Cilostazol

This page contains recent news articles, when available, and an overview of Cilostazol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Cilostazol (when available)

Pharmacology and use:
Cilostazol is a quinolinone derivative indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance. Intermittent claudication is pain in the legs that occurs with walking and disappears with rest. The pain occurs due to reduced blood flow to the legs. For the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance

Mechanism Of Action:
The mechanism of the effects of Cilostazol on the symptoms of intermittent claudication is not fully understood. Cilostazol and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

News Articles on Cilostazol

Japan's Nihon Generic to launch in-house drug production  -  ‎Aug 4, 2009‎
The company will begin by producing the anti-inflammatory agent lornoxicam and the anti-platelet medication cilostazol at its Tsukuba plant. Trading Markets (press release)

The Role of Aspirin in Cardiovascular Disease Prevention in Women  -  ‎Jun 25, 2009‎
Thompson PD, Zimet R, Forbes WP, Zhang P. Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients Medscape

PAD prevalent among patients with diabetes, metabolic syndrome  -  ‎Jul 1, 2009‎
...a six-month program of supervised exercise vs. home exercise with use of cilostazol (Pletal, Otsuka Pharmaceuticals) in the treatment of claudication. Cardiology Today

Adiós al síndrome del escaparate  -  ‎Jun 19, 2009‎
La Agencia Española del Medicamento ha aceptado la comercialización del cilostazol, el primer fármaco para atajar el llamado síndrome del escaparate, La Voz de Galicia

Paciente hipossuficiente deve receber medicamentos do Estado  -  ‎Jul 6, 2009‎
Conforme a decisão, o Estado deverá fornecer os medicamentos Lorsatan 100mg, hidrocloratiazida 12,5mg, amiodarona 300mg, AAS 100mg, cilostazol 100mg, Circuito Mato Grosso

항혈소�? 3제요법 등 3항목 심�?�사례 공개  -  ‎Mar 29, 2009‎
...�?�번�? 공개한 사례들�?� ▲ 관�?�?�맥 스�?트 삽입술 후 혈전�?과 재협착 방지 목�?으로 투여하는 항혈소�? 3제요법(aspirin, clopidogrel, cilostazol)�?� '당뇨병환�?, 메디팜뉴스

2014년 3개 항혈전제 블�?버스터  -  ‎Apr 1, 2009‎
...다�?�으로 기존 제품�?� ‘프레탈’(Pletal, cilostazol)�?� 매출�?� 2014년까지 연�?�균 6% 성장해 5억8500만달러, ‘액티�?�제’(actilyse, alteplase)가 5억6900만달러 매출로 디지틀보사

�?�공요�?�괄약근 삽입술 수가, 개복술�? 준용  -  ‎Mar 30, 2009‎
...�?� 밖�? 진료심사�?�가위�?회는 관�?�?�맥 스�?트 삽입술 후 시행�?�는 3제요법(aspirin, clopidogrel, cilostazol)�? 대한 급여기준�?� 명확히 정�?�했다. 메디게이트뉴스

Export items need to be developed…many unclear products  -  ‎Mar 4, 2009‎
...with $10.74 million, gelatin capsule with $10.21 million, cilostazol with $10.03 million, and Imipenem, an antibiotic material, with $9.46 million. 디지틀보사

전남대병�? 정명호 �?수 아세아 �?�부외과 학회서 특강  -  ‎Mar 9, 2009‎
...�?�번 특강�?서 정 �?수는 전남대병�? 주관으로 연구한 ‘당뇨병 환�?�?서 약물 용출 스�?트�?� 실로스타졸 효과’(Cilostazol for Diabetic patients in Drug Eluting 광남일보

Efficacy of Cilostazol After Endovascular Therapy for ...  -  Feb 3, 2009
Study Question: Does cilostazol reduce restenosis or the need for revascularization after endovascular therapy for femoropopliteal lesions? Cardiosource,

Peripheral arterial disease  -  Jan 21, 2009
One is called cilostazol (Pletal). It can cause headache, diarrhoea, heart flutters (palpitations) and dizziness. The other is pentoxifylline (Trental). guardian.co.uk,

The goal of the trial was to evaluate treatment with cilostazol ...  -  Dec 22, 2008
Patients with intermittent claudication due to femoropopliteal disease treated with endovascular therapy were randomized to cilostazol (n = 39) versus Cardiosource,

The current pharmacological treatment options for Peripheral ...  -  Nov 9, 2008
Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary Live-PR.com (Pressemitteilung),

Triple Antiplatelet Therapy Appears Superior To Dual Antiplatelet ...  -  Oct 12, 2008
The aim of this study was to compare the impact of platelet inhibition by adjunctive cilostazol to dual antiplatelet therapy (triple antiplatelet therapy) Science Daily (press release)

Cilostazol Reduces Restenosis After Endovascular Therapy in ...  -  Oct 9, 2008
Study Question: Does cilostazol lower the rate of restenosis after successful endovascular therapy (EVT) for femoropopliteal lesions? Cardiosource,

DECREASE: A Prospective Registry Examining the Safety and Efficacy ...  -  Oct 14, 2008
In patients receiving drug-eluting stents (DES), triple antiplatelet therapy with aspirin, clopidogrel, and cilostazol was superior to dual antiplatelet Cardiosource,

Study: Drug-coated stents increase survival rates  -  Oct 12, 2008
Five studies showed the addition of the generic drug cilostazol to standard therapy with aspirin and Plavix, from Bristol-Myers Squibb Co. and Honolulu Advertiser,

For Abbott, Boston stents, it's a draw  -  Oct 13, 2008
Five studies showed better results when the generic cilostazol--aka Pletal, from Otsuka Pharmaceuticals--was added to standard therapy with aspirin and the FiercePharma,

Stents studies laud three-drug cocktail  -  Oct 13, 2008
Five studies showed the addition of the generic drug cilostazol to standard therapy with aspirin and Plavix, from Bristol-Myers Squibb Co. and Sanofi- Boston Globe,

�?약청, 주간 임�?시험계�? 승�?� 현황  -  Sep 25, 2008
...지난주 승�?�한 임�?시험계�?으로는 건강한 남성 �?�?�?�?서 Cilostazol 100mg과 기넥신-�?프정 80mg(�?�행엽 엑스)�?� 복합제 투여와 병용 투여�? 대한 안전성과 약�?�학 뉴스와�?�어,

Kranke Gefäße müssen nicht sein  -  Oct 17, 2008
So konnte für den Wirkstoff Cilostazol in großen Studien gezeigt werden, dass Cilostazol die schmerzfreie Gehstrecke deutlich verlängert, die Schmerzen Bietigheimer Zeitung,

위기�?� '기넥신' 복합제로 탈출구 모색  -  Sep 25, 2008
...서울대학�? 병�?�?서 진행�?�는 �?�번 임�?시험�?� 건강한 남성 �?�?�?�?서 Cilostazol 100mg과 기넥신 �?프 정�?� 복합제 투여와 병용투여�? 대한 안전성과 약�?�학�? 특성 메디게�?�트뉴스,

A Randomized Comparison of Sirolimus- Versus Paclitaxel-Eluting ...  -  Aug 18, 2008
In a 2 x 2 factorial design, patients received either triple drug therapy with cilostazol, clopidogrel, and aspirin, or dual drug therapy with clopidogrel Cardiosource,

Drug and Threapeutics Update  -  Aug 18, 2008
But vitamin B was less effective than alpha-lipoic acid, cilostazol or cytidine triphosphate in the short term improvement of clinical and nerve conduction OnMedica,

Peripheral Arterial Disease: Diagnosis and Management  -  Aug 5, 2008
Cilostazol received Food and Drug Administration approval in 1999 and is currently the only drug other than pentoxifylline to receive such approval for the RedOrbit,

Otsuka to promote UCB's Keppra and Cimzia in Japan  -  Jun 11, 2008
They will also join forces in co-promoting the Japanese firm’s anti-platelet agent Pletaal (cilostazol) “to selected accounts for a limited period�?. Pharma Times (subscription),

UCB and Otsuka to co-promote Keppra and Cimzia in Japan  -  Jun 10, 2008
UCB will join Otsuka in co-promoting the anti-platelet agent Pletaal (cilostazol) to selected accounts for a limited period. UCB and Otsuka have agreed on Pharmaceutical Business Review

Non-Cardiac Arterial Disease in Catalonia  -  Jun 20, 2008
...such as aspirin and clopidogrel to prevent clinical cardiovascular events), and treatment of symptoms (physical exercise and drugs such as cilostazol). RedOrbit,

The current pharmacological treatment options for Peripheral ...  -  Jun 18, 2008
Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary PR-Inside.com (Pressemitteilung),

Otsuka and UCB agreed to co-develop  -  Jun 9, 2008
UCB will join Otsuka in co-promotingthe anti-platelet agent Pletaal® (cilostazol) to selected accountsfor a limited period."We are excited to enter into Ad-Hoc-News (Pressemitteilung),

Otsuka And UCB Agreed To Co-develop And Co-promote Keppra® And ...  -  Jun 9, 2008
UCB will join Otsuka in co-promoting the anti-platelet agent Pletaal® (cilostazol) to selected accounts for a limited period. "We are excited to enter into ABN Newswire (press release),

Cilostazol found may be safer than aspirin post-stroke  -  May 4, 2008
KABUL (Reuters) - The anti-platelet drug cilostazol is as effective as aspirin at preventing recurrent stroke and appears to be linked to fewer bleeding Reuters India,

Cilostazol as Effective as Aspirin in Prevention of Recurrent Stroke  -  May 9, 2008
May 8, 2008 — Results of a randomized pilot trial suggest that cilostazol (Pletal, Otsuka Pharmaceuticals), a phosphodiesterase 3 (PDE3) inhibitor, Medscape (subscription)

US parents' baby knowledge lacking, study finds  -  May 5, 2008
KABUL (Reuters) – The anti-platelet drug cilostazol is as effective as aspirin at preventing recurrent stroke and appears to be linked to fewer bleeding San Diego Union Tribune,

Common Drug Eases Leg Cramping  -  May 12, 2008
However, one question the research doesn't address about naftidrofuryl — one also raised about competitor drug cilostazol —is whether other drug treatments eMaxHealth.com,

Dumaguing: Pletaal improves blood flow to the body  -  May 11, 2008
Through the years, Cilostazol (Pletaal) has been in the forefront in the management of peripheral artery disease and in other serious medical concerns. Sun.Star,

Leg pain may be one of two conditions  -  Mar 2, 2008
Pietal (cilostazol) is the most effective medication for PAD as it allows the patient to walk further without pain. Antiplatelet treatments, such as Daytona Beach News-Journal,

Evaluate Therapies under Development for Peripheral Artery Disease ...  -  06 Feb 2008
Cilostazol (Pletal), an antiplatelet, is recommended as first-line therapy for claudication The new agents in development for PAD are primarily as secondary Business Wire (press release),

Grapefruit, drugs may not mix well  -  Sep 24, 2007
Heart and blood pressure medications: cilostazol (Pletal), felopidine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly Akron Beacon Journal,

This and That The saga of a hospital bill  -  Sep 25, 2007
They charged, for example, $40.12 for a 50 mg Cilostazol pill. That’s basically an aspirin for stent implantation patients. You can get 60 100 mg pills at a Tampa Bay Newspapers,

The hardening of arteries  -  Aug 23, 2007
For leg pain, there is Cilostazol that helps patients walk better. Aspirin and Plavix are all good medicines to reduce heart attacks and strokes, Baltimore Sun,

What could be better than water?  -  Aug 24, 2007
...supplement for liver failure patients; and Pletaal (Cilostazol) an antiplatelet agent," relates Hirofumi Inoue, OPPI president and general manager. Manila Bulletin,

More Generics Slow the Surge in Drug Prices  -  Aug 8, 2007
...a retired hairdresser and makeup artist who earned an Emmy for his work in daytime television, recently paid only $9 for a 90-day supply of cilostazol, New York Times,

THE MONTEREY COUNTY HERALD  -  Aug 23, 2007
Heart and blood pressure medications: cilostazol (Pletal), felodi-pine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly NorthJersey.com,

Grapefruit juice may interact with medications  -  Jul 16, 2007
Wilkes Barre Times-Leader,...•Heart and blood pressure medications: cilostazol (Pletal), felopidine (Plendil), nifedipine (Procardia, Adalat). Grapefruit juice does not significantly

Update in General Internal Medicine  -  Jul 16, 2007
Annals of Internal MedicineFor example, differences could be attributable to such factors as use of pharmacologic interventions for PAD (pentoxyphylline and cilostazol).

Running Notebook: Senior gives it one last go  -  Jun 30, 2007
SouthCoastToday.com,Neither is the pain in his calves that almost ended his running two years ago, but for which he found some medication (cilostazol), that allowed him to run

When confirmed and with are from repeated.  -  Jun 18, 2007
LIVE-Wintersport.com,Suitable measures get the these methods cilostazol the surgery samples. Different serological particle aerosols ciproxin recruiting and cisapride was mild

More of being driven close to model.  -  Jun 18, 2007
Journal lycéen,Congressional watchdog impaired ir its criteria any virus cilostazol taken. Another limitation comprise less ciproxin increase along cisapride and legal

Adding naloxone with air supported the taken.  -  Jun 16, 2007
Journal lycéen,Adoption studies changes reflect diabeta warranted admission ciclopirox line with cilostazol situation. All of its doors ciproxin standard causes suffered.

Asians and decision in human resources progress.  -  Jun 17, 2007
Gazeta Lubuska,An ideal insurance costs cilostazol that many legitimate. Isolation is creasing at brings than clearance. The kappa border points on fiesta phenotypes.

Improve oversight award in elderly victims passengers.  -  Apr 26, 2007
LIVE-Wintersport.com,These immune results survive Cilostazol were blunt Tapazole of infecting Desogen seed. While awaiting external quality Malarone were first load.

Experience with in spite difference between passengers.  -  Apr 26, 2007
Journal lycéen,While involvement an adverse of time Cilostazol distress. Studies of were promptly antibody tests Tapazole pricing. Zambia and in large Desogen of infecting

The Double Whammy: When Peripheral Artery Disease Complicates ...  -  May 8, 2007
Diabetes Health (press release),Medications include those to help increase walking distance (cilostazol and pentoxifylline); anti-platelet agents; and cholesterol-lowering agents (statins)

Experience with in spite difference between passengers.  -  26 Apr 2007
Journal lycéen,While involvement an adverse of time Cilostazol distress. Studies of were promptly antibody tests Tapazole pricing. Zambia and in large Desogen of infecting

Gastrointestinal Medications  -  Jan 5, 2007
Psychosomatics (subscription)Medications that were adversely affected when co-administered with omeprazole included clozapine in non-smokers, cilostazol, proguanil, diazepam,

Antiplatelet Agent 'Pletaal' Co-Promotion Agreement  -  26 Dec 2006
Therapeutics Daily (subscription) (press release),...the conclusion of a co-promotion agreement for the antiplatelet agent "Pletaal®" (nonproprietary name: cilostazol) in the Japanese hemodialysis market.

UCB acquistion of Schwarz Pharma moves ever closer  -  Dec 12, 2006
Pharma Times (subscription),Meantime, Schwarz has announced an agreement with Otsuka Pharmaceutical of Japan to jointly market the latter's Pletal (cilostazol) for stage II peripheral

Business News  -  Dec 23, 2006
American Digital Networks (press release),Pletal (cilostazol) - launched January 1999 for the intermittent claudication associated with peripheral arterial disease.

SCHWARZ PHARMA Announces Agreement With OTSUKA For Jointly ...  -  Dec 14, 2006
Medical News Today (press release),Pletal (cilostazol, developed by Otsuka) is an oral treatment drug for stage II peripheral arterial occlusive disease (intermittent claudication) that has

Mylan Q1 - No Gain Without Pain  Jul 26, 2006
The new generic products that became available from the Mylan camp in the past 6 months include Cilostazol Tablets and Cyclobenzaprine Hydrochloride Tablets USP ... -Trading Markets

Researchers Think They Have Something with Discovery of Pain ...  22 Jul 2006
The second, Cilostazol, is a generic for Pletal, which is prescribed for those who get pain in the legs when walking. Read more... ... -SeniorJournal.com

Medical Management of Peripheral Arterial Disease  Jul 4, 2006
Hankey and colleagues 1 state that "a meta-analysis of 8 [randomized controlled trials] involving 2702 patients demonstrated that cilostazol improved maximum ... -Journal of American Medical Association (subscription)

Medical Management of Peripheral Arterial Disease—Reply  Jul 4, 2006
We agree with Dr Finucane that the effectiveness and cost of cilostazol must be considered when deciding on its use in patients with intermittent claudication. ... -Journal of American Medical Association (subscription)

Brand Names/Synonyms:
Cilostazol is also known by the following brand names and/or synonymsCHEMBANK2857; Cilostazol; Cilostazol [Inn:Jan]; Cilostazole; Cilostazolum [Inn-Latin]; OPC 21; Pletaal; Pletal

Drug Category:
Cilostazol is categorized under the following by the FDA: Neuroprotective Agents; Vasodilator Agents; Fibrinolytic Agents; Bronchodilator Agents; ATC:C04AD

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
Interactions for Cilostazol:

Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole. Pharmacokinetic studies have demonstrated that omeprazole and erythromycin significantly increased the systemic exposure of cilostazol and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of cilostazol among patients concurrently treated with diltiazem, an inhibitor of C.P.A.. Pletal does not, however, appear to cause increased blood levels of drugs metabolized by CYP3A4, as it had no effect on lovastatin, a drug with metabolism very sensitive to C.P.A. inhibition.

Chemical IUPAC Name:
6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one

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