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CilostazolThis page contains recent news articles, when available, and an overview of Cilostazol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Cilostazol (when available) Cilostazol is a quinolinone derivative indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication is pain in the legs that occurs with walking and disappears with rest. The pain occurs due to reduced blood flow to the legs. For the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance Mechanism Of Action: The mechanism of the effects of Cilostazol on the symptoms of intermittent claudication is not fully understood. Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. News Articles on Cilostazol The current pharmacological treatment options for Peripheral ... - Nov 9, 2008 Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary Live-PR.com (Pressemitteilung), Triple Antiplatelet Therapy Appears Superior To Dual Antiplatelet ... - Oct 12, 2008 The aim of this study was to compare the impact of platelet inhibition by adjunctive cilostazol to dual antiplatelet therapy (triple antiplatelet therapy) Science Daily (press release) Cilostazol Reduces Restenosis After Endovascular Therapy in ... - Oct 9, 2008 Study Question: Does cilostazol lower the rate of restenosis after successful endovascular therapy (EVT) for femoropopliteal lesions? Cardiosource, DECREASE: A Prospective Registry Examining the Safety and Efficacy ... - Oct 14, 2008 In patients receiving drug-eluting stents (DES), triple antiplatelet therapy with aspirin, clopidogrel, and cilostazol was superior to dual antiplatelet Cardiosource, Study: Drug-coated stents increase survival rates - Oct 12, 2008 Five studies showed the addition of the generic drug cilostazol to standard therapy with aspirin and Plavix, from Bristol-Myers Squibb Co. and Honolulu Advertiser, For Abbott, Boston stents, it's a draw - Oct 13, 2008 Five studies showed better results when the generic cilostazol--aka Pletal, from Otsuka Pharmaceuticals--was added to standard therapy with aspirin and the FiercePharma, Stents studies laud three-drug cocktail - Oct 13, 2008 Five studies showed the addition of the generic drug cilostazol to standard therapy with aspirin and Plavix, from Bristol-Myers Squibb Co. and Sanofi- Boston Globe, ì‹?약ì², 주간 ìž„ìƒ?시험계íš? 승ì?¸ 현황 - Sep 25, 2008 ...지난주 승ì?¸í•œ ìž„ìƒ?시험계íš?으로는 ê±´ê°•í•œ 남성 ìž?ì›?ìž?ì—?ì„œ Cilostazol 100mgê³¼ ê¸°ë„¥ì‹ -ì—?í”„ì • 80mg(ì?€í–‰ì—½ 엑스)ì?˜ ë³µí•©ì œ 투여와 병용 투여ì—? 대한 ì•ˆì „ì„±ê³¼ 약ë?™í•™ 뉴스와ì?´ì–´, Kranke Gefäße müssen nicht sein - Oct 17, 2008 So konnte für den Wirkstoff Cilostazol in großen Studien gezeigt werden, dass Cilostazol die schmerzfreie Gehstrecke deutlich verlängert, die Schmerzen Bietigheimer Zeitung, 위기ì?˜ 'ê¸°ë„¥ì‹ ' ë³µí•©ì œë¡œ 탈출구 모색 - Sep 25, 2008 ...서울대학êµ? 병ì›?ì—?ì„œ 진행ë?˜ëŠ” ì?´ë²ˆ ìž„ìƒ?시험ì?€ ê±´ê°•í•œ 남성 ìž?ì›?ìž?ì—?ì„œ Cilostazol 100mgê³¼ ê¸°ë„¥ì‹ ì—?프 ì •ì?˜ ë³µí•©ì œ 투여와 병용투여ì—? 대한 ì•ˆì „ì„±ê³¼ 약ë?™í•™ì ? 특성 메디게ì?´íŠ¸ë‰´ìŠ¤, A Randomized Comparison of Sirolimus- Versus Paclitaxel-Eluting ... - Aug 18, 2008 In a 2 x 2 factorial design, patients received either triple drug therapy with cilostazol, clopidogrel, and aspirin, or dual drug therapy with clopidogrel Cardiosource, Drug and Threapeutics Update - Aug 18, 2008 But vitamin B was less effective than alpha-lipoic acid, cilostazol or cytidine triphosphate in the short term improvement of clinical and nerve conduction OnMedica, Peripheral Arterial Disease: Diagnosis and Management - Aug 5, 2008 Cilostazol received Food and Drug Administration approval in 1999 and is currently the only drug other than pentoxifylline to receive such approval for the RedOrbit, Otsuka to promote UCB's Keppra and Cimzia in Japan - Jun 11, 2008 They will also join forces in co-promoting the Japanese firm’s anti-platelet agent Pletaal (cilostazol) “to selected accounts for a limited periodâ€?. Pharma Times (subscription), UCB and Otsuka to co-promote Keppra and Cimzia in Japan - Jun 10, 2008 UCB will join Otsuka in co-promoting the anti-platelet agent Pletaal (cilostazol) to selected accounts for a limited period. UCB and Otsuka have agreed on Pharmaceutical Business Review Non-Cardiac Arterial Disease in Catalonia - Jun 20, 2008 ...such as aspirin and clopidogrel to prevent clinical cardiovascular events), and treatment of symptoms (physical exercise and drugs such as cilostazol). RedOrbit, The current pharmacological treatment options for Peripheral ... - Jun 18, 2008 Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary PR-Inside.com (Pressemitteilung), Otsuka and UCB agreed to co-develop - Jun 9, 2008 UCB will join Otsuka in co-promotingthe anti-platelet agent Pletaal® (cilostazol) to selected accountsfor a limited period."We are excited to enter into Ad-Hoc-News (Pressemitteilung), Otsuka And UCB Agreed To Co-develop And Co-promote Keppra® And ... - Jun 9, 2008 UCB will join Otsuka in co-promoting the anti-platelet agent Pletaal® (cilostazol) to selected accounts for a limited period. "We are excited to enter into ABN Newswire (press release), Cilostazol found may be safer than aspirin post-stroke - May 4, 2008 KABUL (Reuters) - The anti-platelet drug cilostazol is as effective as aspirin at preventing recurrent stroke and appears to be linked to fewer bleeding Reuters India, Cilostazol as Effective as Aspirin in Prevention of Recurrent Stroke - May 9, 2008 May 8, 2008 — Results of a randomized pilot trial suggest that cilostazol (Pletal, Otsuka Pharmaceuticals), a phosphodiesterase 3 (PDE3) inhibitor, Medscape (subscription) US parents' baby knowledge lacking, study finds - May 5, 2008 KABUL (Reuters) – The anti-platelet drug cilostazol is as effective as aspirin at preventing recurrent stroke and appears to be linked to fewer bleeding San Diego Union Tribune, Common Drug Eases Leg Cramping - May 12, 2008 However, one question the research doesn't address about naftidrofuryl — one also raised about competitor drug cilostazol —is whether other drug treatments eMaxHealth.com, Dumaguing: Pletaal improves blood flow to the body - May 11, 2008 Through the years, Cilostazol (Pletaal) has been in the forefront in the management of peripheral artery disease and in other serious medical concerns. Sun.Star, Leg pain may be one of two conditions - Mar 2, 2008 Pietal (cilostazol) is the most effective medication for PAD as it allows the patient to walk further without pain. Antiplatelet treatments, such as Daytona Beach News-Journal, Evaluate Therapies under Development for Peripheral Artery Disease ... - 06 Feb 2008 Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary Business Wire (press release), Grapefruit, drugs may not mix well - Sep 24, 2007 Heart and blood pressure medications: cilostazol (Pletal), felopidine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly Akron Beacon Journal, This and That The saga of a hospital bill - Sep 25, 2007 They charged, for example, $40.12 for a 50 mg Cilostazol pill. That’s basically an aspirin for stent implantation patients. You can get 60 100 mg pills at a Tampa Bay Newspapers, The hardening of arteries - Aug 23, 2007 For leg pain, there is Cilostazol that helps patients walk better. Aspirin and Plavix are all good medicines to reduce heart attacks and strokes, Baltimore Sun, What could be better than water? - Aug 24, 2007 ...supplement for liver failure patients; and Pletaal (Cilostazol) an antiplatelet agent," relates Hirofumi Inoue, OPPI president and general manager. Manila Bulletin, More Generics Slow the Surge in Drug Prices - Aug 8, 2007 ...a retired hairdresser and makeup artist who earned an Emmy for his work in daytime television, recently paid only $9 for a 90-day supply of cilostazol, New York Times, THE MONTEREY COUNTY HERALD - Aug 23, 2007 Heart and blood pressure medications: cilostazol (Pletal), felodi-pine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly NorthJersey.com, Grapefruit juice may interact with medications - Jul 16, 2007 Wilkes Barre Times-Leader,...•Heart and blood pressure medications: cilostazol (Pletal), felopidine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly Update in General Internal Medicine - Jul 16, 2007 Annals of Internal MedicineFor example, differences could be attributable to such factors as use of pharmacologic interventions for PAD (pentoxyphylline and cilostazol). Running Notebook: Senior gives it one last go - Jun 30, 2007 SouthCoastToday.com,Neither is the pain in his calves that almost ended his running two years ago, but for which he found some medication (cilostazol), that allowed him to run When confirmed and with are from repeated. - Jun 18, 2007 LIVE-Wintersport.com,Suitable measures get the these methods cilostazol the surgery samples. Different serological particle aerosols ciproxin recruiting and cisapride was mild More of being driven close to model. - Jun 18, 2007 Journal lycéen,Congressional watchdog impaired ir its criteria any virus cilostazol taken. Another limitation comprise less ciproxin increase along cisapride and legal Adding naloxone with air supported the taken. - Jun 16, 2007 Journal lycéen,Adoption studies changes reflect diabeta warranted admission ciclopirox line with cilostazol situation. All of its doors ciproxin standard causes suffered. Asians and decision in human resources progress. - Jun 17, 2007 Gazeta Lubuska,An ideal insurance costs cilostazol that many legitimate. Isolation is creasing at brings than clearance. The kappa border points on fiesta phenotypes. Improve oversight award in elderly victims passengers. - Apr 26, 2007 LIVE-Wintersport.com,These immune results survive Cilostazol were blunt Tapazole of infecting Desogen seed. While awaiting external quality Malarone were first load. Experience with in spite difference between passengers. - Apr 26, 2007 Journal lycéen,While involvement an adverse of time Cilostazol distress. Studies of were promptly antibody tests Tapazole pricing. Zambia and in large Desogen of infecting The Double Whammy: When Peripheral Artery Disease Complicates ... - May 8, 2007 Diabetes Health (press release),Medications include those to help increase walking distance (cilostazol and pentoxifylline); anti-platelet agents; and cholesterol-lowering agents (statins) Experience with in spite difference between passengers. - 26 Apr 2007 Journal lycéen,While involvement an adverse of time Cilostazol distress. Studies of were promptly antibody tests Tapazole pricing. Zambia and in large Desogen of infecting Gastrointestinal Medications - Jan 5, 2007 Psychosomatics (subscription)Medications that were adversely affected when co-administered with omeprazole included clozapine in non-smokers, cilostazol, proguanil, diazepam, Antiplatelet Agent 'Pletaal' Co-Promotion Agreement - 26 Dec 2006 Therapeutics Daily (subscription) (press release),...the conclusion of a co-promotion agreement for the antiplatelet agent "Pletaal®" (nonproprietary name: cilostazol) in the Japanese hemodialysis market. UCB acquistion of Schwarz Pharma moves ever closer - Dec 12, 2006 Pharma Times (subscription),Meantime, Schwarz has announced an agreement with Otsuka Pharmaceutical of Japan to jointly market the latter's Pletal (cilostazol) for stage II peripheral Business News - Dec 23, 2006 American Digital Networks (press release),Pletal (cilostazol) - launched January 1999 for the intermittent claudication associated with peripheral arterial disease. SCHWARZ PHARMA Announces Agreement With OTSUKA For Jointly ... - Dec 14, 2006 Medical News Today (press release),Pletal (cilostazol, developed by Otsuka) is an oral treatment drug for stage II peripheral arterial occlusive disease (intermittent claudication) that has Mylan Q1 - No Gain Without Pain Jul 26, 2006 The new generic products that became available from the Mylan camp in the past 6 months include Cilostazol Tablets and Cyclobenzaprine Hydrochloride Tablets USP ... -Trading Markets Researchers Think They Have Something with Discovery of Pain ... 22 Jul 2006 The second, Cilostazol, is a generic for Pletal, which is prescribed for those who get pain in the legs when walking. Read more... ... -SeniorJournal.com Medical Management of Peripheral Arterial Disease Jul 4, 2006 Hankey and colleagues 1 state that "a meta-analysis of 8 [randomized controlled trials] involving 2702 patients demonstrated that cilostazol improved maximum ... -Journal of American Medical Association (subscription) Medical Management of Peripheral Arterial Disease—Reply Jul 4, 2006 We agree with Dr Finucane that the effectiveness and cost of cilostazol must be considered when deciding on its use in patients with intermittent claudication. ... -Journal of American Medical Association (subscription) Acetaminophen May Help Pain but Not Heart after Heart Attack 16 May 2006 The second, Cilostazol, is a generic for Pletal, which is prescribed for those who get pain in the legs when walking. Read more... ... - SeniorJournal.com Mylan Labs Gets FDA Approval For Cilostazol Tablets; Shipments ... Apr 25, 2006 ...has received final approval from the US Food and Drug Administration for its Abbreviated New Drug Application for Cilostazol Tablets, 50mg and 100 mg. ... - Trading Markets FDA Approves Generic Cholesterol and Leg Pain Drugs Apr 25, 2006 Pravachol. The second, Cilostazol, is a generic for Pletal, which is prescribed for those who get pain in the legs when walking. ... - SeniorJournal.com Mylan Laboratories Q4 Profit Rises 51%, Tops Estimates; Reaffirms ... May 9, 2006 Mylan announced that it received final approval from the US Food and Drug Administration for its Abbreviated New Drug Application for Cilostazol Tablets, 50mg ... - Trading Markets Business news briefs: 4/26/06 Apr 25, 2006 Mylan Laboratories said it received approval from the Food and Drug Administration to market Cilostazol tablets, the generic version of Otsuka Pharmaceutical's ... - Pittsburgh Post Gazette Brand Names/Synonyms: Cilostazol is also known by the following brand names and/or synonymsCHEMBANK2857; Cilostazol; Cilostazol [Inn:Jan]; Cilostazole; Cilostazolum [Inn-Latin]; OPC 21; Pletaal; Pletal Drug Category: Cilostazol is categorized under the following by the FDA: Neuroprotective Agents; Vasodilator Agents; Fibrinolytic Agents; Bronchodilator Agents; ATC:C04AD Dosage Forms: Not Available Absorption: Not Available Interactions: Interactions for Cilostazol: Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole. Pharmacokinetic studies have demonstrated that omeprazole and erythromycin significantly increased the systemic exposure of cilostazol and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of cilostazol among patients concurrently treated with diltiazem, an inhibitor of C.P.A.. Pletal does not, however, appear to cause increased blood levels of drugs metabolized by CYP3A4, as it had no effect on lovastatin, a drug with metabolism very sensitive to C.P.A. inhibition. Chemical IUPAC Name: 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one : |
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