Hcl; Cimetum; Dyspamet; Edalene; Eureceptor; FPF 1002; Gastromet; Peptol; Tagamet; Tagamet Hb; Tagamet Hb 200; Tametin; Tratul; Ulcedin; Ulcedine; Ulcerfen; Ulcimet; Ulcofalk; Ulcomedina; Ulcomet; Ulhys

Drug Category:
Cimetidine is categorized under the following by the FDA: Analgesics; Anti-ulcer Agents; Adjuvants; Histamine Antagonists; ATC:A02BA01

Dosage Forms:
Tablets; Oral solution

Absorption:
Rapid 60-70%

Interactions:
-->Interactions for Cimetidine:

Tagamet, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.

Clinically significant effects have been reported with the warfarin anticoagulants; therefore, close monitoring of prothrombin time is recommended, and adjustment of the anticoagulant dose may be necessary when Tagamet is administered concomitantly. Interaction with phenytoin, lidocaine and theophylline has also been reported to produce adverse clinical effects.

However, a crossover study in healthy subjects receiving either Tagamet 300 mg q.i.d. or 800 mg h.s. concomitantly with a 300 mg b.i.d. dosage of theophylline (Theo-Dur®, Key Pharmaceuticals, Inc.) demonstrated less alteration in steady-state theophylline peak serum levels with the 800 mg h.s. regimen, particularly in subjects aged 54 years and older. Data beyond 10 days are not available. (Note: All patients receiving theophylline should be monitored appropriately, regardless of concomitant drug therapy.)

Dosage of the drugs mentioned above and other similarly metabolized drugs, particularly those of low therapeutic ratio or in patients with renal and/or hepatic impairment, may require adjustment when starting or stopping concomitantly administered Tagamet to maintain optimum therapeutic blood levels.

Alteration of pH may affect absorption of certain drugs (e.g., ketoconazole). If these products are needed, they should be given at least 2 hours before cimetidine administration.

Additional clinical experience may reveal other drugs affected by the concomitant administration of Tagamet.

 




Chemical IUPAC Name:
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine

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